Topic 10

mice treatment induced immunology inflammatory immune anti therapeutic patients increased therapy cells inflammation vivo cancer mouse tumor treated disease vitro chronic il efficacy cell reduced response clinical levels was after decreased significantly macrophages administration infection drug blood against tumors expression effects inhibitor therapies systemic cytokines were derived murine inhibition receptor beta tissue model effect activation survival cytokine targeting pro responses associated enhanced lung resistance injury dose effective immunity antigen potential macrophage following inhibitors exposure liver progression toxicology cd8 pharmacology weeks gamma ifn drugs showed mediated microenvironment induce infections death acute cause signaling protective immunotherapy tnf resistant models bone patient infected

3110 items. Top items listed below.

Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses 88 27 10 3

Circulating levels of epirubicin cause endothelial senescence while compromising metabolic activity and vascular function 10 3

Remodeling gut microbiota by Streptococcus thermophilus 19 attenuates inflammation in septic mice 101 10 3

LAG3 is a Central Regulator of NK Cell Cytokine Production 27 10 3

Treated HIV Infection Alters Phenotype But Not HIV-specific Function of Peripheral Blood Natural Killer Cells 88 27 10 3

Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs 36 1

Short chain fatty acid butyrate promotes virus infection by repressing interferon stimulated genes 27 10 3

Boosting Toll-like receptor 4 signaling enhances the therapeutic outcome of antibiotic therapy in pneumococcal pneumonia 10 3

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis 174 27 10

JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation 10 3

Pre-existing intratumoral CD8 T cells substantially contribute to control tumors following therapeutic anti-CD40 and polyI:C based vaccination 88 14 10 3

Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication 36 1

Lipopolysaccharide administration alters extracellular vesicles in human lung-cancer cells and mice 10 3

Evaluation of IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques 164 10

Dynamic metabolic reprogramming in dendritic cells: an early response to influenza infection that is essential for effector function 27 10 3

The central THαβ immunity associated cytokine: IL-10 has a strong anti-tumor ability toward established cancer models in vivo and toward cancer cells in vitro 188 27 10 3

Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice 110 27 10 3

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages 39 10 3

Priming of MSCs with inflammation-relevant signals affects extracellular vesicle biogenesis, surface markers, and modulation of T cell subsets 110 10 3

Ex vivo Immune Profiling in Patient Blood enables Quantification of innate immune Effector Functions 27 10

Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis. 110 27 10 3

Cyclic pentapeptide cRGDfK enhances the inhibitory effect of sunitinib on TGF-β1-induced epithelial-to-mesenchymal transition in human non-small cell lung cancer cells 98 14 10 3

PYK2 controls intestinal inflammation via activation of IRF5 in macrophages 110 27 10 3

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells 152 14 10 3

Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration 110 32 27 10 3

MeCP2 deficiency exacerbates the neuroinflammatory setting and autoreactive response during an autoimmune challenge: implications for Rett Syndrome. 110 27 10 3

Preclinical modeling of surgery and steroid therapy for glioblastoma reveals changes in immunophenotype that are associated with tumor growth and outcome 126 14 10

PQS-Induced Outer Membrane Vesicles Enhance Biofilm Dispersion in Pseudomonas aeruginosa 52 12 10 3

Mathematical modeling of N-803 treatment in SIV-infected non-human primates 88 10

Protection from viral rebound after therapeutic vaccination with an adjuvanted DNA vaccine is associated with SIV-specific polyfunctional CD8 T cells in the blood and mesenteric lymph nodes 88 27 10

Tamoxifen repurposing to combat infections by multidrug-resistant Gram-negative bacilli 52 10

Antibiotic-induced disturbances of the gut microbiota result in accelerated breast tumour growth via a mast cell-dependent pathway 108 14 10 3

Expression of Tim-3 drives naive Treg to an effector-like state with enhanced suppressive activity 88 27 14 10 3

Alpha-synuclein supports interferon stimulated gene expression in neurons 54 27 10 3

Tumor-specific EphA2 receptor tyrosine kinase inhibits anti-tumor immunity by recruiting suppressive myeloid populations in NSCLC 14 10 3

IL-4 receptor targeting as an effective immunotherapy against triple-negative breast cancer 126 14 10 3

Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition 108 14 10 3

T cells expanded from renal cell carcinoma are tumor-reactive but fail to produce IFN-γ, TNF-α or IL-2 88 27 10 3

Regulation of angiotensin converting enzyme 2 (ACE2) in obesity: implications for COVID-19 36 1

mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2 191 36 24 1

The pleiotropic effects of the MNK1/2-eIF4E axis support immune suppression and metastasis in a model of postpartum breast cancer. 14 10 3

PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity 108 14 10 3

Hedgehog dysregulation contributes to tissue-specific inflammaging of resident macrophages 110 27 10 3

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates 69 10 3

Glucocorticoid treatment exacerbates mycobacterial infection by reducing the phagocytic capacity of macrophages 27 10 3

Sustained Androgen Receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis 108 14 10 3

Multi-organ signaling mobilizes tumor-associated erythroid cells expressing immune checkpoint molecules 14 10 3

Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31 164 10

Myocardial damage induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart. 153 10

Hydroxychloroquine increased psychiatric-like behaviors and disrupted the expression of related genes in the mouse brain 113 10

Suppression of Cytotoxic T Cell Functions and Decreased Levels of Tissue Resident Memory T cell During H5N1 infection 27 10 3

The PD-L1/PD-1 Axis Blocks Neutrophil Cytotoxicity In Cancer 197 27 14 10 3

Immunosuppressive role of PGE2 during human tuberculosis 27 10 3

The magnitude of airway remodelling is not altered by distinct allergic inflammatory responses in BALB/c vs C57BL/6 mice, but matrix composition differs 27 10 3

Characterization of immunoactive and immunotolerant CD4+ T cells in breast cancer by measuring activity of signaling pathways that determine immune cell function 14 10 3

Transcriptional memory-like imprints and enhanced functional activity in γδ T cells following resolution of malaria infection 88 27 10 3

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2 44 1

Sexually dimorphic responses to MPTP found in microglia, inflammation and gut microbiota in a progressive monkey model of Parkinson's disease 164 54 10 2

Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis 174 27 10 3

A human disease model of SARS-CoV-2-induced lung injury and immune responses with a microengineered organ chip 73 1

The Injury Response to DNA Damage Promotes Anti-Tumor Immunity 126 88 10 3

Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses 27 10 3

Integrated metabolic modeling, culturing and transcriptomics explains enhanced virulence of V. cholerae during co-infection with ETEC 114 12

Influenza-induced activation of recruited alveolar macrophages during the early inflammatory phase drives lung injury and lethality 27 10 3

Endothelial cells promote productive HIV infection of resting CD4+ T cells by an integrin-mediated cell adhesion-dependent mechanism 27 3

Restructuring of the Immune Contexture Improves Checkpoint Blockade Efficacy in Murine Lung Cancer 126 14 10

Allergen specific Treg upregulated by lung-stage schistosome infection alleviates allergic airway inflammation via inhibiting IgE secretion 27 10 3

Gut Microbiota Mediates the Protective Effects of Andrographolide Inhibits Inflammation and Nonalcoholic Fatty Liver Disease(NAFLD) in High-Fat Diet induced ApoE(-/-) Mice 39 10 3

Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain. 110 27 10 3

Bidirectional regulation of cognitive and anxiety-like behaviors by dentate gyrus mossy cells in male and female mice 56 11 2

Low doses of radiation increase the immunosuppressive profile of lung macrophages during viral infection and pneumonia 73 27 10 1

A novel mechanism of natural killer cell response to anti-CTLA-4 therapy identified by integrative analysis of mouse and human tumors 14 10 9 3

Voluntary running does not increase capillary blood flow but promotes neurogenesis and short-term memory in the APP/PS1 mouse model of Alzheimers disease 32 10 2

Modelling within-host macrophage dynamics in influenza virus infection 27 10 1

TOLLIP promotes durable alveolar macrophage-mediated immunity during Mycobacterium tuberculosis infection by resolving cellular stress from lipids. 69 27 10 3

Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques 73 27 1

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB 73 27 1

Anti-EGFR Fibronectin Bispecific Chemically Self-Assembling Nanorings (CSANs) Induce Potent T cell Mediated Anti-Tumor Response and Downregulation of EGFR Signaling and PD-1/PD-L1 Expression 126 14 10 3

Interferon-induced Protein-44 and Interferon-induced Protein 44-like restrict replication of Respiratory Syncytial Virus 41 27 10 3

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures 73 1

TNFRSF14 (HVEM) is a novel immune checkpoint blockade that can be targeted by a monoclonal antibody to improve anti-tumor immunity in humanized mice 126 14 10 3

Circulating immune cell phenotype dynamics reflect the strength of tumor-immune cell interactions in patients during immunotherapy 14 10 9

Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model system 114 27 3

NMR Analysis of the Correlation of Metabolic Changes in Blood and Cerebrospinal Fluid in Alzheimer Model Male and Female Mice 32 10

Cyclin G2 inhibits oral squamous cell carcinoma growth and metastasis by binding to insulin-like growth factor binding protein 3 and regulating the FAK-SRC-STAT signaling pathway 108 14 10 3

Adhatoda Vasica ameliorates cellular hypoxia dependent mitochondrial dysfunction in acute and severe asthmatic mice. 10 3

Life-long persistence of infectious Zika virus: Inflammation and behavioral sequela 27 10

Interleukin-11 is a Marker for Both Cancer- and Inflammation-Associated Fibroblasts that Contribute to Colorectal Cancer Progression 110 108 14 10 3

Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques 73 1

Epigenetic downregulation of HER2 during EMT leads to tumor resistance to HER2-targeted therapies in breast cancer 98 14 10 3

ISG15 drives immune pathology and respiratory failure during viral infection 27 10 3

Schistosoma Japonicum infection in Treg-specific USP21 knock-out mice 27 10 3

UBR-Box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target 108 14 3

Amyloid beta acts synergistically as a pro-inflammatory cytokine 32 27 3

Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in PC12 cells 95 10 3

Brucella suppress innate immunity by down-regulating STING expression in macrophages 174 27 3

HDAC and MAPK/ERK inhibitors cooperate to reduce viability and stemness phenotype in medulloblastoma 186 108 14 10 3

Inhibition of inositol-requiring enzyme 1 RNase activity protects pancreatic beta cell and improves diabetic condition in insulin mutation-induced diabetes 109 64 10 3

In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor 7 3

Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers 126 14 10 3