Topic 85

bioengineering tissue mechanical collagen properties matrix scaffolds engineered 3d engineering materials delivery hydrogels hydrogel vitro vivo scaffold fabrication extracellular healing material culture loading biomaterials regenerative regeneration microfluidic applications bone promising ecm formation device stiffness platform cells design tissues repair bioprinting drug mimic vascular cell endothelial biomaterial cultured devices developed porous polymer biomechanical tendon demonstrated dimensional 2d decellularized injectable surface composite implantation poly shear bio controlled fabricated mesenchymal printing fluid muscle improved injury native tunable vessel blood nanoparticles self electrical osteogenic manufacturing system medicine seeded loaded geometry weeks adhesion injuries fibrin viability laden biomimetic compared vessels herein implanted modulus evaluated micro

285 items. Top items listed below.

Success Criteria for Preclinical Testing of Cell-Instructive Hydrogels for Tendon Regeneration 85 57 18 10

3D bioprinting of co-cultured osteogenic spheroids for bone tissue fabrication 85 57 18

Scaffold pore geometry influences bone-like tissue formation in dynamic cell culture conditions 85 18

3D Bioprinting of Graphene Oxide-Incorporated Cell-laden Bone Mimicking Scaffolds for Promoting Scaffold Fidelity, Osteogenic Differentiation and Mineralization 85 57 18 10

BoneMA - Synthesis and Characterization of a Methacrylated Bone-derived Hydrogel for Bioprinting of Vascularized Tissues 85 18

Full cell infiltration and thick tissue formation in vivo in tailored electrospun scaffolds 85 18 4

Effects of Controlled Dual Growth Factor Delivery on Bone Regeneration Following Composite Bone-Muscle Injury 85 10

Temporal Changes Guided by Mesenchymal Stem Cells on a 3D Microgel Platform Enhances Angiogenesis In Vivo at a Low-Cell Dose 85 57 10 3

Effects of chondrogenic priming duration on mechanoregulation of engineered cartilage anlagen. 156 85 57 10 3

Sequential sequestrations increase the incorporation and retention of multiple growth factors in mineralized collagen scaffolds 85 18

3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels 85 57 18 10

Perfusion bioreactor culture of adipose-derived stromal cells on decellularized adipose tissue scaffolds enhances in vivo regeneration 85 57 10

Hydrogel mechanical properties are more important than osteoinductive growth factors for bone formation with MSC spheroids 85 57 10

Mineralized collagen scaffolds fabricated with amniotic membrane matrix increase osteogenesis under inflammatory conditions 85 57 10 3

Increasing salinity of fibrinogen solvent generates stable fibrin hydrogels for cell delivery or tissue engineering 85 18 10

A 3-D Constitutive Model for Finite Element Analyses of Agarose with a Range of Gel Concentrations 85 18 4

Precise, high-throughput production of multicellular spheroids with a bespoke 3D bioprinter 85 18

A New Form of Decellularized Extracellular Matrix Hydrogel for Treating Ischemic Tissue via Intravascular Infusion 85 10

Primary Human Hepatocytes Maintain Long-term Functions in Porous Silk Scaffolds Containing Extracellular Matrix Proteins 85 18

Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages 85 10 3

Identifiability of Tissue Material Parameters from Uniaxial Tests using Multi-start Optimization 85 38 18 4

Nanovibrational stimulation of mesenchymal stem cells induces therapeutic reactive oxygen species and inflammation for 3D bone tissue engineering 85 57 18 10

Development of novel apoptosis-assisted lung tissue decellularization methods 85 18 10

Real-time Ratiometric Imaging of Micelles Assembly State in a Microfluidic Cancer-on-a-chip 85 18 8

A novel Organ-Chip system emulates three-dimensional architecture of the human epithelia and allows fine control of mechanical forces acting on it. 85 18

Plant-derived Cellulose Scaffolds for Bone Tissue Engineering. 85 57 18 10

Tissue specific muscle extracellular matrix hydrogel improves skeletal muscle regeneration in vivo over non-matched tissue source 85 57 10

Subject-specific mechanical loading of bones: Improved healing of mouse vertebral defects using adaptive loading regimes. 85 18

An In situ Collagen-HA Hydrogel System Promotes Survival and Preserves the Proangiogenic Secretion of hiPSC-derived Vascular Smooth Muscle Cells 85 57 10 3

Microengineered three-dimensional collagen landscapes with independently tunable fiber anisotropy and directionality 85 18 8

Evaluation of Alginate-Based Bioinks for 3D Bioprinting, Mesenchymal Stromal Cell Osteogenesis, and Application for Patient-Specific Bone Grafts 85 57 18 15 10

The transcriptional landscape of a hepatoma cell line grown on scaffolds of extracellular matrix proteins 57 9 3

Biofabrication of muscle fibers enhanced with plant viral nanoparticles using surface chaotic flows 85 7

Processing variables of direct-write, near-field electrospinning impact size and morphology of gelatin fibers 85 18

Mechanics and Differential Healing Outcomes of Small and Large Defect Injuries of the Tendon-Bone Attachment in the Rat Rotator Cuff 85 15 10

Improved accuracy and precision of bioprinting through progressive cavity pump-controlled extrusion 85 18

Metabolomic Profiling and Mechanotransduction of Single Chondrocytes Encapsulated in Alginate Microgels 85 18 10

Tyrosine-Derived Polycarbonate Nerve Guidance Tubes Elicit Pro-Regenerative Extracellular Matrix Deposition When Used to Bridge Segmental Nerve Defects in Swine 85 10

Perivascular Secretome Influences Hematopoietic Stem Cell Maintenance in a Gelatin Hydrogel 57 18 10

Fast 3D printing of large-scale biocompatible hydrogel models 85 18

Inclusion of a 3D-printed Hyperelastic bone mesh improves mechanical and osteogenic performance of a mineralized collagen scaffold 85 57 18

Mechanical Regulation of Microvascular Angiogenesis 94 85 3

Myocardial matrix material supports a proliferative microenvironment for cardiomyocytes 128 85 57 10 3

Integrating Engineered Macro Vessels with Self-assembled Capillaries in 3D Implantable Tissue for Promoting Vascular Integration In-vivo 94 85 18 10

A biomimetic liver model recapitulating bio-physical properties and tumour stroma interactions in hepatocellular carcinoma 85 14 10

An Inducible Model for Unraveling the Effects of Advanced Glycation End-Products in Collagen with Age and Diabetes 85 10

Single cell transfection of human induced pluripotent stem cells using a droplet-based microfluidic system. 57 18 4

Acoustofluidic Assembly of 3D Neurospheroids to Model Alzheimer's Disease 32 18 10

An Organoid for woven Bone 57 18 3

Biomimetic system design for engineering biofidelic 3-D respiratory tissues in vitro 7

Engineering Functional Pseudo-Islets of Defined Sizes from Primary Murine Cells Using PEG Microwell Devices 109 85 57 10 3

3D-printed drug testing platform based on a 3D model of aged human skeletal muscle 85 18

Reconstruction of Bone Defect Based on the Fusion of Osteoblasts and MSM/HA/PLGA Porous Scaffolds 85 18

Controlled Release of Anti-inflammatory and Pro-angiogenic Factors from Macroporous Scaffolds 85 10

Capturing Neonatal Cardiomyocyte - Endothelial interactions on-a-Chip 85 18

Anisotropic mineralized collagen scaffolds accelerate osteogenic response in a glycosaminoglycan-dependent fashion 85 57 3

Utilizing Q-Learning to Generate 3D Vascular Networks for Bioprinting Bone 85 18 4

Percolation of Microparticle Matrix Promotes Cell Migration and Integration while Supporting Native Tissue Architecture 85 18 3

Intercellular signaling dynamics from a single cell atlas of the biomaterials response 85 18 9

Tissue mimetic hyaluronan bioink containing collagen fibers with controlled orientation modulating cell morphology and alignment. 85 18

Aptamer based spatiotemporally controlled growth factor patterning for tunable local microvascular network formation in engineered tissues 85 18

Priming of MSCs with inflammation-relevant signals affects extracellular vesicle biogenesis, surface markers, and modulation of T cell subsets 110 10 3

Longitudinal in vivo micro-CT-based approach allows spatio-temporal characterization of fracture healing patterns and assessment of biomaterials in mouse femur defect models 85 18 15 10

Plant Scaffolds Support Motor Recovery and Regeneration in Rat Spinal Cord Injury 85 57 10

An organotypic in vitro model of matured blood vessels 94 85 18

A novel method for sensor-based quantification of single/multi-cellular traction dynamics and remodeling in 3D matrices 85 18 14

Dynamic Loading of Human Engineered Heart Tissue Enhances Contractile Function and Drives Desmosome-linked Disease Phenotype 85 18

3D Hyaluronic Acid Hydrogels for Modeling Oligodendrocyte Progenitor Cell Behavior as a Function of Matrix Stiffness 85 57 18

A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling 85 10

Bi-directional Impacts of Heterotypic Interactions in Engineered 3D Human Cardiac Microtissues Revealed by Single-Cell RNA-Sequencing and Functional Analysis 85 57 9

High-throughput measurements of intra-cellular and secreted cytokine from single spheroids using anchored microfluidic droplets 18

In vitro modeling of tumor spheroid interactions to perfused blood vessels 94 85 57 14 3

Driving Hierarchical Collagen Fiber Formation for Functional Tendon, Ligament, and Meniscus Replacement 85 18

Stiffness of Nanoparticulate Mineralized Collagen Scaffolds Triggers Osteogenesis via Mechanotransduction and Canonical Wnt Signaling 156 85 57 3

Double-layer flexible neuronal probe with closely spaced electrodes for high-density in vivo brain recordings 85 18

Injectable therapeutic organoids using sacrificial hydrogels 85 18

Synergistic effects of conductivity and cell-imprinted topography of chitosan-polyaniline based scaffolds for neural differentiation of adipose-derived stem cells 169 7

Highly efficient cardiac differentiation and maintenance by thrombin-coagulated fibrin hydrogels enriched with decellularized porcine heart extracellular matrix 85 57 18

Engineering of extracellular vesicles for display of protein biotherapeutics 110 85 10 3

Bacterial envelope damage inflicted by bioinspired nanospikes grown in a hydrogel 85 18 8

An in vitro Chondro-osteo-vascular Triphasic Model of the Osteochondral Complex 85 57 18 10

Tough and Tunable Scaffold-Hydrogel Composite Biomaterial for Soft-to-Hard Musculoskeletal Tissue Interfaces 85 18

Biomechanical characterization of endothelial cells exposed to shear stress using acoustic force spectroscopy 85 55 18

Artificial scaffolds that mimic the plant extracellular environment for the culture and attachment of plant cells 85 20 3

Thrombin-free polymerization leads to pure fibrin(ogen) materials with extended processing capacity 85 18

Effect of Cellular and ECM Aging on Human iPSC-derived Cardiomyocyte Performance, Maturity and Senescence 57 10 3

Improved Wound Closure Rates and Mechanical Properties Resembling Native Skin in Murine Diabetic Wounds Treated with a Tropoelastin and Collagen Wound Healing Device 85 10

An Automated Addressable Microfluidics Device for Minimally-Invasive Manipulation of Cells and Fluids within Living Cultures 85 18

Cell shape, and not 2D migration, predicts ECM-driven 3D cell invasion in breast cancer 112 14 4

An acoustic platform for single-cell, high-throughput measurements of the viscoelastic properties of cells 18 8

Measuring the density and viscosity of culture media for optimized computational fluid dynamics analysis of in vitro devices 85 18 15

Mechanical Heterogeneity in the Bone Microenvironment as Characterised by Atomic Force Microscopy 18

Sputtered porous Pt for wafer-scale manufacture of low-impedance flexible microelectrodes 85 18 2

Optimizing 3-dimensional human skin models to facilitate long-term development of Onchocerca volvulus, a debilitating obligatory human parasite 85 10

Development of a finite element model to predict the cellular micromechanical environment in tissue engineering scaffolds 85 18 15

Quantification of iPSC-derived vascular networks in novel phototunable angiogenic hydrogels 6

Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites 85 18 8

Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model 186 14 10 3

Molecular control of interfacial protein structure on graphene-based substrates steers cell fate 85 18 8

Multidimensional hydrogel models reveal endothelial network angiocrine signals increase glioblastoma cell number, invasion, and temozolomide resistance 14 3