bioRxiv topic clustering, 2020 Jan-Oct

Topics are arranged from general to specific. Upvote and downvote topics as you go to home in on a subject of interest.

Topic 0   35234 items

Multi-tissue transcriptome-wide association studies 19 4
Assessing in vivo mutation frequencies and creating a high-resolution genome-wide map of fitness costs of Hepatitis C virus 21 5
Evolutionarily Conserved Transcription Factors Drive the Oxidative Stress Response in Drosophila 134 31 9 3


Topic 1   2069 items
sars cov covid 19 coronavirus
Many bat species are not potential hosts of SARS-CoV and SARS-CoV-2: Evidence from ACE2 receptor usage 36 1
Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement 36 24 1
Monoclonal antibodies for the S2 subunit of spike of SARS-CoV cross-react with the newly-emerged SARS-CoV-2 36 1


Topic 2   5199 items
neuroscience brain neural cortex task
No evidence for effect of reward motivation on coding of behaviorally relevant category distinctions across the frontoparietal cortex 23 22 2
Emergence of Non-Linear Mixed Selectivity in Prefrontal Cortex after Training 100 23 2
Complementary effects of adaptation and gain control on sound encoding in primary auditory cortex 23 2


Topic 3   8877 items
cells cell biology expression signaling
mTOR inhibition in primary neurons and the developing brain represses transcription of cholesterol biosynthesis genes and alters cholesterol levels 133 31 3
Evolutionarily Conserved Transcription Factors Drive the Oxidative Stress Response in Drosophila 134 31 9 3
AMP-activated-kinase (AMPK) is essential sensor and metabolic regulator of retinal neurons and their integrated metabolism with RPE. 72 3


Topic 4   5336 items
bioinformatics methods method data available
A deep learning framework for characterization of genotype data 26 4
A novel single-cell based method for breast cancer prognosis 43 26 4
HippoUnit: A software tool for the automated testing and systematic comparison of detailed models of hippocampal neurons based on electrophysiological data 62 4 2


Topic 5   5636 items
species evolutionary ecology diversity evolution
Soil microbial diversity impacts plant microbiomes more than herbivory 17 5
Phylogenetic and metabolic diversity have contrasting effects on the ecological functioning of bacterial communities 17 5
Evolutionary ecology of natural comammox Nitrospira populations 5


Topic 6   475 items
m_fig o_fig c_fig o_linksmallfig figdir
Improved stability of an engineered function using adapted bacterial strains 6
Untargeted LC-MS metabolomics for the analysis of micro-scaled extracellular metabolites from hepatocytes 6
Comprehensive Transcriptomic Analysis of COVID-19 Blood, Lung, and Airway 6 1


Topic 7   1057 items
declared authors competing statementthe text
Computational Model of G2-M DNA Damage Checkpoint Regulation in Normal and p53-null Cancer Cells 7 3
Independence of 3D chromatin conformation and gene regulation during Drosophila dorsoventral patterning 89 7 3
Simulating bout-and-pause patterns with reinforcement learning 7 2


Topic 8   3046 items
biophysics binding biochemistry proteins structural
State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane 163 91 82 8 3
The electrostatic allostery could be the trigger for the changes in dynamics for the PDZ domain of PICK1 63 8 3
Dynamics of chromosomal target search by a membrane-integrated one-component receptor 127 8 3


Topic 9   2647 items
genes gene expression genomics rna
Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure 89 19 9 4
Transcription initiation mapping in 31 bovine tissues reveals complex promoter activity, pervasive transcription, and tissue-specific promoter usage 134 9
Characterization of the nuclear and cytosolic transcriptomes in human brain tissue reveals new insights into the subcellular distribution of RNA transcripts 120 9 3


Topic 10   3110 items
mice treatment induced immunology inflammatory
Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses 88 27 10 3
Circulating levels of epirubicin cause endothelial senescence while compromising metabolic activity and vascular function 10 3
Remodeling gut microbiota by Streptococcus thermophilus 19 attenuates inflammation in septic mice 101 10 3


Topic 11   1596 items
neurons neuroscience synaptic neuronal excitatory
Hypomyelination leads to alterations in inhibitory function and parvalbumin-positive neuron density in auditory cortex 104 11 2
A critical role for trkB signaling in the adult function of parvalbumin interneurons and prefrontal network dynamics 104 11 2
Reduced dopamine signaling impacts pyramidal neuron excitability in mouse motor cortex 11 2


Topic 12   2192 items
microbiology bacteria bacterial strains resistance
Bacterial single-cell genomics enables phylogenetic analysis and reveals population structures from in vitro evolutionary studies 107 52 12 9 5 4
Comparative genomics reveals different population structures associated with host and geographic origin in antimicrobial-resistant Salmonella enterica 107 52 12 5
Linking phenotype, genotype and ecology: antimicrobial resistance in the zoonotic pathogen Streptococcus suis 107 52 12 5


Topic 13   893 items
github com https bioinformatics available
BATMAN: fast and accurate integration of single-cell RNA-Seq datasets via minimum-weight matching 147 43 13 4
Kmer2SNP: reference-free SNP calling from raw reads based on matching 13 4
Network-based imputation of dropouts in single-cell RNA sequencing data 147 43 13 4


Topic 14   1216 items
cancer tumor tumors biology cells
Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers 126 14 10 3
PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity 108 14 10 3
Epigenetic downregulation of HER2 during EMT leads to tumor resistance to HER2-targeted therapies in breast cancer 98 14 10 3


Topic 15   1819 items
were was age study compared
Effects of long-term in vivo micro-CT imaging on hallmarks of osteopenia and frailty in aging mice 15 2
Neutrophil to Lymphocyte Ratio (NLR) in captive chimpanzees (Pan troglodytes): The effects of sex, age, and rearing 15 5
Effect of MIND Diet Intervention on Cognitive Performance and Brain Structure in Healthy Obese Women: A Randomized Controlled Trial 75 15 2


Topic 16   1011 items
plant plants arabidopsis biology thaliana
Phosphoproteomics after nitrate treatments reveal an important role for PIN2 phosphorylation in control of root system architecture. 16 9 3
Bipartite influence of abscisic acid on xylem differentiation trajectories is dependent on distinct VND transcription factors in Arabidopsis 16 3
Disruption of CYCLOPHILIN 38 function reveals a photosynthesis-dependent systemic signal controlling lateral root emergence 16 3


Topic 17   1413 items
ecology communities species community ecological
Soil microbial diversity impacts plant microbiomes more than herbivory 17 5
Different temporal trends in vascular plant and bryophytes communities along elevational gradients over four decades of warming 17 5
Climate change and intensive land use reduce soil animal biomass through dissimilar pathways 17 5


Topic 18   1616 items
bioengineering imaging microscopy fluorescence biophysics
Three-Dimensional Label-Free Imaging and Quantification of Migrating Cells during Wound Healing 70 18 4
Single-molecule light-sheet microscopy with local nanopipette delivery 70 18 8
Learned SPARCOM: Unfolded Deep Super-Resolution Microscopy 184 70 26 18 4


Topic 19   616 items
association genetics gwas genetic wide
Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations 19 5 4
Pathway Analysis within Multiple Human Ancestries Reveals Novel Signals for Epistasis in Complex Traits 19 4
Detection of complex genetic architecture using two-locus population differentiation: modeling epistasis 19 9 4


Topic 20   1213 items
developmental embryonic stem differentiation biology
Akt is required for artery formation during embryonic vascular development 94 20 3
Notch Signaling Commits Mesoderm to the Cardiac Lineage 20 3
The Drosophila MLR COMPASS-like complex regulates bantam miRNA expression differentially in the context of cell fate 20 3


Topic 21   1223 items
evolutionary evolution selection biology populations
Experimental evolution confirms signatures of sexual selection in genomic divergence. 21 5
Temperature-dependent effects of house fly proto-Y chromosomes on gene expression act independently of the sex determination pathway 21 5
The evolution of sex-biased gene expression in the Drosophila brain 56 21 9 5


Topic 22   947 items
neuroscience brain fmri connectivity functional
Color naming and categorization depend on distinct functional brain networks 22 2
Behavioural relevance of spontaneous, transient brain network interactions in fMRI 22 2
The functional relevance of task-state functional connectivity 22 2


Topic 23   1191 items
neuroscience visual task participants stimulus
No evidence for effect of reward motivation on coding of behaviorally relevant category distinctions across the frontoparietal cortex 23 22 2
Task-Dependent Electrophysiological Signatures of Explicit Perceptual Timing 23 2
Previously reward-associated stimuli capture spatial attention in the absence of changes in the corresponding sensory representations as measured with MEG 23 2


Topic 24   457 items
antibodies neutralizing antibody vaccine spike
Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement 36 24 1
Preclinical study of DNA vaccines targeting SARS-CoV-2 24 1
Potent neutralizing antibodies in the sera of convalescent COVID-19 patients are directed against conserved linear epitopes on the SARS-CoV-2 spike protein 24 1


Topic 25   481 items
reads read sequencing genomics assembly
Comparison of long read methods for sequencing and assembly of a plant genome 25 4
GALA: gap-free chromosome-scale assembly with long reads 25 4
Comparison of the two up-to-date sequencing technologies for genome assembly: HiFi reads of Pacbio Sequel II system and ultralong reads of Oxford Nanopore 25 4


Topic 26   892 items
learning deep machine bioinformatics neural
Annotating Gene Ontology terms for protein sequences with the Transformer model 105 26 4
Detection of pre-microRNA with Convolutional Neural Networks 105 26 4
A Deep Learning Framework for Predicting Human Essential Genes by Integrating Sequence and Functional data 105 26 4


Topic 27   867 items
immunology immune inflammatory infection innate
LAG3 is a Central Regulator of NK Cell Cytokine Production 27 10 3
SARS-CoV-2 induces activation and diversification of human plasmacytoid pre-dendritic cells. 73 27 1
Hedgehog dysregulation contributes to tissue-specific inflammaging of resident macrophages 110 27 10 3


Topic 28   33 items
withdrawn please cited wish manuscript
From SARS-CoV to Wuhan 2019-nCoV Outbreak: Similarity of Early Epidemic and Prediction of Future Trends 28 1
METTL3 inhibitors for epitranscriptomic modulation of cellular processes 28
An All-to-All Approach to the Identification of Sequence-Specific Readers for Epigenetic DNA Modifications on Cytosine 28 7


Topic 29   666 items
microbial microbiome communities microbiology community
Soil microbial diversity impacts plant microbiomes more than herbivory 17 5
The effects of soil depth on the structure of microbial communities in agricultural soils in Iowa, USA 29 17 5
Composition of the North American wood frog (Rana sylvatica) skin microbiome and seasonal variation in community structure 29 17 5


Topic 30   506 items
cognition animal behavior social animals
To group or not to group: Effect of prolonged exposure to predation and resource availability on the shoaling behaviour of zebrafish (Danio rerio) 30 5
Threshold assessment, categorical perception, and the evolution of reliable signaling 30 23 21 5 2
Evolution of behavioral resistance in host-pathogen systems 155 30 21 5


Topic 31   729 items
chromatin transcription regulatory transcriptional histone
The regulatory genome of the malaria vector Anopheles gambiae: integrating chromatin accessibility and gene expression 31 9 3
Defining a critical enhancer near Nanog using chromatin-focused approaches identifies RNA Pol II recruitment as required for expression 31 9
Multiomics analysis reveals extensive epigenome remodeling during cortical development 31 9 3


Topic 32   284 items
alzheimers ad alzheimer amyloid disease
A Consensus Proteomic Analysis of Alzheimer's Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation 32 9
Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer's disease 32 2
Alzheimer's pathology is associated with dedifferentiation of functional memory networks in aging 32 22 2


Topic 33   479 items
crispr cas9 editing genome engineering
A viral guide RNA delivery system for CRISPR-based transcriptional activation and heritable targeted DNA demethylation in Arabidopsis thaliana 33 16
Perturbing proteomes at single residue resolution using base editing 139 33 9 4
Type III-A CRISPR systems as a versatile gene knockdown technology 33 9


Topic 34   1086 items
membrane cell biology proteins protein
The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint 102 34 3
A conformational switch driven by phosphorylation regulates Ykt6 activity in macroautophagy 34 8 3
Activation of Rab11a and endocytosis by Phosphatidylinositol 4-kinase III beta promotes oncogenic signaling in breast cancer 102 34 3


Topic 35   230 items
detection pcr diagnostic rt samples
Robust and sensitive detection of SARS-CoV-2 using PCR based methods 35 1
Rapid direct nucleic acid amplification test without RNA extraction for SARS-CoV-2 using a portable PCR thermocycler 35 1
Development of Reverse Transcription Loop-mediated Isothermal Amplification (RT-LAMP) Assays Targeting SARS-CoV-2 35 1


Topic 36   319 items
ace2 sars cov angiotensin converting
Many bat species are not potential hosts of SARS-CoV and SARS-CoV-2: Evidence from ACE2 receptor usage 36 1
Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement 36 24 1
SARS-CoV-2 manipulates the SR-B1-mediated HDL uptake pathway for its entry 36 1


Topic 37   365 items
sars cov virus coronavirus pandemic
Genomic diversity and hotspot mutations in 30,983 SARS-CoV-2 genomes: moving toward a universal vaccine for the "confined virus"? 37 1
Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide 37 1
Sequence variation among SARS-CoV-2 isolates in Taiwan 37 1


Topic 38   860 items
systems model mathematical dynamics parameters
Predicting global dynamics of spatial microbial communities from local interaction rules 158 99 38 17 5
Biological network growth in complex environments - a computational framework 38 18 4
Uncovering modeling features of viral replication dynamics from high-throughput single-cell virology experiments 38 21 4


Topic 39   229 items
fat diet obesity glucose insulin
PHOSPHO1, a novel skeletal regulator of insulin resistance and obesity 39 10 3
Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia 39 10 3
ANGPTL4 from adipose, but not liver, is responsible for regulating plasma triglyceride partitioning 39 7 3


Topic 40   815 items
evolutionary phylogenetic evolution species genomes
Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods 81 40 31 21 9 5
Bats are key hosts in the radiation of mammal-associated Bartonella bacteria 40 5
A New Tree-Based Methodological Framework to Infer the Evolutionary History of Mesopolyploid Lineages: An Application to the Brassiceae Tribe (Brassicaceae). 40 4


Topic 41   471 items
virus viral viruses replication infection
Computational analysis of microRNA-mediated interactions in SARS-CoV-2 infection 74 41 1
Host-derived Circular RNAs Display Proviral Activities in Hepatitis C Virus - Infected Cells 41 27 3
Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production 41 3


Topic 42   337 items
oscillations hz theta frequency neuroscience
Low-frequency subthalamic neural oscillations are involved in explicit and implicit facial emotional processing - a local field potential study 42 2
Beta2 oscillations in the hippocampal-cortical novelty detection circuit 42 2
Phase-amplitude coupling profiles differ in frontal and auditory cortices 42 2


Topic 43   367 items
seq scrna rna single bioinformatics
Probabilistic gene expression signatures identify cell-types from single cell RNA-seq data 43 4
A novel single-cell based method for breast cancer prognosis 43 26 4
Variance-adjusted Mahalanobis (VAM): a fast and accurate method for cell-specific gene set scoring 43 4


Topic 44   264 items
sars cov antiviral covid drug
Structure of Mpro from COVID-19 virus and discovery of its inhibitors 44 1
Nelfinavir inhibits replication of severe acute respiratory syndrome coronavirus 2 in vitro. 44 1
Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 main protease by tafenoquine in vitro 44 1


Topic 45   382 items
spectrometry mass ms chromatography proteomics
Dynamic changes in the urine proteome of tumor-bearing mouse models of B16 melanoma and RM-1 prostate cancer 45 15 14 9
Systematic protein complex profiling and differential analysis from co-fractionation mass spectrometry data 45 26 4
Global impact of phosphorylation on protein endurance 45 18 4


Topic 46   311 items
dna repair strand double breaks
The bakerss yeast Msh4-Msh5 associates with double-strand break hotspots and chromosome axis during meiosis to promote crossovers 46 34 8 3
De novo deletion mutations at recombination hotspots in mouse germlines 46 34 3
HIV Vpr modulates the host DNA damage response at two independent steps to damage DNA and repress double-strand DNA break repair 46 41 3


Topic 47   177 items
education scientific communication research science
Rigor and Transparency Index, a new metric of quality for assessing biological and medical science methods. 47 15 4
Peer review and preprint policies are unclear at most major journals 47 7
Working groups, gender and publication impact of Canada's ecology and evolution faculty 47 7 5


Topic 48   207 items
mosquito mosquitoes vector aedes aegypti
Temperature alters gene expression in mosquitoes during arbovirus infection 48 41 12
Mosquito densoviruses: the revival of a biological control agent against urban Aedes vectors of arboviruses 48 12 5
Temperature impacts the transmission of malaria parasites by Anopheles gambiae and Anopheles stephensi mosquitoes 48 17 5


Topic 49   485 items
mrna translation mrnas rna ribosome
FMRP Links Optimal Codons to mRNA stability in Neurons 49 3
Functional and structural basis of extreme non-coding conservation in vertebrate mRNAs 134 49 31 9 3
Alteration of the premature tRNA landscape by gammaherpesvirus infection 49 41 31 9 3


Topic 50   495 items
neurons neuroscience cortex cortical sensory
Learning excitatory-inhibitory neuronal assemblies in recurrent networks 104 50 11 2
A Circuit Model of Auditory Cortex 104 50 11 2
Synthesis of higher order feature codes through stimulus-specific supra-linear summation 50 23 2


Topic 51   301 items
cryo em electron structures structure
Cryo-EM structure of the MgtE Mg2+ channel pore domain in Mg2+-free conditions reveals cytoplasmic pore opening 51 8 3
Structure of the Mammalian Mediator 51 8 3
Extraction of Protein Dynamics Information Hidden in Cryo-EM Map Using Deep Learning 111 51 8 4


Topic 52   380 items
antibiotic antibiotics resistance resistant antimicrobial
Collateral Sensitivity Associated with Antibiotic Resistance Plasmids 52 12 5
Linking phenotype, genotype and ecology: antimicrobial resistance in the zoonotic pathogen Streptococcus suis 107 52 12 5
Tamoxifen repurposing to combat infections by multidrug-resistant Gram-negative bacilli 52 10


Topic 53   267 items
breeding plant crop traits yield
A global barley panel revealing genomic signatures of breeding in modern cultivars 53 5
Genotyping by sequencing for identification and mapping of QTLs for bioenergy-related traits in sweet sorghum 53 19 9 5
Grain number and genotype drive nitrogen-dependent yield response in the C4 model Setaria italica (L.) P. Beauv. 53 5


Topic 54   135 items
parkinsons pd synuclein parkinson dopaminergic
A new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease 54 11 9 3
Complement and coagulation cascades are potentially involved in dopaminergic neurodegeneration in alpha-synuclein-based mouse models of Parkinson's disease 54 32
INFLUENCE OF ENERGY DEFICIENCY ON THE MOLECULAR PROCESSES OF SUBSTANTIA NIGRA PARS COMPACTA CELL FOR UNDERSTANDING PARKINSONIAN NEURODEGENERATION: A COMPREHENSIVE BIOPHYSICAL COMPUTATIONAL MODEL 54 38


Topic 55   298 items
actin cytoskeleton mechanical myosin forces
Revealing the polarity of actin filaments by cryo-electron tomography 55 18 8
Role of cell polarity dynamics and motility in pattern formation due to contact dependent signalling 55 38 8
Molecular mechanism for direct actin force-sensing by α-catenin 55 51 8 3


Topic 56   295 items
females males female sex male
The evolution of sex-biased gene expression in the Drosophila brain 56 21 9 5
Sex-specific responses to cold in a very cold-tolerant, northern Drosophila species 56 21 5
Sex-biased gene expression in rhesus macaque and human brains 56 21 9 5


Topic 57   472 items
stem pluripotent differentiation cells cell
Single cell transcriptional and functional analysis of human dopamine neurons in 3D fetal ventral midbrain organoid like cultures 57 20 9 3
Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson's disease. 54 11 3
Interspecies Chimeric Conditions Affect the Developmental Rate of Human Pluripotent Stem Cells 57 20 9


Topic 58   305 items
decision reward task neuroscience making
Neural Correlates of Value Are Intrinsically History Dependent 58 2
EEG correlates of physical effort and reward processing during reinforcement learning 58 23 2
Abstract neuronal choice signals during embodied decisions 58 23 2


Topic 59   463 items
imaging mri neuroscience brain magnetic
Deep Learning Based Segmentation of Brain Tissue from Diffusion MRI 59 26 4 2
Assessing methods for geometric distortion compensation in 7T gradient echo fMRI data 59 22 2
Surface-Based Connectivity Integration 59 22 2


Topic 60   139 items
plasmodium malaria falciparum parasite parasites
Exposure to artemisinin at the trophozoite stage increases sexual conversion rates in the malaria parasite Plasmodium falciparum 60 48
Molecular determinants of SR-B1-dependent Plasmodium sporozoite entry into hepatocytic cells. 60 48 41 3
Gliding motility of Plasmodium merozoites 60 3


Topic 61   87 items
amyotrophic als sclerosis lateral neurodegenerative
TDP-43 stabilizes transcripts encoding stress granule protein G3BP1: potential relevance to ALS/FTD 61 49 3
Cytoplasmic accumulation of FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and defects in inhibitory synapses 61 11 3 2
Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity 61 34 3


Topic 62   317 items
user software bioinformatics users tools
ResistoXplorer: a web-based tool for visual, statistical and exploratory data analysis of resistome data 176 62 4
SimText: A text mining framework for interactive analysis and visualization of similarities among biomedical entities 165 62 13 7 4
BingleSeq: A user-friendly R package for Bulk and Single-cell RNA-Seq Data Analysis 62 43 4


Topic 63   631 items
biochemistry binding crystal structural domain
The electrostatic allostery could be the trigger for the changes in dynamics for the PDZ domain of PICK1 63 8 3
Structure of SARS-CoV-2 main protease in the apo state reveals the inactive conformation 44 1
State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane 163 91 82 8 3


Topic 64   297 items
pharmacology toxicology drug treatment drugs
In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor 7 3
Computationally Guided Design of BCR-ABL Tyrosine Kinase Inhibitors 64 44 10
Development of A Novel Highly Selective TLR8 Agonist for Cancer Immunotherapy 166 64 10 3


Topic 65   249 items
disorder autism neurodevelopmental disorders deficits
Structural and Functional Brain-wide Alterations in A350V IQSEC2 Mutant Mice Displaying Autistic-like Behavior 65 11 2
Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development 65 11 3 2
Acute neonatal oxytocin impacts hippocampal network development and restores adult social memory deficits in a mouse model of autism spectrum disorder. 65 11 2


Topic 66   181 items
memory hippocampal hippocampus neuroscience memories
Hippocampal-medial prefrontal event segmentation and integration contribute to episodic memory formation 66 22 2
Changing reward expectation transforms spatial encoding and retrieval in the hippocampus 66 58 2
Parallel processing of sensory cue and spatial information in the Dentate Gyrus 66 50 2


Topic 67   399 items
metabolic metabolism carbon production growth
Escherichia coli metabolism under short-term repetitive substrate dynamics: Adaptation and trade-offs 67 12 5
Machine Learning and Optimal Control of Enzyme Activities to Preserve Solvent Capacity in the Cell 67 38 26 4
Effects of substrate availability on growth and metabolism in soil microbes: Insights from theoretical modeling of studies of the Warburg effect and substrate-induced respiration 158 67 29 17 12


Topic 68   169 items
spindle mitotic microtubule mitosis microtubules
Deubiquitylase UCHL3 drives error correction at kinetochores and chromosome segregation independent of spindle assembly checkpoint 68 34 3
The association of Plk1 with the Astrin-Kinastrin complex promotes formation and maintenance of a metaphase plate 68 7 3
Cdk1-dependent destabilization of long astral microtubules is required for spindle orientation 68 34 3


Topic 69   179 items
endoplasmic reticulum er membrane stress
Creld2 function during unfolded protein response is essential for liver metabolism homeostasis 69 56 34 3
MANF regulates unfolded protein response and neuronal survival through its ER-located receptor IRE1α 69 34 3
Yeast FIT2 homolog is necessary to maintain cellular proteostasis by regulating lipid homeostasis 69 34 3


Topic 70   198 items
microscopy imaging resolution fluorescence optical
Fast 3D imaging of giant unilamellar vesicles using reflected light-sheet microscopy with single molecule sensitivity 70 18 8
Network-enabled efficient image restoration for 3D microscopy of turbid biological specimens 70 18 4
Super-resolution light-sheet fluorescence microscopy by SOFI. 70 18 11 8


Topic 71   136 items
accumbens nucleus dopamine rats reward
Role of prefrontal cortex projections to the nucleus accumbens core in mediating the effects of ceftriaxone on cued cocaine relapse 71 11 2
Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-related behaviours 71 11 2
Central oxytocin signaling inhibits food reward-motivated behaviors and VTA dopamine responses to food-predictive cues in male rats 71 58 2


Topic 72   138 items
retinal retina ganglion photoreceptor visual
Focal Electrical Stimulation of Human Retinal Ganglion Cells 72 59 2
AMP-activated-kinase (AMPK) is essential sensor and metabolic regulator of retinal neurons and their integrated metabolism with RPE. 72 3
Homeostatic plasticity triggered by rod photoreceptor degenerative disease is associated with maintenance of sensitive night vision 72 11 2


Topic 73   232 items
sars covid cov 19 infection
SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function 73 36 1
SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response 73 1
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery 73 1


Topic 74   160 items
mirna mirnas mir micrornas microrna
Systematic characterization of somatic mutation-mediated microRNA regulatory network perturbations 74 9
Characterizing microRNA-mediated modulation of gene expression noise and its effect on synthetic gene circuits 74 38 9
AGO HITS-CLIP in Adipose Tissue Reveals miR-29 as a Post-Transcriptional Regulator of Leptin 74 39 9 3


Topic 75   147 items
matter white diffusion mri neuroscience
Free-water metrics in medial temporal lobe white matter tract projections relate to longitudinal cognitive decline 75 22 15 2
The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance 75 22 15 2
The white matter network in cognitive normal elderly predict the rate of cognitive decline 75 22 2


Topic 76   114 items
epitopes vaccine epitope mhc sars
Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2 191 76 24 1
Designing of Epitope-Based Vaccine from the Conserved Region of the Spike Glycoprotein of SARS-CoV-2 191 76 24 1
AN IMMUNOINFORMATICS STUDY TO PREDICT EPITOPES IN THE ENVELOPE PROTEIN OF SARS-COV-2 76 1


Topic 77   254 items
synaptic synapses neuroscience plasticity postsynaptic
PKD promotes activity-dependent AMPA receptorendocytosis in hippocampal neurons 77 11 3 2
Ablation of STAT3 in Purkinje Cells Reorganizes Cerebellar Synaptic Plasticity in Long-Term Fear Memory Network 77 11 2
Circadian modulation of neurons and astrocytes controls synaptic plasticity in hippocampal area CA1 77 11 2


Topic 78   292 items
biophysics lipid membrane disordered membranes
Identifying Sequence Perturbations to an Intrinsically Disordered Protein that Determine Its Phase Separation Behavior 78 8
The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregates 78 8
Charge-Driven Phase Condensation of RNA and Proteins Suggests Broad Role of Phase Separation in Cytoplasmic Environments 78 8


Topic 79   495 items
microbiology bacteria bacterial virulence pathogen
Glucose promotes resistance of human commensal Escherichia coli against contact-killing by pandemic Vibrio cholerae 158 79 12 3
Transcriptional profiling of three Pseudomonas syringae pv. actinidiae biovars reveals different responses to apoplast-like conditions related to strain virulence 79 12 3
MogR is a ubiquitous transcriptional repressor affecting motility, biofilm formation and virulence in the Bacillus cereus group 79 12 3


Topic 80   133 items
transcranial stimulation cortex tms magnetic
Beneficial effects of cerebellar tDCS on motor learning are associated with altered putamen-cerebellar connectivity: a simultaneous tDCS-fMRI study 80 22 2
Multi-day rTMS exerts site-specific effects on functional connectivity but does not influence associative memory performance 80 22 2
Dose-dependent enhancement of motion direction discrimination with transcranial magnetic stimulation of visual cortex 80 23 2


Topic 81   84 items
transposable tes te elements element
Impact of transposable elements on methylation and gene expression across natural accessions of Brachypodium distachyon. 81 16 9 5
Dynamics of transposable elements in recently diverged fungal pathogens: lineage-specific transposable element content and efficiency of genome defences 81 40 5
Silencing of Mu elements in maize involves distinct populations of small RNAs and distinct patterns of DNA methylation 81 9


Topic 82   154 items
channels channel voltage gated ion
Alternative splicing tunes sodium channels to support channel- and neuron- specific effects 82 11 2
Focused ultrasound excites neurons via mechanosensitive calcium accumulation and ion channel amplification 82 11 2
Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins 82 69 34 3


Topic 83   245 items
inference evolutionary estimates estimation methods
Towards an evolutionarily appropriate null model: jointly inferring demography and purifying selection 83 21 5 4
Estimating divergence times from DNA sequences 83 21 4
A minimal yet flexible likelihood framework to assess correlated evolution 83 21 4


Topic 84   494 items
ecology conservation species biodiversity management
The Demographic History of Micro-endemics: Have Rare Species Always Been Rare? 84 5 4
Spatio-temporal surveys of the brown meagre Sciaena umbra using passive acoustics for management and conservation 84 17 5
Insect threats and conservation through the lens of global experts 84 17 5


Topic 85   285 items
bioengineering tissue mechanical collagen properties
Success Criteria for Preclinical Testing of Cell-Instructive Hydrogels for Tendon Regeneration 85 57 18 10
3D bioprinting of co-cultured osteogenic spheroids for bone tissue fabrication 85 57 18
Scaffold pore geometry influences bone-like tissue formation in dynamic cell culture conditions 85 18


Topic 86   182 items
temperature temperatures climate thermal warming
Temperatures that sterilise males better predict global distributions of species than lethal temperatures 86 17 5
High developmental temperature leads to low reproduction despite adult temperature 86 5
The impact of microclimate and soil on the ecology and evolution of an arctic plant 86 17 5


Topic 87   147 items
methylation epigenetic dna methylated cpg
Epigenetic aging of classical monocytes from healthy individuals 87 9
Widespread methylation quantitative trait loci and their role in schizophrenia risk 87 19 9 5
Region-level Epimutation Rates in Arabidopsis thaliana 87 21 5


Topic 88   308 items
immunology antigen cd8 immune cells
Transcriptional memory-like imprints and enhanced functional activity in γδ T cells following resolution of malaria infection 88 27 10 3
Single cell transcriptional profiling reveals helper, effector, and regulatory MAIT cell populations enriched during homeostasis and activation 88 27 9 3
Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses 88 27 10 3


Topic 89   99 items
chromatin hi topologically tad tads
Dynamics of the 4D genome during lineage specification, differentiation and maturation in vivo 89 31 20 9 3
Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure 89 19 9 4
3D genome evolution and reorganization in the Drosophila melanogaster species group 89 31 21 9 5


Topic 90   166 items
elegans caenorhabditis nematode worms conserved
NHR-49 acts in distinct tissues to promote longevity versus innate immunity 90 3
The SEM-4 transcription factor is required for regulation of the oxidative stress response in Caenorhabditis elegans 128 90 3
The O-GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress 90 3


Topic 91   229 items
biophysics simulations conformational dynamics molecular
Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding 91 8 3
State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane 163 91 82 8 3
A kinetic ensemble of the Alzheimer's Aβ peptide 91 78 38 8 4


Topic 92   6 items
fraudulently citation names biorxiv withdrawn
Efficient Method for Genomic DNA Mutagenesis in E. coli 92 28
A simple and efficient method for in vitro site-directed mutagenesis 92 28 18
An Efficient Method for Protein Crystallization 92 28


Topic 93   158 items
histone epigenetic chromatin h3 lysine
Altering PRC2 activity partially suppresses ddm1 mutant phenotypes in Arabidopsis 93 81 31 16 9 3
H3K27me3 is dispensable for early differentiation but required to maintain differentiated cell identity 93 20 3
The histone variant H2A.Z is required to establish normal patterns of H3K27 methylation in Neurospora crassa 93 31 9 3


Topic 94   102 items
endothelial vascular vessel angiogenesis blood
Akt is required for artery formation during embryonic vascular development 94 20 3
Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis 94 20 3
Simulating flow induced migration in vascular remodelling 94 38 18


Topic 95   213 items
mitochondrial mitochondria oxidative dysfunction atp
Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation 95 34 3
Metabolism of glucose and glutamine is critical for skeletal muscle stem cell activation. 95 67 3
Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death 95 3


Topic 96   146 items
walking muscles gait muscle limb
Muscle forces comprise a more sensitive measure of post-stroke movement deficits than joint angles 96 23 2
Step width and frequency to modulate: Active foot placement control ensures stable gait 96 15 2
Adaptation of reach action to a novel force-field is not predicted by acuity of dynamic proprioception in either older or younger adults 144 96 23 2


Topic 97   280 items
variants sequencing variant genome genomics
Insights into dispersed duplications and complex structural mutations from whole genome sequencing 706 families 97 19 4
MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data 97 25 9 4
Mobile Element Insertions and Associated Structural Variants in Longitudinal Breast Cancer Samples 97 9


Topic 98   94 items
mesenchymal emt epithelial transition metastasis
P4HA2 is associated with prognosis, promotes proliferation, invasion, migration and EMT in glioma 98 14 3
NFATc acts as a non-canonical phenotypic stability factor for a hybrid epithelial/mesenchymal phenotype 98 14 3
Loss of CPAP expression promotes sustained EGFR signaling and Epithelial-Mesenchymal Transition in oral cancer cells 98 14 3


Topic 99   121 items
ecology communities coexistence community ecological
Priority effects and season length shape long-term competition dynamics 99 17 5
Competitive ecosystems are robustly stabilized by structured environments 99 17 5
Competitive dominance in plant communities: Modeling approaches and theoretical predictions 99 17 5


Topic 100   152 items
neural visual neuroscience representations networks
Face recognition depends on specialized mechanisms tuned to view-invariant facial features: Insights from deep neural networks optimized for face or object recognition 100 23 2
Limited correspondence in visual representation between the human brain and convolutional neural networks 100 23 2
The development of transformation tolerant visual representations differs between the human brain and convolutional neural networks 100 23 2


Topic 101   210 items
gut microbiota microbiome microbial microbiology
Although host-related factors are important for the formation of gut microbiota, environmental factors cannot be ignored 101 29 5
Short-chain fatty acid production by gut microbiota from children with obesity is linked to bacterial community composition and prebiotic choice 101 29 12 5
Children Developing Celiac Disease Have a Distinct and Proinflammatory Gut Microbiota in the First 5 Years of Life 101 29 12 10


Topic 102   273 items
kinase phosphorylation signaling activation kinases
Conserved Roles for Receptor Tyrosine Kinase Extracellular Regions in Regulating Receptor and Pathway Activity 102 3
Activation of Rab11a and endocytosis by Phosphatidylinositol 4-kinase III beta promotes oncogenic signaling in breast cancer 102 34 3
The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint 102 34 3


Topic 103   135 items
respiratory coronavirus syndrome acute severe
Many bat species are not potential hosts of SARS-CoV and SARS-CoV-2: Evidence from ACE2 receptor usage 36 1
Susceptibility of ferrets, cats, dogs, and different domestic animals to SARS-coronavirus-2 103 1
Monoclonal antibodies for the S2 subunit of spike of SARS-CoV cross-react with the newly-emerged SARS-CoV-2 36 1


Topic 104   81 items
interneurons parvalbumin pv inhibitory somatostatin
A critical role for trkB signaling in the adult function of parvalbumin interneurons and prefrontal network dynamics 104 11 2
Learning excitatory-inhibitory neuronal assemblies in recurrent networks 104 50 11 2
Auditory cortex shapes sound responses in the inferior colliculus. 104 50 11 2


Topic 105   230 items
prediction bioinformatics learning predicting predict
Annotating Gene Ontology terms for protein sequences with the Transformer model 105 26 4
A Deep Learning Framework for Predicting Human Essential Genes by Integrating Sequence and Functional data 105 26 4
DeepHE: Accurately Predicting Human Essential Genes based on Deep Learning 105 26 13 4


Topic 106   184 items
plant plants root leaf roots
Investigation of biochemical changes in barley inoculated with Trichoderma harzianum T-22 under salt stress 106 16 5
Copper nanoparticle application enhances plant growth and grain yield in maize under drought stress conditions 106 16 5
Contrasting response of two Lotus corniculatus L. accessions to combined waterlogging-saline stress 106 16 5


Topic 107   177 items
isolates resistance resistant antimicrobial microbiology
Genomic characterisation and context of the blaNDM-1 carbapenemase in Escherichia coli ST101. 107 52 25 12 5
Genomic Epidemiology of Escherichia coli Isolates from a Tertiary Referral Center in Lilongwe, Malawi 107 52 12 5
Genomic Surveillance of Pseudomonas aeruginosa in the Philippines from 2013-2014 107 52 12 5


Topic 108   366 items
cancer tumor proliferation biology growth
P4HA2 is associated with prognosis, promotes proliferation, invasion, migration and EMT in glioma 98 14 3
PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity 108 14 10 3
Induction of intracellular wild-type p53 amyloids leading to cellular transformation and tumor formation in mice 142 108 14 3


Topic 109   69 items
islets insulin diabetes islet pancreatic
Spontaneous restoration of functional β-cell mass in obese SM/J mice 109 39 10 3
The long non-coding RNA Pax6os1/PAX6-AS1 modulates pancreatic β-cell identity and function. 109 39 3
Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a new regulator of insulin secretion 109 89 31 9 3


Topic 110   136 items
inflammatory il cytokines pro tnf
Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain. 110 27 10 3
Interleukin-35 pretreatment attenuates lipopolysaccharide-induced heart injury by inhibition of inflammation, apoptosis and fibrosis 110 10 3
Macrophage-derived miR-21 drives overwhelming glycolytic and inflammatory response during sepsis via repression of the PGE2/IL-10 axis. 110 27 10 3


Topic 111   104 items
cryo electron em structures resolution
Breaking the next Cryo-EM resolution barrier - Atomic resolution determination of proteins! 111 51 18 8 4
Emap2sec+: Detecting Protein and DNA/RNA Structures in Cryo-EM Maps of Intermediate Resolution Using Deep Learning 111 51 26 8 4
Extraction of Protein Dynamics Information Hidden in Cryo-EM Map Using Deep Learning 111 51 8 4


Topic 112   220 items
bioinformatics drug cancer drugs network
Multi-layered network-based pathway activity inference using directed random walks: application to predicting clinical outcomes in urologic cancer 112 13 4
Genome-wide investigation of gene-cancer associations for the prediction of novel therapeutic targets in oncology 112 26 4
A novel single-cell based method for breast cancer prognosis 43 26 4


Topic 113   257 items
neuroscience anxiety cognitive memory social
Reelin deficiency contributes to long-term behavioral abnormalities induced by chronic adolescent exposure to Δ9-tetrahydrocannabinol in mice 113 71 65 11 2
Infralimbic cortical glutamate output is necessary for the neural and behavioral consequences of chronic stress 113 11 2
Social isolation stress in adolescence, but not adulthood, produces hypersocial behavior in adult male and female C57BL/6J mice 141 113 56 30 15 11 2


Topic 114   234 items
virulence pathogen host infection microbiology
Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model system 114 27 3
The small RNA ErsA plays a role in the regulatory network of Pseudomonas aeruginosa pathogenicity in airways infection 114 52 12 3
Intracellular Group A Streptococcus induces Golgi fragmentation to impair host defenses through Streptolysin O and NAD-glycohydrolase 114 79 27 3


Topic 115   238 items
ml extract was were production
Evaluation of Antimicrobial, Antioxidant, Total Phenolic, Total Flavonoids, Metal Content and Proximate Potential of Solanum xanthocarpum L. (Solanaceae) 115 12
Bioconversion of Mango Pulp Industrial Waste into Ellagic acid Using Aspergillus niger 115 67 12
Microbial Production Of Ellagic Acid From Mango Pulp Processing Waste 115 67 12


Topic 116   132 items
neurons neuroscience projection projections nucleus
Whole-brain mapping of monosynaptic inputs to midbrain cholinergic neurons 116 50 11 2
Retrograde labeling illuminates distinct topographical organization of D1 and D2 receptor-positive neurons in the prefrontal cortex of mice 116 71 11 2
Molecular, spatial and projection diversity of neurons in primary motor cortex revealed by in situ single-cell transcriptomics 116 50 11 9 2


Topic 117   90 items
photosynthetic photosynthesis light photosystem cyanobacteria
Impaired chloroplast positioning affects photosynthetic capacity and regulation of the central carbohydrate metabolism during cold acclimation 117 16 5
TIP family aquaporins play role in chloroplast osmoregulation and photosynthesis 117 16 3
ACCLIMATION OF PHOTOSYNTHESIS TO THE ENVIRONMENT 1 regulates Photosystem II Supercomplex dynamics in response to light in Chlamydomonas reinhardtii 117 16 3


Topic 118   267 items
developmental embryonic embryo patterning biology
Timed mesodermal FGF and BMP govern the multi-step thyroid specification 118 20 3
Akt is required for artery formation during embryonic vascular development 94 20 3
Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium of Drosophila embryos 118 20 3


Topic 119   90 items
polymerase transcription rna elongation pol
Spt5 phosphorylation and the Rtf1 Plus3 domain promote Rtf1 function through distinct mechanisms 119 102 49 31 3
A general role of zinc binding domain revealed by structures of σ28-dependent transcribing complexes 119 51 31 8 3
O-GlcNAc Transferase Activity is Essential for RNA Pol II Pausing in a Human Cell-Free Transcription System 119 31 3


Topic 120   276 items
rna expression transcriptome genes expressed
Characterization of the nuclear and cytosolic transcriptomes in human brain tissue reveals new insights into the subcellular distribution of RNA transcripts 120 9 3
Mouse Aging Cell Atlas Analysis Reveals Global and Cell Type Specific Aging Signatures 120 43 9
Single-cell transcriptomic analysis identifies neocortical developmental differences between human and mouse 120 43 9 3


Topic 121   284 items
genomes genome species genomic strains
Revisiting the Genomic Structure of the Genus Pseudomonas with Whole Genome Data: Insights into Diversity and Host-related Genetic Determinants 121 114 12 5
Lytic Bacteroides uniformis bacteriophages exhibiting host tropism congruent with diversity generating retroelement 143 121 29 12 5
Dynamics of infection in a novel group of promiscuous phages and hosts of multiple bacterial genera retrieved from river communities 143 121 29 12 5


Topic 122   12 items
honeybee clean article apis raw
Nanopore long-read transcriptome data of fungal pathogen of chalkbrood disease, Ascosphaera apis 122 25 9
Strand-specific cDNA library-based RNA sequencing dataset of un-infected and Ascosphaera apis-infected larval guts of Apis cerana cerana 122 25
Whole transcriptome data of uninfected and Nosema ceranae-infected midguts of eastern honeybee workers 122 25


Topic 123   173 items
statistical methods method data propose
Using a supervised principal components analysis for variable selection in high-dimensional datasets reduces false discovery rates 123 83 4
Controlling for Human Population Stratification in Rare Variant Association Studies 145 123 19 4
Permutation tests for hypothesis testing with animal social data: problems and potential solutions 123 83 4


Topic 124   45 items
epilepsy seizure seizures epileptic onset
Evidence for spreading seizure as a cause of theta-alpha activity electrographic pattern in stereo-EEG seizure recordings 124 42 2
Dual mechanisms of ictal high frequency oscillations in human rhythmic onset seizures 124 42 2
Interictal epileptiform discharges in focal epilepsy are preceded by a gradual increase in low-frequency oscillations 124 42 2


Topic 125   114 items
sequencing samples taxonomic sample method
Full-length 16S rRNA gene amplicon analysis of human gut microbiota using MinION™ nanopore sequencing confers species-level resolution 125 101 29 25 12 4
Quantitative microbiome profiling in lumenal and tissue samples with broad coverage and dynamic range via a single-step 16S rRNA gene DNA copy quantification and amplicon barcoding 125 29 4
Taxonomic classification method for metagenomics based on core protein families with Core-Kaiju 125 29 4


Topic 126   231 items
cancer tumor therapy treatment tumors
Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers 126 14 10 3
Biomarker-guided treatment strategies for ovarian cancer identified from a heterogeneous panel of patient-derived tumor xenografts 126 14 10 9
Hormonal regulation of Semaphorin 7a in ER+ breast cancer drives therapeutic resistance 126 14 10 3


Topic 127   236 items
biophysics stochastic dynamics model rate
A Parallel Ratchet-Stroke Mechanism Leads to an Optimum Force for Molecular Motor Function. 127 38 8
A stochastic model of gene expression with polymerase recruitment and pause release 127 38
Connecting actin polymer dynamics across multiple scales 127 38 8


Topic 128   86 items
ros oxygen reactive species stress
Plastid gene expression is required for singlet oxygen-induced chloroplast degradation and cell death 128 16 3
JNK signalling regulates antioxidant responses in neurons 128 11 3
Chloroplast-derived photo-oxidative stress causes changes in H2O2 and EGSH in other subcellular compartments 128 95 16 3


Topic 129   291 items
biochemistry enzymes enzyme substrate amino
Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia 129 63 8
Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases 129 63 8 4
Design of optical imaging probes by screening of diverse substrate libraries directly in disease tissue extracts 129 18 14 4


Topic 130   40 items
antibodies elisa serological cov sars
Comparative analyses of SARS-CoV-2 binding (IgG, IgM, IgA) and neutralizing antibodies from human serum samples 130 24 1
Evaluation of the EUROIMMUN Anti-SARS-CoV-2 ELISA Assay for detection of IgA and IgG antibodies 130 35 1
Clinical performance of SARS-CoV-2 IgG antibody tests and potential protective immunity 130 35 1


Topic 131   75 items
images image accuracy deep slide
A deep learning approach for tissue spatial quantification and genomic correlations of histopathological images 131 26 9 4
Image-based patch selection for deep learning to improve automated Gleason grading in histopathological slides 131 26 4
A Deep Learning Approach for Rapid Mutational Screening in Melanoma 131 26 4


Topic 132   146 items
evolutionary traits fitness reproductive evolution
Sex-specific effects of developmental density on life history and age-dependent flight traits 132 56 21 5
Evolution of reproductive traits have no apparent life-history associated cost in populations of Drosophila melanogaster selected for cold shock resistance 132 56 21 5
Population density and temperature influence the return on maternal investment in wild house mice 132 86 5


Topic 133   64 items
neurogenesis progenitor neurons progenitors neuronal
A SMAD1/5-YAP signaling module drives radial glia self-amplification and growth of the developing cerebral cortex 133 20 3
Unraveling the transcriptional networks that drive oligodendrocyte fate specification in Sonic hedgehog-responsive neocortical progenitors 133 20 9 3
In utero gene transfer system for embryos before neural tube closure reveals a role for Hmga2 in the onset of neurogenesis 133 20 3


Topic 134   139 items
regulatory transcription cis gene tf
Unraveling transcription factor functions through integrative inference of transcriptional networks in Arabidopsis thaliana yields novel regulators involved in reactive oxygen species stress signaling 134 31 16 9 4
Co-expression signatures of combinatorial gene regulation 134 31 9 3
Accurate transcription start sites enable mining for the cis-regulatory determinants of tissue specific gene expression 134 31 9 4


Topic 135   56 items
genetically fluorescent fluorescence encoded imaging
P2X-GCaMPs as versatile tools for imaging extracellular ATP signaling 135 18 11
Two-photon voltage imaging of spontaneous activity from multiple neurons reveals network activity in brain tissue 135 50 11 2
Improved genetically encoded near-infrared fluorescent calcium ion indicators for in vivo imaging 135 18


Topic 136   50 items
ribosome ribosomes translation ribosomal mrna
eEF3 promotes late stages of tRNA translocation on the ribosome 136 7 3
Direct measurements of mRNA translation kinetics in living cells 136 49 8
Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation 136 49 1


Topic 137   66 items
genetics variant variants autosomal recessive
Novel Loss-of-Function Mutations in COCH Cause Autosomal Recessive Nonsyndromic Deafness 137 97 9
ZNF423 patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities 137 65 9
Aberrant regulation of a poison exon caused by a non-coding variant in Scn1a-associated epileptic encephalopathy 137 65 49 9


Topic 138   27 items
parp inhibitors ribose cancer parpi
Modulation of Early Mitotic Inhibitor 1 (EMI1) Depletion on the Sensitivity of PARP Inhibitors in BRCA1 Mutated Triple-Negative Breast Cancer Cells 138 126 14 10 3
PARP inhibition in Ewing sarcoma: impact of germline DNA damage repair defects and activation of immunoregulatory pathways 138 126 14 10 3
Role of PARylation and PTEN Mutation on PARP and PARG Inhibitor Efficacy on Glioblastoma 138 126 46 7 3


Topic 139   38 items
screens crispr cas9 genome library
Pooled CRISPR screening at high sensitivity with an empirically designed sgRNA library 139 33 9
Multiplex enCas12a screens show functional buffering by paralogs is systematically absent from genome-wide CRISPR/Cas9 knockout screens 139 33 9
A genome-scale CRISPR interference guide library enables comprehensive phenotypic profiling in yeast 139 33 9


Topic 140   81 items
bioinformatics alignment algorithm sequence efficient
Phylogenetic placement of short reads without sequence alignment 140 25 4
Embedding the de Bruijn graph, and applications to metagenomics 140 26 4
Predicting Alignment Distances via Continuous Sequence Matching 140 26 4


Topic 141   103 items
rats kg male mg exposure
Increased Ethanol Intake is Associated with Social Anxiety in Offspring Exposed to Ethanol on Gestational Day 12 141 56 30 15 2
Adolescent intermittent ethanol exposure induces sex-dependent divergent changes in ethanol drinking and motor activity in adulthood in C57BL/6J mice 141 113 56 15 2
Effects of the GluN2B antagonist, Ro 25-6981, on extinction consolidation following adolescent- or adult-onset methamphetamine self-administration in male and female rats 141 56 15 2


Topic 142   167 items
cancer tumor oncogenic cancers suppressor
Induction of intracellular wild-type p53 amyloids leading to cellular transformation and tumor formation in mice 142 108 14 3
The Oncogenic Function of PLAGL2 is Mediated via Specific Target Genes Through a Wnt-independent Mechanism in Colorectal Cancer 142 108 14 3
Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation 142 108 14 9 3


Topic 143   133 items
bacterial bacteria microbial host microbiome
Heliconius butterflies host characteristic and phylogenetically structured adult-stage microbiomes 143 29 5
Infection with novel Bacteroides phage BV01 alters host transcriptome and bile acid metabolism in a common human gut microbe 143 29 12 9 5
Dynamics of infection in a novel group of promiscuous phages and hosts of multiple bacterial genera retrieved from river communities 143 121 29 12 5


Topic 144   97 items
task neuroscience memory participants motor
Similarity of brain activity patterns during learning and subsequent resting state predicts memory consolidation 144 42 22 2
Load-dependent modulation of alpha oscillations during working memory encoding and retention in young and older adults 144 42 23 15 2
Pre-movement changes in sensorimotor beta oscillations predict motor adaptation drive. 144 42 23 2


Topic 145   124 items
genetics genotype population haplotype genetic
Using high-throughput phenotypes to enable genomic selection by inferring genotypes 145 53 19 4
Controlling for Human Population Stratification in Rare Variant Association Studies 145 123 19 4
Unbalanced Sample Size Introduces Spurious Correlations to Genome-wide Heterozygosity Analyses 145 19 4


Topic 146   47 items
immunology antibodies vaccine antibody immunization
An Epitope-based Malaria Vaccine Targeting the Junctional Domain of Circumsporozoite Protein 146 24 10
Optimizing immunization protocols to elicit broadly neutralizing antibodies 146 24 12
Th2-like T-follicular helper cells promote functional antibody production during Plasmodium falciparum infection 146 88 60 27 24 10 3


Topic 147   88 items
seq github bioinformatics com https
BATMAN: fast and accurate integration of single-cell RNA-Seq datasets via minimum-weight matching 147 43 13 4
scLM: automatic detection of consensus gene clusters across multiple single-cell datasets 147 43 13 4
Alignment of single-cell RNA-seq samples without over-correction using kernel density matching 147 43 13 4


Topic 148   77 items
rna sequencing single heterogeneity scrna
Definition and Signatures of Lung Fibroblast Populations in Development and Fibrosis in Mice and Men 148 120 57 9 3
Defining the transcriptional landscape of infiltrating immune cells in human and mouse bladder cancer. 173 148 14 9 3
A limited set of transcriptional programs define major cell types 148 120 9


Topic 149   61 items
disordered intrinsically proteins idps residues
Intrinsically disordered protein ensembles shape evolutionary rates revealing conformational patterns 149 91 21 8 5
The mechanism of coupled folding-upon-binding of an intrinsically disordered protein 149 91 78 8
Effects of Sequence Composition and Patterning on the Structure and Dynamics of Intrinsically Disordered Proteins 149 91 78 8


Topic 150   149 items
inflammatory activation immunology inflammation macrophages
Transcriptional regulation of ACSL1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation 150 110 49 3
Regulatory T cell activation triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses 150 27 3
Inflammasome- and gasdermin D-independent IL-1β production mobilizes neutrophils to inhibit antitumor immunity 150 27 14 10 3


Topic 151   70 items
proteins complexes membrane protein proximity
The TPLATE subunit is essential for structural assembly of the endocytic TSET complex 151 34 8 3
CBRPP: a new RNA-centric method to study RNA-protein interactions 151 45 33 3
In vivo discovery of RNA proximal proteins in human cells via proximity-dependent biotinylation 151 49 33 3


Topic 152   54 items
tumor cancer tumors patient derived
Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy 152 14 9 3
Transcriptional subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer 152 14 9 3
Stroma transcriptomic and proteomic profile of prostate cancer metastasis xenograft models reveals conservation of bonemicroenvironment signatures 152 14 9 3


Topic 153   55 items
biodistribution delivery therapeutic antibody vivo
Antibody-mediated delivery of LIGHT to the tumor boosts Natural Killer cells and delays tumor progression 153 10 3
Antibody-based delivery of Interleukin-9 to neovascular structures: therapeutic evaluation in cancer and arthritis 153 10 3
Edaravone-Loaded Mesoscale Nanoparticles Treat Cisplatin-Induced Acute Kidney Injury 153 126 10 3


Topic 154   30 items
neurons circuit neuroscience behavior drosophila
A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior 154 11 2
Internal state configures olfactory behavior and early sensory processing in Drosophila larvae 154 50 11 2
Feeding state functionally reconfigures a sensory circuit to drive thermosensory behavioral plasticity 154 11 2


Topic 155   82 items
individuals individual ecology population social
The epidemiological signature of pathogen populations that vary in the relationship between free-living survival and virulence 155 21 5
Using changes in host demographic rates to reveal the effects of infection with hidden variable models 155 83 5 4
No evidence for cross-contextual consistency in spatial learning and behavioural flexibility in a passerine 155 30 21 5 2


Topic 156   51 items
bone marrow mice signaling osteoblasts
Adipose-tissue derived signals control bone remodelling. 156 150 57 10 3
Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo 156 57 3
Bone marrow adipogenic lineage precursors (MALPs) promote osteoclastogenesis in bone remodeling and pathologic bone loss 156 57 3


Topic 157   55 items
decision neuroscience models making empirical
Dual strategies in human confidence judgments 157 23 2
Uncertainty is Maintained and Used in Working Memory 157 58 23 2
Fitting drift-diffusion decision models to trial-by-trial data 157 58 38 30 23 2


Topic 158   75 items
microbial coli nutrient microbes communities
Predicting global dynamics of spatial microbial communities from local interaction rules 158 99 38 17 5
Modeling microbial cross-feeding at intermediate scale portrays community dynamics and species coexistence 158 99 38 29 17 5 4
Resident microbial communities inhibit growth and antibiotic resistance evolution of Escherichia coli in human gut microbiome samples 158 143 29 12 5


Topic 159   111 items
plant plants arabidopsis thaliana biology
Addition of Multiple Introns to a Cas9 Gene Results in Dramatic Improvement in Efficiency for Generation of Gene Knockouts in Plants 159 33 16 9
The circadian clock contributes to the long-term water use efficiency of Arabidopsis 159 16
A role for neutral variation in the evolution of C4 photosynthesis 159 16 5


Topic 160   79 items
ecology conservation species habitat biodiversity
Diversity reduces extinction risk at global scales 160 17 5
Disentangling the effects of sampling scale and size on the shape of species abundance distributions 160 17 5
No one-size-fits-all solution to clean GBIF 160 84 17 5 4


Topic 161   17 items
fda sars sofosbuvir approved coronavirus
Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase 161 44 1
Nucleotide Analogues as Inhibitors of SARS-CoV Polymerase 161 44 1
Nucleotide Analogues as Inhibitors of Viral Polymerases 161 44 1


Topic 162   120 items
com github https bioinformatics available
SCRAPP: A tool to assess the diversity of microbial samples from phylogenetic placements 162 13 4
Balrog: A universal protein model for prokaryotic gene prediction 162 13 4
Deep learning approaches predict non-coding RNA functions from only raw sequence data 162 105 13 4


Topic 163   35 items
domain biophysics domains binding synaptotagmin
State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane 163 91 82 8 3
Coupling of conformational switches in calcium sensor unraveled with local Markov models and transfer entropy 163 91 8
SNARE Complex Alters the Interactions of the Ca2+ sensor Synaptotagmin 1 with Lipid Bilayers 163 78 8


Topic 164   45 items
injury microglia male treatment after
Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31 164 10
Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury 164 113 65 10 2
Hippocampal silent infarct leads to subtle cognitive decline that is associated with inflammation and gliosis at twenty-four hours after injury in a rat model 164 113 10 2


Topic 165   53 items
com bioinformatics https github available
SimText: A text mining framework for interactive analysis and visualization of similarities among biomedical entities 165 62 13 7 4
CandiHap: a toolkit for haplotype analysis for sequence of samples and fast identification of candidate causal gene(s) in genome-wide association study 165 13 4
TBtools - an integrative toolkit developed for interactive analyses of big biological data 165 62 13 4


Topic 166   34 items
schistosomiasis mansoni schistosoma drugs drug
Schistosomes alter expression of immunomodulatory gene products following in vivo praziquantel exposure 166 64 10 3
Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal. 166 52 12 10
Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) is a druggable target involved in parasite survival, oviposition and stem cell proliferation. 166 12 3


Topic 167   23 items
cochlea basilar vibrations ohcs fluid
A role for tectorial membrane mechanics in activating the cochlear amplifier 167 38 18
A simplified analytical model of sound propagationin the human ear 167 96 15
Why the middle ear piston prosthesis is not effective enough and how to change it? 167 96 15


Topic 168   42 items
neurons neuronal neuroscience mice neurogenesis
Neuronal LXR Regulates Neuregulin-1 Expression and Sciatic Nerve-Associated Cell signaling 168 11 3
Intrauterine growth restriction causes cellular, molecular, and behavioral deficits consistent with abnormal dentate gyrus neurogenesis in mice 168 65 11 3 2
Cell-type specific impact of glucocorticoid receptor activation on the developing brain 168 65 57 11 9 3


Topic 169   38 items
declared competing statementthe authors text
Population dynamics and neuronal polyploidy in the developing neocortex 169 7
PaintSHOP enables the interactive design of transcriptome- and genome-scale oligonucleotide FISH experiments 169 7 4
TuNR: Orthogonal Control of Mean and Variability of Endogenous Genes in a Human Cell Line 169 7


Topic 170   40 items
declared statementthe authors competing text
Collective motion as a distinct behavioral state of the individual 170 7
A model to study orienting responses in zebrafish, and applications towards the emotion-cognition interaction 170 7 2
Identification of compounds producing non-visual photosensation via TrpA1 in zebrafish 170 7


Topic 171   22 items
tubulin nucleation microtubule microtubules centrosomes
Phospho-regulated auto-inhibition of Cnn controls microtubule nucleation during cell division 171 68 34 3
Drosophila dTBCE recruits tubulin around chromatin to promote mitotic spindle assembly 171 68 34 8 3
Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome 171 68 34 3


Topic 172   29 items
stem differentiation bone derived regenerative
Single cell RNA sequence analysis of human bone marrow samples reveals new targets for isolation of skeletal stem cells using DNA-coated gold nanoparticles 172 57 43 9 4
Optimising DNA-Coated Gold Nanoparticles to Enrich Skeletal Stem Cells from Human Bone Marrow Samples 172 57 18
Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine. 172 57 20 3


Topic 173   30 items
tumors tumor cancer therapy patients
Defining the transcriptional landscape of infiltrating immune cells in human and mouse bladder cancer. 173 148 14 9 3
Divergent resistance mechanisms to immunotherapy explains response in different skin cancers. 173 14 10 3
Circulating Clonally Expanded T Cells Reflect Functions of Tumor Infiltrating T Cells 173 88 14 9 3


Topic 174   53 items
il immunology inflammatory ifn mice
Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis 174 27 10 3
SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis 174 27 10
SOCS-1 inhibition of type I interferon limits Staphylococcus aureus skin host defense 174 27 10 3


Topic 175   46 items
samples seq sample methods rna
Comprehensive evaluation of human brain gene expression deconvolution methods 175 43 9 4
Bayesian estimation of cell-type-specific gene expression per bulk sample with prior derived from single-cell data 175 43 9 4
Establishment of a simplified preparation method for single-nucleus RNA-sequencing and its application to long-term frozen tumor tissues 175 43 4


Topic 176   34 items
researchers user interface software open
SIMON: open-source knowledge discovery platform 176 62 4
ResistoXplorer: a web-based tool for visual, statistical and exploratory data analysis of resistome data 176 62 4
DeepEthogram: a machine learning pipeline for supervised behavior classification from raw pixels 176 26 13 4 2


Topic 177   16 items
o_fig m_fig c_fig o_linksmallfig figdir
Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons 177 6 3
Differences in mitochondrial activity trigger cell competition during early mouse development. 177 6 3
Context-specific functions of Notch in Drosophila blood cell progenitors 177 6 3


Topic 178   7 items
diaphorina citri citrus uap usmg5
Characterization of Wnt Signaling Genes in Diaphorina citri 178 118
Chitin Biosynthesis Genes in Diaphorina citri 178 129
Characterization of Viral Insulins Reveals White Adipose Tissue Specific Effects in Mice 178 3


Topic 179   36 items
cancer stem cells hematopoietic renewal
Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood 179 21 9
Hematopoietic stem cells self-renew symmetrically or gradually proceed to differentiation 179 57 20 3
A Computational Model of Stem Cell Molecular Mechanism to Maintain Tissue Homeostasis 179 20 3


Topic 180   47 items
plant insect field pest laboratory
Low aflatoxin levels and flowering delay in Aspergillus flavus-resistant maize lines are correlated with increased corn earworm damage and enhanced seed fumonisin content 180 53 5
Reduced levels of membrane-bound alkaline phosphatase in Vip3Aa-resistant Heliothis virescens 180 12
Is there a genetic correlation between movement and immobility in field populations of a beetle? 180 30 5


Topic 181   7 items
f508del biochemistry depends conformation cftr
A Topological Switch Enables Misfolding of the Cystic Fibrosis Transmembrane Conductance Regulator 181 63 8 3
Preferred Conformations in the Intrinsically Disordered Region of Human CPEB3 Explain its Role in Memory Consolidation 181 6
Fluorescence assay for simultaneous quantification of CFTR ion-channel function and plasma membrane proximity 181 64 8


Topic 182   43 items
models random prediction performance predict
Multi-model evaluation of phenology prediction for wheat in Australia 182 53 5 4
How well do crop modeling groups predict wheat phenology, given calibration data from the target population? 182 83 38 4
Machine learning reveals time-varying microbial predictors with complex effects on glucose regulation 182 101 26 15 4


Topic 183   45 items
ecology life history size traits
Short-lived plants have stronger demographic responses to climate 183 86 17 5
Polyandry and senescence shape egg size variation in a precocial bird. 183 132 21 5
Quality versus quantity: The balance between egg and clutch size among Australian amphibians is related to life history and environmental conditions 183 132 5


Topic 184   41 items
text interest competing declared statementthe
PRER: A Patient Representation with Pairwise Relative Expression of Proteins on Biological Networks 184 7 4
Hybridized distance- and contact-based hierarchical structure modeling for folding soluble and membrane proteins 184 105 13 4
AE-LGBM: Sequence-Based Novel Approach To Detect Interacting Protein Pairs via Ensemble of Autoencoder and LightGBM. 184 105 26 7 4


Topic 185   36 items
evolutionary environments environmental theory evolution
The impact of dominance on adaptation in changing environments 185 21 5
Dominance patterns in dynamic environments 185 21 5
Phenotypic delay in the evolution of bacterial antibiotic resistance: mechanistic models and their implications 185 21 5


Topic 186   53 items
cancer signaling tumor akt pathways
Metastatic signaling of hypoxia-related genes across TCGA Pan-Cancer types 186 14 9 3
A novel role for the tumor suppressor gene ITF2 in lung tumorigenesis and chemotherapy response 186 14 9 3
HDAC and MAPK/ERK inhibitors cooperate to reduce viability and stemness phenotype in medulloblastoma 186 108 14 10 3


Topic 187   21 items
o_fig figdir c_fig m_fig o_linksmallfig
Why do pathway methods work better than they should? 187 6
The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists 187 6
Mechano-bactericidal nanopillars require external forces to effectively kill bacteria 187 6


Topic 188   29 items
mice mouse anti term myelin
Long term AAV2/9-mediated silencing of PMP22 prevents CMT1A disease in rats and validates skin biomarkers as treatment outcome measure 188 10
The central THαβ immunity associated cytokine: IL-10 has a strong anti-tumor ability toward established cancer models in vivo and toward cancer cells in vitro 188 27 10 3
Sodium valproate protects against neuronal ferroptosis in epilepsy via suppressing lysyl oxidase 188 10 3


Topic 189   29 items
cancer tumor patients patient prognostic
Human Prostate Cancer-Associated Macrophage Subtypes with Prognostic Potential Revealed by Single-cell Transcriptomics 189 148 14 9 3
Genome profiles of lymphovascular breast cancer cells reveal multiple clonally differentiated outcomes with multi-regional LCM and G&T-seq 189 14 9 3
Identification of stromal genes differentially expressed in lobular breast cancer highlights role for pregnancy-associated-plasma protein-A 189 14 9 3


Topic 190   26 items
ecology habitats ecosystems vegetation communities
Divergent impact of grazing on plant communities of created wetlands with varying hydrology and antecedent land use 190 17 5
Does rainforest biodiversity stand on the shoulders of giants? Effect of disturbances by forest elephants on trees and insects on Mount Cameroon 190 17 5
Trophic guild and forest type explain phyllostomid bat abundance variation from human habitat disturbance. 190 17 5


Topic 191   47 items
epitopes vaccine sars cov epitope
Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2 191 76 24 1
Multi-epitope vaccine design using an immunoinformatics approach for 2019 novel coronavirus (SARS-CoV-2) 191 76 24 1
Designing of Epitope-Based Vaccine from the Conserved Region of the Spike Glycoprotein of SARS-CoV-2 191 76 24 1


Topic 192   44 items
chromatin transcriptional methyltransferase stem transcription
The transcription factor CLAMP is required for neurogenesis in Drosophila melanogaster. 192 133 20 3
DOT1L Methyltransferase Activity Preserves SOX2-Enhancer Accessibility And Prevents Activation of Repressed Genes In Murine Stem Cells 192 93 31 20 3
Chromatin accessibility and histone acetylation in the regulation of competence in early development 192 31 20 3


Topic 193   16 items
brain resonance magnetic organization biobank
The functional foundations of episodic memory remain stable throughout the lifespan 193 22 2
Large-scale Phenomic and Genomic Analysis of Brain Asymmetrical Skew 193 22 19 2
The genetic organization of subcortical volumetric change is stable throughout the lifespan 193 75 22 15 2


Topic 194   21 items
rarely laboratory consisting advance districts
Genetic diversity, haplotype analysis, and risk factor assessment of hepatitis a virus (HAV) isolates from the West Bank, Palestine during the period between 2014 and 2016 194 15 5
Genetic diversity, haplotype analysis, and risk factor assessment of hepatitis a virus (HAV) isolates from the West Bank, Palestine during the period between 2014 and 2016 194 15 5
Social relationships among captive male pygmy slow lorises (Nyctycebus pygmaeus): Is forming male same-sex pairs a feasible management strategy? 194 15 5


Topic 195   32 items
automated user microscopy fluorescence optical
Pocket MUSE: an affordable, versatile and high performance fluorescence microscope using a smartphone 195 70 18 4
Democratising "Microscopi": a 3D printed automated XYZT fluorescence imaging system for teaching, outreach and fieldwork 195 7 4
Multiplexed End-point Microfluidic Chemotaxis Assay using Centrifugal Alignment 195 18 4


Topic 196   31 items
living fluorescence synthetic functions enables
A sample preparation protocol for high throughput immunofluorescence of suspension cells 196 18 4
Stealth fluorescence labeling for live microscopy imaging of mRNA delivery 196 18 8 7
Enzymatic RNA Biotinylation for Affinity Purification and Identification of RNA-protein Interactions 196 151 45 8 3


Topic 197   33 items
vesicle vesicles cells cell cancer
PAC-mediated AKI protection is critically mediated but does not exclusively depend on cell-derived microvesicles 197 10
PAC-mediated AKI protection is critically mediated but does not exclusively depend on cell-derived microvesicles 197 10
The PD-L1/PD-1 Axis Blocks Neutrophil Cytotoxicity In Cancer 197 27 14 10 3


Topic 198   27 items
spectrometry mass modifications ms amino
Glycopeptide variable window SWATH for improved Data Independent Acquisition glycoprotein analysis 198 45 8 4
Discovery of protein modifications using high resolution differential mass spectrometry proteomics 198 45 13 4
DIALib: an automated ion library generator for data independent acquisition mass spectrometry analysis of peptides and glycopeptides 198 45 4


Topic 199   34 items
engineering enzyme metabolic production biosynthetic
Functional analysis of the fatty acid and alcohol metabolism of Pseudomonas putida using RB-TnSeq 199 67 12
Discovery and biosynthesis of gladiochelins: unusual lipodepsipeptide siderophores from Burkholderia gladioli 199 79 12
Enzyme-constrained models and omics analysis of Streptomyces coelicolor reveal metabolic changes that enhance heterologous production 199 67 12