Topic 32

alzheimers ad alzheimer amyloid disease beta pathology neuroscience brain tau app neurodegenerative cognitive pathological dementia neuronal aggregation microglia plaques neurodegeneration progression brains precursor accumulation decline impairment onset mouse 42 pathogenesis mice risk age early deposition microglial apoe plaque dysfunction associated synaptic ps1 hippocampal patients transgenic familial neurofibrillary peptide deficits memory hippocampus therapeutic changes model fibrils increased tangles aging related alterations cognitively neuroinflammation 5xfad tauopathy neurons diseases protein aggregates oligomers type pet cortex astrocytes mild neuropathological mci hallmark cerebral cortical progressive neuropathology human astrocyte sporadic late cerebrospinal atrophy levels controls decreased induced suggest reduced psen1 entorhinal stages loss may pathologies

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A Consensus Proteomic Analysis of Alzheimer's Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation 32 9

Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer's disease 32 2

Alzheimer's pathology is associated with dedifferentiation of functional memory networks in aging 32 22 2

NMR Analysis of the Correlation of Metabolic Changes in Blood and Cerebrospinal Fluid in Alzheimer Model Male and Female Mice 32 10

Thiamine pyrophosphokinase deficiency induces Alzheimer's pathology 32 10 3

Dysregulation of the secretory pathway connects Alzheimer's disease genetics to aggregate formation 32 9 3

The role of Aβ circRNA in Alzheimer's disease: alternative mechanism of Aβ biogenesis from Aβ circRNA translation 32 3

The coupling of global brain activity and cerebrospinal fluid inflow is correlated with Alzheimer's disease related pathology 32 22 2

Voluntary running does not increase capillary blood flow but promotes neurogenesis and short-term memory in the APP/PS1 mouse model of Alzheimers disease 32 10 2

Live cell imaging of single neurotrophin receptor molecules on human neuron in Alzheimer's disease 32 11 10 3 2

Neuroticism alters the transcriptome of the frontal cortex to contribute to the cognitive decline and onset of Alzheimer's disease 32 9 2

Transcriptome analysis of a protein-truncating mutation in sortilin-related receptor 1 associated with early-onset familial Alzheimer's disease indicates effects on mitochondrial and ribosome function in young-adult zebrafish brains 32 9 3

Prostacyclin promotes degenerative pathology in a model of Alzheimer's disease 32 10 3

Dysregulation of the de novo proteome accompanies pathology progression in the APP/PS1 mouse model of Alzheimer's disease 32 11 3

Early-life stress facilitates the development of Alzheimer's disease pathology via angiopathy 32 10 3 2

Multiplexed fractionated proteomics reveals synaptic factors associated with cognitive resilience in Alzheimer's Disease 32 10

Effects of optogenetic stimulation of basal forebrain parvalbumin neurons on Alzheimer's disease pathology 32 11 2

Endothelial expression of human APP leads to cerebral amyloid angiopathy in mice 32 10 3

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol 32 10 3

Tip60 protects against amyloid-β peptide-induced transcriptomic alterations via different modes of action in early versus late stages of neurodegenerative progression 32 11 10 3 2

Neuroinflammation characterizes the earliest changes in Alzheimer's disease pathology and associated subjective cognitive impairment in adult hydrocephalus biopsies 32 9

A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease 32 11 2

PLCG2 as a Risk Factor for Alzheimer's Disease 32 10 3

INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia 32 10 9 3

Amyloid beta acts synergistically as a pro-inflammatory cytokine 32 27 3

Microvascular Injury in Mild Traumatic Brain Injury Accelerates Alzheimer-like Pathogenesis in Mice 32 10 3

Brain geometry matters in Alzheimer disease progression: a simulation study 32

Naphthalene monoimide derivative ameliorates amyloid burden and cognitive decline in a transgenic mouse model of Alzheimer's disease 32 10 3

Molecular characterization of selectively vulnerable neurons in Alzheimer's Disease 32 11 9

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids 32 3

Effects of salvianolic acid A on β-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease 32 10


Aβ oligomers induce sex-selective differences in mGluR5 pharmacology and pathophysiological signaling in Alzheimer mice 32 11 10 3

TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ42 in HMC3 cells 32 10 3

AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans 32 10 9 3

Inactive variants of death receptor p75NTR reduce Alzheimer's neuropathology by interfering with APP internalization 32 11 3

Syndapin-2 mediates amyloid-β transcytosis at the brain endothelium: implications in Alzheimer's disease 32 3

The Neuroprotective Beta Amyloid Hexapeptide Core Reverses Deficits in Synaptic Plasticity in the 5xFAD APP/PS1 Mouse Model 32 11 10 3

Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice 32 3

The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration 32 11 3

Local and global dichotomic dysfunction in resting and evoked functional connectivity precedes tauopathy 32 22 2

Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability 32 11 3

Broad kinase inhibition mitigates early neuronal dysfunction and cognitive deficits in tauopathy 32 10 3

Brain connectivity during Alzheimer's disease progression and its cognitive impact in a transgenic rat model 32 22 2

Imaging stable isotope labelling kinetics (iSILK) for following spatial Aβ plaque aggregation dynamics in evolving Alzheimers disease pathology 32

Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer's disease 32 11 3

APP accumulates around dense-core amyloid plaques with presynaptic proteins in Alzheimer's disease brain 32

Depletion of the AD risk gene SORL1 selectively impairs neuronal endosomal traffic independent of amyloidogenic APP processing 32 3

Linking the association between circRNAs and Alzheimer's disease progression by multi-tissue circular RNA characterization 32 9

Telomere length and oxidative stress variations in a murine model of Alzheimer's disease progression 32 15 10

Identification of amyloid beta oligomers in locus coeruleus (LC) neurons of Alzheimer's patients and their impact on LC oxidative stress, inhibitory neurotransmitter receptors and neuronal excitability 32 11 10 3 2

Tocotrienol decreases β-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease 32 10

Inhibitory parvalbumin basket cell activity is selectively reduced during hippocampal sharp wave ripples in a mouse model of familial Alzheimer's disease 32 11 2

A Temporal Quantitative Profiling of Newly Synthesized Proteins during Aβ Accumulation 32 3

Aβ induces acute oxidative stress leading to brain glucose hypometabolism and hyperactivity in Alzheimer's disease pathogenesis 32 10 3

LRP::FLAG reduces phosphorylated tau levels in Alzheimer's Disease 32 10 3

Behavioural and transcriptomic characterization of the comorbidity between Alzheimer s disease and Major Depression 32 11 2

Dendritic spines are lost in clusters in patients with Alzheimers disease 77 32 11 2

Molecular and cellular pathology of monogenic Alzheimer's disease at single cell resolution 32 9

ECSIT prevents Alzheimer's disease pathology by regulating neuronal mitochondrial ROS and mitophagy 32 10 3

Deep learning detection of informative features in tau PET for Alzheimer' s disease classification 32 22 2

Repeated multi-domain, but not single-domain, cognitive training prevents cognitive decline and amyloid pathology found in the APPNL-G-F mouse model of Alzheimer disease 32 30 15 2

Probing the functions of microglial cyclin-dependent kinase 5 under physiological and pathological conditions 32 11 3

Alteration of perivascular spaces in early cognitive decline 32 22 2

Dystrophic microglia are a disease associated microglia morphology in the human brain 32 22 2

Role of sex and high fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer's disease 39 32 10

3D analysis of the synaptic organization in the Entorhinal cortex in Alzheimer's disease 32 11 2

Deciphering cellular transcriptional alterations in Alzheimer's disease brains 32 9 4

Molecular estimation of neurodegeneration pseudotime in older brains 32 9

The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer's disease mutations 32 8

Functional brain age prediction suggests accelerated aging in preclinical familial Alzheimer's disease, irrespective of fibrillar amyloid-beta pathology 32 22 15 2

Vascular burden is associated with a decline in default-mode and global resting-state functional connectivity in individuals at risk for Alzheimer's disease 32 22 15 2

Genetic dissection of Down syndrome-associated alterations in APP/amyloid-β biology using mouse models 32

Transcriptional profiling of Multiple System Atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease 32 9

Tau pathology spreads between anatomically-connected regions of the brain and is modulated by a LRRK2 mutation 32 22 2

MARK4 with an Alzheimer's disease-related mutation promotes tau hyperphosphorylation directly and indirectly and exacerbates neurodegeneration 32 3

Epoxy fatty acid dysregulation and neuroinflammation in Alzheimer's disease is resolved by a soluble epoxide hydrolase inhibitor 32 10 3

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain 32 10 3

Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity 32 11 3

Hippocampal hyperactivity in a rat model of Alzheimers disease 32 11 2

Predicting future regional tau accumulation in asymptomatic and early Alzheimer's disease 32 26 4 2

Partial inhibition of mitochondrial complex I attenuates neurodegeneration and restores energy homeostasis and synaptic function in a symptomatic Alzheimers mouse model 32 10 3

APOE2 promotes longevity independent of Alzheimer's disease 32 15 10

GPCR-mediated clearance of tau in post-synaptic compartments attenuates tau pathology in vivo 32 11 10 3

Single-soma transcriptomics of tangle-bearing neurons in Alzheimer's disease reveals the signatures of tau-associated synaptic dysfunction 32 9 3

Amyloid precursor protein causes fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load 32 3

Differential brain atrophy and neurogenetic profiles in cognitively-defined Alzheimer's disease subgroups 32 22 9 2

Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner. 32 11 9 3

Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy 32 22 2

STEP inhibition prevents Aβ mediated damage in dendritic complexity and spine density in Alzheimer's disease. 32 11 10 3

Functional biological paths altered in Alzheimer's disease: from genes to bile acids 32 19 9

Cholinergic basal forebrain degeneration due to obstructive sleep apnoeaincreases Alzheimer's pathology in mice 32 10 3

Molecular structure of a prevalent amyloid-β fibril polymorph from Alzheimer's disease brain tissue 32 8

Canine cognitive dysfunction (CCD) patients have reduced total hippocampal volumes compared with aging control dogs: a comparative MRI study 32 15 2

Assessment of Neurovascular Coupling & Cortical Spreading Depression in Mixed Models of Atherosclerosis & Alzheimer's Disease 32 10

Inflammation in Alzheimer's disease: do sex and APOE matter? 32 15 10

Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer's disease model 32 10

Bundle-specific associations between white matter microstructure and Aβ and tau pathology at their connecting cortical endpoints in older adults at risk of Alzheimer's disease 75 32 22 15 2

The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes beneficial microglial functions 32 27 10 3

Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration 32 10 3