Topic 20

developmental embryonic stem differentiation biology cells development cell during fate lineage progenitors transcription progenitor embryos expression mouse embryo pluripotent early regulates patterning factor specification signaling chromatin drosophila required transcriptional tissue loss proliferation regulation morphogenesis defects formation epithelial zebrafish mammalian wnt embryogenesis regulated adult gene germ differentiated regulatory developing here genes regulate maintenance transition show regeneration essential factors identity role vertebrate tissues regulator function epithelium cellular expressed vivo pluripotency stages conserved specific histone mesoderm distinct program fates mature regulating stage understood regulators germline organ renewal activation proper hematopoietic mechanisms axis divisions promotes mesenchymal muscle fetal process differentiate epigenetic regenerative mutant signalling

1213 items. Top items listed below.

Akt is required for artery formation during embryonic vascular development 94 20 3

Notch Signaling Commits Mesoderm to the Cardiac Lineage 20 3

The Drosophila MLR COMPASS-like complex regulates bantam miRNA expression differentially in the context of cell fate 20 3

Timed mesodermal FGF and BMP govern the multi-step thyroid specification 118 20 3

CHD4-NURD controls spermatogonia survival and differentiation 20 3

SOX9 is sufficient to drive endothelial cells towards a mesenchymal fate by altering the chromatin landscape. 31 20 3

Intronic enhancers regulate the expression of genes involved in tissue-specific functions and homeostasis 20 9 3

The conserved regulatory basis of mRNA contributions to the early Drosophila embryo differs between the maternal and zygotic genomes 31 20 9 5

The transcription factor CLAMP is required for neurogenesis in Drosophila melanogaster. 192 133 20 3

Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell fates in embryonic stem cells 20 3

Eomesodermin is functionally conserved between zebrafish and mouse in spite of different mutant phenotypic severities, and controls left/right organiser formation via interlocking feedforward loops 118 20 3

Epigenetic regulations follow cell cycle progression during differentiation of human pluripotent stem cells. 20 9 3

Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells 20 3

Differential expression of transposable elements in stem cell lineages of the preimplantation embryo 81 20 9 3

GLP-1 Notch - LAG-1 CSL control of the germline stem cell fate is mediated by transcriptional targets lst-1 and sygl-1 20 9 3

ID4 represses myoepithelial differentiation of mammary stem cells through its interaction with HEB 20 3

Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition 49 20 3

Independence of 3D chromatin conformation and gene regulation during Drosophila dorsoventral patterning 89 7 3

In utero gene transfer system for embryos before neural tube closure reveals a role for Hmga2 in the onset of neurogenesis 133 20 3

Dissecting Hes-centered transcriptional networks in neural stem cell maintenance and tumorigenesis in Drosophila 20 3

Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation 20 3

USP9X deubiquitinase couples the pluripotency network and cell metabolism to regulate ESC differentiation potential 20 3

Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1 and TIA1 192 20 9 3

β-catenin-Mediated Wnt Signal Transduction Proceeds Through an Endocytosis-Independent Mechanism 20 3

Single cell transcriptional and functional analysis of human dopamine neurons in 3D fetal ventral midbrain organoid like cultures 57 20 9 3

Single cell resolution regulatory landscape of the mouse kidney highlights cellular differentiation programs and renal disease targets 31 20 9 3

Interspecies Chimeric Conditions Affect the Developmental Rate of Human Pluripotent Stem Cells 57 20 9

Foxm1 regulates neuronal progenitor fate during spinal cord regeneration 133 20 3

A spatially resolved single cell atlas of human gastrulation 118 20 9

Intestinal progenitor P-bodies maintain stem cell identity by suppressing pro-differentiation factors. 20 3

p53 drives premature neuronal differentiation in response to radiation-induced DNA damage during early neurogenesis 133 20 3

P-bodies are sites of rapid RNA decay during the neural crest epithelial-mesenchymal transition 98 20 3

Regulation of human development by ubiquitin chain editing of chromatin remodelers 20 3

Modulation of Aplnr signaling is required during the development and maintenance of the hematopoietic system 57 20 3

Patterning the embryonic pulmonary mesenchyme 118 20 3

DOT1L primarily acts as a transcriptional repressor in hematopoietic progenitor cells 93 20 3

Auxin-degron system identifies immediate mechanisms of Oct4 20 3

Characterization of histone inheritance patterns in the Drosophila female germline 20 3

Allele-specific gene regulation by KDM6A 93 20 3

Single cell epigenomic atlas of the developing human brain and organoids 133 120 20 9 3

Cell signaling coordinates global Polycomb Repressive Complex 2 recruitment and gene expression in murine embryonic stem cells 93 31 20 3

The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation 55 20 3

Heterogeneity of Neuroepithelial Cells and Radial Glia 133 120 20 9

Transcriptional control of apical protein clustering drives de novo cell polarity establishment in the early mouse embryo 20 3

Human microglia upregulate cytokine signatures and accelerate maturation of neural networks 57 20 9 3

Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model 20 9 3

Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity. 94 20 3

Sox2 and canonical Wnt signaling interact to activate a developmental checkpoint coordinating morphogenesis with mesodermal fate acquisition 118 20 3

DUX4 regulates oocyte to embryo transition in human 20 3

Single-cell transcriptomic analysis identifies neocortical developmental differences between human and mouse 120 43 9 3

Chromatin accessibility and histone acetylation in the regulation of competence in early development 192 31 20 3

Unraveling the transcriptional networks that drive oligodendrocyte fate specification in Sonic hedgehog-responsive neocortical progenitors 133 20 9 3

Planarian CREB-binding protein (CBP) gene family regulates stem cell maintenance and differentiation 20 3

Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans 20 3

A Casz1 - NuRD complex regulates temporal identity transitions in neural progenitors 133 20 3

Essential amnion signals for primate primitive streak formation resolved by scRNA map 118 20 3

An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution 118 20 9 3

CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression 89 31 20 3

JAK/STAT pathway promotes Drosophila neuroblast proliferation via the direct CycE regulation 20 3

Atypical neurogenesis in induced pluripotent stem cell (iPSC) from autistic individuals 57 20 11 9 3 2

Analysis of Endothelial-to-Haematopoietic Transition at the Single Cell Level identifies Cell Cycle Regulation as a Driver of Differentiation 20 3

Spatiotemporal single-cell RNA sequencing of developing hearts reveals interplay between cellular differentiation and morphogenesis 120 20 9 3

Alternative splicing is a developmental switch for hTERT expression 192 31 20 3

Single cell RNA-Seq analysis identifies molecular mechanisms controlling hypothalamic patterning and differentiation. 43 20 9 3

Single-cell analysis identifies TCF4 and ID3 as a molecular switch of mammary epithelial stem cell differentiation. 20 9 3

Transcriptional networks are dynamically regulated during cell cycle progression in human Pluripotent Stem Cells 31 20 9 3

Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition 98 20 3

CTCF Promotes Long-range Enhancer-promoter Interactions and Lineage-specific Gene Expression in Mammalian Cells 89 31 20 9 3

CTCF-binding element regulates ESC differentiation via orchestrating long-range chromatin interaction between enhancers and HoxA 89 20 3

Dual function of perivascular fibroblasts in vascular stabilization in zebrafish 94 20 3

Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis 20 3

Global Dynamic Molecular Profiles of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing 120 9 3

Comparative Parallel Multi-Omics Analysis During the Induction of Pluripotent and Trophectoderm States 20 9 3

Lung lineage transcription factor NKX2-1 epigenetically resolves opposing cell fates in vivo 20 3

X-chromosome upregulation is dynamically linked to the X-inactivation state 20 3

Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant common complex traits 7 3

Dach1 extends artery networks and protects against cardiac injury 94 20 3

NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells 20 3

Temporal transitions in post-mitotic neurons throughout the C. elegans nervous system 20 11 9 3

Loss of PRC2 subunits primes lineage choice during exit of pluripotency 93 20 3

Dynamic neurotransmitter specific transcription factor expression profiles during Drosophila development 120 20 9 3

Single cell RNA sequencing reveals the landscape of early female germ cell development 120 20 9 3

mTOR inhibition in primary neurons and the developing brain represses transcription of cholesterol biosynthesis genes and alters cholesterol levels 133 31 3

Histone lysine crotonylation regulates cell-fate determination of neural stem/progenitor cells by activating bivalent promoters 93 31 20 3

Mechanical Regulation of Stem Cell Proliferation and Fate Decisions by their Differentiated Daughters 57 20 3

3D cell culture models demonstrate a role for FGF and WNT signaling in regulation of lung epithelial cell fate and morphogenesis 57 20 3

Integrative Analysis Reveals Histone Demethylase LSD1/KDM1A Associates with RNA Polymerase II Pausing 31 20 3

Multidimensional Chromatin Regulation of Cell Lineage Differentiation in a Metazoan Embryo 118 20 9 3

Common postzygotic mutational signature in multiple healthy adult tissues related to embryonic hypoxia 9 3

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development 109 20 9 3

Selective silencing rather than targeted activation of gene expression underlies fate choice in human hematopoietic stem cells. 31 20 9 3

Single-cell transcriptomics, scRNA-Seq and C1 CAGE discovered distinct phases of pluripotency during naïve-to-primed conversion in mice 57 20 9 3

Genome-wide Studies Reveal the Essential and Opposite Roles of ARID1A in Controlling Human Cardiogenesis and Neurogenesis from Pluripotent Stem Cells 31 20 3

TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation 20 3

The neocortical progenitor specification program is established throughcombined modulation of SHH and FGF signaling 133 20 3

Asymmetric neurogenic commitment of retinal progenitors is regulated via the Notch endocytic pathway 7 3

TATA and paused promoters active in differentiated tissues have distinct expression characteristics 31 9

Bidirectional Wnt signaling between endoderm and mesoderm confer tracheal identity in mouse and human. 20 3

Changing and stable chromatin accessibility supports transcriptional overhaul during neural stem cell activation 31 20 3

A SMAD1/5-YAP signaling module drives radial glia self-amplification and growth of the developing cerebral cortex 133 20 3