Topic 54
parkinsons pd synuclein parkinson dopaminergic disease neurons neuroscience substantia nigra neurodegenerative neurodegeneration dopamine aggregation lrrk2 syn motor alpha neuronal lewy synucleinopathies pathology dysfunction midbrain fibrils g2019s parkinsonian aggregates pathogenesis pathological neuron inclusions symptoms fibril induced disorders mice sporadic familial hallmark patients loss brain accumulation deficits cause mitochondrial kinase compacta striatal mechanisms bodies progressive model therapeutic synucleinopathy microglia dementia linked mouse onset a53t early neuroprotective misfolded degeneration protein overexpression altered asyn synaptic oxidative pars vitro risk mutations diseases progression vesicle nigral abnormal snca dysregulation pathway striatum implicated seeding common treatment pathogenic function aggregate levels atrophy injection autophagy toxicity pathophysiology induces formation
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