Topic 32
alzheimers ad alzheimer amyloid disease beta pathology neuroscience brain tau app neurodegenerative cognitive pathological dementia neuronal aggregation microglia plaques neurodegeneration progression brains precursor accumulation decline impairment onset mouse 42 pathogenesis mice risk age early deposition microglial apoe plaque dysfunction associated synaptic ps1 hippocampal patients transgenic familial neurofibrillary peptide deficits memory hippocampus therapeutic changes model aβ fibrils increased tangles aging related alterations cognitively neuroinflammation 5xfad tauopathy neurons diseases protein aggregates oligomers type pet cortex astrocytes mild neuropathological mci hallmark cerebral cortical progressive neuropathology human astrocyte sporadic late cerebrospinal atrophy levels controls decreased induced suggest reduced psen1 entorhinal stages loss may pathologies
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