Topic 124

epilepsy seizure seizures epileptic onset neuroscience patients eeg ictal oscillations interictal lobe epileptiform focal recordings soz intracranial hfos frequency zone discharges neuronal brain temporal surgical electrodes mesial patterns activity recorded hippocampus granule sudden amplitude excitability hz hfo events characterized analyzed ieeg drug sudep kindling tle early cortical intractable biomarker pathological duration model scn8a dentate electrode mouse encephalopathy features electroencephalography decreased hippocampal neurons localization models dynamics generalized terminates mice potentials clinically neurological wave suppression epileptogenic sleep propagation channel gabaergic controls resistant local during marked out thalamocortical dynamotypes firing mechanistic comorbidities gyrus pharmacological retrospectively first optogenetic spikes pges electroencephalogram therapies detected slices

45 items. Top items listed below.

Evidence for spreading seizure as a cause of theta-alpha activity electrographic pattern in stereo-EEG seizure recordings 124 42 2

Dual mechanisms of ictal high frequency oscillations in human rhythmic onset seizures 124 42 2

Interictal epileptiform discharges in focal epilepsy are preceded by a gradual increase in low-frequency oscillations 124 42 2

Impacted Spike Frequency Adaptation Associated with Reduction of KCNQ2/3 Promotes Seizure Activity in Temporal Lobe Epilepsy 124 11

Thalamic activity patterns unfolding over multiple time scales predict seizure onset in absence epilepsy 124 42 2

Anterior Nucleus of Thalamus Gates Progression of Mesial Temporal Seizures by Modulating Thalamocortical Synchrony 124 42 2

Towards automatic classification of pathological epileptic tissue with interictal high frequency oscillations 124 42 2

Optogenetic low-frequency stimulation of dentate granule cells prevents seizure generation in experimental epilepsy 124 10 2

Neuronal firing and waveform alterations through ictal recruitment in humans 124 2

Seizure-associated spreading depression is a major feature of ictal events in two animal models of chronic epilepsy 124 2

Optogenetic activation of CA1 pyramidal neurons in vivo induces hypersynchronous and low voltage fast seizures 124 11 2

Deficits in Behavioral and Neuronal Pattern Separation in Temporal Lobe Epilepsy 124 66 65 11 2

Patient-specific optimization of automated detection improves seizure onset zone localization based on high frequency oscillations 124 59 15 4

Deficiency of cyclin-dependent kinase-like 5 causes spontaneous epileptic seizures in neonatal mice 124 65 11 3

Impaired state-dependent potentiation of GABAergic synaptic currents triggers seizures in an idiopathic generalized epilepsy model 124 11 2

Active probing to highlight approaching transitions to ictal states in coupled neural mass models 124 38 2

Spectral harmonicity distinguishes two types of ictal phase-amplitude cross frequency couplings in patients candidate to epilepsy surgery 124 42 2

Multimodal in vivo recording using transparent graphene microelectrodes illuminates spatiotemporal seizure dynamics at the microscale 124 2

Local propagation dynamics of MEG interictal spikes: source reconstruction with traveling-wave priors 124 59 2

Fast oscillations >40Hz localize the epileptogenic zone: an electrical source imaging study using high-density electroencephalography 124 15

Maladaptive myelination promotes epileptogenesis in absence epilepsy 124 65 11 2

Closed-loop stimulation of the medial septum terminates epileptic seizures 124 11 2

Microglial phagocytosis dysfunction is related to local neuronal activity in a genetic model of epilepsy 124 65 11 10 2

Spatiotemporal patterns of high-frequency activity (80-170 Hz) in long-term intracranial EEG 124 42 15 2

Sleep-wake Characteristics in a Mouse Model of Severe Traumatic Brain Injury: Relation to Post-Traumatic Epilepsy. 124 113 15 2

Amplitude of high frequency oscillations as a biomarker of the seizure onset zone 124 26 15 4 2

Nodal Fragility of Intracranial EEG Networks: Towards an EEG Fingerprint for the Seizure Onset Zone 124 15 2

Early EEG and behavioral alterations in Dravet mice 124 65 2

Adult-born granule cells support pathological microcircuits in the chronically epileptic dentate gyrus 124 11 2

Multi-modal characterization and simulation of human epileptic circuitry 124 65 11 10

A taxonomy of seizure dynamotypes 124 38

Variant-specific changes in persistent or resurgent Na+ current in SCN8A-EIEE13 iPSC-derived neurons 124 82 65 11 10

Effects of constitutive and acute Connexin 36 deficiency on brain-wide susceptibility to PTZ-induced neuronal hyperactivity 124 11 3

Mosaic trisomy of chromosome 1q in human brain tissue associates with unilateral polymicrogyria, very early-onset focal epilepsy, and severe developmental delay 124 9

Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of Excitability 124 65 11 10 3 2

Post-ictal generalized EEG suppression and seizure-induced mortality are reduced by enhancing dorsal raphe serotonergic neurotransmission 124 11 10 2

Multiband entropy-based feature-extraction method for automatic identification of epileptic focus based on high- frequency components in interictal iEEG 124 26 4

Orientation of Temporal Interference for Non-Invasive Deep Brain Stimulation in Epilepsy 124 2

Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model 124 10 3

An unbiased drug screen for seizure suppressors in Dup15q syndrome reveals 5HT1A and dopamine pathway activation as potential therapies 124

Biomarkers of Memory Variability in Traumatic Brain Injury 124 42 22 2

Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency 65 11 9 3

Seizure onset location shapes dynamics of initiation 42 2

Visualization of Phase-Amplitude Coupling Using Rhythmic High-Frequency Activity 42 2

Carbamazepine and GABA have distinct effects on seizure onset dynamics in mouse brain slices 124

Scalp EEG interictal high frequency oscillations as an objective EEG biomarker of infantile spasms 124 15 2

Implantation technique, safety and complications of robot-assisted stereoelectroencephalography exploration of the limbic thalamus in human focal epilepsy 124 15 2

Proteomic and Transcriptomic Analyses of the Hippocampus and Cortex in SUDEP and High-Risk SUDEP Cases 124 120 9

Proteomic Differences in the Hippocampus and Cortex of Epilepsy Brain Tissue 65 45 11 2

Antisense oligonucleotide therapy for SCN2A gain-of-function epilepsy 65 11 10 2

A KCNQ2 variant causing Early Onset Epileptic Encephalopathy increases spontaneous network-driven activity and excitability of pyramidal cells in the layer II/III and V of the motor cortex during a limited period of development 11 2

Higher-order hub cells involved in feedforward motifs as critical factors in epileptic network instability 2

Low frequency traveling waves in the human cortex coordinate neural activity across spatial scales 42 2

Neuronal kinase SGK1.1 protects against brain damage after status epilepticus 10 3

Spatio-temporal heterogeneity in hippocampal metabolism in control and epilepsy conditions. 2

In vivo assessment of mechanisms underlying the neurovascular basis of postictal amnesia 66 11 2

Time cells in the human hippocampus and entorhinal cortex support episodic memory 66 2

Saccadic modulation of neural activity in the human anterior thalamus during visual active sensing 42 2

Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures 32 11 10 3 2

A Rat Model of a Focal Mosaic Expression of PCDH19 Replicates Human Brain Developmental Abnormalities and Behaviors 65 11 2

A unified physiological framework of transitions between seizures, status epilepticus and depolarization block at the single neuron level 38

Probing the polarity of spontaneous perisomatic GABAergic synaptic transmission during epileptogenesis in the mouse CA3 circuit in vivo 11 2

Focal cortical surface cooling is a novel and safe method for intraoperative functional brain mapping 15 2

Automated Detection of Ripple Oscillations in Long-Term Scalp EEG from Patients with Infantile Spasms 15 2

Sodium valproate protects against neuronal ferroptosis in epilepsy via suppressing lysyl oxidase 188 10 3

Focal epilepsy modulates vesicular positioning at cortical synapses 77 11 2

Direct brain recordings identify hippocampal and cortical networks that distinguish successful versus failed episodic memory retrieval 22 2

Functional connectome contractions in temporal lobe epilepsy: microstructural underpinnings and associations to surgical outcome 22 2

High concordance between hippocampal transcriptome of the intraamygdala kainic acid model and human temporal lobe epilepsy 10 9

Temporal dynamics of functional networks in long-term infant scalp EEG 22 2

Heterozygous deletion of SYNGAP enzymatic domains in rats causes selective learning, social and seizure phenotypes 65 11 3

Spatiotemporal dynamics between interictal epileptiform discharges and ripples during associative memory processing 66 2

Aberrant regulation of a poison exon caused by a non-coding variant in Scn1a-associated epileptic encephalopathy 137 65 49 9

Boosting L-type Ca2+ channel activity in tuberous sclerosis mitigates excess glutamate receptors and seizures 65 10 3

Dexmedetomidine - commonly used in functional imaging studies - increases susceptibility to seizures in rats but not in wild type mice 2

SIFNet: Electromagnetic Source Imaging Framework Using Deep Neural Networks 26 4 2

In vivo Interictal Neuronal Signatures of Human Periventricular Nodular Heterotopia 7

Mecamylamine inhibits seizure-like activity in CA1-CA3 hippocampus through antagonism to nicotinic receptors 11 2

Enhanced synaptic transmission in the extended amygdala and altered excitability in an extended amygdala to brainstem circuit in a Dravet syndrome mouse model 11 10 2

Human SYNGAP1 Regulates the Development of Neuronal Activity by Controlling Dendritic and Synaptic Maturation 65 11 3 2

Simultaneous human intracerebral stimulation and HD-EEG: ground-truth for source localization methods 59 2

Limb-clasping, cognitive deficit and increased vulnerability to kainic acid -induced seizures in neuronal GPI anchor deficiency mouse models 65 11 10 3

Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic network oscillations 11 2

Taenia larvae possess distinct acetylcholinesterase profiles with implications for host cholinergic signalling 11 2

Rapid adaptation to elevated extracellular potassium in the pyloric circuit of the crab, Cancer borealis 11 2

Beta2 oscillations in the hippocampal-cortical novelty detection circuit 42 2

Aberrant axonal pathfinding and exuberant myelination in an inducible model of neocortical heterotopia 11 2

TLR4 signaling in neurons enhances calcium-permeable AMPAR currents and drives post-traumatic epileptogenesis 150 11 10 3 2

An important role of the interplay between Bdnf transcription and histone acetylation in epileptogenesis 11 3

Converging evidence for shared genetic underpinnings of genetic generalized epilepsy and EEG beta power 19 15

Neuronal firing in the medial temporal lobe reflects human working memory workload, performance and capacity. 66 23 2

RHEB/mTOR-hyperactivity causing cortical malformations drives seizures through increased axonal connectivity 65 11 3 2

Altered Temporal Variability of Local and Large-scale Resting-state Brain Functional Connectivity Patterns in Schizophrenia and Bipolar Disorder 22 2

Transient amplitude modulation of alpha-band oscillations by short-time intermittent closed-loop tACS 42 2

Genuine cross-frequency coupling networks in human resting-state electrophysiological recordings 42 22 2

Hippocampal theta oscillations support successful associative memory formation 66 42 2

Stability of ripple events during task engagement in human hippocampus 66 42 2

Decoding the neural dynamics of oculomotor decision making in humans 42 2

Preferential Pharmacological Inhibition of Nav1.6, but not Nav1.1, Abolishes Epileptiform Activity Induced by 4-AP in Mouse Cortical Slices 82 11 10 2

Electrophysiological foundations of the human default-mode network revealed by brain-wide intracranial-EEG recordings during resting-state and cognition 22 2