Topic 98

mesenchymal emt epithelial transition metastasis cancer tumor invasion metastatic biology cells migration phenotype breast cell invasive aggressive promotes expression carcinoma tgf proliferation matrix cadherin factor cancers tumors prognosis adhesion zeb1 tumour progression extracellular signaling transcription survival vimentin patient wnt pathways stem upregulation associated levels mammary beta upregulated growth ecm plasticity therapeutic microenvironment pathway partial migratory phenotypes met poor kinase enhanced metastases snail drives hybrid knockdown hypoxia dissemination like genes markers tumorigenesis invasiveness subtype loss hypoxic undergo program slug role regulating distant induces acquire thus catenin induction patients increased transcriptional tyrosine lines overexpression epigenetic together marker correlated enriched hallmark process overexpressed

94 items. Top items listed below.

P4HA2 is associated with prognosis, promotes proliferation, invasion, migration and EMT in glioma 98 14 3

NFATc acts as a non-canonical phenotypic stability factor for a hybrid epithelial/mesenchymal phenotype 98 14 3

Loss of CPAP expression promotes sustained EGFR signaling and Epithelial-Mesenchymal Transition in oral cancer cells 98 14 3

Cyclic pentapeptide cRGDfK enhances the inhibitory effect of sunitinib on TGF-β1-induced epithelial-to-mesenchymal transition in human non-small cell lung cancer cells 98 14 10 3

Modeling the effects of EMT-immune dynamics on epithelial cancer progression 98 14 9 3

PRP4K is a haploinsufficient tumour suppressor negatively regulated during epithelial-to-mesenchymal transition 98 14 3

MITF reprograms the extracellular matrix and focal adhesion in melanoma 98 3

Differential RNA editing between epithelial and mesenchymal tumors impacts mRNA abundance in immune response pathways 98 14 9 3

Aged Breast Extracellular Matrix Drives Mammary Epithelial Cells to an Invasive and Cancer-Like Phenotype 98 14 10 3

Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer 98 14 3

Epigenetic downregulation of HER2 during EMT leads to tumor resistance to HER2-targeted therapies in breast cancer 98 14 10 3

Flotillin-upregulation acts as an epithelial-mesenchymal transition driver by promoting sphingosine kinase 2-dependent AXL stabilization 98 34 14 3

Protein arginine methyltransferase 5 promotes metastasis via enhancing EGFR transcription and modulating AKT1 activation by methylation 98 14 3

Comparative study of transcriptomics-based scoring metrics for the epithelial-hybrid-mesenchymal spectrum 98 14 9 4

A computational systems biology approach identifies SLUG as a mediator of partial Epithelial-Mesenchymal Transition (EMT) 98 14 3

TRAF4 inhibits bladder cancer progression by promoting BMP/SMAD signalling pathway 98 14 3

PDZ and LIM domain protein 2 plays dual and context-dependent roles in breast cancer development 98 14 3

Circulating microRNA-762 upregulates colorectal cancer might through Wnt-1/b-catenin signaling 98 74 14 10 3

RUNX1 mitotically bookmarks target genes that are important for the mammary epithelial-to-mesenchymal transition 98 31 20 3

Merkel Cell Polyomavirus Small Tumor Antigen Activates Matrix Metallopeptidase-9 Gene Expression for Cell Migration and Invasion 98 14 3

Partial epithelial-to-mesenchymal transition is prognostic and associates with Slug in head and neck cancer 98 14 10 9 3

Systems biomedicine of primary and metastatic colorectal cancer reveals potential therapeutic targets 98 14 9 3

A novel 3D atomistic-continuum cancer invasion model: In silico simulations of an in vitro organotypic invasion assay 98 38 14

Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition 98 20 3

Adhesion to type I collagen fibrous gels induces E- to N- cadherin switching without other EMT-related phenotypes in lung carcinoma cell A549 98 57 3

CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways 98 3

Transglutaminase-2 facilitates extracellular vesicle-mediated establishment of the metastatic niche 98 14 3

Calumenin contributes to epithelial-mesenchymal transition and predicts poor survival in glioma 98 7

Phenotypic plasticity and partial EMT underlie local invasion and distant metastasis in colon cancer 98 14 3

IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma 98 7 3

Autocrine Signaling by Receptor Tyrosine Kinases in Urothelial Carcinoma of the Bladder 98 14 9 3

scATAC-Seq reveals epigenetic heterogeneity associated with an EMT-like process in male germline stem cells and its regulation by G9a 98 31 9 3

Epigenetic feedback and stochastic partitioning during cell division can drive resistance to EMT 98 14

Epithelial-mesenchymal transition sensitizes breast cancer cells to cell death via the fungus-derived sesterterpenoid ophiobolin A 98 14 10 3

Tasmanian devil facial tumour-derived extracellular vesicles reveal mesenchymal transition markers and adhesion molecules related to metastasis. 98 14 3

Twist, Snail, and Sox9 form an allosterically regulated complex, the EMTosome, on a bipartite E-box site. 98 3

Cross talk between tumor stroma and cancer cells plays a critical role in progressive enrichment of cancer stem cell phenotype in primary breast tumors 98 14 10 9 3

Iron and lipocalin-2 modulate cellular responses in the tumor micro-environment of pancreatic ductal adenocarcinoma 98 14 10 3

Disseminating cells in human tumours acquire an EMT stem cell state that is predictive of metastasis 98 14

LADON, a natural antisense transcript of NODAL, promotes metastasis in melanoma by repressing NDRG1 98 14 3

P-bodies are sites of rapid RNA decay during the neural crest epithelial-mesenchymal transition 98 20 3

Gene expression and chromatin accessibility during progressive EMT and MET linked to dynamic CTCF engagement 98 31 3

Frizzled-7 Identifies Platinum Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis 98 14 10 3

Vimentin is Required for Tumor Progression and Metastasis in a Mouse Model of Non-Small Cell Lung Cancer 98 14 3

Interplay between Desmoglein2 and hypoxia controls metastasis in breast cancer 98 14 3

SOX9 is sufficient to drive endothelial cells towards a mesenchymal fate by altering the chromatin landscape. 31 20 3

Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer 98 14 3

Genomic signatures of the unjamming transition in compressed human bronchial epithelial cells 98 55 3

Targeting subtype-specific metabolic preferences in nucleotide biosynthesis inhibits tumor growth in a breast cancer model 98 14 10 9 3

Human papillomavirus 16 E2 repression of TWIST1 transcription is a potential mediator of HPV16 cancer outcomes 98 14 3

The quorum sensing peptide EntF* promotes colorectal cancer metastasis in mice: a new factor in the microbiome-host interaction. 98 10

KMT2D Links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell Plasticity 98 14 3

CENP-A overexpression drives distinct cell fates depending on p53 status 98 14 3

Single cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype 98 14 3

EMT-induced cell mechanical changes enhance mitotic rounding strength 98 68 55 14 3

Downregulation of E-cadherin in pluripotent stem cells triggers partial EMT 98 57 20 3

Novel mechanistic targets of Forkhead box Q1 transcription factor in human breast cancer cells 98 14 3

A novel single-cell based method for breast cancer prognosis 43 26 4

Transcriptional mediators of treatment resistance in lethal prostate cancer 98 14 10 9 3

Hybrid E/M phenotype(s) and stemness: a mechanistic connection embedded in network topology 98 38 14

Quantitative Analysis of Tissue Secretome Reveals the Diagnostic and Prognostic Value of Carbonic Anhydrase II in Hepatocellular Carcinoma 98 14 10 3

Role of c-Met/β1 integrin complex in the metastatic cascade 98 14 3

E-cadherin: Unexpected actor of invadopodia formation in pancreatic cancer 98 14 3

Proteomic and phosphoproteomic analysis identifies novel liver-related signaling in retinal pigment epithelial cells during epithelial-mesenchymal transition 98 57 14 3

Early detection of biomarkers for circulating tumor cells in Bone marrow and Peripheral blood in a fast-progressing gastric cancer model. 98 10 3

Cadherin-11 is required for neural crest determination and survival 98 20 3

IGF2BP1 is a targetable SRC/MAPK-dependent driver of invasive growth in ovarian cancer 98 14 3

Gene expression profiles of inflammatory breast cancer reveal high heterogeneity across the epithelial-hybrid-mesenchymal spectrum 98 14 9 4

Pseudomonas aeruginosa secreted protein PA3611 promotes bronchial epithelial cells epithelial-mesenchymal transition through TGF-β1 inducing p38/miRNA/NF-κB pathway 98 74 10 3

Elevated phosphate mediates extensive cellular toxicity: from abnormal proliferation to cell death 98 69 3

Resolving an underrepresented circulating tumor cell population in lung cancer enabled by Hexokinase 2 analysis 98 14 9

Epigenetic reprogramming towards mesenchymal-epithelial transition in ovarian cancer-associated mesenchymal stem cells drives metastasis 98 14 3

Urine single cell RNA-sequencing in focal segmental glomerulosclerosis reveals inflammatory signatures in immune cells and podocytes 148 98 9

Genome-wide identification of binding sites of GRHL2 in luminal-like and basal A subtypes of breast cancer 98 9 3

SARS-CoV-2 infection induces EMT-like molecular changes, including ZEB1-mediated repression of the viral receptor ACE2, in lung cancer models 73 36 1

Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT states 98 14 9

Mathematical modeling of metastasis, a feasible way to detect the weakness 98 14 10

Infection with CagA+ Helicobacter pylori induces epithelial to mesenchymal transition in human cholangiocytes 98 3

Human Endogenous Retrovirus K Rec forms a regulatory loop with MITF that opposes the progression of melanoma to an invasive stage 98 9 3

Ubiquilin proteins regulate EGFR levels and activity in lung adenocarcinoma cells 98 69 3

Exploration of endogenous miRNA-200b/c activity and regulation through a functional dual fluorescence reporter 74 33 3

Investigating TNS4 in the Colorectal Tumour Microenvironment Using 3D Spheroid Models of Invasion 98 14 10 3

Colorectal adenocarcinomas downregulate the mitochondrial Na+/Ca2+ exchanger NCLX to drive metastatic spread 6 3

Calpain-2 regulates hypoxia/HIF-induced amoeboid reprogramming and metastasis 98 14 3

Quantitation analysis by flow cytometry shows that Wt1 is required for development of the proepicardium and epicardium 98 57 20 3

Glycosyltransferase POMGNT1 deficiency affects N-cadherin-mediated cell-cell adhesion 98 3

Expression of Toll like Receptor 4 in the ductal epithelial cells of the Breast tumor microenvironment is correlated with the invasiveness of the tumor 189 98 14 10 3

Localized activation of ependymal progenitors induces EMT-mediated glial bridging after spinal cord injury 98 20 3

Obesity-driven changes in ECM composition promote local invasion and metastasis of breast tumors 14 10 3

Cancer exosomes harbor diverse hypoxia-targeted mRNAs and contribute toward tumor angiogenesis 98 74 14 9 3

Imaging translation dynamics in live embryos reveals spatial heterogeneities 98 49 20 18 3

Nutritional stress alone can control in vitro tumor formation and its invasive nature 98 14 3

Proliferation genes repressed by TGF-β are downstream of Slug/Snail2 in normal bronchial epithelial progenitors and are deregulated in COPD 6 3

Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy 156 98 3

Computational pharmacogenomics screen identifies synergistic statin-compound combinations as anti-breast cancer therapies 14 10 3

Single-cell transcriptomics, scRNA-Seq and C1 CAGE discovered distinct phases of pluripotency during naïve-to-primed conversion in mice 57 20 9 3

A SNAI2-PEAK1 stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting a cytokine expression profile that converges on PI3K/Akt signaling 14 3

Locally-invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging 98 14 10 3

Convergent Met and voltage-gated Ca2+ channel signaling on Ras-Erk MAPK drives migratory activation of dendritic cells parasitized by Toxoplasma gondii 102 98 3

The long noncoding RNA Meg3 regulates myoblast plasticity and muscle regeneration through epithelial-mesenchymal transition 20 3