Topic 174

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53 items. Top items listed below.

Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis 174 27 10 3

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis 174 27 10

SOCS-1 inhibition of type I interferon limits Staphylococcus aureus skin host defense 174 27 10 3

Brucella suppress innate immunity by down-regulating STING expression in macrophages 174 27 3

Disease stage-specific pathogenicity of CD138 (syndecan 1)-expressing T cells in systemic lupus erythematosus 174 88 27 10 3

The persistence of Nontypeable Haemophilus influenzae fuels airway inflammation 174 27 10 3

Growth differentiation factor-15 is associated with age-related monocyte immunosenescence 174 27 10 3

ICOS enhances follicular T helper responses and deteriorates the pathogenic process of liver in mice infected with Schistosoma japonicum 174 27 10 3

LAG3 is a Central Regulator of NK Cell Cytokine Production 27 10 3

Macrophage Inflammatory State Influences Susceptibility to Lysosomal Damage 174 150 27 10 3

Peripheral Natural Killer cells from chronic hepatitis B patients display molecular hallmarks of T cell exhaustion 174 27 10 3

Humanized TLR4 immunocompetent mice are more susceptible to kidney disease after infection with Leptospira interrogans than wild-type mice 174 10

Cutaneous Wounds in Mice Lacking Tumor Necrosis Factor-stimulated Gene-6 Exhibit Delayed Closure and an Abnormal Inflammatory Response 174 110 27 10 3

Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice 110 27 10 3

Calprotectin modulates inflammatory collateral tissue damage during intraperitoneal origin systemic candidiasis 174 27 10 3

A Novel Role for the Nuclear Receptor, NR4A1, in Klebsiella pneumoniae Lung Infection 27 10 3

Cryptococcus neoformans evades pulmonary immunity by modulating xylose precursor transport 174 27 10 3

The role of HMGB1 in invasive Candida albicans infection 174 110 10 3

Activation of oral epithelial EphA2-EFGR signaling by Candida albicans virulence factors 174 114 27 3

A Newly Identified Role for IL-22 in Bladder Immunity 174 156 27 10 3

Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of immune-mediated kidney disease 174 10 3

EOMES and IL-10 regulate anti-tumor activity of PD-1+ CD4+ T-cells in B-cell Non-Hodgkin lymphoma 174 88 27 10 3

Treated HIV Infection Alters Phenotype But Not HIV-specific Function of Peripheral Blood Natural Killer Cells 88 27 10 3

Fetal innate immunity contributes to the induction of atypical behaviors in a mouse model of maternal immune activation 174 65 27 10 3

Adenosine diphosphate contributes to wound healing in diabetic mice through P2Y1 and P2Y12 receptors activation 174 110 10 3

The healing potential of wild type and recombinant S100A8 to attenuate skin wound inflammation 174 110 10

Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain. 110 27 10 3

STING deficiency-associated aberrant CXCL10 expression contributes to pathogenesis of arthritogenic alphaviruses 174 27 10 3

The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent. 174 27 10 3

Lymphatic type-1 interferon responses are critical for control of systemic reovirus dissemination 174 41 27 3

A loss-of-function mutation in IL-17F enhances susceptibility of mice to oropharyngeal candidiasis 174 27 10 3

RNA-binding protein RBM3 negatively regulates innate lymphoid cells (ILCs) and lung inflammation 27 3

Genetic variants drive altered epigenetic regulation of endotoxin tolerance in BTBR macrophages 174 27 9 3

CyTOF analysis identifies unusual immune cells in urine of BCG-treated bladder cancer patients 174 27 10 9

Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis. 110 27 10 3

Loss of IL-10 signaling promotes IL-22 dependent host defenses against acute Clostridioides difficile infection 27 10 3

Tet2 Controls Beta cells Responses to Inflammation in Type 1 Diabetes 174 27 10 3

Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses 88 27 10 3

MeCP2 deficiency exacerbates the neuroinflammatory setting and autoreactive response during an autoimmune challenge: implications for Rett Syndrome. 110 27 10 3

Expansion of CD14+HLA-DRneg/low monocytes and CD10neg neutrophils driving proinflammatory responses in patients with acute myocardial infarction 174 27 10 3

Extracellular ATP released from Candida albicans activates non-peptidergic neurons to augment host defense 174 10 3

CD56 regulates human NK cell cytotoxicity through Pyk2 174 27 3

Blocking IL-10 signaling with soluble IL-10 receptor restores specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum 174 27 10 3

γδ T cells mediate a requisite portion of a wound healing response triggered by cutaneous poxvirus infection 27 10 3

Neutrophils Mediate Kidney Inflammation Following Acute Skin Exposure to UVB Light 27 10 3

Macrophage-derived miR-21 drives overwhelming glycolytic and inflammatory response during sepsis via repression of the PGE2/IL-10 axis. 110 27 10 3

Neuraminidase activity mediates IL-6 production through TLR4 and p38/ERK MAPK signaling in MRL/lpr mesangial cells 110 27 10 3

Short chain fatty acid butyrate promotes virus infection by repressing interferon stimulated genes 27 10 3

IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type 2 immune response to nematode infection 27 10 3

T cells expanded from renal cell carcinoma are tumor-reactive but fail to produce IFN-γ, TNF-α or IL-2 88 27 10 3

Schistosoma Japonicum infection in Treg-specific USP21 knock-out mice 27 10 3

Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs 36 1

Interleukin-19 alleviates experimental autoimmune encephalomyelitis by attenuating antigen-presenting cell activation 110 27 10 3

ISG15 drives immune pathology and respiratory failure during viral infection 27 10 3

The inflammasome of circulatory collapse: single cell analysis of survival on extracorporeal life support. 174 27 10

SARS-CoV-2 induces activation and diversification of human plasmacytoid pre-dendritic cells. 73 27 1

Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection 27 10 3

Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses 27 10 3

Hedgehog dysregulation contributes to tissue-specific inflammaging of resident macrophages 110 27 10 3

PYK2 controls intestinal inflammation via activation of IRF5 in macrophages 110 27 10 3

FcRn, but not FcgRs, drives maternal-fetal transplacental transport of human IgGantibodies 174 88 10 3

Pro-inflammatory response of non-inflammatory Classical monocytes stimulated with LPS in vitro. 174 27 10

Microbiome signatures in a fast and slow progressing gastric cancer murine model and their contribution to gastric carcinogenesis 174 101 10

Ex vivo Immune Profiling in Patient Blood enables Quantification of innate immune Effector Functions 27 10

Extracellular adenosine signaling reverses the age-driven decline in the ability of neutrophils to kill S. pneumoniae 174 27 10 3

Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling 27 10 3

Low doses of radiation increase the immunosuppressive profile of lung macrophages during viral infection and pneumonia 73 27 10 1

An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19 174 27 10 3

Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells 27 10 3

Rewiring PBMC responses to prevent CHIKV infection-specific monocyte subset redistribution and cytokine responses 27 10 3

The Toll-Like Receptor 5 agonist flagellin prevents Non-typeable Haemophilus influenzae-induced exacerbations in cigarette smoke-exposed mice 27 10 3

Intraepithelial T cells diverge by intestinal location as pigs age 174 88 27 10

Alpha-synuclein supports interferon stimulated gene expression in neurons 54 27 10 3

IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection 27 3

The microbiota plays a critical role in the reactivity of lung immune components to innate ligands 27 10 3

Monocytes mediate Salmonella Typhimurium-induced tumour growth inhibition 110 27 10 3

Galectin-1-deficient mice are protected against Trypanosoma cruzi infection through altered neutrophil migration and production of reactive oxygen species and nitric oxide 27 10 3

BAP31 regulated polarization of macrophages through C/EBP β in cutaneous wound healing 150 27 3

MDA5 is an essential vita-PAMP sensor necessary for host resistance against Aspergillus fumigatus 174 27 3

The central THαβ immunity associated cytokine: IL-10 has a strong anti-tumor ability toward established cancer models in vivo and toward cancer cells in vitro 188 27 10 3

Dynamic metabolic reprogramming in dendritic cells: an early response to influenza infection that is essential for effector function 27 10 3

Influenza-induced activation of recruited alveolar macrophages during the early inflammatory phase drives lung injury and lethality 27 10 3

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures 73 1

Early life glucocorticoid exposure modulates immune function in zebrafish (Danio rerio) larvae 174 10 3

ILC1-derived IFN-gamma mediates cDC1-dependent host resistance against Toxoplasma gondii 27 3

Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice 110 27 10 3

Immunosuppressive role of PGE2 during human tuberculosis 27 10 3

Interleukin-17 pathway activation in Equus caballus supporting limb laminitis 174 27 10 3

Functionally distinct neutrophils sequentially promote Th1-type responses upon antiviral antibody therapy 27 10 3

IL-23 production is regulated via an MSK1/2 - CREB dependent signaling pathway downstream of Toll like receptors. 110 27 10 3

Intestinal infection results in impaired lung innate immunity to secondary respiratory infection. 27 10 3

Neonatal immune challenge induces female-specific changes in social behavior and somatostatin cell number, independent of microglial inflammatory signaling 110 56 27 11 10 2

Transcriptional memory-like imprints and enhanced functional activity in γδ T cells following resolution of malaria infection 88 27 10 3

Natural killer activation for bladder cancer elimination can be achieved in vitro by heat-killed BCG 174 27 10 3

A human disease model of SARS-CoV-2-induced lung injury and immune responses with a microengineered organ chip 73 1

Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques 73 1

Suppression of Cytotoxic T Cell Functions and Decreased Levels of Tissue Resident Memory T cell During H5N1 infection 27 10 3

A distinct innate immune signature marks progression from mild to severe COVID-19 73 27 1

Comprehensive single cell analysis of pandemic influenza A virus infection in the human airways uncovers cell-type specific host transcriptional signatures relevant for disease progression and pathogenesis. 73 27 9 1

Mycobacterium tuberculosis evasion of Guanylate Binding Protein-mediated host defense in mice requires the ESX1 secretion system. 114 27 12 3