Topic 76

epitopes vaccine epitope mhc sars cov peptide hla immune peptides against vaccines covid immunology predicted design immunogenic 19 antigen coronavirus silico coverage bioinformatics antigenicity virus antigenic spike immunoinformatics immunogenicity docking binding alleles cd8 pandemic potential ii class cell based immunity glycoprotein viral allergenicity effective candidate designing candidates outbreak cd4 designed prediction population 2019 selected coronaviruses protein vaccinology leukocyte sequences caused affinity development tools adjuvant global respiratory construct approach proteome immunodominant responses antigens iedb sequence nucleocapsid ctl presentation human infection novel syndrome proteins severe recognition molecules presented public worldwide immuno deaths validated protection humoral world informatics multi linkers acute suitable infected

114 items. Top items listed below.

Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2 191 76 24 1

Designing of Epitope-Based Vaccine from the Conserved Region of the Spike Glycoprotein of SARS-CoV-2 191 76 24 1


Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approaches 191 76 1

Multi-epitope vaccine design using an immunoinformatics approach for 2019 novel coronavirus (SARS-CoV-2) 191 76 24 1

Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies 76 1

Epitope-Based Peptide Vaccine Against Severe Acute Respiratory Syndrome-Coronavirus-2 Nucleocapsid Protein: An in silico Approach 191 76 1

Immuno-informatics Design of a Multimeric Epitope Peptide Based Vaccine Targeting SARS-CoV-2 Spike Glycoprotein 191 76 24 1

Rational Design of SARS-CoV-2 Spike Glycoproteins To Increase Immunogenicity By T Cell Epitope Engineering 76 24 1

Inferring MHC interacting SARS-CoV-2 epitopes recognized by TCRs towards designing T cell-based vaccines 191 76 1

Understanding the B and T cells epitopes of spike protein of severe respiratory syndrome coronavirus-2: A computational way to predict the immunogens 191 76 1

SARS-CoV-2 transcriptome analysis and molecular cataloguing of immunodominant epitopes for multi-epitope based vaccine design 76 1

COVID-19 Vaccine Candidates: Prediction and Validation of 174 SARS-CoV-2 Epitopes 191 76 24 1

Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2 etiologic agent of global pandemic COVID-19: an in silico approach 191 76 1

In silico approach for designing of a multi-epitope based vaccine against novel Coronavirus (SARS-COV-2) 191 76 24 1

Towards the design of multiepitope-based peptide vaccine candidate against SARS-CoV-2 191 76 36 1

Multi-epitope Based Peptide Vaccine Design Using Three Structural Proteins (S, E, and M) of SARS-CoV-2: An In Silico Approach 76 1

Potential T-cell and B-cell Epitopes of 2019-nCoV 191 76 24 1

Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2: toward universal blueprints for vaccine designs 76 1

CD8+ T cell cross-reactivity against SARS-CoV-2 conferred by other coronavirus strains and influenza virus 191 76 1

In silico multi-epitope vaccine against covid19 showing effective interaction with HLA-B*15:03 76 1

In silico Design of novel Multi-epitope recombinant Vaccine based on Coronavirus surface glycoprotein 76 24 1

Design an efficient multi-epitope peptide vaccine candidate against SARS-CoV-2: An in silico analysis 191 76 24 1

Genome based Evolutionary study of SARS-CoV-2 towards the Prediction of Epitope Based Chimeric Vaccine 191 76 24 1

Attenuated Subcomponent Vaccine Design Targeting the SARS-CoV-2 Nucleocapsid Phosphoprotein RNA Binding Domain: In silico analysis 191 76 1

Sequence-based prediction of vaccine targets for inducing T cell responses to SARS-CoV-2 utilizing the bioinformatics predictor RECON 191 76 1

Immuno-informatics approach for multi-epitope vaccine designing against SARS-CoV-2 191 76 1

Identification of potential vaccine candidates against SARS-CoV-2, A step forward to fight COVID-19: A Reverse Vaccinology Approach 191 76 1

COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning 76 1

Identification of peptide candidate against COVID-19 through reverse vaccinology: An immunoinformatics approach 76 1

Design of multi epitope-based peptide vaccine against E protein of human COVID-19: An immunoinformatics approach 76 37 1

Candidate targets for immune responses to 2019-Novel Coronavirus (nCoV): sequence homology- and bioinformatic-based predictions 76 1

Scrutinizing the SARS-CoV-2 protein information for the designing an effective vaccine encompassing both the T-cell and B-cell epitopes 191 76 24 1

Design of an Epitope-Based Peptide Vaccine against the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): A Vaccine Informatics Approach 191 76 1

Predicting the Immunogenicity of T cell epitopes: From HIV to SARS-CoV-2 191 76 24 1

Immunoinformatic identification of B cell and T cell epitopes in the SARS-CoV-2 proteome 76 24 1

A SARS-CoV-2 Vaccination Strategy Focused on Population-Scale Immunity 191 76 24 1

Bioinformatic analysis of shared B and T cell epitopes amongst relevant coronaviruses to human health: Is there cross-protection? 76 1

Sampling SARS-CoV-2 proteomes for predicted CD8 T-cell epitopes as a tool for understanding immunogenic breadth and rational vaccine design 191 76 24 1

An immunodominance hierarchy exists in CD8+ T cell responses to HLA-A*02:01-restricted epitopes identified from the non-structural polyprotein 1a of SARS-CoV-2. 191 76 24 1

SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs 191 76 24 1

The immunodominant and neutralization linear epitopes for SARS-CoV-2 24 1

In silico design and characterization of multiepitopes vaccine for SARS-CoV2 from its Spike proteins 191 76 24 1

Epitopes targeted by T cells in convalescent COVID-19 patients 76 24 1

Potent neutralizing antibodies in the sera of convalescent COVID-19 patients are directed against conserved linear epitopes on the SARS-CoV-2 spike protein 24 1

Designing a multi-epitope peptide-based vaccine against SARS-CoV-2 191 76 24 1

mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2 191 36 24 1

The influence of major S protein mutations of SARS-CoV-2 on the potential B cell epitopes 24 1

Strategies for vaccine design for corona virus using Immunoinformatics techniques 76 24

Generation of SARS-CoV-2 S1 spike glycoprotein putative antigenic epitopes in vitro by intracellular aminopeptidases 76 24 1

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients. 191 24 1

SARS-CoV-2 mutations and where to find them: An in silico perspective of structural changes and antigenicity of the Spike protein 103 1

An Effective CTL Peptide Vaccine for Ebola Zaire Based on Survivors' CD8+ Targeting of a Particular Nucleocapsid Protein Epitope with Potential Implications for COVID-19 Vaccine Design 191 76 24 1

Proteome Exploration of Legionella pneumophila for Identifying Novel Therapuetics: A Hierarchical Subtractive Genomics and Reverse Vaccinology Approach 76 12

Mapping the Immunodominance Landscape of SARS-CoV-2 Spike Protein for the Design of Vaccines against COVID-19 24 1

Genome-Wide Asymptomatic B-Cell, CD4+ and CD8+ T-Cell Epitopes, that are Highly Conserved Between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Immune Targets for Pre-Emptive Pan-Coronavirus Vaccines 191 76 1

A vaccine built from potential immunogenic pieces derived from the SARS-CoV-2 spike glycoprotein 6 1

The Essential Facts of Wuhan Novel Coronavirus Outbreak in China and Epitope-based Vaccine Designing against COVID-19 76 1

Designing Novel Subunit Vaccines against Herpes Simplex Virus-1 using Reverse Vaccinology Approach 76 24 12 1

Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections 24 1

AI aided design of epitope-based vaccine for the induction of cellular immune responses against SARS-CoV-2 76 24 1

Structure-based modeling of SARS-CoV-2 peptide/HLA-A02 antigens 191 76 24 1

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells 191 76 24 1

Multi-epitope based peptide vaccine design against SARS-CoV-2 using its spike protein 76 24 1

Robust computational design and evaluation of peptide vaccines for cellular immunity with application to SARS-CoV-2 76 4

Antigenic variation of SARS-CoV-2 in response to immune pressure 191 76 24 1

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection 191 76 24 1

Antigenic evolution on global scale reveals potential natural selection of SARS-CoV-2 by pre-existing cross-reactive T cell immunity 76 1

COVIEdb: A database for potential immune epitopes of coronaviruses 76 1

Spike protein binding prediction with neutralizing antibodies of SARS-CoV-2 1

Zika viral proteome analysis reveals an epitope cluster within NS3 helicase as a potential vaccine candidate: an in silico study 76 24

The landscape of antibody binding to SARS-CoV-2 24 1

Preclinical study of DNA vaccines targeting SARS-CoV-2 24 1

SARS-CoV-2 proteome microarray for mapping COVID-19 antibody interactions at amino acid resolution 76 24 1

SARS-CoV-2-induced humoral immunity through B cell epitope analysis and neutralizing activity in COVID-19 infected individuals in Japan 24 1

The immune vulnerability landscape of the 2019 Novel Coronavirus, SARS-CoV-2 191 76 37 1

Utilizing Computational Machine Learning Tools to Understand Immunogenic Breadth in the Context of a CD8 T-Cell Mediated HIV Response 76 24 4

Comprehensive Genome Based Analysis of Vibrio parahaemolyticus for Identifying Novel Drug and Vaccine Molecules: Subtractive Proteomics and Vaccinomics Approach 76 12

Tissue-resident memory CD8 T-cell responses elicited by a single injection of a multi-target COVID-19 vaccine 24 1

CD8 T cell epitope generation toward the continually mutating SARS-CoV-2 spike protein in genetically diverse human population: Implications for disease control and prevention 191 76 24 1

Epitope-Based Peptide Vaccine Design Against Fructose Bisphosphate Aldolase of Candida Glabrata: An Immunomics Approach 76 7

Immuno-informatics Characterization SARS-CoV-2 Spike Glycoprotein for Prioritization of Epitope based Multivalent Peptide Vaccine 76 24 1

SARS-CoV-2 genome-wide mapping of CD8 T cell recognition reveals strong immunodominance and substantial CD8 T cell activation in COVID-19 patients 191 76 24 1

A Multiple Peptides Vaccine against nCOVID-19 Designed from the Nucleocapsid phosphoprotein (N) and Spike Glycoprotein (S) via the Immunoinformatics Approach 76 24 1

Landscape and Selection of Vaccine Epitopes in SARS-CoV-2 6 1

Tracking SARS-CoV-2 T cells with epitope T-cell receptor recognition models 76 1

COVID19: Exploring uncommon epitopes for a stable immune response through MHC1 binding 191 76 24 1

A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses 24 1

Assessment of SARS-CoV-2 Specific CD4(+) and CD8 (+) T Cell Responses Using MHC Class I and II Tetramers 191 76 24

Insights into Cross-species Evolution of Novel Human Coronavirus 2019-nCoV and Defining Immune Determinants for Vaccine Development 37 1

Predicted Cellular Immunity Population Coverage Gaps for SARS-CoV-2 Subunit Vaccines and their Augmentation by Compact Peptide Sets 76 24 1

SARS-CoV2 spike protein displays biologically significant similarities with paramyxovirus surface proteins; a bioinformatics study 76 1

Phage-DMS: a comprehensive method for fine mapping of antibody epitopes 76 24 4

Ex vivo detection of SARS-CoV-2-specific CD8+ T cells: rapid induction, prolonged contraction, and formation of functional memory 24 1

Peptide vaccine candidate mimics the heterogeneity of natural SARS-CoV-2 immunity in convalescent humans and induces broad T cell responses in mice models 191 76 24 1

An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targets 76 1

Epstein Barr virus epitope/MHC interaction combined with convergent recombination drive selection of diverse T cell receptor a and b repertoires 76 27 24

Epitope - based peptide vaccine against glycoprotein GPC precursor of Lujo virus using immunoinformatics approaches 76

Scrutinizing surface glycoproteins and poxin-schlafen protein to design a heterologous recombinant vaccine against monkeypox virus 76 24

Structural basis to design multi-epitope vaccines against Novel Coronavirus 19 (COVID19) infection, the ongoing pandemic emergency: an in silico approach 6 1