Topic 37

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365 items. Top items listed below.

Genomic diversity and hotspot mutations in 30,983 SARS-CoV-2 genomes: moving toward a universal vaccine for the "confined virus"? 37 1

Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide 37 1

Sequence variation among SARS-CoV-2 isolates in Taiwan 37 1

Chasing the origin of SARS-CoV-2 in Canada's COVID-19 cases: A genomics study 37 1

Analysis of SARS-CoV-2 genomes from across Africa reveals potentially clinically relevant mutations. 37 1

Evidence of the Recombinant Origin and Ongoing Mutations in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) 37 1

Genomic, geographic and temporal distributions of SARS-CoV-2 mutations 37 1

Exploring the genomic and proteomic variations of SARS-CoV-2 spike glycoprotein: a computational biology approach 37 1

Introductions and early spread of SARS-CoV-2 in France 37 1

Controlling the SARS-CoV-2 outbreak, insights from large scale whole genome sequences generated across the world 37 1

Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations 37 1

Mutations, Recombination and Insertion in the Evolution of 2019-nCoV 37 1

Genomic analysis of early SARS-CoV-2 strains introduced in Mexico 37 1

Characterizing geographical and temporal dynamics of novel coronavirus SARS-CoV-2 using informative subtype markers 37 1

PAN-INDIA 1000 SARS-CoV-2 RNA Genome Sequencing Reveals Important Insights into the Outbreak 37 1

A virus that has gone viral: Amino acid mutation in S protein of Indian isolate of Coronavirus COVID-19 might impact receptor binding and thus infectivity 37 1

A SARS-CoV-2 vaccine candidate would likely match all currently circulating strains 37 1

Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin 37 1

Analysis of the potential impact of genomic variants in SARS-CoV-2 genomes from India on molecular diagnostic assays 37 35 1

Initial insights into the genetic epidemiology of SARS-CoV-2 isolates from Kerala suggest local spread from limited introductions 37 1

Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies 76 1

Identification of unique mutations in SARS-CoV-2 strains isolated from India suggests its attenuated pathotype 37 1

Insights into Cross-species Evolution of Novel Human Coronavirus 2019-nCoV and Defining Immune Determinants for Vaccine Development 37 1

Genomic Mutations and Changes in Protein Secondary Structure and Solvent Accessibility of SARS-CoV-2 (COVID-19 Virus) 103 37 1

Genetic analysis of SARS-CoV-2 isolates collected from Bangladesh: insights into the origin, mutation spectrum, and possible pathomechanism 37 1

When Darkness Becomes a Ray of Light in the Dark Times: Understanding the COVID-19 via the Comparative Analysis of the Dark Proteomes of SARS-CoV-2, Human SARS and Bat SARS-Like Coronaviruses 103 1

Molecular characterization of SARS-CoV-2 from Bangladesh: Implications in genetic diversity, possible origin of the virus, and functional significance of the mutations 37 1

Origin of Novel Coronavirus (COVID-19): A Computational Biology Study using Artificial Intelligence 37 1

Within-patient genetic diversity of SARS-CoV-2 37 1

RdRp mutations are associated with SARS-CoV-2 genome evolution 37 1

Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structure 37 1

Genome-wide data inferring the evolution and population demography of the novel pneumonia coronavirus (SARS-CoV-2) 37 1

Multiple SARS-CoV-2 introductions shaped the early outbreak in Central Eastern Europe: comparing Hungarian data to a worldwide sequence data-matrix 37 1

Many bat species are not potential hosts of SARS-CoV and SARS-CoV-2: Evidence from ACE2 receptor usage 36 1

Three adjacent nucleotide changes spanning two residues in SARS-CoV-2 nucleoprotein: possible homologous recombination from the transcription-regulating sequence 37 1

Comparative analyses of SAR-CoV2 genomes from different geographical locations and other coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis 103 1

Population genomics insights into the recent evolution of SARS-CoV-2 37 1

Multivariate Analyses of Codon Usage of SARS-CoV-2 and other betacoronaviruses 103 37 1

The origin and underlying driving forces of the SARS-CoV-2 outbreak 37 1

In-silico analysis of SARS-CoV-2 genomes: Insights from SARS encoded non-coding RNAs 37 1

SARS-CoV-2 exhibits intra-host genomic plasticity and low-frequency polymorphic quasispecies 37 1

Using nucleocapsid proteins to investigate the relationship between SARS-CoV-2 and closely related bat and pangolin coronaviruses 37 1

Sequence analysis of Indian SARS-CoV-2 isolates shows a stronger interaction of mutated receptor binding domain with ACE2 receptor 37 1

New Pathways of Mutational Change in SARS-CoV-2 Proteomes Involve Regions of Intrinsic Disorder Important for Virus Replication and Release 37 1

Emergence of multiple variants of SARS-CoV-2 with signature structural changes 37 1

SARS-CoV2 genome analysis of Indian isolates and molecular modelling of D614G mutated spike protein with TMPRSS2 depicted its enhanced interaction and virus infectivity 37 1

Multiple introductions, regional spread and local differentiation during the first week of COVID-19 epidemic in Montevideo, Uruguay 37 1

Characterization of the substitution hotspots in SARS-CoV-2 genome using BioAider and detection of a SR-rich region in N protein providing further evidence of its animal origin 37 1

Are pangolins the intermediate host of the 2019 novel coronavirus (2019-nCoV) ? 37 1

The 2019-new Coronavirus epidemic: evidence for virus evolution 37 1

The novel Coronavirus enigma: Phylogeny and mutation analyses of SARS-CoV-2 viruses circulating in India during early 2020. 37 1

SARS-CoV-2 sequence typing, evolution and signatures of selection using CoVa, a Python-based command-line utility 37 1

Mutations of SARS-CoV-2 nsp14 exhibit strong association with increased genome-wide mutation load 37 1

Insights into molecular evolution recombination of pandemic SARS-CoV-2 using Saudi Arabian sequences 37 1

Unsupervised cluster analysis of SARS-CoV-2 genomes indicates that recent (June 2020) cases in Beijing are from a genetic subgroup that consists of mostly European and South(east) Asian samples, of which the latter are the most recent 37 1

Phylogenomics reveals multiple introductions and early spread of SARS-CoV-2 into Peru 37 1

SARS-CoV-2 mutations and where to find them: An in silico perspective of structural changes and antigenicity of the Spike protein 103 1

Protein covariance networks reveal interactions important to the emergence of SARS coronaviruses as human pathogens 37 1

Interaction of the spike protein RBD from SARS-CoV-2 with ACE2: similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism 36 1

Genomic variations in SARS-CoV-2 genomes from Gujarat: Underlying role of variants in disease epidemiology 37 1

Positive selection of ORF3a and ORF8 genes drives the evolution of SARS-CoV-2 during the 2020 COVID-19 pandemic 37 1

Mutation density changes in SARS-CoV-2 are related to the pandemic stage but to a lesser extent in the dominant strain with mutations in spike and RdRp 37 1

Intra-host Variation and Evolutionary Dynamics of SARS-CoV-2 Population in COVID-19 Patients 37 1

Insights on cross-species transmission of SARS-CoV-2 from structural modeling 103 1

SARS-CoV-2 has observably higher propensity to accept uracil as nucleotide substitution: Prevalence of amino acid substitutions and their predicted functional implications in circulating SARS-CoV-2 in India up to July, 2020 37 1

in-silica Analysis of SARS-CoV-2 viral strain using Reverse Vaccinology Approach: A Case Study for USA 37 1

Synonymous mutations and the molecular evolution of SARS-Cov-2 origins 37 1

Global Geographic and Temporal Analysis of SARS-CoV-2 Haplotypes Normalized by COVID-19 Cases during the First Seven Months of the Pandemic 37 1

Phylogenetic Analysis of the Novel Coronavirus Reveals Important Variants in Indian Strains 37 1

Phylogenetic Analysis of SARS-CoV-2 Genomes in Turkey 37 1

Strong evolutionary convergence of receptor-binding protein spike between COVID-19 and SARS-related coronaviruses 36 1

Molecular Architecture of Early Dissemination and Evolution of the SARS-CoV-2 Virus in Metropolitan Houston, Texas 37 1

Limited SARS-CoV-2 diversity within hosts and following passage in cell culture 37 1

Comparative Genomic Analysis of Rapidly Evolving SARS-CoV-2 Viruses Reveal Mosaic Pattern of Phylogeographical Distribution 37 1

Genomic surveillance of SARS-CoV-2 reveals community transmission of a major lineage during the early pandemic phase in Brazil 37 1

WHOLE-GENOME SEQUENCING AND DE NOVO ASSEMBLY OF A 2019 NOVEL CORONAVIRUS (SARS-COV-2) STRAIN ISOLATED IN VIETNAM 37 25 1

Genetic analysis of SARS-CoV-2 strains collected from North Africa: viral origins and mutational spectrum 37 1

Temporal evolution and adaptation of SARS-COV 2 codon usage 37 1

Alignment-free machine learning approaches for the lethality prediction of potential novel human-adapted coronavirus using genomic nucleotide 37 26 1

Mutational Analysis of SARS-CoV-2 Genome in African Population 37 1

Emergence and expansion of highly infectious spike:D614G mutant SARS-CoV-2 in central India 37 1

SARS-CoV-2 genome evolution exposes early human adaptations 37 21 1

Decoding the lethal effect of SARS-CoV-2 (novel coronavirus) strains from global perspective: molecular pathogenesis and evolutionary divergence 37 1

Comparative genomics suggests limited variability and similar evolutionary patterns between major clades of SARS-Cov-2 37 21 5 1

Spike protein binding prediction with neutralizing antibodies of SARS-CoV-2 1

Characterization of SARS-CoV-2 viral diversity within and across hosts 37 1

Potential microenvironment of SARS-CoV-2 infection in airway epithelial cells revealed by Human Protein Atlas database analysis 36 1

Functional and Genetic Analysis of Viral Receptor ACE2 Orthologs Reveals a Broad Potential Host Range of SARS-CoV-2 36 1

Emergence of SARS-CoV-2 spike RBD mutants that enhance viral infectivity through increased human ACE2 receptor binding affinity 37 1

Snapshot of the evolution and mutation patterns of SARS-CoV-2 37 7 1

Effects of SARS-CoV-2 Mutations on Protein Structures and Intraviral Protein-Protein Interactions 37 1

An evolutionary portrait of the progenitor SARS-CoV-2 and its dominant offshoots in COVID-19 pandemic 37 1

No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2 37 1

Characterizations of SARS-CoV-2 mutational profile, spike protein stability and viral transmission 37 1

SARS-CoV-2 transmission chains from genetic data: a Danish case study 37 7 1

Emerging phylogenetic structure of the SARS-CoV-2 pandemic 37 1

Genomic diversity and evolution of coronavirus (SARS-CoV-2) in France from 309 COVID-19-infected patients 37 1

Companion vaccine Bioinformatic design tool reveals limited functional genomic variability of SARS-Cov-2 Spike Receptor Binding Domain 37 1

SARS-CoV-2, an evolutionary perspective of interaction with human ACE2 reveals undiscovered amino acids necessary for complex stability 1

Computational simulations reveal the binding dynamics between human ACE2 and the receptor binding domain of SARS-CoV-2 spike protein 36 1