Topic 186

cancer signaling tumor akt pathways pi3k tumors oncogenic kinase biology pathway expression patient glioblastoma cells mapk therapeutic ras crosstalk primary activation activated microenvironment downregulated breast phosphorylation downstream inhibition patients transcriptome metabolism cell survival vitro resistance lines genes therapy protein altered identified receptor inhibitors kinases overexpressed aggressive upregulated key tcga factor erk temozolomide malignancy glioma tyrosine frequently gbm clinically revealed mek phosphatases mechanisms therapies activating vivo cascades transcriptional proliferation inhibitor alterations analysis chemotherapy proliferator targeted negatively pan metastasis regulated receptors peroxisome regulator lymphoma define identify oncogene differentially samples translational oncogenes comprehensive reveals raf specimens targets spectrometry egfr potential among axis overall

53 items. Top items listed below.

Metastatic signaling of hypoxia-related genes across TCGA Pan-Cancer types 186 14 9 3

A novel role for the tumor suppressor gene ITF2 in lung tumorigenesis and chemotherapy response 186 14 9 3

HDAC and MAPK/ERK inhibitors cooperate to reduce viability and stemness phenotype in medulloblastoma 186 108 14 10 3

PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK 186 102 14 3

P4HA2 is associated with prognosis, promotes proliferation, invasion, migration and EMT in glioma 98 14 3

The landscape of metabolic pathway dependencies in cancer cell lines 186 9 3

EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma 186 142 31 3

LNX1 Modulates Notch1 Signaling to Promote Expansion of the Glioma Stem Cell Population During Temozolomide Therapy in Glioblastoma 186 126 14 10 3

Global proteome and phosphoproteome alterations in third generation EGFR TKI resistance reveal drug targets to circumvent resistance 186 7 3

Persistent cell proliferation signals correlates with increased glycolysis in tumor hypoxia microenvironment across cancer types 186 9

Dampened PI3K/AKT signaling contributes to cancer resistance of the naked mole rat 186 142 108 14 3

CBL mutations promote activation of PI3K/AKT signaling via LYN kinase 186 108 102 14 3

The glycolysis regulator PFKFB4 interacts with ICMTand activates RAS/AKT signaling-dependent cell migration in melanoma. 186 102 34 3

Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG 186 95 3

Mapping the unique and shared functions of oncogenic KRAS and RIT1 with proteome and transcriptome profiling 186 142 102 14 3

Data-driven inference of crosstalk in the tumor microenvironment 186 14 9 3

Epigenetic downregulation of HER2 during EMT leads to tumor resistance to HER2-targeted therapies in breast cancer 98 14 10 3

Computational response modeling reveals context dependent Akt activity in luminal breast cancer cells 186 102 14 3

PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response 186 14 10 3

Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model 186 14 10 3

RIT1: A Novel Biomarker in Glioblastoma 186 142 14 9 3

Prognostic significance of SOCS1 and SOCS3 tumor suppressors in hepatocellular carcinoma and its correlation to key oncogenic signaling pathways 186 108 14 10 3

UBR-Box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target 108 14 3

FER-mediated tyrosine phosphorylation and PIK3R2/p85β recruitment on IRS4 promotes the PI3K-AKT signaling pathway and tumorigenesis in ovarian cancer 186 102 14 3

Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches 186 14 10 9 3

Transcription factor-based gene therapy to treat glioblastoma through direct neuronal conversion 186 14 11 3

Differential B-cell receptor signaling requirement for adhesion of mantle cell lymphoma cells to stromal cells 186 14 3

Quantitative analysis of tyrosine phosphorylation from FFPE tissues reveals patient specific signaling networks 186 14 9 3

Kinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 As Candidate Therapeutic Target 186 14 9 3

Obesity-driven changes in ECM composition promote local invasion and metastasis of breast tumors 14 10 3

Development of a Notch pathway assay and quantification of functional Notch pathway activity in T-cell acute lymphoblastic leukemia 186 14 10

Single cell analysis of colorectal cancer identifies mitogen-activated protein kinase as a key driver of tumor cell plasticity 152 148 142 14 9 3

The immune landscape of primary central nervous system diffuse large B cell lymphoma 186 14 10 3

Immunophenotyping of HER4/YAP axis in breast cancer brain metastasis 186 14 10 3

Glioblastoma Cell Migration is Directed by Electrical Signals 186 108 10 3

Human Transcription Factor and Protein Kinase Gene Fusions in Human Cancer 186 9

The CoREST Repressor Complex Mediates Phenotype Switching and Therapy Resistance in Melanoma 186 14 3

Multiplex-inhibitor bead mass spectrometry reveals differential kinome signatures in newly diagnosed and recurrent glioblastoma 152 14 9 3

ATM Inhibition Synergizes with Fenofibrate in High Grade Serous Ovarian Cancer Cells 126 14 10 9 3

A tyrosine kinase protein interaction map reveals targetable EGFR network oncogenesis in lung cancer 186 108 102 14 3

A Proteogenomic workflow reveals distinct molecular phenotypes related to breast cancer appearance 186 45 14 9

AMPK-Fyn signaling promotes Notch1 stability to potentiate hypoxia-induced breast cancer stemness and drug resistance 108 102 14 3

Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers 126 14 10 3

Identification of Wee1 as Target in Combination with Avapritinib for the Treatment of Gastrointestinal Stromal Tumors 152 126 14 10 3

Downregulation of muscle cell Insr and insulin receptor signaling by hyperinsulinemia in vitro and in vivo 186 10 3

Nogo-A Beyond the RhoA/ROCK Pathway - Novel Components of Intracellular Nogo-A Signaling Cascades 186 102 3

Cell intrinsic signaling in MEN1 mutant pancreatic neuroendocrine tumors unveils novel signaling pathways associated with de-differentiation 186 142 14 9 3

Transcriptome profiling-based evidences reiterate the intrinsic role of MAPKAPK2 in facilitating molecular crosstalk during HNSCC pathogenesis 186 14 9 3

Time-resolved profiling reveals ATF3 as a novel mediator of endocrine resistance in breast cancer 108 14 3

Genome-wide Screens Identify Lineage- and Tumor Specific-Genes Modulating MHC-I and MHC-II Immunosurveillance in Human Lymphomas 186 142 14 9 3

A pan-cancer metabolic atlas of the tumor microenvironment 186 14 9 3

A SNAI2-PEAK1 stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting a cytokine expression profile that converges on PI3K/Akt signaling 14 3

Patient-derived glioblastoma cells (GBM) exhibit distinct biomechanical profiles associated with altered activity in the cytoskeleton regulatory pathway 152 14 9 3

Double-targeted knockdown of miR-21 and CXCR4 inhibits malignant glioma progression by suppression of the PI3K/AKT and Raf/MEK/ERK pathways 108 14 10 3

Frizzled-7 Identifies Platinum Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis 98 14 10 3

PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity 108 14 10 3

Cyclopamine sensitizes Glioblastoma cells to Temozolomide treatment through Sonic Hedgehog pathway 186 126 108 14 10 3

Connexin 43 confers chemoresistance through activating PI3K 186 126 108 14 3

Phosphoproteomics after nitrate treatments reveal an important role for PIN2 phosphorylation in control of root system architecture. 16 9 3

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy 152 14 9 3

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells 152 14 10 3

Characterization of immunoactive and immunotolerant CD4+ T cells in breast cancer by measuring activity of signaling pathways that determine immune cell function 14 10 3

Evolutionarily Conserved Transcription Factors Drive the Oxidative Stress Response in Drosophila 134 31 9 3

TRAF4 inhibits bladder cancer progression by promoting BMP/SMAD signalling pathway 98 14 3

Stroma transcriptomic and proteomic profile of prostate cancer metastasis xenograft models reveals conservation of bonemicroenvironment signatures 152 14 9 3

Autocrine Signaling by Receptor Tyrosine Kinases in Urothelial Carcinoma of the Bladder 98 14 9 3

Cyclin G2 inhibits oral squamous cell carcinoma growth and metastasis by binding to insulin-like growth factor binding protein 3 and regulating the FAK-SRC-STAT signaling pathway 108 14 10 3

Ibrutinib blocks YAP1 activation and reverses BRAFi resistance in melanoma cells 126 14 10 3

Therapy-induced transdifferentiation promotes glioma growth independent of EGFR signaling 108 14 10 3

SREBP1 regulates mitochondrial metabolism in oncogenic KRAS expressing NSCLC 108 95 14 3

ORN: Extracting Latent Pathway Activities in Cancer with OR-gate Network 186 112 14 9

Identification of new therapeutic targets in CRLF2-overexpressing B-ALL through discovery of2 TF-gene regulatory interactions. 31 9 3

Genome-wide analyses of transcription factors and co-regulators across seven cohorts identified reduced PPARGC1A expression as a driver of prostate cancer progression 186 142 9 3

Deciphering the Signaling Network Landscape of Breast Cancer Improves Drug Sensitivity Prediction 179 14 9

Transcriptome analysis reveals the effects of transgenic expression of the Gal4 protein on normal gene expression in silkworm tissues 186 120 9

Hormonal regulation of Semaphorin 7a in ER+ breast cancer drives therapeutic resistance 126 14 10 3

Machine learning-based investigation of the cancer protein secretory pathway 112 14 9 4

Oncogenic GLI1 and STAT1/3 activation drives immunosuppressive tryptophan/kynurenine metabolism via synergistic induction of IDO1 in skin cancer cells 108 14 10 3

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancer 108 14 3

Oxygen-glucose deprivation and reoxygenation on human cerebral organoids alters expression related to lipid metabolism 186 57 10 9 3

TCGA Pan-Cancer genomic analysis of Alternative Lengthening of Telomeres (ALT) related genes 9

Abl kinase deficiency promotes AKT pathway activation and prostate cancer progression and metastasis 108 14 10 3

Estrogen controls mTOR signaling and mitochondrial function via WNT4 in lobular carcinoma cells 108 14 3

Non-Canonical Targets of HIF1a Drive Cell-Type-Specific Dysfunction 186 20 3

Oncogenic H-Ras Signaling Differentially Targets Replicative and Specialized DNA Polymerases for Depletion 7 3

A multi-layered systems approach for renal cell carcinoma 14 9

CBX2 and CBX7 antagonistically regulate metabolic reprogramming in breast cancer 189 14 9 3

Marked Synergy by Vertical Inhibition of EGFR signaling in NSCLC Spheroids: SOS1 as a therapeutic target in EGFR-mutated cancer 126 14 10 3

RIPK2 Stabilizes c-Myc and is an Actionable Target for Inhibiting Prostate Cancer Metastasis 108 14 10 3

An integrative oncogene-dependency map identifies unique vulnerabilities of oncogenic EGFR, KRAS, and RIT1 in lung cancer 7 3

Gamma secretase inhibitors inhibit ovarian cancer development and enhance olaparib's anti-ovarian cancer activity and its mechanism 126 108 14 10 3

Cyclic pentapeptide cRGDfK enhances the inhibitory effect of sunitinib on TGF-β1-induced epithelial-to-mesenchymal transition in human non-small cell lung cancer cells 98 14 10 3

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma 108 14 3

STIL a novel link in Shh and Wnt signaling, endowing oncogenic and stem like attributes to colorectal cancer 108 14 3

IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma 98 7 3

Tumor -Associated MUC1 Regulates TGF-β Signaling and Function in Pancreatic Ductal Adenocarcinoma 108 14 3

High Throughput RNA Sequencing of Mice Retina Reveals Metabolic Pathways Involved in the Gut-Retina Axis 186 120 9 3

mTOR inhibition in primary neurons and the developing brain represses transcription of cholesterol biosynthesis genes and alters cholesterol levels 133 31 3

Blocking of EGFR Signaling is a Latent Strategy for the Improvement of Prognosis of HPV Induced Cancer 14 10 3

CASCADES, a novel SOX2 super-enhancer associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma multiforme 14 3