Topic 187

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21 items. Top items listed below.

Why do pathway methods work better than they should? 187 6

The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists 187 6

Mechano-bactericidal nanopillars require external forces to effectively kill bacteria 187 6

Molecularly Targeted Magnetic Resonance Imaging and Spectroscopy 187 6

A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers 187 6

GW182 Proteins Restrict Extracellular Vesicle Mediated Selective Export of Used miRNAs In Mammalian Cancer Cells 187 6 3

Characterization of interstitial heterogeneity in the developing kidney 187 6 3

Exosomes are predominantly loaded with mRNA transcript encoding cytoplasmic proteins and exclude mRNA transcript encoding nuclear proteins 187 6

A series of Orai1 gating checkpoints in transmembrane and cytosolic regions requires clearance for CRAC channel opening 187 6 3

Insights into the Polyhexamethylene Biguanide (PHMB) Mechanism of Action on Bacterial Membrane and DNA: A Molecular Dynamics Study 187 6

Ultra-fast electroporation of giant unilamellar vesicles -- Experimental validation of a molecular model 187 6

The Drosophila EGFR ligand mSpitz is delivered to cytoplasmic capes at sites of non-canonical RNA export on the nuclear envelope via the endosomal system 187 6 3

Formin FHOD1 regulates the size of EPEC pedestals 187 6 3

Exploring G and C-quadruplex structures as potential targets against the severe acute respiratory syndrome coronavirus 2 187 6 1

Improved stability of an engineered function using adapted bacterial strains 6

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex 187 6

Climate change and green sea turtle sex ratio - Preventing possible extinction 187 6 5

Untargeted LC-MS metabolomics for the analysis of micro-scaled extracellular metabolites from hepatocytes 6

Dataset Augmentation Allows Deep Learning-Based Virtual Screening To Better Generalize To Unseen Target Classes, And Highlight Important Binding Interactions 6 4

Extensive 5'-Surveillance Guards Against Non-Canonical NAD-Caps of Nuclear mRNAs in Yeast 187 6

The phosphatase inhibitor LB-100 acts synergistically with the NPR2 agonist BMN-111 to improve bone growth 187 6 3

An asymmetry in the frequency and position of mitosis in the epiblast precedes gastrulation and suggests a role for mitotic rounding in cell delamination during primitive streak epithelial-mesenchymal transition. 187 6

Comprehensive Transcriptomic Analysis of COVID-19 Blood, Lung, and Airway 6 1

An automated, high throughput methodology optimized for quantitative cell-free mitochondrial and nuclear DNA isolation from plasma 6

The nervous system is the major target for Gold nanoparticle: Evidence from RNA sequencing data of C. elegans 6

Small molecule enhancers of endosome-to-cytosol import augment anti-tumour immunity 187 6 3

Atomistic Molecular Dynamics Simulations of Trioleoylglycerol - Phospholipid Membrane Systems 187 6

Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis 6 3

Cytoplasmic CPSF6 regulates HIV-1 capsid trafficking and infection in a cyclophilin A-dependent manner 6 3

Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses 6 1

Discovery and biosynthesis of clostyrylpyrones from the obligate anaerobe Clostridium roseum 6

Pre-existing cutaneous conditions could increase the risk for SARS-COV-2 infection. 6 1

Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons 177 6 3

Proliferation genes repressed by TGF-β are downstream of Slug/Snail2 in normal bronchial epithelial progenitors and are deregulated in COPD 6 3

Identification of a Nonsense-Mediated Decay pathway at the Endoplasmic Reticulum 6 3

Context-specific functions of Notch in Drosophila blood cell progenitors 177 6 3

Label-free three-dimensional observations and quantitative characterisation of on-chip vasculogenesis using optical diffraction tomography 6

Notch1 switches progenitor competence in inducing medulloblastoma 6 3

CD45 pre-exclusion from the tips of microvilli establishes a phosphatase-free zone for early TCR triggering 6 3

The use of hybrid data-dependent and -independent acquisition spectral libraries empower dual-proteome profiling 6

STING Promotes Breast Cancer Cell Survival by an Inflammatory-Independent Nuclear Pathway Enhancing the DNA Damage Response 6 3

Independent apical and basal mechanical systems determine cell and tissue shape in the Drosophila wing disc 6

Location specific small RNA annealing to the HCV 5' UTR promotes Hepatitis C Virus replication by favoring IRES formation and stimulating virus translation 6

Focused ultrasound blood brain barrier opening mediated delivery of MRI-visible albumin nanoclusters to the rat brain for localized drug delivery with temporal control 6

Quantitative analysis questions the role of MeCP2 as a global regulator of alternative splicing 6

CELLector: Genomics Guided Selection of Cancer in vitro Models 6 4

Age-dependent glycomic response to the 2009 pandemic H1N1 influenza virus and its association with disease severity 6 1

Differences in mitochondrial activity trigger cell competition during early mouse development. 177 6 3

The 'hidden side' of spin labeled oligonucleotides: Molecular Dynamics study focusing on the EPR-silent components of base pairing 6

Combined CTL and NK cell cytotoxicity against cancer cells 6

rec-Y2H matrix screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins 6 3

A Liquid-to-Solid Phase Transition Enhances the Catalytic Activity of SARM1 6 3

A family of contact-dependent nuclease effectors contain an exchangeable, species-identifying domain 6

Regulation of protein abundance in genetically diverse mouse populations 6

Robustness testing and scalability of phosphate regulated promoters useful for two-stage autoinduction in E. coli 6

14-3-3ζ mediates an alternative, non- thermogenic mechanism to reduce heat loss and improve cold tolerance 6 3

An investigation into the critical role of fibre orientation in the ultimate tensile strength and stiffness of human carotid plaque caps 6

Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct 6

Cell states beyond transcriptomics: integrating structural organization and gene expression in hiPSC-derived cardiomyocytes 6

Generation of human bronchial organoids for SARS-CoV-2 research 6 1

Visualization of individual cell division history in complex tissues 6 3

KCNQ gene family members act as both tumor suppressors and oncogenes in gastrointestinal cancers 6 3

Molecular dynamics reveals complex compensatory effects of ionic strength on the SARS-CoV-2 Spike/hACE-2 interaction 6 1

Localized cell-surface sampling of a secreted factor using cell-targeting beads 6 3

A benzene-mapping approach for uncovering cryptic pockets in membrane-bound proteins 6

Negative controls of chemical probes can be misleading 6

Single-cell transcriptome analysis reveals cell-cell communication and thyrocyte diversity in the zebrafish thyroid gland 6 3

Proposed allosteric inhibitors bind to the ATP site of CK2α 6

The architecture of protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit 6 3

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis 6 1

Optical TrkB activation in Parvalbumin interneurons regulates intrinsic states to orchestrate cortical plasticity 177 6 3 2

Mass Spectrometry Imaging of N-Glycans Reveals Racial Discrepancies in Low Grade Prostate Tumors 6

Degradation of Alzheimers Amyloid-beta by a Catalytically Inactive Insulin Degrading Enzyme 6

Clinical Knowledge Graph Integrates Proteomics Data into Clinical Decision-Making 6 4

GPR183 regulates interferons and bacterial growth during Mycobacterium tuberculosis infection: interaction with type 2 diabetes and TB disease severity 6 3

Lineage and Spatial Mapping of Glioblastoma-associated Immunity 6 3

Germline APOBEC3B deletion in Asian women increases somatic hypermutation in breast cancer that is associated with Her2 subtype, PIK3CA mutations, immune activation, and increased survival 6

Long-term live imaging of epithelial organoids and corresponding multiscale analysis reveal high heterogeneity and identify core regulatory principles 6

Specialized DNA structures act as genomic beacons for integration by evolutionarily diverse retroviruses. 6

Tau in the brain interstitial fluid is fragmented and seeding-competent 6

Anterior thalamic function is required for spatial coding in the subiculum and is necessary for spatial memory 6

The role of pregnancy-specific glycoproteins on trophoblast motility in three-dimensional gelatin hydrogels 6

Quantitative study of unsaturated transport of glycerol through aquaglyceroporin that has high affinity for glycerol 6

High-resolution line-scanning reveals distinct visual response properties across human cortical layers 6 2

Lipid droplets disrupt mechanosensing in human hepatocytes 6 3

Optogenetic activation of heterotrimeric Gi proteins by LOV2GIVe - a rationally engineered modular protein 6

Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses 6 4

A prevalent and culturable microbiota links ecological balance to clinical stability of the human lung after transplantation 6

Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells 6 3

SAMHD1 promotes oncogene-induced replication stress 6 3

Transcriptional changes are regulated by metabolic pathway dynamics but decoupled from protein levels 6 3

Quantifying the monomer-dimer equilibrium of tubulin with mass photometry 6

A joint reaction coordinate for computing the free energy landscape of pore nucleation and pore expansion in lipid membranes 6

Press xenobiotic disturbance favors deterministic assembly with a shift in function and structure of bacterial communities in sludge bioreactors 6 5

Energy landscape steering in SecYEG mediates dynamic coupling in ATP driven protein translocation 6

An active chromatin interactome in relevant cell lines elucidates biological mechanisms at genetic risk loci for dermatological traits 6

Parietal cell-Specific SLC26A9 Deletion induces spontaneous Gastric Carcinogenesis in Mice 6 3

Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects 6 1

Integrated intra- and intercellular signaling knowledge for multicelullar omics analysis 6

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS- S and MERS-S pseudotyped particles 6 1