Topic 57

stem pluripotent differentiation cells cell derived progenitor regeneration mesenchymal progenitors bone culture differentiated vitro regenerative hematopoietic human marrow lineage tissue vivo biology proliferation organoids induced ipsc adult transplantation organoid bioengineering developmental epithelial cultures cellular injury mature markers differentiate repair expression hsc mscs fate niche embryonic hscs cultured renewal stromal ipscs osteogenic capacity fetal mouse muscle development msc multipotent mice epithelium single hematopoiesis therapeutic into endothelial maturation cardiomyocytes 3d formation rna maintenance after wnt potential skeletal hpsc therapies self expansion cardiac matrix proliferative hipsc types medicine tissues phenotype aged homeostasis disease murine fibroblasts tracing blood recapitulate patient collagen pluripotency generate system

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Single cell transcriptional and functional analysis of human dopamine neurons in 3D fetal ventral midbrain organoid like cultures 57 20 9 3

Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson's disease. 54 11 3

Interspecies Chimeric Conditions Affect the Developmental Rate of Human Pluripotent Stem Cells 57 20 9

Evolving Transcriptomic Signature of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cells With Age 57 9 3

Differentiation of human intestinal organoids with endogenous vascular endothelial cells 57 20 9 3

Human microglia upregulate cytokine signatures and accelerate maturation of neural networks 57 20 9 3

Extra-hematopoietic immunomodulatory role of the SCID-susceptibility gene DOCK-2 identified by stepwise maturation of human iPSCs into clonogenic mesodermal stromal progenitors 57 10 3

Lactate promotes cardiomyocyte dedifferentiation through metabolic reprogramming 57 3

Single cell RNA sequence analysis of human bone marrow samples reveals new targets for isolation of skeletal stem cells using DNA-coated gold nanoparticles 172 57 43 9 4

Doxycycline Significantly Enhances Induction of iPSCs to Endoderm by Enhancing survival via AKT Phosphorylation 57 20 3

Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity 57 11 10 3

Revealing cellular heterogeneity and in vitro differentiation trajectory of cultured human endometrial mesenchymal-like stem cells using single-cell RNA sequencing 172 57 9 3

3D cell culture models demonstrate a role for FGF and WNT signaling in regulation of lung epithelial cell fate and morphogenesis 57 20 3

Cell-type specific impact of glucocorticoid receptor activation on the developing brain 168 65 57 11 9 3

Novel epigenetic clock for fetal brain development predicts fetal epigenetic age for iPSCs and iPSC-derived neurons. 57 20 11 9

Characterization of human-iPSCs derived spinal motor neurons by single-cell RNA sequencing 57 9

Generation of kidney ureteric bud and collecting duct organoids that recapitulate kidney branching morphogenesis 57 20 3

Scalable generation of mesenchymal stem cells and adipocytes from human pluripotent stem cells 172 57 20 3

Effect of Cellular and ECM Aging on Human iPSC-derived Cardiomyocyte Performance, Maturity and Senescence 57 10 3

Self-assembly of progenitor cells under the aegis of platelet factors facilitates human skin organoid formation and vascularized wound healing 57 20 10 3

Modeling cellular crosstalk and organotypic vasculature development with human iPSC-derived endothelial cells and cardiomyocytes 57 20 3


Notch Signaling Commits Mesoderm to the Cardiac Lineage 20 3

Derivation of Isogenic Mesodermal and Ectomesodermal Chondrocytes from Human Induced Pluripotent Stem Cells for Articular Cartilage Regeneration 57 20 9 3

Transcriptome and epigenome diversity and plasticity of muscle stem cells following transplantation 57 20 9 3

Definition and Signatures of Lung Fibroblast Populations in Development and Fibrosis in Mice and Men 148 120 57 9 3

Atypical neurogenesis in induced pluripotent stem cell (iPSC) from autistic individuals 57 20 11 9 3 2

Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of mesenchymal stem cells upon ageing 57 3

Perivascular Secretome Influences Hematopoietic Stem Cell Maintenance in a Gelatin Hydrogel 57 18 10

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism 73 57 1

Time-course single-cell RNA sequencing reveals transcriptional dynamics and heterogeneity of limbal stem cells derived from human pluripotent stem cells 172 57 20 9

Leveraging complex interactions between signaling pathways involved in liver development to robustly improve the maturity and yield of pluripotent stem cell-derived hepatocytes 172 57 20 3

Modulation of Aplnr signaling is required during the development and maintenance of the hematopoietic system 57 20 3

Impact of sustained TGFβ receptor inhibition on chromatin accessibility and gene expression in cultured human endometrial MSC 57 20 3

Establishing cell-intrinsic limitations in cell cycle progression controls graft growth and promotes differentiation of pancreatic endocrine cells 57 20 3

Developing Human Pluripotent Stem Cell-Based Cerebral Organoids with a Controllable Microglia Ratio for Modeling Brain Development and Pathology 57 11 3

Single-cell sequencing of human iPSC-derived cerebellar organoids shows recapitulation of cerebellar development 57 20 9 3

Integrated analysis of high throughput transcriptomic data revealed specific gene expression signature of cardiomyocytes 172 120 57 9

Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine. 172 57 20 3

Activated iPSC-microglia from C9orf72 ALS/FTD patients exhibit endosomal-lysosomal dysfunction 61 57 3

Single-cell transcriptomics, scRNA-Seq and C1 CAGE discovered distinct phases of pluripotency during naïve-to-primed conversion in mice 57 20 9 3

Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells 57 20 3

Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA 57 20 18 3

Controlling the switch from neurogenesis to pluripotency during marmoset monkey somatic cell reprogramming with self-replicating mRNAs and small molecules 57 20 18 10

Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation 57 9

Mitochondrial, cell cycle control and neuritogenesis alterations in an iPSC-based neurodevelopmental model for schizophrenia 95 57 3

Cathepsin K maintains the number of lymphocytes in vivo 57 20 3

Cell-intrinsic differences between human airway epithelial cells from children and adults 73 57 1

Lineage recording reveals dynamics of cerebral organoid regionalization 169 7

TWIST1 controls cellular senescence and energy metabolism in mesenchymal stem cells 57 3

Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors 73 36 1

Transcriptomic analysis of naïve human embryonic stem cells cultured in three-dimensional PEG scaffolds 57 20 3

An Organoid for woven Bone 57 18 3

Docosahexaenoic acid has stem cell-specific effects in the SVZ and restores olfactory neurogenesis and function in the aging brain 57 3

Hematopoietic progenitors polarize in contact with bone marrow stromal cells by engaging CXCR4 receptors. 57 20 3

A single cell atlas of human cornea that defines its development, limbal stem and progenitor cells and the interactions with the limbal niche 57 20 9 3

Cell-type specific in vitro gene expression profiling of stem-cell derived neural models 57 9 3

Reconstitution of intestinal stem cell niche in vitro with pharmacological inhibitors or L-WRN conditioned medium differentially regulates epithelial proliferation, differentiation and barrier function in rabbit caecum organoids 57 18

Direct reprogramming of adult hepatocytes to generate LGR5+ endodermal progenitor 57 20 3

Quantitative and molecular differences distinguish adult human medullary and extramedullary haematopoietic stem and progenitor cell landscapes 57 20 9 3

3D bioprinting of co-cultured osteogenic spheroids for bone tissue fabrication 85 57 18

The transcriptional landscape of a hepatoma cell line grown on scaffolds of extracellular matrix proteins 57 9 3

Profiling of the reprogramome and quantification of fibroblast reprogramming to pluripotency 57 20 9 3

Characterizing and inferring quantitative cell cycle phase in single-cell RNA-seq data analysis 43 9 4

Mechanical Regulation of Stem Cell Proliferation and Fate Decisions by their Differentiated Daughters 57 20 3

Organ-on-a-chip model of vascularized human bone marrow niches 57 18 3

Single-cell RNA-seq analysis of human iPSC-derived motor neurons resolves early and predictive ALS signatures 61 57 20 9 3

Single cell transfection of human induced pluripotent stem cells using a droplet-based microfluidic system. 57 18 4

Zinc Metabolic Defect of Aging Alveolar Progenitors in Progressive Pulmonary Fibrosis 57 3

Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells 148 57 9 3

Human iPSC-derived cerebral organoids model features of Leigh Syndrome and reveal abnormal corticogenesis 57 20 10 3

Transcriptomic entropy benchmarks stem cell-derived cardiomyocyte maturation against endogenous tissue at single cell level 43 4

Enteric glia as a source of neural progenitors in adult zebrafish 57 20 11 3

SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response 73 1

Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells 20 3

Heterogeneity of Neuroepithelial Cells and Radial Glia 133 120 20 9

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy 152 14 9 3

Transcription factors involved in stem cell maintenance are downstream of Slug/Snail2 and repressed by TGF-β in bronchial basal stem/progenitor cells from COPD 57 20 9 3

Skeletal muscle-derived Human Mesenchymal Stem Cells: influence of different culture conditions on proliferative and myogenic capabilities 57 10

Selective silencing rather than targeted activation of gene expression underlies fate choice in human hematopoietic stem cells. 31 20 9 3

Boolean Implication Analysis Improves Prediction Accuracy of In Silico Gene Reporting of Retinal Cell Types 43 4

Single Cell Transcriptomics-guided Antisense Treatment Improves Endoderm Differentiation of iPSCs 57 20 9 3

Neuronal Modeling of Alternating Hemiplegia of Childhood Reveals Transcriptional Compensation and Replicates a Trigger-Induced Phenotype 57 10 3

Integrated analysis of glycan and RNA in single cells 57 43 9 4

Integrative Single-cell RNA-Seq and ATAC-Seq Analysis of Human Foetal Liver and Bone Marrow Haematopoiesis 57 31 20 9 3

A systematic dissection of human primary osteoblasts in vivo at single-cell resolution 120 43 9 3

Single cell analysis of colorectal cancer identifies mitogen-activated protein kinase as a key driver of tumor cell plasticity 152 148 142 14 9 3

Differentiation of ciliated human midbrain-derived LUHMES neurons 57 20 3

High-throughput organoid screening enables engineering of intestinal epithelial composition 57 18 3

Over-Confluence of expanded bone marrow mesenchymal stem cells ameliorates their chondrogenic capacity in 3D cartilage tissue engineering 57 20 18 3

Type II collagen-positive progenitors are major stem cells to control skeleton development and vascular formation 57 20 3

Orthotopic Transplantation and Engraftment of Human Induced Pluripotent Stem Cell-Derived Alveolar Progenitor Cells into Murine Lungs 57 20 10 3

Single-cell RNA sequencing of human, macaque, and mouse testes uncovers conserved and divergent features of mammalian spermatogenesis 120 57 20 9 3

Optimising DNA-Coated Gold Nanoparticles to Enrich Skeletal Stem Cells from Human Bone Marrow Samples 172 57 18

GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells 57 20 18

An organoid and multi-organ developmental cell atlas reveals multilineage fate specification in the human intestine 57 20 9 3

Modeling human TBX5 haploinsufficiency predicts regulatory networks for congenital heart disease 57 20 9 3

Lithium directs embryonic stem cell differentiation versus hemogenic endothelium 57 20 3

3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels 85 57 18 10

Evidence of Increased Hemangioblastic and Early Hematopoietic Potential in Chronic Myeloid Leukemia (CML)-derived Induced Pluripotent Stem Cells (iPSC) 57 20 3