Topic 88

immunology antigen cd8 immune cells cd4 cell effector antigens responses immunity memory tcr lymphocytes subsets receptor antibody repertoire peripheral naive specific cytotoxic infection antibodies lymphoid expansion response mice germinal immunotherapy vaccination expressing blood gamma helper vaccine receptors tumor mhc lymph lymphocyte against activation cytometry anti immunological bcr nk repertoires clonal hla autoimmunity ifn differentiation il subset hiv resident peptide presentation tcrs humoral protective class pd adaptive single autoimmune dendritic expression follicular phenotype vaccines clones mucosal presenting tumors infiltrating treg immunotherapies patients th1 surface immunization challenge killer mouse after enhanced affinity generation infections human adoptive vivo protection innate induction peptides tissue

308 items. Top items listed below.

Transcriptional memory-like imprints and enhanced functional activity in γδ T cells following resolution of malaria infection 88 27 10 3

Single cell transcriptional profiling reveals helper, effector, and regulatory MAIT cell populations enriched during homeostasis and activation 88 27 9 3

Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses 88 27 10 3

Ly6C defines a subset of memory-like CD27+ γδ T cells with inducible cancer-killing function 88 27 10 3

Circulating Clonally Expanded T Cells Reflect Functions of Tumor Infiltrating T Cells 173 88 14 9 3

Treated HIV Infection Alters Phenotype But Not HIV-specific Function of Peripheral Blood Natural Killer Cells 88 27 10 3

Th2-like T-follicular helper cells promote functional antibody production during Plasmodium falciparum infection 146 88 60 27 24 10 3

Expression of Tim-3 drives naive Treg to an effector-like state with enhanced suppressive activity 88 27 14 10 3

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection 191 76 24 1

Transcriptomic profiling of human effector and regulatory T cell subsets identifies predictive population signatures 88 27 9 3

Single cell BCR and transcriptome analysis after respiratory virus infection reveals spatiotemporal dynamics of antigen-specific B cell responses. 88 27 24 9 3

mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2 191 36 24 1

Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon vaccination 88 27 24 10

Pre-existing intratumoral CD8 T cells substantially contribute to control tumors following therapeutic anti-CD40 and polyI:C based vaccination 88 14 10 3

Ex vivo detection of SARS-CoV-2-specific CD8+ T cells: rapid induction, prolonged contraction, and formation of functional memory 24 1

CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells. 88 27 10 3

IL-4-induced hysteresis in naive T cell activation 88 27 3

A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses 24 1

TRM Integrins CD103 and CD49a Differentially Support Adherence and Motility After Resolution of Influenza Virus Infection 88 27 10 3

Impaired cytotoxic CD8+ T cell response in elderly COVID-19 patients 73 27 1

Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation. 88 27 9 3

SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs 191 76 24 1

T cell competition profoundly reduces the effect of initial precursor frequency on the generation of CD4 T cell memory 88 27 21 5

Tissue-resident memory CD8 T-cell responses elicited by a single injection of a multi-target COVID-19 vaccine 24 1

Molecular determinants and heterogeneity of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing 88 27 9 3

Missing-In-Metastasis / Metastasis Suppressor 1 modulates B cell receptor signaling, B cell metabolic potential and T cell-independent immune responses. 146 88 27 3

Antigen-specific competitive inhibition of CD4+ T cell recruitment into the primary immune response 88 27 10 3

Vaccination reshapes the virus-specific T cell repertoire in unexposed adults 88 27 24

T cells expanded from renal cell carcinoma are tumor-reactive but fail to produce IFN-γ, TNF-α or IL-2 88 27 10 3

LAG3 is a Central Regulator of NK Cell Cytokine Production 27 10 3

Atypical B cells are a normal component of immune responses to vaccination and infection in humans 88 27 10

Lymphatic PD-L1 expression restricts tumor-specific CD8+ T cell responses 88 14 10 3

Human CD8+ T cells exhibit a shared antigen threshold for different effector responses 88 27 10

Human Microbial Transplant Restores T Cell Cytotoxicity and Anti-Tumor Response to PD-L1 Blockade in Gnotobiotic Mice 88 27 10 3

Redefining CD4 T cell residency: Helper T cells orchestrate protective humoral immunity in the lung 88 27 10 3

CCR5 deficiency impairs CD4+ T cell memory responses and antigenic sensitivity through increased ceramide synthesis 88 27 10 3

Profiling virus-specific Tcf1+ T cell repertoires during acute and chronic viral infection 88 27 10

Peptide:MHC dependent activation of natural killer cells through KIR2DS2 generates anti-tumor responses 88 14 10 3

Single-cell metabolic dynamics of early activated CD8 T cells during the primary immune response to infection 88 27 3

Dendritic cells focus CTL responses toward highly conserved and topologically important HIV epitopes 191 88 76 24 10

Longitudinal single-cell immune profiling revealed distinct innate immune response in asymptomatic COVID-19 patients 73 27 1

Dissecting the landscape of activated CMV-stimulated CD4+ T cells in human by linking single-cell RNA-seq with T-cell receptor sequencing 88 27 9 3

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients. 191 24 1

Developing human fetal skin demonstrates a unique lymphocyte signature 88 27 20 3

Mucosal immune stimulation with HSV-2 and polyICLC boosts control of viremia in SIVΔNef vaccinated rhesus macaques with breakthrough SIV infection 88 27 10

Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells 126 88 14 10 3

Control of Mycobacterium tuberculosis Infection in Lungs is Associated with Recruitment of Antigen-Specific Th1 and Th17 cells Co-expressing CXCR3 and CCR6. 88 27 10 3

Epstein Barr virus epitope/MHC interaction combined with convergent recombination drive selection of diverse T cell receptor a and b repertoires 76 27 24

CD4+ follicular helper-like T cells are key players in anti-tumor immunity 88 14 10 3

Effective neoantigen vaccination correlates with cDC1-dependent generation of antigen-specific CX3CR1+CD8+ T cells in mice 88 14 10 3

Postnatal expansion, maturation and functionality of MR1 T cells in humans 88 27 10

A novel strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations 88 27 3

Rapid GMP-compliant expansion of SARS-CoV-2-specific T cells from convalescent donors for use as an allogeneic cell therapy for COVID-19 88 24 1

TCF-1 regulates the stem-like memory potential of HIV-specific CD8+ T cells in elite controllers 88 27 3

Disease stage-specific pathogenicity of CD138 (syndecan 1)-expressing T cells in systemic lupus erythematosus 174 88 27 10 3

PD-1 Specific 'Blocking' Antibodies That Deplete PD-1+ T Cells Present An Inconvenient Variable In Pre-clinical Immunotherapy Experiments 88 14 10

Calcium-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells 150 88 27 3

Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population 88 27 10 3

Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4+ T cells 73 27 1

Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation 102 88 27 3

Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia 88 27 10 3

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8+ cells 88 27 10 3

Age related defects in NK cell immunity revealed by deep immune profiling of pediatric cancer patients 88 27 10 3

Identification of human CD4+ T cell populations with distinct antitumor activity 88 27 10 3

A population of CD4+ T cells with a naive phenotype stably polarized to the TH1 lineage 88 27 20 3

PD-L1hi plasmablasts limit the T cell response during the acute phase of parasite infections 88 27 10 3

Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth 146 88 24 10

Convergent selection in antibody repertoires is revealed by deep learning 88 24

Latent Plasticity of Effector-like Exhausted CD8 T cells contributes to memory responses 88 27 10 3

Protection from viral rebound after therapeutic vaccination with an adjuvanted DNA vaccine is associated with SIV-specific polyfunctional CD8 T cells in the blood and mesenteric lymph nodes 88 27 10

SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques 146 24 1

Quantifying memory CD8 T cell-mediated immune pressure on influenza A virus infection in vivo 88 24 10

PD-1 blockade-driven anti-tumor CD8+ T cell immunity requires XCR1+ dendritic cells 88 27 14 10 3

In vivo CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer 192 88 31 27 3

Functional delineation of tissue-resident CD8 T cell heterogeneity during infection and cancer 88 27 10 3

Mathematical modeling of N-803 treatment in SIV-infected non-human primates 88 10

Immature dendritic cells promote high avidity tuning of vaccine T cell response 88 10 3

ZENITH: A flow cytometry based method for functional profiling energy metabolism with single cell resolution 88 14 10 9

Immunologically distinct responses occur in the CNS of COVID-19 patients 88 73 24 1

A circulating T-cell differentiation marker to predict response to immune checkpoint inhibitors 126 14 10 3

Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment 88 14 9

A novel subset of follicular helper-like MAIT cells has capacity for B cell help and antibody production in the mucosa. 146 88 27 10 3

Development of a humanized mouse model to analyze antibodies specific for human leukocyte antigen (HLA) 88 27 10 3

Structural basis of Blastomyces Endoglucanase-2adjuvancy in anti-fungal and -viral immunity 24 10 1

Modelling the effects of lymph node swelling on T-cell response 88 27 10 3

A Single Dose of Self-Transcribing and Replicating RNA Based SARS-CoV-2 Vaccine Produces Protective Adaptive Immunity In Mice 24 1

Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependant protection against pulmonary tuberculosis 27 10 3

CD8 co-receptor enhances T cell activation without any effect on initial attachment 88 8

Three-Compartment Model of CAR T-cell Immunotherapy 88 10

cGAMP loading enhances the immunogenicity of VLP vaccines 146 88 24 10 3

γδ T cells mediate a requisite portion of a wound healing response triggered by cutaneous poxvirus infection 27 10 3

Acute lymph node slices are a functional model system to study immunity ex vivo 88 27 10

Single-cell landscape of immunological responses in COVID-19 patients 73 27 1

Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations 146 88 27 24 10

Spliced peptides and cytokine driven changes in the immunopeptidome of melanoma 88 45 14 10

Peripheral tolerance checkpoints imposed by ubiquitous antigen expression limit antigen-specific B-cell responses under strongly immunogenic conditions 88 27 10 3

Antigen responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir 88 27 10

The human small intestine comprises two subsets of regulatory Foxp3+ CD4 T cells with very different life span and functional properties. 88 27 10 3

RNA-seq of Human T-Cells After Hematopoietic Stem Cell Transplantation Identifies Linc00402 as a Novel Regulator of T-Cell Alloimmunity 88 27 10 9 3

A functional screening platform for engineering chimeric antigen receptors with reduced on-target, off-tumour activation 33 14 10 3