Topic 168

neurons neuronal neuroscience mice neurogenesis underlying disorders increased brain neuron adult mechanisms dependent signaling induced vivo insulin glucose effects hippocampal dentate receptor reduced nerve granule overexpression expression affects central outgrowth drosophila alzheimers hippocampus understood decreased metabolic altered born growth poorly disease pathway mouse proper function impairment impaired collectively formation silencing regulating modulates together through intake suggest alterations its activity behaviors hypertensive beta activation via associated unknown pathology physiology however causes suppression increases amyloid dysregulation effect obesity suggesting peripheral levels knockdown additionally nervous altering loss metabolism found hyperphagic axon may app abnormal significantly disturbances neurodegenerative factor unclear role mechanism findings further

42 items. Top items listed below.

Neuronal LXR Regulates Neuregulin-1 Expression and Sciatic Nerve-Associated Cell signaling 168 11 3

Intrauterine growth restriction causes cellular, molecular, and behavioral deficits consistent with abnormal dentate gyrus neurogenesis in mice 168 65 11 3 2

Cell-type specific impact of glucocorticoid receptor activation on the developing brain 168 65 57 11 9 3


Fibroblast growth factor 9 stimulates neurite outgrowth through NF-kB signaling in striatal cell Huntington's disease models 168 11 3

The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis 168 11 3 2

Ghrelin signaling regulates feeding behavior, metabolism, and memory through the vagus nerve 168 11 3 2

Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice 168 66 65 11 3 2

Haploinsufficiency of the psychiatric risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms 168 65 11 3

Molecular Diversity Among Adult Hippocampal and Entorhinal Cells 168 32 11 9 3

Production of the Short Chain Fatty Acid, Acetic Acid/Acetate from Ethanol Metabolism Activates NMDAR 168 11 3

IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis 168 10 3

Insulin-Like Growth Factor I Modulates Sleep Through Hypothalamic Orexin Neurons 168 11 3 2

Transient high glucose causes delayed wound healing by the DNMT1-mediated Ang-1/NF-κB pathway 168 94 10 3

Light stimuli and circadian clock affect neural development in Drosophila melanogaster 168 3

EphrinB1 modulates glutamatergic inputs into POMC neurons and controls glucose homeostasis 168 11 3

A non-linear relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin 168 11 10 3

Insulin signaling mediates neurodegeneration in glioma 168 11 10 3

Abnormal energy metabolism can alter foraging behavior in termites in different social contexts 168 30

PTBP1 Regulates Injury Responses and Sensory Pathways in Adult Peripheral Neurons 168 11 3

Hericerin derivatives from Hericium erinaceus exert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory 168 11 10 3

A limbic circuit selectively linking active escape to food suppression 168 11 3 2

Glucose extends lifespan through enhanced intestinal barrier integrity in Drosophila 168 90 10 3

Cold-induced hyperphagia requires AgRP-neuron activation in mice 168 11 2

Leptin Receptors in RIP-Cre25Mgn neurons Mediate Anti-Dyslipidemia Effects of Leptin in Insulin-Deficient Male Mice 168 39 10 3

Adenosine signaling and its downstream target mod(mdg4) modify the pathogenic effects of polyglutamine in a Drosophila model of Huntington's disease 168 3

Discrete TrkB-expressing neurons of the dorsomedial hypothalamus regulate feeding and thermogenesis 168 11 3

Bidirectional regulation of cognitive and anxiety-like behaviors by dentate gyrus mossy cells in male and female mice 56 11 2

A neurogenetic mechanism of experience-dependent suppression of aggression 168 11 3

Mechanical impact on the head has an antihypertensive effect 168 11 3

Loss of α7 nicotinic acetylcholine receptors in GABAergic interneurons causes sex-dependent impairments in postnatal neurogenesis and cognitive and social behavior 65 11 2

Fibroblast Growth Factor 21 (FGF21) creates sugar-specific taste aversion to fructose through action in the brain in mice. 168 39 10 3

Alpha-synuclein supports interferon stimulated gene expression in neurons 54 27 10 3

A critical period terminates the differentiation of olfactory sensory neurons 168 11 3

AMP-activated-kinase (AMPK) is essential sensor and metabolic regulator of retinal neurons and their integrated metabolism with RPE. 72 3

Probing the functions of microglial cyclin-dependent kinase 5 under physiological and pathological conditions 32 11 3

Axonal TAU sorting requires the C-terminus of TAU but is independent of ANKG and TRIM46 enrichment at the AIS 168 57 11 3

mTOR inhibition in primary neurons and the developing brain represses transcription of cholesterol biosynthesis genes and alters cholesterol levels 133 31 3

Protecting synapses from amyloid β-associated degeneration by manipulations of Wnt/planar cell polarity signaling 168 32 3

Tuba1a is uniquely important for axon guidance through midline commissural structures 168 11 3

Voluntary running does not increase capillary blood flow but promotes neurogenesis and short-term memory in the APP/PS1 mouse model of Alzheimers disease 32 10 2

AAV Ablates Neurogenesis in the Adult Murine Hippocampus 168 57 10

Inhibitory effects of Akt on neuronal FoxO4 activation after subarachnoid hemorrhage in vivo and in vitro 168 11 10 3

Reactive Oxygen Species Modulate Activity-Dependent AMPA Receptor Transport in C. elegans 77 11 3

N6-methyladenine DNA demethylase ALKBH1 regulates mammalian axon regeneration 3

Docosahexaenoic acid has stem cell-specific effects in the SVZ and restores olfactory neurogenesis and function in the aging brain 57 3

The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration 32 11 3

Deletion of the mitochondrial matrix protein cyclophilin-D prevents parvalbumin interneuron dysfunction and cognitive deficits in a mouse model of NMDA hypofunction 104 11 3 2

Glutathione S-transferase Pi (Gstp) Proteins Regulate Neuritogenesis in the Developing Cerebral Cortex 65 11 3 2

Roles of sarcoplasmic reticulum Ca2+ ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model 168 39 10 3

Transgenic mice expressing human alpha-synuclein in noradrenergic neurons develop locus coeruleus pathology and non-motor features of Parkinson's disease 54 11 10 3 2

The Impact of Oxytocin on Neurite Outgrowth and Synaptic Proteins in Magel2-Deficient Mice 65 11 3 2

De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis 133 31 11 3 2

Live cell imaging of single neurotrophin receptor molecules on human neuron in Alzheimer's disease 32 11 10 3 2

Altered Expression of Cadherin-8 and Cadherin-11 in Neural Circuit Development: Implications for Autism 65 11 2

Endothelial expression of human APP leads to cerebral amyloid angiopathy in mice 32 10 3

A critical role for trkB signaling in the adult function of parvalbumin interneurons and prefrontal network dynamics 104 11 2

Genetic reduction of PERK-eIF2α signaling in dopaminergic neurons drives cognitive and age-dependent motor dysfunction 54 11 3

Activation of endogenous retroviruses during brain development causes neuroinflammation 133 11 3

Canonical Wnt-signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons 133 11 3 2

Chemogenetic activation of astrocytes in the hippocampus and cortex changes the transcriptome of microglia and other cell types. 120 11 3

Reelin deficiency contributes to long-term behavioral abnormalities induced by chronic adolescent exposure to Δ9-tetrahydrocannabinol in mice 113 71 65 11 2

Epigenetic gene-expression links heart failure to memory impairment 65 11 10 3

The Drosophila Amyloid Precursor Protein homologue mediates neuronal survival and neuro-glial interactions 32 3

BDNF/TrkB signaling endosomes mediate long-distance dendritic growth by activating CREB/PI3K-mTOR-dependent translation in neuronal cell bodies. 11 3

Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical circuit assembly 77 11 3 2

EGCG modulates nuclear formaldehyde-induced Tau phosphorylation in Neuronal cells 168 32 3

Glutamate and γ-aminobutyric acid differentially modulate glymphatic clearance of amyloid β through pulsation- and aquaporin-4 dependent mechanisms 168 10 3


Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates 69 10 3

Reduced dopamine signaling impacts pyramidal neuron excitability in mouse motor cortex 11 2

Syngap1 Dynamically Regulates the Fine-Scale Reorganization of Cortical Circuits in Response to Sensory Experience 77 11 2

APP binds to the EGFR ligands HB-EGF and EGF, acting synergistically with EGF to promote ERK signaling and neuritogenesis 32 3

A new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease 54 11 9 3

CREB is Required in Excitatory Neurons in the Forebrain to Sustain Wakefulness 102 11 3 2

PEDF-Rpsa-Itga6 signaling regulates cortical neuronal morphogenesis 168 11 3

Mathematical modelling of megakaryopoiesis in Mpl-deficient and continuously thrombopoietin-stimulated mice points to an unknown control mechanism 168 3

COUP-TFI regulates diameter of the axon initial segment in the mammalian neocortex 11 2

SK3-overexpression drives sex-dimorphic working and social memory impairment in mice. 56 11 3 2

Thiamine pyrophosphokinase deficiency induces Alzheimer's pathology 32 10 3

TRPM7 is a critical regulator of pancreatic endocrine development and high-fat diet-induced β-cell proliferation. 109 39 20 3

Sexually divergent cortical control of affective-autonomic integration 56 11 2

Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis (ALS) 61 39 10

Microglial phagocytosis dysfunction is related to local neuronal activity in a genetic model of epilepsy 124 65 11 10 2

A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment 65 11 3

Infralimbic cortical glutamate output is necessary for the neural and behavioral consequences of chronic stress 113 11 2

Regenerative neurogenic response from glia requires insulin driven neuron-glia communication 133 57 11 3

Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner. 32 11 9 3

Diabetes induced decreases in PKA signaling in cardiomyocytes: the role of insulin 102 95 3

Nestin selectively facilitates the phosphorylation of the Lissencephaly-linked protein doublecortin (DCX) by cdk5/p35 to regulate growth cone morphology and Sema3a sensitivity in developing neurons 55 34 11 3

Hydroxychloroquine increased psychiatric-like behaviors and disrupted the expression of related genes in the mouse brain 113 10

The AMPK-related kinase NUAK1 controls cortical axons branching though a local modulation of mitochondrial metabolic functions 95 11 3

FOXO regulates neuromuscular junction homeostasis during Drosophila aging 90 3

Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development 65 11 3 2

MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus 49 11 3

Subanesthetic ketamine reactivates adult cortical plasticity to restore vision from amblyopia 104 11 2

A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease 32 11 2

Anti-inflammatory role of GM1 and modulatory effects of gangliosides on microglia functions 110 10 3

Arc1 modulates microbiota-responsive developmental and metabolic traits in Drosophila 90 3

Chronic hyperglycaemia drives functional impairment of lymphocytes in diabetic INSC94Y transgenic pigs 168 10 3