Topic 191

epitopes vaccine sars cov epitope hla cd8 peptide immunology immune mhc covid antigen 19 peptides antigenic predicted coronavirus spike against cd4 immunogenic antigenicity virus immunity silico vaccines pandemic leukocyte design cell glycoprotein alleles 2019 immunogenicity allergenicity coverage designing docking binding severe respiratory responses immunodominant validated informatics class immunoinformatics syndrome nucleocapsid humoral population candidate protein ii response potential effective infection cloning outbreak global tlr3 designed caused candidates coronaviruses acute deaths viral based human simulation combat proteins gamma construct need approach development multiepitope safety elicit toll receptor multi bioinformatics repertoire cytotoxic novel restricted fight who immuno identified physiochemical induce antigens public affinity

47 items. Top items listed below.

Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2 191 76 24 1

Multi-epitope vaccine design using an immunoinformatics approach for 2019 novel coronavirus (SARS-CoV-2) 191 76 24 1

Designing of Epitope-Based Vaccine from the Conserved Region of the Spike Glycoprotein of SARS-CoV-2 191 76 24 1

Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approaches 191 76 1

Immuno-informatics Design of a Multimeric Epitope Peptide Based Vaccine Targeting SARS-CoV-2 Spike Glycoprotein 191 76 24 1

Understanding the B and T cells epitopes of spike protein of severe respiratory syndrome coronavirus-2: A computational way to predict the immunogens 191 76 1

Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2 etiologic agent of global pandemic COVID-19: an in silico approach 191 76 1

Epitope-Based Peptide Vaccine Against Severe Acute Respiratory Syndrome-Coronavirus-2 Nucleocapsid Protein: An in silico Approach 191 76 1

Inferring MHC interacting SARS-CoV-2 epitopes recognized by TCRs towards designing T cell-based vaccines 191 76 1

Towards the design of multiepitope-based peptide vaccine candidate against SARS-CoV-2 191 76 36 1

CD8+ T cell cross-reactivity against SARS-CoV-2 conferred by other coronavirus strains and influenza virus 191 76 1

Attenuated Subcomponent Vaccine Design Targeting the SARS-CoV-2 Nucleocapsid Phosphoprotein RNA Binding Domain: In silico analysis 191 76 1

Design an efficient multi-epitope peptide vaccine candidate against SARS-CoV-2: An in silico analysis 191 76 24 1

Immuno-informatics approach for multi-epitope vaccine designing against SARS-CoV-2 191 76 1

COVID-19 Vaccine Candidates: Prediction and Validation of 174 SARS-CoV-2 Epitopes 191 76 24 1

In silico approach for designing of a multi-epitope based vaccine against novel Coronavirus (SARS-COV-2) 191 76 24 1

mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2 191 36 24 1

Potential T-cell and B-cell Epitopes of 2019-nCoV 191 76 24 1

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients. 191 24 1

Scrutinizing the SARS-CoV-2 protein information for the designing an effective vaccine encompassing both the T-cell and B-cell epitopes 191 76 24 1

Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies 76 1

Identification of potential vaccine candidates against SARS-CoV-2, A step forward to fight COVID-19: A Reverse Vaccinology Approach 191 76 1

Predicting the Immunogenicity of T cell epitopes: From HIV to SARS-CoV-2 191 76 24 1

Sequence-based prediction of vaccine targets for inducing T cell responses to SARS-CoV-2 utilizing the bioinformatics predictor RECON 191 76 1

Genome based Evolutionary study of SARS-CoV-2 towards the Prediction of Epitope Based Chimeric Vaccine 191 76 24 1

Design of an Epitope-Based Peptide Vaccine against the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): A Vaccine Informatics Approach 191 76 1

An immunodominance hierarchy exists in CD8+ T cell responses to HLA-A*02:01-restricted epitopes identified from the non-structural polyprotein 1a of SARS-CoV-2. 191 76 24 1

In silico design and characterization of multiepitopes vaccine for SARS-CoV2 from its Spike proteins 191 76 24 1

AN IMMUNOINFORMATICS STUDY TO PREDICT EPITOPES IN THE ENVELOPE PROTEIN OF SARS-COV-2 76 1

SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs 191 76 24 1

Sampling SARS-CoV-2 proteomes for predicted CD8 T-cell epitopes as a tool for understanding immunogenic breadth and rational vaccine design 191 76 24 1

Designing a multi-epitope peptide-based vaccine against SARS-CoV-2 191 76 24 1

Multi-epitope Based Peptide Vaccine Design Using Three Structural Proteins (S, E, and M) of SARS-CoV-2: An In Silico Approach 76 1

Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2: toward universal blueprints for vaccine designs 76 1

SARS-CoV-2 transcriptome analysis and molecular cataloguing of immunodominant epitopes for multi-epitope based vaccine design 76 1

Genome-Wide Asymptomatic B-Cell, CD4+ and CD8+ T-Cell Epitopes, that are Highly Conserved Between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Immune Targets for Pre-Emptive Pan-Coronavirus Vaccines 191 76 1

A SARS-CoV-2 Vaccination Strategy Focused on Population-Scale Immunity 191 76 24 1

Rational Design of SARS-CoV-2 Spike Glycoproteins To Increase Immunogenicity By T Cell Epitope Engineering 76 24 1

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells 191 76 24 1

Antigenic variation of SARS-CoV-2 in response to immune pressure 191 76 24 1

The immunodominant and neutralization linear epitopes for SARS-CoV-2 24 1

An Effective CTL Peptide Vaccine for Ebola Zaire Based on Survivors' CD8+ Targeting of a Particular Nucleocapsid Protein Epitope with Potential Implications for COVID-19 Vaccine Design 191 76 24 1

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection 191 76 24 1

Potent neutralizing antibodies in the sera of convalescent COVID-19 patients are directed against conserved linear epitopes on the SARS-CoV-2 spike protein 24 1

SARS-CoV-2 genome-wide mapping of CD8 T cell recognition reveals strong immunodominance and substantial CD8 T cell activation in COVID-19 patients 191 76 24 1

Structure-based modeling of SARS-CoV-2 peptide/HLA-A02 antigens 191 76 24 1

CD8+ T cell responses in convalescent COVID-19 individuals target epitopes from the entireSARS-CoV-2 proteome and show kinetics of early differentiation 191 24 1

In silico multi-epitope vaccine against covid19 showing effective interaction with HLA-B*15:03 76 1

COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning 76 1

Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections 24 1

Identification of peptide candidate against COVID-19 through reverse vaccinology: An immunoinformatics approach 76 1

Induction of SARS-CoV-2 protein S-specific CD8+ T cells in the lungs of gp96-Ig-S vaccinated mice 191 24 1

The immune vulnerability landscape of the 2019 Novel Coronavirus, SARS-CoV-2 191 76 37 1

In silico Design of novel Multi-epitope recombinant Vaccine based on Coronavirus surface glycoprotein 76 24 1

Peptide vaccine candidate mimics the heterogeneity of natural SARS-CoV-2 immunity in convalescent humans and induces broad T cell responses in mice models 191 76 24 1

Mapping the Immunodominance Landscape of SARS-CoV-2 Spike Protein for the Design of Vaccines against COVID-19 24 1

CD8 T cell epitope generation toward the continually mutating SARS-CoV-2 spike protein in genetically diverse human population: Implications for disease control and prevention 191 76 24 1

Tissue-resident memory CD8 T-cell responses elicited by a single injection of a multi-target COVID-19 vaccine 24 1

Assessment of SARS-CoV-2 Specific CD4(+) and CD8 (+) T Cell Responses Using MHC Class I and II Tetramers 191 76 24

The influence of major S protein mutations of SARS-CoV-2 on the potential B cell epitopes 24 1

Immunoinformatic identification of B cell and T cell epitopes in the SARS-CoV-2 proteome 76 24 1

Design of multi epitope-based peptide vaccine against E protein of human COVID-19: An immunoinformatics approach 76 37 1

COVID19: Exploring uncommon epitopes for a stable immune response through MHC1 binding 191 76 24 1

The landscape of antibody binding to SARS-CoV-2 24 1

SARS-CoV-2 mutations and where to find them: An in silico perspective of structural changes and antigenicity of the Spike protein 103 1

Bioinformatic analysis of shared B and T cell epitopes amongst relevant coronaviruses to human health: Is there cross-protection? 76 1

Candidate targets for immune responses to 2019-Novel Coronavirus (nCoV): sequence homology- and bioinformatic-based predictions 76 1

Preclinical study of DNA vaccines targeting SARS-CoV-2 24 1

A vaccine built from potential immunogenic pieces derived from the SARS-CoV-2 spike glycoprotein 6 1

A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses 24 1

Epitopes targeted by T cells in convalescent COVID-19 patients 76 24 1

SARS-CoV-2-induced humoral immunity through B cell epitope analysis and neutralizing activity in COVID-19 infected individuals in Japan 24 1

A systematic, unbiased mapping of CD8+ and CD4+ T cell epitopes in Yellow Fever vaccinees 191 76 24

Ex vivo detection of SARS-CoV-2-specific CD8+ T cells: rapid induction, prolonged contraction, and formation of functional memory 24 1

Antigenic evolution on global scale reveals potential natural selection of SARS-CoV-2 by pre-existing cross-reactive T cell immunity 76 1

Spike protein binding prediction with neutralizing antibodies of SARS-CoV-2 1

SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike 24 1

Generation of SARS-CoV-2 S1 spike glycoprotein putative antigenic epitopes in vitro by intracellular aminopeptidases 76 24 1

Dendritic cells focus CTL responses toward highly conserved and topologically important HIV epitopes 191 88 76 24 10

Landscape and Selection of Vaccine Epitopes in SARS-CoV-2 6 1

Zebrafish studies on the vaccine candidate to COVID-19, the Spike protein: Production of antibody and adverse reaction 24 1

The Essential Facts of Wuhan Novel Coronavirus Outbreak in China and Epitope-based Vaccine Designing against COVID-19 76 1

Strategies for vaccine design for corona virus using Immunoinformatics techniques 76 24

Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice 24 1

Monoclonal antibodies for the S2 subunit of spike of SARS-CoV cross-react with the newly-emerged SARS-CoV-2 36 1

Structural basis to design multi-epitope vaccines against Novel Coronavirus 19 (COVID19) infection, the ongoing pandemic emergency: an in silico approach 6 1

Identification of conserved epitopes in SARS-CoV-2 spike and nucleocapsid protein. 103 1

COVIEdb: A database for potential immune epitopes of coronaviruses 76 1

Insights into Cross-species Evolution of Novel Human Coronavirus 2019-nCoV and Defining Immune Determinants for Vaccine Development 37 1

Utilizing Computational Machine Learning Tools to Understand Immunogenic Breadth in the Context of a CD8 T-Cell Mediated HIV Response 76 24 4

Comparative analyses of SAR-CoV2 genomes from different geographical locations and other coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis 103 1

Computationally validated SARS-CoV-2 CTL and HTL Multi-Patch Vaccines designed by reverse epitomics approach, shows potential to cover large ethnically distributed human population worldwide 6 1

AI aided design of epitope-based vaccine for the induction of cellular immune responses against SARS-CoV-2 76 24 1

Immuno-informatics Characterization SARS-CoV-2 Spike Glycoprotein for Prioritization of Epitope based Multivalent Peptide Vaccine 76 24 1

Development of a Synthetic Poxvirus-Based SARS-CoV-2 Vaccine 24 7 1

SARS-CoV-2 proteome microarray for mapping COVID-19 antibody interactions at amino acid resolution 76 24 1

Zika viral proteome analysis reveals an epitope cluster within NS3 helicase as a potential vaccine candidate: an in silico study 76 24

NeutrobodyPlex - Nanobodies to monitor a SARS-CoV-2 neutralizing immune response 24 1

SARS-CoV-2 Elicits Robust Adaptive Immune Responses Regardless of Disease Severity 24 1

Multi-epitope based peptide vaccine design against SARS-CoV-2 using its spike protein 76 24 1