Topic 55

actin cytoskeleton mechanical myosin forces force filaments biophysics adhesion cytoskeletal actomyosin cell contractility cells migration filament adhesions cellular contractile tension mechanics stiffness shape protrusions focal motility membrane polymerization dynamics formation matrix extracellular integrin epithelial microtubules motors biology microscopy morphogenesis arp2 proteins properties microtubule contraction drive mediated apical deformation mechanotransduction remodeling tissues regulate mechanosensitive junctions how collective regulates mechanism tissue dependent assembly ii traction organization dynamic polarity stress physical active required mechanically show driven nucleus processes motor edge vinculin movement through protrusion mechanosensing filamentous integrins here disassembly unclear fibers division filopodia cortical imaging understood formin form migrating intracellular binding network polarization

298 items. Top items listed below.

Revealing the polarity of actin filaments by cryo-electron tomography 55 18 8

Role of cell polarity dynamics and motility in pattern formation due to contact dependent signalling 55 38 8

Molecular mechanism for direct actin force-sensing by α-catenin 55 51 8 3

Src-dependent NM2A tyrosine-phosphorylation regulates actomyosin dynamics 55 34 3

Force-dependent Piezo1 recruitment to focal adhesions regulates adhesion maturation and turnover specifically in non-transformed cells 55 34 3

The C-terminal actin binding domain of talin forms an asymmetric catch bond with F-actin 55 8 3

Vimentin Intermediate Filaments Stabilize Dynamic Microtubules by Direct Interactions 55 8 3

Actin bundle architecture and mechanics regulate myosin II force generation 55 8

An Active Chemo-mechanical Model to Predict Adhesion and Microenvironmental Regulation of 3D Cell Shapes 55 18 8

Microtubules tune mechanosensitive cell responses 55 34 3

Myosin-driven actin-microtubule networks exhibit self-organized contractile dynamics 55 8

Tensile Force Induced Cytoskeletal Reorganization: Mechanics Before Chemistry 55 8

Post-mitotic expansion of cell nuclei requires ACTN4-mediated nuclear actin filament bundling 55 34 8 3

Generation of stress fibers through myosin-driven re-organization of the actin cortex 55 34 20 3

Stick-Slip model for actin-driven cell protrusions, cell polarisation and crawling. 55 38 8

Stress fibers are embedded in a contractile cortical network. 55 18 8

Vimentin intermediate filaments mediate cell shape on visco-elastic substrates 55 8 3

Actin accumulates nesprin-2 at the front of the nucleus during confined cell migration 55 34 8 3

ERRα coordinates actin and focal adhesion dynamics 55 34 3

Mechanosensitive calcium signaling in filopodia 55 3

Dynamic crosslinking of the actin cytoskeleton governs the cytoplasm's transition to fluid-like behavior 55 8 3

Reconstitution of contractile actomyosin rings in vesicles 55 8

Tuning Intermediate Filament Mechanics by Variation of pH and Ion Charges 55 8

Tension causes structural unfolding of intracellular intermediate filaments 55 8

The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation 55 20 3

Bond type and discretization of non-muscle myosin II are critical for simulated contractile dynamics 55 38 8

Filopodia rotate and coil by actively generating twist in their actin shaft 55 8 3

Calponin-Homology Domain mediated bending of membrane associated actin filaments 55 8 3

Endosomal spatio-temporal modulation of the cortical RhoA zone conditions epithelial cell organization 55 34 3

Physical properties and actin organization in embryonic stem cells depend on differentiation stage 55 20 18 8 3

WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motility 55 34 3

Mechanosensing through direct binding of tensed F-actin by LIM domains 55 34 8 3

Src/FAK complex phosphorylates cardiac myosin binding protein c (cMyBP-C) in vitro and in vivo 102 55 34 3

Post-Translational Modifications Soften Vimentin Intermediate Filaments 55 8 3

Extraction of accurate cytoskeletal actin velocity distributions from noisy measurements 55 18 8

Fmn2 regulates growth cone motility by mediating a molecular clutch to generate traction forces 55 11 3

Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions 55 34 8 3

Substrate Resistance to Traction Forces Controls Fibroblast Polarization 55 18 8

Filopodia-based contact stimulated collective migration drives tissue morphogenesis 55 34 3

Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion 55 34 20 3

Cell substrate patterns driven by curvature-sensitive actin polymerization: waves and podosomes. 55 8

Protocadherin 7 localizes to the plasma membrane during mitosis and promotes cytokinesis by a palmitoylation-dependent mechanism 55 34 3

Apico-basal cell compression regulates Lamin A/C levels in Epithelial tissues 55 34 3

Cell clusters adopt a collective amoeboid mode of migration in confined non-adhesive environments 55 34 18 3

Shear flow-driven actin re-organization induces ICAM-1 nanoclustering on endothelial cells that impact T-cell migration 55 3

Physical biology of cell-substrate interactions under cyclic stretch 55 8 3

Genomic signatures of the unjamming transition in compressed human bronchial epithelial cells 98 55 3

LSP1-myosin1e bi-molecular complex regulates focal adhesion dynamics and cell migration 55 34 3

Biased localization of actin binding proteins by actin filament conformation 55 8 3

Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion 55 34 3

Mechanically induced cytoskeletal remodeling in trabecular meshwork cells requires TRPV4 - Rho signaling interactions 55 34 3

Homophilic and heterophilic cadherin bond rupture forces in homo- or hetero-cellular systems measured by AFM based SCFS 55 8

Epithelial organ shape is generated by patterned actomyosin contractility and maintained by the extracellular matrix 118 55 20 3

Lamin A/C Deficiency Enables Increased Myosin2 Bipolar Filament Ensembles Which Promote Divergent Actomyosin Network Anomalies Through Self Organization 55 34 3

Cell-Cell Adhesion During Nephron Development Is Driven by Wnt/PCP Formin Daam1 55 34 20 3

Computational estimates of mechanical constraints on cell migration through the extracellular matrix 55 38 18

N-terminal modification of actin by acetylation and arginylation determines the architecture and assembly rate of linear and branched actin networks 55 34 8 3

Lamin A redistribution mediated by nuclear deformation determines dynamic localization of YAP 55 34 8 3

Modeling cell turning by mechanics at the cell rear 55 38 18 8

Visualization of myosin II filament dynamics in remodeling acto-myosin networks with interferometric scattering microscopy 55 18 8

Pinching the cortex of live cells reveals thickness instabilities caused by Myosin II motors 55 18 8

Inside-out regulation of E-cadherin conformation and adhesion 55 8 3

Correlating nuclear morphology and external force with combined atomic force microscopy and light sheet imaging separates roles of chromatin and lamin A/C in nuclear mechanics 55 18 8

Mechanical principles governing the shapes of dendritic spines 77 55 11 8

Stiffening of prostate cancer cells driven by actin filaments - microtubules crosstalk confers resistance to microtubule-targeting drugs 55 8 3

TRIP6 is required for tension at adherens junctions 55 34 3

Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism 55 34 8 3

The Formin Inhibitor, SMIFH2, Inhibits Members of the Myosin Superfamily 55

Generation of anisotropic strain dysregulates wild-type cell division at the interface between host and oncogenic tissue 55 20 3

Structural basis of αE-catenin-F-actin catch bond behavior 55 51 8 3

Cell cycle-dependent active stress drives epithelia remodeling 127 55 38 20 18 3

Ndel1 promotes keratin assembly and desmosome stability 34 3

T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex 55 27 3

Non-muscle myosin-2 contractility-dependent actin turnover limits the length of epithelial microvilli 55 34 3

Nestin selectively facilitates the phosphorylation of the Lissencephaly-linked protein doublecortin (DCX) by cdk5/p35 to regulate growth cone morphology and Sema3a sensitivity in developing neurons 55 34 11 3

Myosin-gelsolin cooperativity in actin filament severing and actomyosin motor activity 55 8

Extracellular domains of E-cadherin determine key mechanical phenotypes of an epithelium through cell- and non-cell-autonomous outside-in signalling 55 3

Loss of clathrin heavy chain enhances actin-dependent stiffness of mouse embryonic stem cells 55 3

Genetic interaction between profilin and myosin II reveals a potential role for myosin II in actin filament disassembly in vivo 55 34 3

ARHGEF18/p114RhoGEF coordinates PKA/CREB signaling and actomyosin remodeling to drive trophoblast cell-cell fusion during placenta morphogenesis 55 20 3

Cell-type specific mechanical response and myosin dynamics during retinal lens development in Drosophila 55 20 18 3

Mechanical competition alters the cellular interpretation of an endogenous genetic programme 55 38 20 18

Actin crosslinker competition and sorting drive emergent GUV size-dependent actin network architecture 55 8

mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex 133 55 20 11 3

Single depolymerizing and transport kinesins stabilize microtubule ends 127 55 8 3

Connecting actin polymer dynamics across multiple scales 127 38 8

A bleb initiation model for chemotaxis suggests a role for myosin II clusters and cortex rupture 55 34 8

Mechanotransduction and dynamic outflow regulation in trabecular meshwork requires Piezo1 channels 55 3

Multiscale modelling of motility wave propagation in cell migration 55 38 8

SETD2 is an actin lysine methyltransferase 55 34 3

Binding dynamics of α-actinin-4 in dependence of actin cortex tension 55 18 8

Differential cellular responses to adhesive interactions with galectin-8 and fibronectin coated substrates 55 8 3

Mechanochemical modelling of dorsal closure reveals emergent cell behaviour in tissue morphogenesis 55 38 18 3

Septins and a formin have distinct functions in anaphase chiral cortical rotation in the C. eleganszygote. 55 34 20 3

Optical flow analysis reveals that Kinesin-mediated advection impacts on the orientation of microtubules in the Drosophila oocyte 55 34 3

Endothelial cell invasiveness is controlled by myosin IIA-dependent inhibition of Arp2/3 activity 94 55 3

Structural and mechanical remodeling of the cytoskeleton maintains tensional homeostasis in 3D microtissues under acute dynamic stretch 55 18

Glycolysis Inhibition Regulates Endothelial Junctions by Perturbing Actin and Focal Adhesions 55 3

Leading edge stability in motile cells is an emergent property of branched actin network growth 55 38 18 8

Coupling of dynamic microtubules to F-actin by Fmn2 regulates chemotaxis of neuronal growth cones 55 34 3