Topic 65

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249 items. Top items listed below.

Structural and Functional Brain-wide Alterations in A350V IQSEC2 Mutant Mice Displaying Autistic-like Behavior 65 11 2

Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development 65 11 3 2

Acute neonatal oxytocin impacts hippocampal network development and restores adult social memory deficits in a mouse model of autism spectrum disorder. 65 11 2

Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated Chd8 haploinsufficient mice 65 11 2

Zbtb16 regulates social cognitive behaviors and neocortical development. 65 11 9 2

Inhibition of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) Activity Reverses Behavioral Deficits in a Rodent Model of Autism. 65 11 2

Human SYNGAP1 Regulates the Development of Neuronal Activity by Controlling Dendritic and Synaptic Maturation 65 11 3 2

Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling 65 11 3 2

DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopmental disorders 65 11 3

Scribble controls social behaviors through the regulation of the ERK/Mnk1 pathway 65 11 3 2

A human TSC1 mutation screening platform in GABAergic cortical interneurons for Genotype to Phenotype assessments 65 11

Altered Expression of Cadherin-8 and Cadherin-11 in Neural Circuit Development: Implications for Autism 65 11 2

Alterations in neuronal physiology, development, and function associated with a common duplication of chromosome 15 involving CHRNA7 65 57 11 9 3

Myosin Va Brain-Specific Mutation Alters Mouse Behavior and Disrupts Hippocampal Synapses 65 11 7 3

Inhibiting proBDNF to mature BDNF conversion leads to autism-like phenotypes in vivo 65 11 10 3

A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment 65 11 3

Effects of gene by microbiome interactions on behavioral and neurobiological phenotypes in a mouse model for autism spectrum disorder 65 10

Genome-wide molecular effects of the neuropsychiatric 16p11 CNVs in an iPSC-to-iN neuronal model 65 9

Abnormal AMPAR-mediated synaptic plasticity, cognitive and autistic-like behaviors in a missense Fmr1 mutant mouse model of Fragile X syndrome 65 11 3

Heterozygous deletion of SYNGAP enzymatic domains in rats causes selective learning, social and seizure phenotypes 65 11 3

Neuroanatomy and Behaviour in Mice with a Haploinsufficiency of AT-Rich Interactive Domain 1B (ARID1B) Throughout Development 65 56 2

Inhibition of mTOR during a postnatal sensitive window rescues deficits in GABAergic PV cell connectivity and social behavior caused by loss of TSC1. 65 11 3 2

Hyperexcitability and loss of feedforward inhibition in the Fmr1KO lateral amygdala. 65 11 2

Disruption of the transcription factor NEUROD2 causes an autism syndrome via cell-autonomous defects in cortical projection neurons 65 11 3

The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota 65 11 10 2

Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes 65 11 2

Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring 65 39 11 2

Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders 65 30 15 2

Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations 65 9

Cell-type specific impact of glucocorticoid receptor activation on the developing brain 168 65 57 11 9 3

Vorinostat corrects cognitive and non-cognitive symptoms in a mouse model of fragile X syndrome 65 11 10

The Impact of Oxytocin on Neurite Outgrowth and Synaptic Proteins in Magel2-Deficient Mice 65 11 3 2

Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency 65 11 9 3

Targeting the RHOA pathway improves learning and memory in Kctd13 and 16p11.2 deletion mouse models. 65 30

Characterization of a gene-trap knockout mouse model of Scn2a encoding voltage-gated sodium channel Nav1.2 65 11 10

Adolescent sleep is critical for the developmental shaping of social novelty preference 65 11 2

Cortical Organoids Model Early Brain Development Disrupted by 16p11.2 Copy Number Variants in Autism 65 11 2

Glutathione S-transferase Pi (Gstp) Proteins Regulate Neuritogenesis in the Developing Cerebral Cortex 65 11 3 2

The role of matrix metalloproteinase-9 (MMP-9) in neurodevelopmental deficits and experience-dependent structural plasticity in Xenopus laevis tadpoles 65 11 2

Co-expression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders 65 9 3

Carbamazepine restores neuronal signaling, protein synthesis and cognitive function in a mouse model of fragile X syndrome 65 11 10 3

FMR1 loss results in early changes to intrinsic membrane excitability in human cellular models 65 11 3

Autism genetics perturb prenatal neurodevelopment through a hierarchy of broadly-expressed and brain-specific genes 65 11 9 3

Aberrant regulation of a poison exon caused by a non-coding variant in Scn1a-associated epileptic encephalopathy 137 65 49 9

Astroglial FMRP modulates synaptic signaling and behavior phenotypes in FXS mouse model 65 11 2

Single cell 3'UTR analysis identifies changes in alternative polyadenylation throughout neuronal differentiation and in autism 65 49 9 3

Loss of α7 nicotinic acetylcholine receptors in GABAergic interneurons causes sex-dependent impairments in postnatal neurogenesis and cognitive and social behavior 65 11 2

Wide phenotypic spectrum of human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations 65 11 3 2

A Drosophila Model of Pontocerebellar Hypoplasia Reveals a Critical Role for the RNA Exosome in Neurons 137 65 49 9 3

Lack of dcf1 leads to neuronal migration delay, axonal swollen and autism-related deficits 65 11 3

Deficiency of cyclin-dependent kinase-like 5 causes spontaneous epileptic seizures in neonatal mice 124 65 11 3

Loss of O-GlcNAcylation on MeCP2 Thr 203 Leads to Neurodevelopmental Disorders 65 11 3

Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation 104 65 11 2

Effects of a postnatal Atrx conditional knockout in neurons on autism-like behaviours in male and female mice 65 30 15 11 2

Early loss of Scribble affects cortical development and interhemispheric connectivity resulting in psychomotor dysregulation. 65 11 3 2

14-3-3 shuttles Activity-dependent neuroprotective protein to the cytoplasm to promote appropriate neuronal morphogenesis, cortical connectivity and calcium signaling 65 11 3 2

The K-Cl co-transporter 2 is a point of convergence for multiple autism spectrum disorder and epilepsy risk gene products. 65 11 3

Deletion of the voltage-gated calcium channel, CaV1.3, causes deficits in motor performance and associative learning 65 11 2

Induction of core symptoms of autism spectrum disorders by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys 65 33 11 2

A Rat Model of a Focal Mosaic Expression of PCDH19 Replicates Human Brain Developmental Abnormalities and Behaviors 65 11 2

Deletion of the mitochondrial matrix protein cyclophilin-D prevents parvalbumin interneuron dysfunction and cognitive deficits in a mouse model of NMDA hypofunction 104 11 3 2

Assessment of autism zebrafish mutant models using a high-throughput larval phenotyping platform 65 33 4

Antisense oligonucleotide therapy for SCN2A gain-of-function epilepsy 65 11 10 2

Integration of behavioral and biological variables using penalized regression: an application to the maternal immune activation model of autism 65 15

Episignatures stratifying ADNP syndrome show modest correlation with phenotype 65 9

Reelin deficiency contributes to long-term behavioral abnormalities induced by chronic adolescent exposure to Δ9-tetrahydrocannabinol in mice 113 71 65 11 2

Deep multitask learning of gene risk for comorbid neurodevelopmental disorders 65 26 9 4 2

Cellular and behavioral characterization of Pcdh19 mutant mice: subtle molecular changes, increased exploratory behavior and an impact of social environment. 65 11 3 2

Cytoplasmic accumulation of FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and defects in inhibitory synapses 61 11 3 2

Age- and Sex-Specific Fear Conditioning Deficits in Mice Lacking Pcdh10, an Autism Associated Gene 56 11 2

The microbiota promotes social behavior by neuro-immune modulation of neurite complexity 65 11 3 2

mTOR inhibition in primary neurons and the developing brain represses transcription of cholesterol biosynthesis genes and alters cholesterol levels 133 31 3

Isoform transcriptome of developing human brain provides new insights into autism risk variants 65 9 3

Investigating autism associated genes in C. elegans reveals candidates with a role in social behaviour 65 30 9

Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by mutation of the psychiatric risk gene Cacna1c 65 11 3 2

Epigenetic gene-expression links heart failure to memory impairment 65 11 10 3

Autism and Williams syndrome: dissimilar socio-cognitive profiles with similar patterns of abnormal gene expression in the blood 65 2

Gene functional networks and autism spectrum characteristics in young people with intellectual disability 65 9 5

Proteomic Differences in the Hippocampus and Cortex of Epilepsy Brain Tissue 65 45 11 2

Aberrant astrocyte protein secretion contributes to altered neuronal development in diverse disorders 65 11 3

ZNF423 patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities 137 65 9

Heterozygous mutation of Sonic Hedgehog receptor (Ptch) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice 65 56 11 2

Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning 65 11 2

A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions 65 11 10 3

Functional Predictors of Causative Cis-Regulatory Mutations in Mendelian Disease 137 65 9

Transcriptomic analysis of dystonia-associated genes reveals functional convergence within specific cell types and shared neurobiology with psychiatric disorders 54 9

Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of Excitability 124 65 11 10 3 2

Characterization of Mice Bearing Humanized Androgen Receptor Genes (h/mAr) Varying in Polymorphism Length 65 56 2

Dissecting Autism Genetic Risk Using Single-cell RNA-seq Data 9 4

scRNA-Sequencing uncovers a TCF-4-dependent transcription factor network regulating commissure development 65 9 3

Early defects in lysosomal storage diseases disrupt excitatory synaptic transmission 65 11 10 2

Abundance and localization of human UBE3A protein isoforms 65 33 20 3

Identification and functional analysis of long non-coding RNAs in autism spectrum disorders 9

The chromatin remodeler ISWI acts during Drosophila development to regulate adult sleep 65 11 3 2

Atypical neurogenesis in induced pluripotent stem cell (iPSC) from autistic individuals 57 20 11 9 3 2

Synaptic protein DLG2 controls neurogenic transcriptional programs disrupted in schizophrenia and related disorders 65 20 9 3

Identification of CDH11 as an ASD risk gene by matched-gene co-expression analysis and mouse behavioral studies 65 9

Prenatal Environmental Stressors Impair Postnatal Microglia Function and Adult Behavior in Males 65 56 11 2

Multi-parametric analysis of 58 SYNGAP1 variants reveal impacts on GTPase signaling, localization and protein stability 65 8 3

MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus 49 11 3