Topic 169

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38 items. Top items listed below.

Population dynamics and neuronal polyploidy in the developing neocortex 169 7

PaintSHOP enables the interactive design of transcriptome- and genome-scale oligonucleotide FISH experiments 169 7 4

TuNR: Orthogonal Control of Mean and Variability of Endogenous Genes in a Human Cell Line 169 7

Targeted molecular profiling of rare cell populations identifies olfactory sensory neuron fate and wiring determinants 169 7 3

Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm 169 7 3

Chip-seq and gene expression data for the identification of functional sub-pathways: a proof of concept in lung cancer 169 7 4

Lineage recording reveals dynamics of cerebral organoid regionalization 169 7

FGF signaling in development beyond canonical pathways 169 7 3

Resolving Cargo-motor-track Interactions in Living Cells with Bifocal Parallax Single Particle Tracking 169 7

A Minimal Self-Organization model of the Golgi Apparatus 169 7

Scalable Analysis of Authentic Viral Envelopeson FRONTERA 169 7 1

Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives 169 7 3

Computational Model of G2-M DNA Damage Checkpoint Regulation in Normal and p53-null Cancer Cells 7 3

Rewiring the specificity of extra-cytoplasmic function sigma factors 169 7

Synthetic Turing patterns in engineered microbial consortia 169 7

Light-activated signaling in DNA-encoded sender-receiver architectures 169 7

On the diversity of chemical power supply as a determinant of biological diversity 7 5

Mapping cell structure across scales by fusing protein images and interactions 169 7 4

Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis 169 60 7

Independence of 3D chromatin conformation and gene regulation during Drosophila dorsoventral patterning 89 7 3

DeepGANnel: Synthesis of fully annotated single molecule patch-clamp data using generative adversarial networks 169 7 4

Image-based pooled whole genome CRISPR screening for Parkin and TFEB subcellular localization 169 7

Nested Stochastic Block Models Applied to the Analysis of Single Cell Data 7 4

Evaluation of TH-Cre knock-in cell lines for detection and specific targeting of stem cell-derived dopaminergic neurons 169 57 7

MORONET: Multi-omics Integration via Graph Convolutional Networks for Biomedical Data Classification 7 4

Mapping cellular nanoscale viscoelasticity and relaxation times relevant to growth of living Arabidopsis thaliana plants using multifrequency AFM 169 7

Method for identification of heme-binding proteins and quantification of their interactions 7 4

A robust method for generating, quantifying and testing large amounts of Escherichia coli persisters 7 4

Simulating bout-and-pause patterns with reinforcement learning 7 2

Rational Design of Minimal Synthetic Promoters for Plants 7

Identification of antibiotics for use in selection of the chytrid fungi Batrachochytrium dendrobatidis and Batrachochytrium salamandrivorans 169 7

Measurement of hindered diffusion in complex geometries for high-speed single-molecule experiments 169 7

High-surety isothermal amplification and detection of SARS-CoV-2, including with crude enzymes 169 7

A one-enzyme RT-qPCR assay for SARS-CoV-2, and procedures for reagent production 169 35 7 1

Invasion of homogeneous and polyploid populations in nutrient-limiting environments 169 7

Designer protein assemblies with tunable phase diagrams in living cells 7

Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in C. elegans 169 7 3

Achieving functional neuronal dendrite structure through sequential stochastic growth and retraction 169 7

LIVE-PAINT: Super-Resolution Microscopy Inside Live Cells Using Reversible Peptide-Protein Interactions 7 4

MAGIC: Mosaic Analysis by gRNA-Induced Crossing-over 7 4

Noncanonical targeting contributes significantly to miRNA-mediated regulation. 7

Association of cellular and subcellular calcification with phosphorylated tau in the brains of Alzheimer's disease patients. 7

Computational Elucidation of self-organization of E. coli chromosome underlying HI-C data 169 7

Lyophilized cell-free systems display tolerance to organic solvent exposure 169 7

Dissecting the impact of metabolic environment on three common cancer cell phenotypes 7

Conformational state switching and pathways of chromosome dynamics in cell cycle 7

Integrating deep learning with microfluidics for biophysical classification of sickle red blood cells 169 7 4

Antithetic integral feedback for the robust control of monostable and oscillatory biomolecular circuits 7 4

A predictive model of gene expression reveals the role of regulatory motifs in the mating response of yeast 7

Structure of the full SARS-CoV-2 RNA genome in infected cells 1

Improved detection of tumor suppressor events in single-cell RNA-Seq data 7 4

Macroscale network feedback structure of transcriptome during cell fate transition 7

Calculation of fungal and bacterial inorganic nitrogen immobilization rates in soil 7 5

Intuitive, reproducible high-throughput molecular dynamics in Galaxy: a tutorial 7 4

First responders shape a prompt and sharp NF-κB-mediated transcriptional response to TNF-α 7 3

Genome-wide assessment of REST binding profiles reveals distinctions between human and mouse hippocampus 7 3

Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant common complex traits 7 3

Upregulation and cell specificity of C4 genes are derived from ancestral C3 gene regulatory networks 7 3

CoRE-ATAC: A deep learning model for the functional classification of regulatory elements from single cell and bulk ATAC-seq data 31 7 4

Generation of clonal male and female mice through CRISPR/Cas9-mediated Y chromosome deletion in embryonic stem cells 7 3

Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation 7

Zinc finger protein SALL4 functions through an AT-rich motif to regulate gene expression 7 3

Linking the dynamics of chromatin occupancy and transcription with predictive models 7

Synergistic effects of conductivity and cell-imprinted topography of chitosan-polyaniline based scaffolds for neural differentiation of adipose-derived stem cells 169 7

Multicellular feedback control of a genetic toggle-switch in microbial consortia 7

Scaled Recoupling of Chemical Shift Anisotropies at High Magnetic Fields under MAS with Interspersed C-elements 169 7

Insights into gene expression changes under conditions that facilitate horizontal gene transfer (mating) of a model Archaeon 7

Biophysical modeling of the SARS-CoV-2 viral cycle reveals ideal antiviral targets 7 1

MicroRNA-19b regulates proliferation and differentiation along the medial-lateral axis of the developing avian pallium 7 3

Spatial Variation of Microtubule Depolymerization in Large Asters Suggests Regulation by MAP Depletion 7

A two-step approach to testing overall effect of gene-environment interaction for multiple phenotypes 7 4

Allostery through DNA drives phenotype switching 7 3

DiffNets: Self-supervised deep learning to identify the mechanistic basis for biochemical differences between protein variants 7

Molecular architecture of the developing mouse brain 7 3

Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV 7 1

Imaging LexA degradation in cells explains regulatory mechanisms and heterogeneity of the SOS response 7 3

Measuring both microbial load and diversity with a single amplicon sequencing library 7 4

PRER: A Patient Representation with Pairwise Relative Expression of Proteins on Biological Networks 184 7 4

Tunable phenotypic variability through an autoregulatory alternative sigma factor circuit 7

Protein context shapes the specificity of domain-peptide interactions in vivo 7

Binding of the SARS-CoV-2 Spike Protein to Glycans 7 1

Analysis of neuronal Ca2+ handling properties by combining perforated patch clamp recordings and the added buffer approach 169 7

Asymmetric representation of aversive prediction errors in Pavlovian threat conditioning 7 2

Loop extrusion model predicts CTCF interaction specificity 7

Adaptation of STARR-seq method to be used with 3rd generation integrase-deficient promoterless lentiviral vectors 7 4

Bacterial Controller Aided Wound Healing: A Case Study in Dynamical Population Controller Design 7

Asymmetric neurogenic commitment of retinal progenitors is regulated via the Notch endocytic pathway 7 3

Disentangling the biological information encoded in disordered mitochondrial morphology through its rapid elicitation by iCMM 7

Proof of concept continuous event logging in living cells 7

The adaptive architecture is shaped by population ancestry and not by selection regime 7 5

Two classes of active transcription sites and their roles in developmental regulation 7 3

NK cells acquire PD-1 from the membrane of tumor cells. 7 3

Scale-free structure of cancer networks and their vulnerability to hub-directed combination therapy 7

Sequential Activation of Guide RNAs for Algorithmic Multiplexing of Cas9 Activities 169 33 7

Modulation of the promoter activation rate dictates the transcriptional response to graded BMP signaling levels in the Drosophila embryo 7 3

A CRISPR-based SARS-CoV-2 diagnostic assay that is robust against viral evolution and RNA editing 35 7 1

Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations 7

The potential role of miR-21-3p in coronavirus-host interplay 7 1

Scalable recombinase-based gene expression cascades 7

Global and local tension measurements in biomimetic skeletal muscle tissues reveals early mechanical homeostasis 169 18 7