Topic 146

immunology antibodies vaccine antibody immunization antigen germinal vaccines protective responses vaccination against protection neutralizing affinity circumsporozoite antigens humoral hiv immunity broadly plasmodium bcr malaria bnabs falciparum immune influenza infection igg center csp bnab sporozoites centers sporozoite elicit immunized mice response gc naive generation follicular maturation potent helper titers epitope rts as01 virus pfcsp recognition cells specific titer high macaques memory trimers durable efficacy lymph surface viremia cell pathogens hypermutation vlps epitopes immunogenicity induced plasma immunodominant serum protect monoclonal immunogens berghei igm avidity pf induce capacity clonal nanoparticle induction elicitation gcs parasite lived lymphoid boost tfh elicits lasting receptor envelope rhesus

47 items. Top items listed below.

An Epitope-based Malaria Vaccine Targeting the Junctional Domain of Circumsporozoite Protein 146 24 10

Optimizing immunization protocols to elicit broadly neutralizing antibodies 146 24 12

Th2-like T-follicular helper cells promote functional antibody production during Plasmodium falciparum infection 146 88 60 27 24 10 3

Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes 146 60 24 10

The importance of the immunodominant CD8+ T cell epitope of Plasmodium berghei circumsporozoite protein in parasite- and vaccine-induced protection 146 60 24 10 3

Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells 146 24 10 3

Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers 146 24 10

B cells engineered to express an anti-HIV antibody allow memory retention, class switch recombination and clonal selection in mice 146 88 24 10

Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium liver stage 146 24 10

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity 146 60 24 8

SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques 146 24 1

Virus-Like Particle Based-Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide 146 24 10 1

Mapping of safe and early chemo-attenuated live Plasmodium falciparum immunization identifies immune signature of vaccine efficacy 146 60 24 10

Immunogenicity, safety and efficacy of sequential immunizations with an SIV-based IDLV expressing CH505 Envs 146 24 10

Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines 146 24 10

Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination 146 60 24 10

Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies 146 24

Conditional Antibody Expression to Avoid Central B Cell Deletion in a Humanized HIV-1 Vaccine Mouse Models 146 24 10

Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth 146 88 24 10

Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations 146 88 27 24 10

Broadly reactive influenza antibodies are not limited by germinal center competition with high affinity antibodies 146 24

cGAMP loading enhances the immunogenicity of VLP vaccines 146 88 24 10 3

Intrinsic defects in lymph node stromal cells underpin poor germinal center responses during aging 146 88 27 10 3

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates 146 24 10

Recreation of an antigen-driven germinal center in vitro by providing B cells with phagocytic antigen 146 88 27 24

Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum 146 24 8

A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses 24 1

Model-based inference of neutralizing antibody avidities against influenza virus 146 24 10

Mechanisms underlying vaccination protocols that may optimally elicit broadly neutralizing antibodies against highly mutable pathogens 146 24 21 5

Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11 146 60 24 8 3

Reduced placental transfer of antibodies against microbial and vaccine antigens in HIV-infected women in Mozambique 146 88 24 10

Missing-In-Metastasis / Metastasis Suppressor 1 modulates B cell receptor signaling, B cell metabolic potential and T cell-independent immune responses. 146 88 27 3

Single-shot Mesoporous Silica Rods Scaffold for Induction of Humoral Responses Against Small Antigens 146 88 24 10

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection 24 1

Simultaneous aerosol and intra-muscular immunization with influenza vaccine induces powerful protective local T cell and systemic Ab immune responses in pigs 146 24 10 1

B cells expressing authentic naive human VRC01-class BCRs can be primed and recruited to germinal centers in multiple independent mouse models 146 88 24 10

A Vaccine Composed of Antigen Fused to a Ligand for a Receptor on Immature Dendritic Cells Elicits Elevated Antibody Responses to Malaria Sporozoites in Infant Macaques 146 88 24 10

A self-assembled protein nanoparticle serving as a one-shot vaccine carrier 146 24 8

Ex vivo detection of SARS-CoV-2-specific CD8+ T cells: rapid induction, prolonged contraction, and formation of functional memory 24 1

Injectable hydrogels for sustained co-delivery of subunit vaccines enhance humoral immunity 146 85 27 10

Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses 88 27 10 3

Endophilin A2 regulates B cell protein trafficking and humoral responses 146 88 27 3

Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers 146 88 38

Neutrophils are required during immunization with the pneumococcal conjugate vaccine for protective antibody responses and host defense against infection 146 27 10

SARS-CoV-2 protein subunit vaccination elicits potent neutralizing antibody responses 24 1

A novel subset of follicular helper-like MAIT cells has capacity for B cell help and antibody production in the mucosa. 146 88 27 10 3

A single immunization with spike-functionalized ferritin vaccines elicits neutralizing antibody responses against SARS-CoV-2 in mice 24 1

Development of a Synthetic Poxvirus-Based SARS-CoV-2 Vaccine 24 7 1

What determines the FDC polarization and GC size in affinity maturation 146 88 27

Single cell BCR and transcriptome analysis after respiratory virus infection reveals spatiotemporal dynamics of antigen-specific B cell responses. 88 27 24 9 3

Soluble Spike DNA vaccine provides long-term protective immunity against SAR-CoV-2 in mice and nonhuman primates 24 1

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2 24 1

Evidence of antigenic imprinting in sequential Sarbecovirus immunization 24 1

Immune response to vaccine candidates based on different types of nanoscaffolded RBD domain of the SARS-CoV-2 spike protein 24 1

Epitopes targeted by T cells in convalescent COVID-19 patients 76 24 1

Preclinical study of DNA vaccines targeting SARS-CoV-2 24 1

Tissue-resident memory CD8 T-cell responses elicited by a single injection of a multi-target COVID-19 vaccine 24 1

Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge 24 10 1

Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India 24 1

Epigraph Hemagglutinin Vaccine Induces Broad Cross-reactive Immunity Against Swine H3 Influenza Virus 24 10 1

Phylogenetic analysis of migration, differentiation, and class switching in B cells 146 88 83 4

Structural basis of Blastomyces Endoglucanase-2adjuvancy in anti-fungal and -viral immunity 24 10 1

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates 24 1

Plasmodium falciparum-specific IgM B cells dominate in children, expand with malaria and produce parasite inhibitory IgM 146 60 27 10 3

Defining levels of dengue virus serotype-specific neutralizing antibodies induced by a live attenuated tetravalent dengue vaccine (TAK-003) 24 10

Specific induction of double negative B cells during protective and pathogenic immune responses 146 88 27 10 3

Characterization of neutralizing antibodies from a SARS-CoV-2 infected individual 24 1

Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model 24 1

Impact of a rapid decline in malaria transmission on antimalarial IgG subclasses and avidity 7

B Cell Division Capacity in Germinal Centers Depends on Myc Transcript Stabilization Through m6A mRNA Methylation and IGF2BP3 Functions 146 49 3

Prime-boost protein subunit vaccines against SARS-CoV-2 are highly immunogenic in mice and macaques 24 1

Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection 24 1

SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike 24 1

Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals 24 1

Tailored intestinal IgA responses can set an evolutionary trap for Salmonella Typhimurium 146 88 12 10

Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates 24 1

mRNA based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus neutralizing antibodies and mediates protection in rodents 24 1

Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2 24 1

Enhanced SARS-CoV-2 Neutralization by Secretory IgA in vitro 24 1

S protein-reactive IgG and memory B cell production after human SARS-CoV-2 infection includes broad reactivity to the S2 subunit 24 1

Quantifying memory CD8 T cell-mediated immune pressure on influenza A virus infection in vivo 88 24 10

Modified Vaccinia Ankara Based SARS-CoV-2 Vaccine Expressing Full-Length Spike Induces Strong Neutralizing Antibody Response 24 1

The histone methyltransferase DOT1L is essential for humoral immune responses 88 27 3

mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2 191 36 24 1

Intranasal Vaccination with a Lentiviral Vector Strongly Protects against SARS-CoV-2 in Mouse and Golden Hamster Preclinical Models 24 1

Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependant protection against pulmonary tuberculosis 27 10 3

Zebrafish studies on the vaccine candidate to COVID-19, the Spike protein: Production of antibody and adverse reaction 24 1

PD-L1hi plasmablasts limit the T cell response during the acute phase of parasite infections 88 27 10 3

Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon vaccination 88 27 24 10

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens 24

Intradermal-delivered DNA vaccine provides anamnestic protection in a rhesus macaque SARS-CoV-2 challenge model 24 1

The receptor binding domain of SARS-CoV-2 spike is the key target of neutralizing antibody in human polyclonal sera. 24 1

Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation. 88 27 9 3

SARS-CoV-2 Elicits Robust Adaptive Immune Responses Regardless of Disease Severity 24 1

Rapid development of an inactivated vaccine for SARS-CoV-2 24 1

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer 24 8

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine 24 1

Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement 24 1

The immunodominant and neutralization linear epitopes for SARS-CoV-2 24 1

Attenuated influenza virions expressing the SARS- CoV-2 receptor-binding domain induce neutralizing antibodies in mice 24 1