Topic 69

endoplasmic reticulum er membrane stress protein unfolded proteins cell golgi lipid upr organelles biology pathway transport cells organelle calcium ire1 homeostasis ca2 intracellular trafficking cargo cellular signaling copii secretory mitochondria membranes release transmembrane contact response xbp1 synthesis plasma lumen localized accumulation mammalian proteostasis role activation induced mitochondrial atf6 cytosolic lipids autophagy mechanism droplets essential complex promotes perk regulated resident secretion mediated luminal coat domain localize yeast together ld defects dependent regulates biogenesis causes cytoplasmic deficiency regulator through eukaryotic induces storage subcellular via export machinery copi sites degradation lds transfer exit components metabolism localization contacts elevated misfolded terminal channels erad inhibition

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Creld2 function during unfolded protein response is essential for liver metabolism homeostasis 69 56 34 3

MANF regulates unfolded protein response and neuronal survival through its ER-located receptor IRE1α 69 34 3

Yeast FIT2 homolog is necessary to maintain cellular proteostasis by regulating lipid homeostasis 69 34 3

Lipid droplet biogenesis is driven by a liquid-liquid phase separation. 69 34 8 3

Endoplasmic Reticulum Associated Degradation (ERAD) Deficiency Promotes Mitochondrial Dysfunction and Transcriptional Rewiring in Human Hepatic Cells 69 3

A Molecular Mechanism for Turning off IRE1α Signaling During Endoplasmic Reticulum Stress 69 34 3

Endoplasmic reticulum stress induces a novel Ca2+ signalling system initiated by Ca2+ microdomains 69 34 3

Pregnancy associated plasma protein-aa regulates endoplasmic reticulum-mitochondria associations 69 34 3

Atf-6 regulates lifespan through ER-mitochondrial calcium homeostasis 69 34 3

Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae 69 34 3

ORP5 Transfers Phosphatidylserine To Mitochondria And Regulates Mitochondrial Calcium Uptake At Endoplasmic Reticulum - Mitochondria Contact Sites 69 34 8 3

Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling 69 34 3

TOLLIP promotes durable alveolar macrophage-mediated immunity during Mycobacterium tuberculosis infection by resolving cellular stress from lipids. 69 27 10 3

Deficient ER acetyl-CoA import in acinar cells leads to chronic pancreatitis 69 3

Toxoplasma gondii co-opts the unfolded protein response to enhance migration and dissemination of infected host cells 69 34 3

Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors 69 34 3

Multiple roles for the ESCRT machinery in maintaining plasma membrane homeostasis 69 34 3

Deciphering the postsynaptic calcium-mediated energy homeostasis through mitochondria-endoplasmic reticulum contact sites using systems modeling 69 11 8 3

Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites 69 34 8 3

Characterization of Constitutive macro-ER-phagy 69 34 3

Complementary and divergent roles for Ctage5 and Tango1 in zebrafish 69 34 3

UFMylation regulates translational homeostasis and cell cycle progression 69 34 3

The GET Pathway Safeguards Against Non-Imported Mitochondrial Protein Stress 69 34 3

Exostosin-1 Glycosyltransferase Regulates Endoplasmic Reticulum Architecture and Dynamics 69 34 8 3

Epitope-tagging of the endogenous murine BiP/GRP78/Hspa5 locus allows direct analysis of the BiP interactome and protein misfolding in vivo. 69 3

Activation of the membrane-bound Nrf1 transcription factor by USP19, a tail-anchored ubiquitin-specific protease in the endoplasmic reticulum 69 3

Identification of select G-protein coupled receptors as regulators of the ER-mitochondria contacts by drug screening 69 34 3

Reflux of Endoplasmic Reticulum proteins to the cytosol yields inactivation of tumor suppressors 69 34 3

Rab18 Binds PLIN2 and ACSL3 to Mediate Lipid Droplet Dynamics 69 34 3

The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form 69 34 8 3

Viral mediated tethering to SEL1L facilitates ER-associated degradation of IRE1 69 41 34 3

The conserved ER-transmembrane protein TMEM39 coordinates with vesicular COPII to promote collagen secretion and prevent ER stress 69 34 3

Antagonistic crosstalk fine-tunes sensitivities of IRE1 and PERK signaling during unfolded protein response 69 34 3

Structural basis for the initiation of COPII vesicle biogenesis 69 34 8 3

ATG8-interacting (ATI) 1 and 2 define a plant starvation-induced ER-phagy pathway and serve as MSBP1 (MAPR5) cargo-receptors 69 16 3

Osh6 requires Ist2 for localization to the ER-PM contacts and efficient phosphatidylserine transport 69 34 8 3

Control of endoplasmic reticulum membrane biogenesis by regulators of lipid metabolism 69 34 3

ER Proteostasis Regulators Reduce Amyloidogenic Light Chain Secretion Through an On-Target, ATF6-Independent Mechanism 69 34 3

Split-TurboID enables contact-dependent proximity labeling in cells 69 34 8 3

Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network. 69 51 34 8 3

The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi contact sites 69 34 3

Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs. 69 34 3

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates 69 10 3

Control of mammalian brain aging by the unfolded protein response (UPR) 69 65 11 3

Optogenetic control of small GTPases reveals RhoA-mediated intracellular calcium signaling 69 34 3

REEP4 is recruited to the inner nuclear membrane by ELYS and promotes nuclear pore complex formation 69 34 8 3

Characterization of nuclear pore complex targeting domains in Pom152 in Saccharomyces cerevisiae 69 34 8 3

Comparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus non-structural proteins identifies unique and shared host-cell dependencies 1

Neuronal autophagy regulates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum 69 11 3

The Endoplasmic Reticulum Proteostasis Regulator ATF6 is Essential for Human Cone Photoreceptor Development 72 69 3

Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activity 109 39 10 3

A paralog-specific role of the COPI pathway in the neuronal differentiation of murine pluripotent cells 69 34 3

Synaptotagmins Maintain Diacylglycerol Homeostasis at Endoplasmic Reticulum-Plasma Membrane Contact Sites during Abiotic Stress 69 34 16 3

Spontaneous Axonal ER Ca2+ Waves Mediate a Shift From Action Potential-Dependent to Independent Glutamate Release in the YAC128 HD-Model 77 69 11 3 2

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress 69 34 3

Dually localized proteins found in both the apicoplast and mitochondrion utilize the Golgi-dependent pathway for apicoplast targeting in Toxoplasma gondii 69 34 3

ER-PM contacts regulate apical domain formation in hepatocytes 69 34 8 3

Activation of STING due to COPI-deficiency 69 27 10 3

Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease 69 34 3

Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation 69 34 3

Inhibiting endoplasmic reticulum stress decreases tumor burden in a mouse model for hepatocellular carcinoma. 69 14 10 3

Focused ultrasound stimulates ER localized mechanosensitive PANNEXIN-1 to mediate intracellular calcium release in invasive cancer cells 69 34 3

A miR-494 dependent feedback loop regulates ER stress 69 3

The structure and global distribution of the endoplasmic reticulum network is actively regulated by lysosomes 69 34 3

The Arabidopsis N-terminal Acetyltransferase NAA50 Regulates Plant Growth and Defense 69 16 3

Elevated phosphate mediates extensive cellular toxicity: from abnormal proliferation to cell death 98 69 3

Disarrangement of Endoplasmic reticulum-mitochondria communication impairs Ca2+ homeostasis in FRDA 69 3

Novel IRE1-dependent proinflammatory signaling controls tumor infiltration by myeloid cells. 69 14 3

Rethinking the role of lipids in lager yeast cell during beer fermentation from a transcriptome and systems biology perspective 69 34 3

Quantitative proteomics links the LRRC59 interactome to mRNA translation on the ER membrane 69 49 34 8 3

FOXO1 promotes HIV Latency by suppressing ER stress in T cells 69 27 3

The interdomain helix between the kinase and RNase domains of IRE1α transmits the conformational change that underlies ER stress-induced activation. 69 34 8 3

Sphingolipids mediate polar sorting of PIN2 through phosphoinositide consumption at the trans-Golgi Network 69 34 3

Autoregulatory circuit regulating basolateral cargo export from the TGN: role of the orphan receptor GPRC5A in PKD signaling and cell polarity. 69 34 3

Local PI(4,5)P2 pool dynamics detected by the coincidence biosensor tubbyCT maintain the integrity of ER-PM junctions during PLC signaling 69 34 8 3

Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins 82 69 34 3

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients 51 8 3

Recombinant Helicobacter pylori CagA protein induces endoplasmic reticulum stress and autophagy in human cells 69 3

Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis in an ER stress-dependent manner. 69 3

Calcium ions trigger the exposure of phosphatidylserine on the surface of necrotic cells 69 34 3

The stress-induced protein NUPR1 orchestrates protein translation during ER-stress by interacting with eIF2α 69 3

Actin and an unconventional myosin motor, TgMyoF, control the organization and dynamics of the endomembrane network in Toxoplasma gondii. 69 34 8 3

Di-arginine and FFAT-like motifs retain a subpopulation of PRA1 at ER-mitochondria membrane contact sites 69 34 3


Human INCL fibroblasts display abnormal mitochondrial and lysosomal networks and heightened susceptibility to ROS-induced cell death 95 69 3

Calcium signaling through a Transient Receptor Channel is important for Toxoplasma gondii growth 69 34 3

Calnexin mediates the maturation of GPI-anchors through ER retention 7 3

DYNC1LI2 regulates localization of the chaperone-mediated autophagy-receptor LAMP2A and improves cellular homeostasis in cystinosis 69 34 3

A physical mechanism of TANGO1-mediated bulky cargo export 69 34 8 3

Quantitative live-cell PALM reveals nanoscopic Faa4 redistributions and dynamics on lipid droplets during metabolic transitions of yeast 69 34 8 3

ESCargo: a regulatable fluorescent secretory cargo for diverse model organisms 69 34 18 8 3

TMEM16K is an interorganelle regulator of endosomal sorting 69 34 3

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling 69 34 3

The proteasomal deubiquitinating enzyme PSMD14 regulates macroautophagy by controlling Golgi-to-ER retrograde transport 69 34 3

Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum 69 3

Hypercholesterolemia Impairs Clearance of Extracellular DNA and Promotes Inflammation and Atherosclerotic Plaque Progression 69 10 3

Dwarf open reading frame (DWORF) peptide is a direct activator of the sarcoplasmic reticulum calcium pump SERCA. 69 8 3

N-acetylaspartate improves cell survival when glucose is limiting 69 14 3

Inhibition of inositol-requiring enzyme 1 RNase activity protects pancreatic beta cell and improves diabetic condition in insulin mutation-induced diabetes 109 64 10 3

Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation 69 34 3