Topic 34

membrane cell biology proteins protein assembly localization required microtubule cells formation essential dependent er actin trafficking yeast complex regulates transport microtubules endoplasmic reticulum plasma mitotic kinase regulated promotes domain function spindle recruitment mediated cytoplasmic golgi role mitosis cellular binding mechanism division cytoskeleton machinery during here show pathway defects regulate conserved functions its phosphorylation complexes cargo depletion proper degradation chromosome vesicles terminal ubiquitin interaction organelles intracellular localizes segregation nuclear localized regulation promote components meiotic binds meiosis membranes regulator regulating unclear budding endosomes mutants mitochondria critical biogenesis fission form integrity requires endosomal containing chromosomes plays through gtpase endocytic roles endocytosis together understood

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The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint 102 34 3

A conformational switch driven by phosphorylation regulates Ykt6 activity in macroautophagy 34 8 3

Activation of Rab11a and endocytosis by Phosphatidylinositol 4-kinase III beta promotes oncogenic signaling in breast cancer 102 34 3

Ndel1 promotes keratin assembly and desmosome stability 34 3

Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast 102 34 3

The low complexity regions in the C-terminus are essential for the subcellular localisation of Leishmania casein kinase 1 but not for its activity 34 3

Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae 69 34 3

Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation 34 8 3

Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis 34 8 3

The p97-UBXN1 complex regulates aggresome formation 34 3

Exportin Crm1 is important for Swi6 nucleocytoplasmic shuttling and MBF transcription activation in Saccharomyces cerevisiae 34 3

The SARS-CoV-2 Envelope and Membrane proteins modulate maturation and retention of the Spike protein, allowing optimal formation of VLPs in presence of Nucleoprotein 103 1

A G protein-coupled receptor-like module regulates Cellulose Synthase secretion from the endomembrane system in Arabidopsis 34 16 3

Rab14/MACF2/CAMSAP3 Complex Regulates Endosomal Targeting to the Abscission Site During Cytokinesis 68 34 3

Kinetochore protein Spindly controls microtubule polarity in Drosophila axons 68 34 3

Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling 69 34 3

Post-mitotic expansion of cell nuclei requires ACTN4-mediated nuclear actin filament bundling 55 34 8 3

Deubiquitylase UCHL3 drives error correction at kinetochores and chromosome segregation independent of spindle assembly checkpoint 68 34 3

Local RNA translation controls cell migration and Rab GTPase function 34 3

Identification of a new regulation pathway of EGFR and E-cadherin dynamics 102 34 3

Critical role for cold shock protein YB-1 in cytokinesis 102 34 3

In vivo control of the ezrin/radixin/moesin protein ERM-1 in C. elegans 34 8 3

Bartonella effector protein C mediates actin stress fiber formation via recruitment of GEF-H1 to the plasma membrane 102 79 34 3

WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motility 55 34 3

A Glu-Glu-Tyr sequence in the cytoplasmic tail of the M2 protein renders IAV susceptible to restriction of HA-M2 association in primary human macrophages 41 34 8 3

Paladin is a PI(4,5)P2 phosphoinositide phosphatase that regulates endosomal signaling and angiogenesis 94 34 3

Cdk1-dependent destabilization of long astral microtubules is required for spindle orientation 68 34 3

Negative feedback between the APC/C and Cep152 at the centrosome regulates mitotic spindle assembly 68 34 3

Force-dependent Piezo1 recruitment to focal adhesions regulates adhesion maturation and turnover specifically in non-transformed cells 55 34 3

Pancreatic beta-cell specific deletion of VPS41 causes diabetes due to defects in insulin secretion 109 34 3

p27 regulates the autophagy-lysosomal pathway via the control of Ragulator and mTOR activity in amino acid deprived cells 34 3

BPIFB3 interacts with ARFGAP1 and TMED9 to regulate non-canonical autophagy and RNA virus infection 41 34 3

Modulation of fungal virulence through CRZ1 regulated F-BAR-dependent actin remodeling and endocytosis in chickpea infecting phytopathogen Ascochyta rabiei 34 16 3

Mask, the Drosophila Ankyrin Repeat and KH domain-containing protein, regulates microtubule dynamics 34 3

Clock proteins regulate spatiotemporal organization of clock genes to control circadian rhythms 34 3

Autoregulatory circuit regulating basolateral cargo export from the TGN: role of the orphan receptor GPRC5A in PKD signaling and cell polarity. 69 34 3

Ebola virus inclusion body formation and RNA synthesis are controlled by a novel domain of NP interacting with VP35 41 34 3

Clathrin senses membrane curvature 151 34 8

Actin and an unconventional myosin motor, TgMyoF, control the organization and dynamics of the endomembrane network in Toxoplasma gondii. 69 34 8 3

Drosophila dTBCE recruits tubulin around chromatin to promote mitotic spindle assembly 171 68 34 8 3

Multiple roles for the ESCRT machinery in maintaining plasma membrane homeostasis 69 34 3

Kinetochore-independent sister chromosome separation is driven by plus-end microtubule dynamics 68 34 3

REEP4 is recruited to the inner nuclear membrane by ELYS and promotes nuclear pore complex formation 69 34 8 3

Cooperativity of membrane-protein and protein-protein interactions control membrane remodeling by epsin 1 and regulate clathrin-mediated endocytosis 78 34 8 3

iDePP: a genetically encoded system for the inducible depletion of PI(4,5)P2 in Arabidopsis thaliana. 16 3

NuMA interaction with chromatin is vital for proper nuclear architecture in human cells 68 34 3

Yeast FIT2 homolog is necessary to maintain cellular proteostasis by regulating lipid homeostasis 69 34 3

ERRα coordinates actin and focal adhesion dynamics 55 34 3

Lamin C regulates genome organization after mitosis 89 68 34 20 3

Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites 69 34 8 3

Structure and mechanism of TRAPPIII-mediated Rab1 activation 51 34 8 3

TGN/EE SNARE protein SYP61 is ubiquitinated and required for carbon/nitrogen-nutrient responses in Arabidopsis 16 3

Nestin selectively facilitates the phosphorylation of the Lissencephaly-linked protein doublecortin (DCX) by cdk5/p35 to regulate growth cone morphology and Sema3a sensitivity in developing neurons 55 34 11 3

L-bodies are novel RNA-protein condensates driving RNA transport in Xenopus oocytes 49 34 20 3

Human Prefoldin Modulates Co-transcriptional Pre-mRNA Splicing 119 49 34 31 3

MANF regulates unfolded protein response and neuronal survival through its ER-located receptor IRE1α 69 34 3

A complex of distal appendage-associated kinases linked to human disease regulates ciliary trafficking and stability 34 3

Clustering-based positive feedback between a kinase and its substrate enables effective T-cell receptor signaling 102 34 8 3

The actin nucleation factors JMY and WHAMM enable a rapid p53-dependent pathway of apoptosis 34 3

An Acentriolar Centrosome At The C. elegans Ciliary Base 68 34 20 3

Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts 3

Characterization of the Novel Mitochondrial Genome Segregation Factor TAP110 in Trypanosoma brucei 34 3

MARCKS domain phosphorylation regulates the differential interaction of Diacylglycerol Kinase ζ with Rac1, RhoA and Syntrophin 102 34 3

Lipid droplet biogenesis is driven by a liquid-liquid phase separation. 69 34 8 3

State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane 163 91 82 8 3

Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state 151 34 8 3

Oxidized RNA Bodies compartmentalize translation quality control in Saccharomyces cerevisiae 49 34 3

CHMP2B regulates TDP-43 phosphorylation and proteotoxicity via modulating CK1 turnover independent of the autophagy-lysosomal pathway 61 34 3

Src/FAK complex phosphorylates cardiac myosin binding protein c (cMyBP-C) in vitro and in vivo 102 55 34 3

The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment 68 34 8 3

Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation 95 34 3

ARF1 dimerization is essential for vesicle trafficking and dependent on activation by ARF-GEF dimers in Arabidopsis 34 8 3

NBR1 directly promotes the formation of p62 - ubiquitin condensates via its PB1 and UBA domains 34 3

Chlamydia trachomatis Encodes a Dynamic, Ring-Forming Bactofilin Critical for Maintaining Cell Size and Shape 79 34 8 3

Miro recruits VPS13D to mitochondria 34 8 3

The Ndr/LATS kinase Cbk1 regulates a specific subset of Ace2 functions and suppresses the hyphae-to-yeast transition in Candida albicans 102 79 3

Endoplasmic Reticulum Associated Degradation (ERAD) Deficiency Promotes Mitochondrial Dysfunction and Transcriptional Rewiring in Human Hepatic Cells 69 3

Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation 51 8 3

Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network. 69 51 34 8 3

Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I 68 34 3

Acute inhibition of centriolar satellite function and positioning reveals their functions at the primary cilium 68 34 3

Characterization of Constitutive macro-ER-phagy 69 34 3

Tyrosine phosphorylation-dependent localization of TmaR, a novel E. coli polar protein that controls activity of the major sugar regulator by polar sequestration 79 34 3

Defining endogenous TACC3-chTOG-clathrin-GTSE1 interactions at the mitotic spindle using induced relocalization 7 3

Mechanosensitive calcium signaling in filopodia 55 3

A novel role for the C-terminal domain of the influenza A virus host shutoff endoribonuclease PA-X in mediating rapid turnover of the PA-X protein 41 3

Src-dependent NM2A tyrosine-phosphorylation regulates actomyosin dynamics 55 34 3

Dynamic expression and localization of the LIN-2/7/10 protein scaffolding complex during C. elegans vulval development 34 3

Characterization of nuclear pore complex targeting domains in Pom152 in Saccharomyces cerevisiae 69 34 8 3


Akt is required for artery formation during embryonic vascular development 94 20 3

Reconstitution of human kinetochore in mitotic cell extracts reveals permitted and restricted assembly steps 68 34 8 3

The Drosophila Amyloid Precursor Protein homologue mediates neuronal survival and neuro-glial interactions 32 3

An essential membrane protein modulates the proteolysis of LpxC to control lipopolysaccharide synthesis in Escherichia coli 79 34 3

Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine 34 3

A polarity pathway for exocyst-dependent intracellular tube extension 34 3

Wnt-inducible Lrp6-APEX2 Interacting Proteins identify ESCRT Machinery and Trk-Fused Gene as Components of the Wnt Signaling Pathway 151 34 3

Phosphorylation of luminal region of the SUN-domain protein Mps3 promotes nuclear envelope localization during meiosis 34 8 3

A Polybasic Domain in aPKC Mediates Par-6-Dependent Control of Plasma Membrane Targeting and Kinase Activity 34 8 3

Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans 20 3