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sars cov covid 19 coronavirus pandemic virus viral spike respiratory infection ace2 severe 2019 syndrome acute vaccine receptor entry host antiviral against coronaviruses microbiology viruses disease rbd infected antibodies vaccines caused replication binding human neutralizing outbreak angiotensin spread antibody protein converting global patients health immunology glycoprotein domain lung clinical worldwide public china immune infections enzyme rna effective drug therapeutic epitopes transmission wuhan 2020 mers drugs protease therapeutics potent potential has world ongoing neutralization tmprss2 approved rapid infectious rapidly s1 urgent deaths design epitope nucleocapsid ncov pathogenesis agent december currently assay cov2 convalescent novel target development structural cases anti treatment infectivity
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