Topic 27

immunology immune inflammatory infection innate macrophages il responses immunity cells inflammation response ifn cytokine cytokines activation cell host cd4 macrophage mice cd8 induced infected infections effector antigen interferon gamma pro mediated receptor monocytes production anti viral expression lung tnf tissue role virus blood subsets peripheral pathogen against type chronic neutrophils dendritic stimulated murine signaling induction activated monocyte disease protective pathogens increased systemic vivo enhanced myeloid resident neutrophil defense mouse beta antiviral lymphocytes intestinal stimulation mucosal dependent antigens lps immunological lymphoid patients pathogenesis epithelial receptors deficient induce intracellular phenotype associated nf diseases memory during bacterial derived upon helper specific differentiation th1

867 items. Top items listed below.

LAG3 is a Central Regulator of NK Cell Cytokine Production 27 10 3

SARS-CoV-2 induces activation and diversification of human plasmacytoid pre-dendritic cells. 73 27 1

Hedgehog dysregulation contributes to tissue-specific inflammaging of resident macrophages 110 27 10 3

Treated HIV Infection Alters Phenotype But Not HIV-specific Function of Peripheral Blood Natural Killer Cells 88 27 10 3

Dynamic metabolic reprogramming in dendritic cells: an early response to influenza infection that is essential for effector function 27 10 3

ILC1-derived IFN-gamma mediates cDC1-dependent host resistance against Toxoplasma gondii 27 3

Transcriptional memory-like imprints and enhanced functional activity in γδ T cells following resolution of malaria infection 88 27 10 3

Short chain fatty acid butyrate promotes virus infection by repressing interferon stimulated genes 27 10 3

Modelling within-host macrophage dynamics in influenza virus infection 27 10 1

Rewiring PBMC responses to prevent CHIKV infection-specific monocyte subset redistribution and cytokine responses 27 10 3

Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses 88 27 10 3

Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection 27 10 3

TOLLIP promotes durable alveolar macrophage-mediated immunity during Mycobacterium tuberculosis infection by resolving cellular stress from lipids. 69 27 10 3

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis 174 27 10

The microbiota plays a critical role in the reactivity of lung immune components to innate ligands 27 10 3

Comprehensive single cell analysis of pandemic influenza A virus infection in the human airways uncovers cell-type specific host transcriptional signatures relevant for disease progression and pathogenesis. 73 27 9 1

Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain. 110 27 10 3

PYK2 controls intestinal inflammation via activation of IRF5 in macrophages 110 27 10 3

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB 73 27 1

Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses 27 10 3

Suppression of Cytotoxic T Cell Functions and Decreased Levels of Tissue Resident Memory T cell During H5N1 infection 27 10 3

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures 73 1

Influenza-induced activation of recruited alveolar macrophages during the early inflammatory phase drives lung injury and lethality 27 10 3

STAT1-dependent tolerance of intestinal viral infection 27 10 3

Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice 110 27 10 3

Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis 174 27 10 3

Functionally distinct neutrophils sequentially promote Th1-type responses upon antiviral antibody therapy 27 10 3

γδ T cells mediate a requisite portion of a wound healing response triggered by cutaneous poxvirus infection 27 10 3

Developmental pathways regulate cytokine-driven effector and feedback responses in the intestinal epithelium 27 3

RNA-binding protein RBM3 negatively regulates innate lymphoid cells (ILCs) and lung inflammation 27 3

Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells 27 10 3

Immunosuppressive role of PGE2 during human tuberculosis 27 10 3

A Novel Role for the Nuclear Receptor, NR4A1, in Klebsiella pneumoniae Lung Infection 27 10 3

Impaired cytotoxic CD8+ T cell response in elderly COVID-19 patients 73 27 1

A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation 27 3

SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function 73 36 1

IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection 27 3

Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling 27 10 3

Alpha-synuclein supports interferon stimulated gene expression in neurons 54 27 10 3

Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication 41 27 3

mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2 191 36 24 1

Brucella suppress innate immunity by down-regulating STING expression in macrophages 174 27 3

Loss of IL-10 signaling promotes IL-22 dependent host defenses against acute Clostridioides difficile infection 27 10 3

Low doses of radiation increase the immunosuppressive profile of lung macrophages during viral infection and pneumonia 73 27 10 1

STAT3 Serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression 110 27 10 3

Title: Acetylcholine regulates pulmonary inflammation and facilitates the transition from active immunity to tissue repair during respiratory viral infection 27 10 3

High expression of angiotensin-converting enzyme-2 (ACE2) on tissue macrophages that may be targeted by virus SARS-CoV-2 in COVID-19 patients 36 1

Interleukin-19 alleviates experimental autoimmune encephalomyelitis by attenuating antigen-presenting cell activation 110 27 10 3

ISG15 drives immune pathology and respiratory failure during viral infection 27 10 3

Modulation of the mTOR pathway plays a central role in dendritic cell functions after Echinococcus granulosus antigen recognition. 27 10 3

Role for both myeloid and plasmacytoid DC in driving primary T helper cell response to Burkholderia pseudomallei in healthy individuals. 27 10 3

Single cell transcriptional profiling reveals helper, effector, and regulatory MAIT cell populations enriched during homeostasis and activation 88 27 9 3

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection 73 27 1

Transcriptomic profiling of human effector and regulatory T cell subsets identifies predictive population signatures 88 27 9 3

Discriminating Mild from Critical COVID-19 by Innate and Adaptive Immune Single-cell Profiling of Bronchoalveolar Lavages 27 10 1

Intestinal infection results in impaired lung innate immunity to secondary respiratory infection. 27 10 3

Longitudinal single-cell immune profiling revealed distinct innate immune response in asymptomatic COVID-19 patients 73 27 1

Host-cell interactions and innate immune response to an enteric pathogen in a human intestinal enteroid-neutrophil co-culture 27 10 3

Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependant protection against pulmonary tuberculosis 27 10 3

The PD-L1/PD-1 Axis Blocks Neutrophil Cytotoxicity In Cancer 197 27 14 10 3

Endothelial cells promote productive HIV infection of resting CD4+ T cells by an integrin-mediated cell adhesion-dependent mechanism 27 3

IL-4-induced hysteresis in naive T cell activation 88 27 3

T cells expanded from renal cell carcinoma are tumor-reactive but fail to produce IFN-γ, TNF-α or IL-2 88 27 10 3

Ex vivo detection of SARS-CoV-2-specific CD8+ T cells: rapid induction, prolonged contraction, and formation of functional memory 24 1

Macrophage-derived miR-21 drives overwhelming glycolytic and inflammatory response during sepsis via repression of the PGE2/IL-10 axis. 110 27 10 3

GM-CSF differentiation of human monocytes stabilizes macrophage state via oxidative signaling 27 10 3

Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques 73 27 1

Expression of Tim-3 drives naive Treg to an effector-like state with enhanced suppressive activity 88 27 14 10 3

Th2-like T-follicular helper cells promote functional antibody production during Plasmodium falciparum infection 146 88 60 27 24 10 3

Pneumolysin is responsible for differential gene expression and modifications in the epigenetic landscape of primary monocyte derived macrophages. 27 3

Mycobacterium tuberculosis evasion of Guanylate Binding Protein-mediated host defense in mice requires the ESX1 secretion system. 114 27 12 3

Nasal commensal, Staphylococcus epidermidis shapes the mucosal environment to prevent influenza virus invasion through Serpine1 induction 27 10 3 1

Tissue-resident memory CD8 T-cell responses elicited by a single injection of a multi-target COVID-19 vaccine 24 1

A human disease model of SARS-CoV-2-induced lung injury and immune responses with a microengineered organ chip 73 1

ETV7 limits antiviral gene expression and control of SARS-CoV-2 and influenza viruses 41 27 3 1

TRM Integrins CD103 and CD49a Differentially Support Adherence and Motility After Resolution of Influenza Virus Infection 88 27 10 3

IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type 2 immune response to nematode infection 27 10 3

Intestinal-epithelial LSD1 controls cytoskeletal-mediated cell identity including goblet cell effector responses required for gut inflammatory and infectious diseases 27 10 3

Ly6C defines a subset of memory-like CD27+ γδ T cells with inducible cancer-killing function 88 27 10 3

Antigen-specific competitive inhibition of CD4+ T cell recruitment into the primary immune response 88 27 10 3

Rora regulates activated T helper cells during inflammation 27 3

Infected macrophages engage alveolar epithelium to metabolically reprogram myeloid cells and promote antibacterial inflammation 27 10 3

A distinct innate immune signature marks progression from mild to severe COVID-19 73 27 1

Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5 27 10 3

Metabolic Immunomodulation, Transcriptional Regulation, and Signal Protein Expression Define the Metabotype and Effector Functions of Five Polarized Macrophage Phenotypes 27 10 3

Regulatory T cell activation triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses 150 27 3

Mucosal immune stimulation with HSV-2 and polyICLC boosts control of viremia in SIVΔNef vaccinated rhesus macaques with breakthrough SIV infection 88 27 10

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques 27 10 3

A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α. 150 27 3

NF-kappa-B activation unveils the presence of inflammatory hotspots in human gut xenografts 27 10 3

Inflammasome- and gasdermin D-independent IL-1β production mobilizes neutrophils to inhibit antitumor immunity 150 27 14 10 3

Blimp-1 is essential for Th2 cell development and allergic asthma 27 3

Growth differentiation factor-15 is associated with age-related monocyte immunosenescence 174 27 10 3

SOCS-1 inhibition of type I interferon limits Staphylococcus aureus skin host defense 174 27 10 3

Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs 36 1

Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model system 114 27 3

Regulation of early growth response-1 (Egr-1) gene expression by Stat1-independent type I interferon signaling and respiratory viruses 73 27 3 1

Ex vivo Immune Profiling in Patient Blood enables Quantification of innate immune Effector Functions 27 10

Calcium-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells 150 88 27 3

Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins 41 27 10 3