Topic 71

accumbens nucleus dopamine rats reward neuroscience ventral tegmental vta administration cocaine neurons behavior seeking addiction behavioral motivation male nac behaviors conditioned self amygdala area anxiety opioid induced receptor cues cue prefrontal abuse drug reinforcement kg locomotor effects preference aversive relapse mg alcohol projecting cortex reinstatement exposure consumption striatal responding following increased medial mice sucrose motivated disorders basolateral disorder role increases intake extinction abstinence chemogenetic bla neuronal incentive dopaminergic projections antagonist d2 neurobiological d1 sensitization glutamate intermittent withdrawal alters brain pavlovian synaptic related during reinforcing dorsal prelimbic circuit administered striatum activity place gaba motivational female did kor mpfc effect underlying neuron

136 items. Top items listed below.

Role of prefrontal cortex projections to the nucleus accumbens core in mediating the effects of ceftriaxone on cued cocaine relapse 71 11 2

Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-related behaviours 71 11 2

Central oxytocin signaling inhibits food reward-motivated behaviors and VTA dopamine responses to food-predictive cues in male rats 71 58 2

Regulation of dopamine-dependent transcription and cocaine action by Gadd45b 71 11 3

Dopamine release and its control over early Pavlovian learning differs between the NAc core and medial NAc shell 71 58 2

Hippocampus-lateral septum circuitry mediates foraging-related spatial memory in rats 71 66 11 2

Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in relapse prone male rats 71 2

Granulocyte-Colony Stimulating Factor reduces cocaine-seeking and downregulates glutamatergic synaptic proteins in medial prefrontal cortex 71 11 10 2

Mu Opioid Receptor Gene Dosage Influences Reciprocal Social Behaviors and Nucleus Accumbens Microcircuitry 71 11 2

Dopamine D2R upregulation in nucleus accumbens indirect pathway does not affect Pavlovian or Go/No-Go Learning 71 11 2

The Basolateral amygdala --> Nucleus Accumbens core circuit mediates the conditioned reinforcing effects of cocaine-paired cues on cocaine seeking. 71 11 2

Distinct dopamine circuits transmit the reinforcing and anxiogenic effects of nicotine 71 11 2

Prior cocaine exposure increases firing to immediate reward while attenuating cue and context signals related to reward value in anterior insula 71 58 2

Kappa-opioid receptor stimulation in the nucleus accumbens shell: Differential effects across the rostro-caudal axis on dopamine transmission and affective behavior 71 11 2

Adolescent intermittent ethanol exposure effects on kappa opioid receptor mediated dopamine transmission: Sex and age of exposure matter 141 71 56 11 2

The mesolimbic dopamine signatures of relapse to alcohol-seeking 71 2

Chemogenetic activation of mesoaccumbal {Gamma}-Aminobutyric Acid projections selectively tunes responses to predictive cues when reward value is abruptly decreased 71 58 11 2

Moderate adolescent chronic intermittent ethanol exposure sex-dependently disrupts synaptic transmission and kappa opioid receptor function in the basolateral amygdala of adult rats 141 71 56 11 2

Testing The Role Of Δ9-Tetrahydrocannabinol During Adolescence As A Gateway Drug: Behavioural, Brain Imaging And Transcriptomic Studies 71 56 2

Dose-Dependent Induction Of CPP Or CPA By Intra-pVTA Ethanol: Role Of Mu Opioid Receptors And Effects On NMDA Receptors 71 11 10 2

A unique multi-synaptic mechanism regulates dopamine release in the nucleus accumbens during adolescence 71 11 2

Chronic stress induces sex-specific functional and morphological alterations in cortico-accumbal and cortico-tegmental pathways 71 11 2

Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats. 71 30 2

Muscarinic M1 receptor stimulation prevents and reverses addiction-related effects of cocaine 71 11 10 2

Differential modulation of ventral tegmental area circuits by the nociceptin/orphanin FQ system 71 11 2

Alterations of the rewarding actions of amphetamine by prior nicotine and alcohol treatment: The role of age and dopamine 141 71 15 10 2

Interruption of Continuous Opioid Exposure Exacerbates Drug-Evoked Adaptations in the Mesolimbic Dopamine System 71 11 2

Amphetamine Maintenance Therapy During Intermittent Cocaine Self-Administration in Rats: Reduction of Addiction-like Behavior is Associated with Attenuation of Psychomotor and Dopamine Sensitization 71 10 2

The effects of cannabidiol on cue- and stress-induced reinstatement of cocaine seeking behavior in mice are reverted by the CB1 receptor antagonist AM4113. 71 10 2

Nucleus accumbens melanin-concentrating hormone signaling promotes feeding in a sex-specific manner 71 56 11 10 2

Accumbens cholinergic interneurons mediate cue-induced nicotine seeking and associated glutamatergic plasticity 71 11 2

Intermittent self-administration of fentanyl induces a multifaceted addiction state associated with persistent changes in the orexin system. 71 11 2

Zinc potentiates dopamine neurotransmission and cocaine seeking 71 11 10 3 2

Reelin deficiency contributes to long-term behavioral abnormalities induced by chronic adolescent exposure to Δ9-tetrahydrocannabinol in mice 113 71 65 11 2

Locus coeruleus patterns differentially modulate learning and valence in rat via the ventral tegmental area and basolateral amygdala respectively 71 11 2

Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity 71 11 2

Heroin self-administration and extinction increases prelimbic cortical astroglia-synapse proximity and alters dendritic spine morphometrics that are reversed by N-acetylcysteine 71 11 2

Age dependent effects of protein restriction on dopamine release 71 11 2

The fragile X mental retardation protein promotes adjustments in cocaine self-administration that preserve reinforcement level 71 11 2

Extended access self-administration of methamphetamine is associated with age- and sex-dependent differences in drug taking behavior and recognition memory deficits in rats 141 71 56 30 15 2

Activation of VTA GABA Neurons Disrupts Reward Seeking by Altering Temporal Processing 71 58 2

Neuron-specific cilia loss alters locomotor responses to amphetamine. 141 71 56 11 2

Fentanyl-induced antinociception, reward, reinforcement, and withdrawal in Hnrnph1 mutant mice 71 56 10

Forced Abstinence from Alcohol Induces Sex-Specific Depression-like Behavioral and Neural Adaptations in Somatostatin Neurons in Cortical and Amygdalar Regions 71 11 2

Dopamine neurons gate the intersection of cocaine use, decision making, and impulsivity 71 56 30 2

Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula 71 11 2

Neuroendocrine and behavioral measures of negative valence in male sign-tracker and goal-tracker rats 71 30 2

The dual orexin/hypocretin receptor antagonist suvorexant reduces addiction-like behaviors for the opioid fentanyl 71 64 10

A ventral striatal-orexin/hypocretin circuit modulates approach but not consumption of food. 71 11 2

Neurochemical signaling of reward and aversion by ventral tegmental area glutamate neurons 71 11 2

Cocaine-dependent acquisition of locomotor sensitization and conditioned place preference requires D1 dopaminergic signaling through a cyclic AMP, NCS-Rapgef2, ERK and Egr-1/Zif268 pathway 71 11 3 2

Sexually divergent cortical control of affective-autonomic integration 56 11 2

Ventral tegmental area GABA neurons mediate stress-induced anhedonia. 71 11 2

Alcohol Drinking Alters Stress Response to Predator Odor via Extended Amygdala Kappa Opioid Receptor Signaling in Male Mice 71 11 10 2

Reduced cue-induced reinstatement of cocaine seeking behavior in Plcb1+/- mice 71 10

Sex differences in the effect of acute fasting on excitatory and inhibitory synapses onto ventral tegmental area dopamine neurons 71 11 2

Transcriptomic signatures of sex-specific nicotine sensitization and imprinting of self-administration in rats inform GWAS findings on human addiction phenotypes 71 9

Chronic activation of fear engrams induces extinction-like behavior in ethanol-exposed mice 71 11 2

The synthetically produced predator odor 2,5-dihydro-2,4,5-trimethylthiazoline increases alcohol self-administration and alters basolateral amygdala response to alcohol in rats. 71 2

A comparison of dopaminergic and cholinergic populations reveals unique contributions of VTA dopamine neurons to short-term memory 71 2

Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction 71 11 2

Ventral Pallidum GABA Neurons Mediate Motivation Underlying Risky Choice 71 58 30 11 2

Chemogenetic stimulation of mouse central amygdala corticotropin-releasing factor neurons: Effects on cellular and behavioral correlates of alcoholdependence 71 11 10 2

Meso-limbic Gene Expression Findings from Mouse Cocaine Self-Administration Recapitulate Human Cocaine Use Disorder 71 9

Ketamine blocks morphine-induced conditioned place preference and anxiety-like behaviors in mice. 141 71 15 10 2

Midbrain dopamine neurons encode internal effort signal 71 58 11 2

Effects of dopamine receptor antagonism and amphetamine-induced psychomotor sensitization on sign- and goal-tracking after extended training 71 15 10 2

Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration 71 2

Taking rapid and intermittent cocaine infusions enhances both incentive motivation for the drug and cocaine-induced gene regulation in corticostriatal regions 71 2

Retrograde labeling illuminates distinct topographical organization of D1 and D2 receptor-positive neurons in the prefrontal cortex of mice 116 71 11 2

The gut microbiome and its metabolites are necessary for morphine reward 71 11 3

The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues 71 2

A Whole-Brain Map and Assay Parameter Analysis of Mouse VTA Dopaminergic Activation 71 11 2

Diazepam attenuates the effects of cocaine on locomotion, 50-kHz ultrasonic vocalizations and phasic dopamine release in the nucleus accumbens of rats 71 64 15 10

Dopamine neurons of the VTA encode active conspecific interaction and promote social learning through social reward prediction error. 71 58 11 2

Infralimbic cortical glutamate output is necessary for the neural and behavioral consequences of chronic stress 113 11 2

Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density 113 71 65 11 2


Chronic Chemogenetic Manipulation of Ventral Pallidum Targeted Neurons in Rats Fed an Obesogenic Diet. 71 11 2

CB1 receptor signaling modulates amygdalar plasticity during context-cocaine memory reconsolidation to promote subsequent cocaine seeking 71 11 3 2

A midbrain dynorphin circuit promotes threat generalization 71 11 2

Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure 71 11 10

Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation 71 11 3

Divergent behavioral consequences of manipulations enhancing pyramidal neuron excitability in the prelimbic cortex 71 11 2

Activation of the kappa opioid receptor / dynorphin system alters stress and threat responding during acute withdrawal from intermittent alcohol drinking in male mice. 71 11 2

Bidirectional regulation of cognitive and anxiety-like behaviors by dentate gyrus mossy cells in male and female mice 56 11 2

Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning 71 11 2

Effects of the GluN2B antagonist, Ro 25-6981, on extinction consolidation following adolescent- or adult-onset methamphetamine self-administration in male and female rats 141 56 15 2

Adolescent Social Isolation Reprograms the Medial Amygdala: Transcriptome and Sex Differences in Reward 56 11 2

Dopamine-related striatal neurophysiology is associated with specialization of frontostriatal reward circuitry through adolescence 71 22 2

Suppression of cortico-striatal circuit activity improves cognitive flexibility and prevents body weight loss in activity-based anorexia in rats 71 11 2

Chronic Intermittent Ethanol and Lipopolysaccharide Exposure Differentially Alter Iba-1-Derived Microglia Morphology in the Prelimbic Cortex and Nucleus Accumbens Core 71 11 10 2

Translational profiling of mouse dopaminoceptive neurons reveals a role of PGE2 in dorsal striatum 71 11 2

A Multi-Gene Synaptic Plasticity Array Identifies Candidate Molecular Underpinnings Of Cognitive And Mood Deficits In Rats With Heart Failure 71 11 2

Chemogenetic inhibition of a monosynaptic projection from the basolateral amygdala to the ventral hippocampus reduces appetitive and consummatory alcohol drinking behaviors 71 11 2

Chronic environmental or genetic elevation of galanin in noradrenergic neurons confers stress resilience in mice 71 11 10 2

The anterior insular cortex in the rat exerts an inhibitory influence over the loss of control of heroin intake and subsequent propensity to relapse 71 10 2

Dorsal raphe dopamine neurons signal motivational salience dependent on internal and external states 71 58 2

High-frequency stimulation of ventral CA1 neurons reduces amygdala activity and inhibits fear 66 2

Central amygdala mineralocorticoid receptors modulate alcohol self-administration. 141 71 10 2