Topic 150

inflammatory activation immunology inflammation macrophages immune signaling receptor activated mediated cells macrophage caspase recruitment kappa induced response nf dependent inflammasome responses toll innate il deficient pro cell tlr4 receptors activate dendritic upon lps cytokine pathway mice role vivo pyroptosis promote bone factor regulates secretion stimulation ligands neutrophils death tlr monocyte kinase induces marrow beta dcs mechanistically release injury nuclear derived extracellular phosphorylation cytokines apoptosis leading neutrophil like understood canonical expression regulatory triggers through protein downstream promotes sensing intracellular production activates ifn regulated immunity mechanism activating monocytes tnf proinflammatory deficiency deletion myeloid primary agonist ligand sepsis mechanisms dc show mediators blocking

149 items. Top items listed below.

Transcriptional regulation of ACSL1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation 150 110 49 3

Regulatory T cell activation triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses 150 27 3

Inflammasome- and gasdermin D-independent IL-1β production mobilizes neutrophils to inhibit antitumor immunity 150 27 14 10 3

Priming Is Dispensable For NLRP3 Inflammasome Activation In Human Monocytes 150 27 3

STAT3 Serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression 110 27 10 3

TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration 150 110 27 3

Irgm2 and Gate-16 cooperatively dampen targeting of caspase-11 to Gram-negative bacterial products 150 27 3

Urokinase receptor associates with TLR4 interactome to promote LPS response 150 110 27 3

DNA damage independent inhibition of NF-κB transcription by anthracyclines 150 27 3

Extracellular DJ-1 induces sterile inflammation in the ischemic brain 150 110 27 10 3

LPS induces GFAT2 expression to promote O-GlcNAcylation and attenuate inflammation in macrophages 150 110 27 3

A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α. 150 27 3

PYK2 controls intestinal inflammation via activation of IRF5 in macrophages 110 27 10 3

Calcium-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells 150 88 27 3

Hedgehog dysregulation contributes to tissue-specific inflammaging of resident macrophages 110 27 10 3

miR-424(322) is a molecular switch controlling pro-inflammatory vs anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling 150 27 3

Characterization of the signalling modalities of prostaglandin E2 receptors EP2 and EP4 reveals crosstalk and a role for microtubules 150 27 3

Interactions with Commensal and Pathogenic Bacteria Induce HIV-1 Latency in Macrophages through Altered Transcription Factor Recruitment to the LTR 150 27 10 3

Macrophage Inflammatory State Influences Susceptibility to Lysosomal Damage 174 150 27 10 3

Leukotriene B4 licenses inflammasome activation to enhance skin host defense 150 110 27 10 3

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence. 150 108 27 3

AMPKα1 is essential for Glucocorticoid Receptor triggered anti-inflammatory macrophage activation 7 3

Mechanism of negative regulation of NF-κB by N4BP1 150 27 3

Staphylococcus aureus secretes immunomodulatory RNA and DNA via membrane vesicles 150 27 3

Short chain fatty acid butyrate promotes virus infection by repressing interferon stimulated genes 27 10 3

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation 150 27 3

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages 39 10 3

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner 110 32 27 10 3

Macrophage-derived miR-21 drives overwhelming glycolytic and inflammatory response during sepsis via repression of the PGE2/IL-10 axis. 110 27 10 3

Dynamic metabolic reprogramming in dendritic cells: an early response to influenza infection that is essential for effector function 27 10 3

LRRK2-dependent Rab GTPase phosphorylation in response to endolysosomal damage depends on macrophage differentiation 150 27 3

NFκB dynamics determine stimulus-responsive epigenomic reprogramming in macrophages 150 31 27 3

Human GBP1 differentially targets Salmonella and Toxoplasma to license recognition of microbial ligands and caspase-mediateddeath 150 27 3

Arachidonic acid metabolism controls macrophage alternative activation through regulating oxidative phosphorylation in PPARG dependent manner 150 27 3

Membrane receptor MerTK is a newly identified transcriptional regulator that associates to chromatin as nanoclusters during human DC differentiation 150 102 3

The microbiota plays a critical role in the reactivity of lung immune components to innate ligands 27 10 3

IL-23 production is regulated via an MSK1/2 - CREB dependent signaling pathway downstream of Toll like receptors. 110 27 10 3

Dynamin-related Irgm proteins modulate LPS-induced caspase-4 activation and septic shock 150 27 3

Human GBP1 promotes pathogen vacuole rupture and inflammasome activation during Legionella pneumophila infection 150 27 3

Notch and TLR signaling coordinate monocyte cell fate and inflammation 150 27 20 3

Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells 150 27 3

LXR alters CD4+ T cell function through direct regulation of glycosphingolipid synthesis 150 27 3

Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain. 110 27 10 3

Transcription factor PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress 150 27 3

Extracellular histones trigger disseminated intravascular coagulation by lytic cell death 150 27 3

Paxillin Promotes ATP-induced Activation of P2X7 Receptor and NLRP3 Inflammasome 150 110 27 3

BAP31 regulated polarization of macrophages through C/EBP β in cutaneous wound healing 150 27 3

Attenuation of homeostatic signaling from apoptotic thymocytes triggers a global regenerative response in the thymus 150 27 10 3

Drainage of inflammatory macromolecules from brain to periphery targets the liver for macrophage infiltration 150 27 10 3

Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection 27 10 3

Phosphatidylinositol-4-kinase IIα licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells 150 102 34 3

NAD+ prevents septic shock by non-canonical inflammasome blockade and IL-10 110 27 10 3

Brucella suppress innate immunity by down-regulating STING expression in macrophages 174 27 3

ELAVL1 Primarily Couples mRNA Stability with the 3'UTRs of Interferon Stimulated Genes 49 27 3

Lipin-1 regulates lipid catabolism in pro-resolving macrophages. 150 27 3

Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation 102 88 27 3

Missing-In-Metastasis / Metastasis Suppressor 1 modulates B cell receptor signaling, B cell metabolic potential and T cell-independent immune responses. 146 88 27 3

Soluble mannose receptor induces pro-inflammatory macrophage activation and metaflammation 39 27 10 3

Mutant glucocorticoid receptor binding elements on Interleukin-6 promoter regulate dexamethasone effects 110 27 10 3

Amyloid beta acts synergistically as a pro-inflammatory cytokine 32 27 3

MECP2 DEFICIENCY ALTERS M1/M2 GENE EXPRESSION IN BONE MARROW-DERIVED MACROPHAGES UPON STIMULATION 27 3

Macrophage-associated lipin-1 transcriptional co-regulatory activity is involved in atherosclerosis 150 110 27 3

TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation 150 27 3

The PD-L1/PD-1 Axis Blocks Neutrophil Cytotoxicity In Cancer 197 27 14 10 3

Influenza-induced activation of recruited alveolar macrophages during the early inflammatory phase drives lung injury and lethality 27 10 3

GM-CSF differentiation of human monocytes stabilizes macrophage state via oxidative signaling 27 10 3

NF-kappa-B activation unveils the presence of inflammatory hotspots in human gut xenografts 27 10 3

ISG15 drives immune pathology and respiratory failure during viral infection 27 10 3

An integrin receptor complex mediates filamentous Tau-induced activation of primary astrocytes 110 102 3

The JAK2-STAT pathway epigenetically regulates tolerized genes during the first encounter with bacterial antigens 150 27 3

Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis. 110 27 10 3

IRE1? regulates macrophage polarization, PD-L1 expression and tumor survival 150 27 14 10 3

Single-cell secretion analysis reveals a dual role for IL-10 in restraining and resolving the TLR4-induced inflammatory response 110 27 10 3

Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis 150 64 3

Identification of Hyal2-expressing tumor-associated myeloid cells in cancer: implications for cancer-related inflammation through enhanced hyaluronan degradation 110 27 10 3

Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5 27 10 3

Innovation in NLR and TLR sensing drives the MHC-II free Atlantic cod immune system. 150 27 3

Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila 150 3

DDX50 is a viral restriction factor thay enhances TRIF-dependent IRF3 activation 27 3

TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin 150 27 3

TLR9-activated B cells improve their regulatory function by endogenously produced catecholamines 150 27 10 3

Pneumolysin is responsible for differential gene expression and modifications in the epigenetic landscape of primary monocyte derived macrophages. 27 3

Metabolic Immunomodulation, Transcriptional Regulation, and Signal Protein Expression Define the Metabotype and Effector Functions of Five Polarized Macrophage Phenotypes 27 10 3

Endothelial cells promote productive HIV infection of resting CD4+ T cells by an integrin-mediated cell adhesion-dependent mechanism 27 3

Modelling within-host macrophage dynamics in influenza virus infection 27 10 1

RNA-binding protein RBM3 negatively regulates innate lymphoid cells (ILCs) and lung inflammation 27 3

ASC oligomer favor caspase-1CARD domain recruitment after intracellular potassium efflux 150 27 3

Sec22b regulates inflammatory responses by controlling the nuclear translocation of NF-κB 150 110 34 27 3

Peptide:MHC dependent activation of natural killer cells through KIR2DS2 generates anti-tumor responses 88 14 10 3

Neuraminidase activity mediates IL-6 production through TLR4 and p38/ERK MAPK signaling in MRL/lpr mesangial cells 110 27 10 3

LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activation 150 3

TLR5 signalling activates the alternative NF-κB signalling pathway in Cystic Fibrosis bronchial epithelial cells in response to infection with Prevotella histicola. 150 27 10 3

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB 73 27 1

Chicken cGAS senses fowlpox virus infection and regulates macrophage effector function 27 3

The adaptor protein NumbL is involved in the control of glucolipotoxicity-induced pancreatic beta cell apoptosis 150 3

Adipose-tissue derived signals control bone remodelling. 156 150 57 10 3

LAG3 is a Central Regulator of NK Cell Cytokine Production 27 10 3

Inflammation Drives Alternative First Exon usage to Regulate Immune Genes including a Novel Iron Regulated Isoform of Aim2 7 3

Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling Through the Interleukin-1 Receptor 114 27 10 3

Regulation of early growth response-1 (Egr-1) gene expression by Stat1-independent type I interferon signaling and respiratory viruses 73 27 3 1