Topic 6

m_fig o_fig c_fig o_linksmallfig figdir gif highwire dtlvardef dtl alt src figure width height org version 200 larger view graphical abstract small c_li toc graphic 33k 20k 35k 30k 25k 28k 24k bioengineering c_floatno 40k 43k 21k table 32k 29k 26k 109 o_floatnofigure c_lio_lithe 38k 17k 44k 37k 19k 23k protein nanoparticles 199 molecular 42k simulations energy biochemistry c_lio_lia 31k surface 48k 36k delivery 18k 150 41k 34k therapeutic formation 49k contents conformational 47k biophysics cytoplasmic 27k extracellular aggregation ligand 51k resulting peptide like 103 mediated turn entry blood 177 peripheral molecule spectroscopy chemical induce vitro free charge 39k pathway

475 items. Top items listed below.

Improved stability of an engineered function using adapted bacterial strains 6

Untargeted LC-MS metabolomics for the analysis of micro-scaled extracellular metabolites from hepatocytes 6

Comprehensive Transcriptomic Analysis of COVID-19 Blood, Lung, and Airway 6 1

Dataset Augmentation Allows Deep Learning-Based Virtual Screening To Better Generalize To Unseen Target Classes, And Highlight Important Binding Interactions 6 4

The nervous system is the major target for Gold nanoparticle: Evidence from RNA sequencing data of C. elegans 6

An automated, high throughput methodology optimized for quantitative cell-free mitochondrial and nuclear DNA isolation from plasma 6

Why do pathway methods work better than they should? 187 6

Pre-existing cutaneous conditions could increase the risk for SARS-COV-2 infection. 6 1

Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses 6 1

Cytoplasmic CPSF6 regulates HIV-1 capsid trafficking and infection in a cyclophilin A-dependent manner 6 3

Discovery and biosynthesis of clostyrylpyrones from the obligate anaerobe Clostridium roseum 6

The use of hybrid data-dependent and -independent acquisition spectral libraries empower dual-proteome profiling 6

Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons 177 6 3

Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis 6 3

Proliferation genes repressed by TGF-β are downstream of Slug/Snail2 in normal bronchial epithelial progenitors and are deregulated in COPD 6 3

Age-dependent glycomic response to the 2009 pandemic H1N1 influenza virus and its association with disease severity 6 1

Notch1 switches progenitor competence in inducing medulloblastoma 6 3

Label-free three-dimensional observations and quantitative characterisation of on-chip vasculogenesis using optical diffraction tomography 6

The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists 187 6

STING Promotes Breast Cancer Cell Survival by an Inflammatory-Independent Nuclear Pathway Enhancing the DNA Damage Response 6 3

Quantitative analysis questions the role of MeCP2 as a global regulator of alternative splicing 6

Combined CTL and NK cell cytotoxicity against cancer cells 6

Focused ultrasound blood brain barrier opening mediated delivery of MRI-visible albumin nanoclusters to the rat brain for localized drug delivery with temporal control 6

Differences in mitochondrial activity trigger cell competition during early mouse development. 177 6 3

Location specific small RNA annealing to the HCV 5' UTR promotes Hepatitis C Virus replication by favoring IRES formation and stimulating virus translation 6

Regulation of protein abundance in genetically diverse mouse populations 6

CD45 pre-exclusion from the tips of microvilli establishes a phosphatase-free zone for early TCR triggering 6 3

Cell states beyond transcriptomics: integrating structural organization and gene expression in hiPSC-derived cardiomyocytes 6

Identification of a Nonsense-Mediated Decay pathway at the Endoplasmic Reticulum 6 3

Context-specific functions of Notch in Drosophila blood cell progenitors 177 6 3

Robustness testing and scalability of phosphate regulated promoters useful for two-stage autoinduction in E. coli 6

Localized cell-surface sampling of a secreted factor using cell-targeting beads 6 3

Generation of human bronchial organoids for SARS-CoV-2 research 6 1

A Liquid-to-Solid Phase Transition Enhances the Catalytic Activity of SARM1 6 3

A family of contact-dependent nuclease effectors contain an exchangeable, species-identifying domain 6

CELLector: Genomics Guided Selection of Cancer in vitro Models 6 4

14-3-3ζ mediates an alternative, non- thermogenic mechanism to reduce heat loss and improve cold tolerance 6 3

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis 6 1

Visualization of individual cell division history in complex tissues 6 3

Molecular dynamics reveals complex compensatory effects of ionic strength on the SARS-CoV-2 Spike/hACE-2 interaction 6 1

Mechano-bactericidal nanopillars require external forces to effectively kill bacteria 187 6

rec-Y2H matrix screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins 6 3

An investigation into the critical role of fibre orientation in the ultimate tensile strength and stiffness of human carotid plaque caps 6

Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects 6 1

Independent apical and basal mechanical systems determine cell and tissue shape in the Drosophila wing disc 6

Negative controls of chemical probes can be misleading 6

Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct 6

KCNQ gene family members act as both tumor suppressors and oncogenes in gastrointestinal cancers 6 3

Proposed allosteric inhibitors bind to the ATP site of CK2α 6

The architecture of protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit 6 3

Degradation of Alzheimers Amyloid-beta by a Catalytically Inactive Insulin Degrading Enzyme 6

Molecularly Targeted Magnetic Resonance Imaging and Spectroscopy 187 6

Optical TrkB activation in Parvalbumin interneurons regulates intrinsic states to orchestrate cortical plasticity 177 6 3 2

Lineage and Spatial Mapping of Glioblastoma-associated Immunity 6 3

Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathy 6 3

GPR183 regulates interferons and bacterial growth during Mycobacterium tuberculosis infection: interaction with type 2 diabetes and TB disease severity 6 3

The role of pregnancy-specific glycoproteins on trophoblast motility in three-dimensional gelatin hydrogels 6

A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers 187 6

The 'hidden side' of spin labeled oligonucleotides: Molecular Dynamics study focusing on the EPR-silent components of base pairing 6

Daily mitochondrial dynamics in cone photoreceptors 6

Integrated intra- and intercellular signaling knowledge for multicelullar omics analysis 6

High-resolution line-scanning reveals distinct visual response properties across human cortical layers 6 2

Clinical Knowledge Graph Integrates Proteomics Data into Clinical Decision-Making 6 4

SAMHD1 promotes oncogene-induced replication stress 6 3

Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells 6 3

A prevalent and culturable microbiota links ecological balance to clinical stability of the human lung after transplantation 6

Optogenetic activation of heterotrimeric Gi proteins by LOV2GIVe - a rationally engineered modular protein 6

Parietal cell-Specific SLC26A9 Deletion induces spontaneous Gastric Carcinogenesis in Mice 6 3

De Novo Discovery of High Affinity Peptide Binders for the SARS-CoV-2 Spike Protein 6 1

Single-cell transcriptome analysis reveals cell-cell communication and thyrocyte diversity in the zebrafish thyroid gland 6 3

Specialized DNA structures act as genomic beacons for integration by evolutionarily diverse retroviruses. 6

An active chromatin interactome in relevant cell lines elucidates biological mechanisms at genetic risk loci for dermatological traits 6

A benzene-mapping approach for uncovering cryptic pockets in membrane-bound proteins 6

Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses 6 4

Tau in the brain interstitial fluid is fragmented and seeding-competent 6

Germline APOBEC3B deletion in Asian women increases somatic hypermutation in breast cancer that is associated with Her2 subtype, PIK3CA mutations, immune activation, and increased survival 6

Cholesterol metabolism drives regulatory B cell function 6 3

Press xenobiotic disturbance favors deterministic assembly with a shift in function and structure of bacterial communities in sludge bioreactors 6 5

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS- S and MERS-S pseudotyped particles 6 1

Release of potential pro-inflammatory peptides from SARS-CoV-2 spike glycoproteins in neutrophil-extracellular traps 6 1

Anterior thalamic function is required for spatial coding in the subiculum and is necessary for spatial memory 6

Mass Spectrometry Imaging of N-Glycans Reveals Racial Discrepancies in Low Grade Prostate Tumors 6

Automated design and optimization of multitarget schizophrenia drug candidates by deep learning 6

Long-term live imaging of epithelial organoids and corresponding multiscale analysis reveal high heterogeneity and identify core regulatory principles 6

Increasing glucose uptake into neurons antagonizes brain aging and promotes health and life span under dietary restriction in Drosophila 6 3

The spatial structure of feedforward information in mouse primary visual cortex 6 2

Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis 6 3

Quantifying the monomer-dimer equilibrium of tubulin with mass photometry 6

Tau amyloidogenesis begins with a loss of its conformational polymorphism 6 3

Macrophages Promote Aortic Valve Cell Calcification Through STAT3 Splicing 6 3

GW182 Proteins Restrict Extracellular Vesicle Mediated Selective Export of Used miRNAs In Mammalian Cancer Cells 187 6 3

Lipid droplets disrupt mechanosensing in human hepatocytes 6 3

Multiple freeze-thaw cycles lead to a loss of consistency in poly(A)-enriched RNA sequencing 6 4

Mapping of Neuropeptide Y Expression in Octopus Brains 6

Characterization of interstitial heterogeneity in the developing kidney 187 6 3

Mapping glycan-mediated galectin-3 interactions by live cell proximity labeling 6

Tracking crystallophore nucleating properties: setting-up a database for statistical analysis. 6

Transcriptional changes are regulated by metabolic pathway dynamics but decoupled from protein levels 6 3

Niche-derived soluble DLK1 promotes glioma stemness and growth 6 3

The CD28-transmembrane domain mediates chimeric antigen receptor heterodimerization with CD28 6 3