Topic 126
cancer tumor therapy treatment tumors inhibitors therapeutic efficacy resistance anti combination inhibitor targeting patients biology chemotherapy therapies survival drug clinical vivo patient cancers inhibition cells preclinical effective immunotherapy drugs resistant targeted blockade cell glioblastoma checkpoint vitro models agents glioma response growth lines xenografts breast immune pd xenograft approved bearing myeloid aggressive trials ovarian microenvironment treated derived treatments radiation care expression primary metastatic agent standard strategy sensitivity alone gbm leukemia promising cytotoxic induced benefit sensitive mice antitumor clinically viability solid target radiotherapy synergistic pdx combined chemotherapeutic poor signaling increased malignancies antibody kinase l1 parp temozolomide car apoptosis upregulation murine toxicity syngeneic
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