Topic 172

stem differentiation bone derived regenerative adipose mesenchymal cells cell skeletal biology multipotent developmental stromal adipocytes marrow cartilage tissue organoids fate fetal markers osteogenic chondrocytes differentiate therapeutic sscs organoid identify adult mscs human culture vitro intestinal regeneration marker hpscs knowledge differentiated robustly potential adipogenic hpsc specific proliferation pluripotent subpopulations formation epithelium hbmscs development cultures enrich protocol medicine proved progenitor epigenetic lsd1 describe have grown characteristics heterogeneity notch single intestine muscle injury new endochondral reparative paneth ssc scalable chondrogenic electrically osteocytes identified tissues expressed ossification undefined best spp1 contain cultured osteoblasts trajectory wnt protocols lack pseudotime counterparts concept study chondrocyte population there

29 items. Top items listed below.

Single cell RNA sequence analysis of human bone marrow samples reveals new targets for isolation of skeletal stem cells using DNA-coated gold nanoparticles 172 57 43 9 4

Optimising DNA-Coated Gold Nanoparticles to Enrich Skeletal Stem Cells from Human Bone Marrow Samples 172 57 18

Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine. 172 57 20 3

Revealing cellular heterogeneity and in vitro differentiation trajectory of cultured human endometrial mesenchymal-like stem cells using single-cell RNA sequencing 172 57 9 3

Scalable generation of mesenchymal stem cells and adipocytes from human pluripotent stem cells 172 57 20 3

Mechanisms of interaction of staphylococcus aureus with human mesenchymal stem cells and their differentiated phenotypes 172 57 3

Hypoxia Depletes Contaminating CD45+ Hematopoietic Cells from Bone Marrow Stromal Cell (BMSC) Cultures: Methods for BMSC Culture Purification 172 57 10

Integrated analysis of high throughput transcriptomic data revealed specific gene expression signature of cardiomyocytes 172 120 57 9

Time-course single-cell RNA sequencing reveals transcriptional dynamics and heterogeneity of limbal stem cells derived from human pluripotent stem cells 172 57 20 9

Leveraging complex interactions between signaling pathways involved in liver development to robustly improve the maturity and yield of pluripotent stem cell-derived hepatocytes 172 57 20 3

A theoretical framework to study the influence of electrical fields on mesenchymal stem cells 172 127 38 18

Unravelling the developmental roadmap towards human brown adipose tissue 172 57 39 20 10

LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium 172 57 20 3

High-resolution architecture of human epiphysis formation 172 57 20

Isolation, culture and maintenance of rabbit intestinal organoids, and organoid-derived cell monolayers 172 57 20 18

High-content analysis reveals senescence of cultured canine adipose-derived mesenchymal stromal cells to be reversible with a novel immortalization approach 172 57 3

A semi-automated intestinal organoid screening method demonstrates epigenetic control of epithelial maturation 172 57

Inferring metabolic rewiring in embryonic neural development using single cell data 172 20 9

Notch effector Hes1 marks an early perichondrial population of skeletal progenitor cells at the onset of endochondral bone development 172 20 9 3

Osteogenic differentiation potential and marker gene expression of different porcine bone marrow mesenchymal stem cell subpopulations selected in different basal media 172 57

Developmental co-emergence of cardiac and gut tissues modeled by human iPSC-derived organoids 172 57 20 3

Characterization of SOX2, OCT4 and NANOG in ovarian cancer tumor-initiating cells 172 14 9

Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle 172 20 3

Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells 148 57 9 3

Smooth muscle-specific MMP17 (MT4-MMP) defines the intestinal ECM niche 172 57 20 3

miR-206 knockout shows it is critical for myogenesis and directly regulates newly identified target mRNAs 172 74 49 33 3

Differentiation of human intestinal organoids with endogenous vascular endothelial cells 57 20 9 3

Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson's disease. 54 11 3

Transcriptome and epigenome diversity and plasticity of muscle stem cells following transplantation 57 20 9 3

Evolving Transcriptomic Signature of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cells With Age 57 9 3

Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity 57 11 10 3

The transcriptome of regenerating zebrafish scales identifies genes involved in human bone disease 172 9

Derivation of Isogenic Mesodermal and Ectomesodermal Chondrocytes from Human Induced Pluripotent Stem Cells for Articular Cartilage Regeneration 57 20 9 3

Interspecies Chimeric Conditions Affect the Developmental Rate of Human Pluripotent Stem Cells 57 20 9

Single cell transcriptional and functional analysis of human dopamine neurons in 3D fetal ventral midbrain organoid like cultures 57 20 9 3

Reconstitution of intestinal stem cell niche in vitro with pharmacological inhibitors or L-WRN conditioned medium differentially regulates epithelial proliferation, differentiation and barrier function in rabbit caecum organoids 57 18

TWIST1 controls cellular senescence and energy metabolism in mesenchymal stem cells 57 3

Transcriptomic entropy benchmarks stem cell-derived cardiomyocyte maturation against endogenous tissue at single cell level 43 4

Boolean Implication Analysis Improves Prediction Accuracy of In Silico Gene Reporting of Retinal Cell Types 43 4

Doxycycline Significantly Enhances Induction of iPSCs to Endoderm by Enhancing survival via AKT Phosphorylation 57 20 3

Human microglia upregulate cytokine signatures and accelerate maturation of neural networks 57 20 9 3

An organoid and multi-organ developmental cell atlas reveals multilineage fate specification in the human intestine 57 20 9 3


Over-Confluence of expanded bone marrow mesenchymal stem cells ameliorates their chondrogenic capacity in 3D cartilage tissue engineering 57 20 18 3

Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells 20 3

Impact of sustained TGFβ receptor inhibition on chromatin accessibility and gene expression in cultured human endometrial MSC 57 20 3

Lactate promotes cardiomyocyte dedifferentiation through metabolic reprogramming 57 3

Type II collagen-positive progenitors are major stem cells to control skeleton development and vascular formation 57 20 3

An Organoid for woven Bone 57 18 3

Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA 57 20 18 3

A mesh microelectrode array for non-invasive electrophysiology within neural organoids 172 85 18

3D cell culture models demonstrate a role for FGF and WNT signaling in regulation of lung epithelial cell fate and morphogenesis 57 20 3

Single-cell analysis identifies TCF4 and ID3 as a molecular switch of mammary epithelial stem cell differentiation. 20 9 3

Direct reprogramming of adult hepatocytes to generate LGR5+ endodermal progenitor 57 20 3

Bone marrow stromal cells induce an ALDH+ stem cell-like phenotype in AML cells through TGF-β-p38-ALDH2 pathway 108 14 10 3

3D bioprinting of co-cultured osteogenic spheroids for bone tissue fabrication 85 57 18

Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of mesenchymal stem cells upon ageing 57 3

Single-cell analyses of the corneal epithelium: Unique cell types and gene expression profiles 148 120 20 9 3

3D chromatin organization changes modulate adipogenesis and osteogenesis 31 9 3

Differentiation reveals the plasticity of age-related change in murine muscle progenitors 57 20

Global computational alignment of tumor and cell line transcriptional profiles 43 14 9 4

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy 152 14 9 3

Definition and Signatures of Lung Fibroblast Populations in Development and Fibrosis in Mice and Men 148 120 57 9 3

Notch Signaling Commits Mesoderm to the Cardiac Lineage 20 3

Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport 172 10 3

GLP-1 Notch - LAG-1 CSL control of the germline stem cell fate is mediated by transcriptional targets lst-1 and sygl-1 20 9 3

Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model 20 9 3

Single cell transfection of human induced pluripotent stem cells using a droplet-based microfluidic system. 57 18 4

Integrative Single-cell RNA-Seq and ATAC-Seq Analysis of Human Foetal Liver and Bone Marrow Haematopoiesis 57 31 20 9 3

High-throughput organoid screening enables engineering of intestinal epithelial composition 57 18 3

A single cell atlas of human cornea that defines its development, limbal stem and progenitor cells and the interactions with the limbal niche 57 20 9 3

scATAC-Seq reveals epigenetic heterogeneity associated with an EMT-like process in male germline stem cells and its regulation by G9a 98 31 9 3

HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signaling 39 3

TGF-β-driven downregulation the expression of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα+ fibroblasts 57 20 3

Single-cell transcriptomics, scRNA-Seq and C1 CAGE discovered distinct phases of pluripotency during naïve-to-primed conversion in mice 57 20 9 3

Transcription factors involved in stem cell maintenance are downstream of Slug/Snail2 and repressed by TGF-β in bronchial basal stem/progenitor cells from COPD 57 20 9 3

Effect of Cellular and ECM Aging on Human iPSC-derived Cardiomyocyte Performance, Maturity and Senescence 57 10 3

Global Profiling of the Lysine Crotonylome in Different Pluripotent States 45 20 3

Generation of kidney ureteric bud and collecting duct organoids that recapitulate kidney branching morphogenesis 57 20 3

Skeletal muscle-derived Human Mesenchymal Stem Cells: influence of different culture conditions on proliferative and myogenic capabilities 57 10

Single-cell sequencing of human iPSC-derived cerebellar organoids shows recapitulation of cerebellar development 57 20 9 3

Unsupervised cell interaction profiling reveals major architectural differences between small intestinal and colonic epithelial crypts 148 57 43 20 9

Characterization of human-iPSCs derived spinal motor neurons by single-cell RNA sequencing 57 9

Cell-type specific impact of glucocorticoid receptor activation on the developing brain 168 65 57 11 9 3

Single-cell transcriptome profiling an adult human cell atlas of 15 major organs 120 9 3

Single cell analysis of colorectal cancer identifies mitogen-activated protein kinase as a key driver of tumor cell plasticity 152 148 142 14 9 3

ID4 represses myoepithelial differentiation of mammary stem cells through its interaction with HEB 20 3

Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohns disease 148 57 20 9 3

Novel epigenetic clock for fetal brain development predicts fetal epigenetic age for iPSCs and iPSC-derived neurons. 57 20 11 9

Differential expression of transposable elements in stem cell lineages of the preimplantation embryo 81 20 9 3

Enteric glia as a source of neural progenitors in adult zebrafish 57 20 11 3

Single-Cell RNAseq of Out-of-Thaw Mesenchymal Stromal Cells Shows Striking Tissue-of-Origin Differences and Inter-donor Cell-Cycle Variations 120 43 9

Single-Cell Transcriptomic Attributes and Unbiased Computational Modeling for the Prediction of Immunomodulatory Potency of Mesenchymal Stromal Cells 57 10 9

Perivascular Secretome Influences Hematopoietic Stem Cell Maintenance in a Gelatin Hydrogel 57 18 10

Epigenetic regulation of Wnt7b expression by the cis-acting long noncoding RNA lnc-Rewind in muscle stem cells 192 93 20 3

GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells 57 20 18

Profiling of the reprogramome and quantification of fibroblast reprogramming to pluripotency 57 20 9 3

Identification of rare transient somatic cell states induced by injury and required for whole-body regeneration 20 3

Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation 57 9

Chikungunya Virus Infection Impairs The Function Of Osteogenic Cells 41 10 3