Topic 73

sars covid cov 19 infection respiratory severe coronavirus infected lung viral virus patients acute syndrome disease immune pandemic pathogenesis inflammatory epithelial interferon host antiviral cytokine replication 2019 ace2 response immunology microbiology severity responses human innate clinical mild cells infections cytokines alveolar pneumonia airway epithelium inflammation rna caused lungs tmprss2 distress symptoms pulmonary tract therapeutic viruses induced influenza il vaccines course macaques blood mortality storm damage rhesus cases transcriptomic cell ifn therapeutics observed chemokines ards treatment interferons bronchoalveolar peripheral expression systemic entry urgently illness nasal susceptibility signs pathways pathology signaling death type patient immunity drugs asymptomatic monocytes cov2 worldwide receptor infectious

232 items. Top items listed below.

SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function 73 36 1

SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response 73 1

SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery 73 1

Genetic analysis of the novel SARS-CoV-2 host receptor TMPRSS2 in different populations. 36 1

SARS-CoV-2 causes severe alveolar inflammation and barrier dysfunction 73 1

Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19 73 1

A human disease model of SARS-CoV-2-induced lung injury and immune responses with a microengineered organ chip 73 1

Re-analysis of SARS-CoV-2 infected host cell proteomics time-course data by impact pathway analysis and network analysis. A potential link with inflammatory response. 73 1

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures 73 1

Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques 73 1

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide 73 36 1

Critical role of type III interferon in controlling SARS-CoV-2 infection, replication and spread in primary human intestinal epithelial cells 73 1

Prediction of SARS-CoV interaction with host proteins during lung aging reveals a potential role for TRIB3 in COVID-19. 73 36 1

Robust three-dimensional expansion of human adult alveolar stem cells and SARS-CoV-2 infection 73 1

The neuropeptides VIP and PACAP inhibit SARS-CoV-2 replication in monocytes and lung epithelial cells, decrease the production of proinflammatory cytokines, and VIP levels are associated with survival in severe Covid-19 patients. 73 1

Comparative transcriptome analysis reveals the intensive early-stage responses of host cells to SARS-CoV-2 infection 73 1

CD147 (BSG) but not ACE2 expression is detectable in vascular endothelial cells within single cell RNA sequencing datasets derived from multiple tissues in healthy individuals 36 1

Comparative Pathogenesis Of COVID-19, MERS And SARS In A Non-Human Primate Model 73 1

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB 73 27 1

Mechanistic modeling of the SARS-CoV-2 and immune system interplay unravels design principles for diverse clinicopathological outcomes 73 1

Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication 36 1

SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus 73 1

Infection of human lymphomononuclear cells by SARS-CoV-2 73 1

Lymphopenia-induced T cell proliferation is a hallmark of severe COVID-19 73 1

Lung epithelial stem cells express SARS-CoV-2 entry factors: implications for COVID-19 73 36 1

Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19. 73 36 1

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling 36 1

Alpha-1 antitrypsin inhibits SARS-CoV-2 infection 103 73 1

Human Embryonic Stem Cell-derived Lung Organoids: a Model for SARS-CoV-2 Infection and Drug Test 73 36 1

Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men 36 1

Detection of Viral RNA Fragments in Human iPSC-Cardiomyocytes following Treatment with Extracellular Vesicles from SARS-CoV-2 Coding-Sequence-Overexpressing Lung Epithelial Cells 36 1

K18-hACE2 Mice for Studies of COVID-19 Treatments and Pathogenesis Including Anosmia 73 1

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium 73 1

Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques 73 27 1

CD8+ T cell cross-reactivity against SARS-CoV-2 conferred by other coronavirus strains and influenza virus 191 76 1

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection 73 27 1

High expression of angiotensin-converting enzyme-2 (ACE2) on tissue macrophages that may be targeted by virus SARS-CoV-2 in COVID-19 patients 36 1

Co-expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19 Infection 73 36 1

Age-dependent progression of SARS-CoV-2 infection in Syrian hamsters 73 1

Regulation of angiotensin converting enzyme 2 (ACE2) in obesity: implications for COVID-19 36 1

Generation of tonsil organoids as an ex vivo model for SARS-CoV-2 infection 103 73 44 1

Potential microenvironment of SARS-CoV-2 infection in airway epithelial cells revealed by Human Protein Atlas database analysis 36 1

Many bat species are not potential hosts of SARS-CoV and SARS-CoV-2: Evidence from ACE2 receptor usage 36 1

Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection 36 1

Identification of TMEM106B as proviral host factor for SARS-CoV-2 73 1

Single-cell RNA-sequencing reveals dysregulation of molecular programs associated with SARS-CoV-2 severity and outcomes in patients with chronic lung disease 73 36 27 1

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice. 44 1

Antiviral effects of miRNAs in extracellular vesicles against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mutations in SARS-CoV-2 RNA virus 73 1

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids 73 44 1

Establishment of an African green monkey model for COVID-19 103 73 1

A distinct innate immune signature marks progression from mild to severe COVID-19 73 27 1

Oral epithelial expression of angiotensin converting enzyme-2: Implications for COVID-19 diagnosis and prognosis. 36 1

SARS-CoV-2 induces activation and diversification of human plasmacytoid pre-dendritic cells. 73 27 1

Impact of Comorbidities on SARS-CoV-2 Viral Entry-Related Genes 36 1

Lack of Reinfection in Rhesus Macaques Infected with SARS-CoV-2 73 1

SARS-CoV-2 infects brain choroid plexus and disrupts the blood-CSF-barrier 36 1

SARS-CoV-2 infection dynamics in lungs of African green monkeys 73 1

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity 44 1

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice 36 1

Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identifies molecular targets for therapeutic intervention 73 1

Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract 36 1

Meta-analysis of transcriptomes of SARS-Cov2 infected human lung epithelial cells identifies transmembrane serine proteases co-expressed with ACE2 and biological processes related to viral entry, immunity, inflammation and cellular stress. 36 1

Comparative transcriptome analyses reveal genes associated with SARS-CoV-2 infection of human lung epithelial cells 73 1

Integrative Network Biology Framework Elucidates Molecular Mechanisms of SARS-CoV-2 Pathogenesis 73 1

K18-hACE2 mice develop respiratory disease resembling severe COVID-19 73 1

Transcriptional profiling of immune and inflammatory responses in the context of SARS-CoV-2 fungal superinfection in a human airway epithelial model 73 1

SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species 73 27 1

TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets 44 1

Low baseline pulmonary levels of cytotoxic lymphocytes as a predisposing risk factor for severe COVID-19 73 36 1

In-depth blood proteome profiling analysis revealed distinct functional characteristics of plasma proteins between severe and non-severe COVID-19 patients 73 1

TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2 36 1

Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium 73 36 1

Age-related expression of SARS-CoV-2 priming protease TMPRSS2 in the developing lung 73 36 1

Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease 73 36 1

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes 73 1

Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge 73 1

Functional Immune Deficiency Syndrome via Intestinal Infection in COVID-19 73 36 1

Modulating the transcriptional landscape of SARS-CoV-2 as an effective method for developing antiviral compounds 73 44 1

Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement 36 24 1

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis 73 1

Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2 36 1

Single-cell analysis reveals the function of lung progenitor cells in COVID-19 patients 73 1

Development of CRISPR as a prophylactic strategy to combat novel coronavirus and influenza 103 1

Functional characterization of SARS-CoV-2 infection suggests a complex inflammatory response and metabolic alterations 73 1

Prophylactic intranasal administration of a TLR2 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model 73 1

Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stemcell-derived airway repair response 73 1

Type III interferons disrupt the lung epithelial barrier upon viral recognition. 73 1

Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis 36 24 1

Impact of Thiol-Disulfide Balance on the Binding of Covid-19 Spike Protein with Angiotensin Converting Enzyme 2 Receptor 36 1

SARS-CoV-2 manipulates the SR-B1-mediated HDL uptake pathway for its entry 36 1

Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection 73 1

Plasmin cascade mediates thrombolytic events in SARS-CoV-2 infection via complement and platelet-activating systems 73 1

Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells 73 1

scRNA-seq reveals ACE2 and TMPRSS2 expression in TROP2+ Liver Progenitor Cells: Implications in COVID-19 associated Liver Dysfunction 36 1

Longitudinal single-cell immune profiling revealed distinct innate immune response in asymptomatic COVID-19 patients 73 27 1

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity 36 1

Colon Cancer and SARS-CoV-2: Impact of ACE2 Expression in Susceptibility to COVID-19 36 1

The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 73 1

Multiple expression assessments of ACE2 and TMPRSS2 SARS-CoV-2 entry molecules in the urinary tract and their associations with clinical manifestations of COVID-19 73 36 1

Daytime variation in SARS-CoV-2 infection and cytokine production 73 1