Topic 102

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273 items. Top items listed below.

Conserved Roles for Receptor Tyrosine Kinase Extracellular Regions in Regulating Receptor and Pathway Activity 102 3

Activation of Rab11a and endocytosis by Phosphatidylinositol 4-kinase III beta promotes oncogenic signaling in breast cancer 102 34 3

The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint 102 34 3

PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK 186 102 14 3

Requirement of FLCN tumor suppressor gene for mTORC1-mediated inhibition of TFE3 transcriptional activity 102 3

Clustering-based positive feedback between a kinase and its substrate enables effective T-cell receptor signaling 102 34 8 3

AMPK-Fyn signaling promotes Notch1 stability to potentiate hypoxia-induced breast cancer stemness and drug resistance 108 102 14 3

Identification of a new regulation pathway of EGFR and E-cadherin dynamics 102 34 3

Src/FAK complex phosphorylates cardiac myosin binding protein c (cMyBP-C) in vitro and in vivo 102 55 34 3

Phosphorylation-dependent sub-functionalization of the calcium-dependent protein kinase CPK28 102 16 3

Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation 102 88 27 3

Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast 102 34 3

MARCKS domain phosphorylation regulates the differential interaction of Diacylglycerol Kinase ζ with Rac1, RhoA and Syntrophin 102 34 3

SLAP2 adaptor binding disrupts c-CBL autoinhibition to activate ubiquitin ligase function. 102 63 34 8 3

Anti-GPR56 monoclonal antibody potentiates GPR56-mediated Src-Fak signaling to modulate cell adhesion 102 3

Zn2+ influx activates ERK and Akt signaling pathways through a common mechanism 102 3

Identification of PIM1 substrates reveals a role for NDRG1 in prostate cancer cellular migration and invasion 108 102 14 3

The glycolysis regulator PFKFB4 interacts with ICMTand activates RAS/AKT signaling-dependent cell migration in melanoma. 186 102 34 3

Proteasome Regulation by Reversible Tyrosine Phosphorylation at the Membrane 102 34 3

P4HA2 is associated with prognosis, promotes proliferation, invasion, migration and EMT in glioma 98 14 3

Rice Calcium/Calmodulin-Dependent Protein Kinase Directly Phosphorylates a Mitogen-Activated Protein Kinase Kinase to Regulate Abscisic Acid Responses 102 16 3

Phosphorylation barcode-dependent signal bias of the dopamine D1 receptor 102 3

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit 102 34 3

Diabetes induced decreases in PKA signaling in cardiomyocytes: the role of insulin 102 95 3

MYPT1 O-GlcNAc modification controls the sensitivity of fibroblasts to sphingosine-1-phosphate mediated cellular contraction 102 3

A rate threshold mechanism regulates MAPK stress signaling and survival 102 3

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals 102 3

T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells 7 3

CREB is Required in Excitatory Neurons in the Forebrain to Sustain Wakefulness 102 11 3 2

AGC kinase members phosphorylate ubiquitin. 102 34 3

Direct phosphorylation of HY5 by SPA1 kinase to regulate photomorphogenesis in Arabidopsis 102 16 3

Bartonella effector protein C mediates actin stress fiber formation via recruitment of GEF-H1 to the plasma membrane 102 79 34 3

RBM20 phosphorylation on serine/arginine domain is crucial to regulate pre-mRNA splicing and protein shuttling in the heart 102 34 3

The Receptor Kinase BRI1 promotes cell proliferation in Arabidopsis by phosphorylation- mediated inhibition of the growth repressing peptidase DA1. 102 16 3

Regulation of trehalase activity by multi-site phosphorylation and 14-3-3 interaction 102 63 8 3

NLRP3 controls ATM activation in response to DNA damage. 46 3

Model-driven experimental design identifies counter-acting feedback regulation in the osmotic stress response of yeast 102 38 3

A conformational switch driven by phosphorylation regulates Ykt6 activity in macroautophagy 34 8 3

Evolutionarily Conserved Transcription Factors Drive the Oxidative Stress Response in Drosophila 134 31 9 3

Intravital imaging reveals cell cycle-dependent satellite cell migration during muscle regeneration. 102 3

Co-ordinated regulation of cell survival and cell cycle pathways by DDR2-dependent SRF transcription factor in cardiac fibroblasts 102 3

Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling 102 63 3

Sphingosine 1-phosphate activates the MAP3K1-JNK pathway to promote epithelial movement and morphogenesis 102 20 3

Bid as a novel interacting partner of IRE1 differentially regulating its RNAse activity 102 34 3

SILAC proteomics implicates the ubiquitin conjugating enzyme UBE2D in SOCS1-mediated downmodulation of the MET receptor in hepatocytes 102 3

Phosphorylation of the RB C-terminus regulates condensin II release from chromatin 102 3

The Ndr/LATS kinase Cbk1 regulates a specific subset of Ace2 functions and suppresses the hyphae-to-yeast transition in Candida albicans 102 79 3

Identification of a plant kinase that phosphorylates the bacterial effector AvrPtoB 102 16 3

Peptide-based Inhibitors of Protein-Protein Interactions of Src Homology 2 Domain-Containing Phosphatase 2 102 63 3

Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs. 69 34 3

Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi 102 3

FER-mediated tyrosine phosphorylation and PIK3R2/p85β recruitment on IRS4 promotes the PI3K-AKT signaling pathway and tumorigenesis in ovarian cancer 186 102 14 3

β-arrestin-dependent ERK signaling positively correlates with reduced anxiety-like and conditioned fear-related behavior in mice 102 11 3 2

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein 63 8 3

Critical role for cold shock protein YB-1 in cytokinesis 102 34 3

Casein Kinase 1G2 Suppresses Necroptosis-Promoted Testis Aging by Inhibiting Receptor-Interacting Kinase 3 102 3

An interaction between Gβγ and RNA polymerase II regulates transcription in cardiac fibroblasts 119 102 3

Real-time measurement of E2:ERα transcriptional activity in living cells. 102 3

A regulatory interface on RIPK2 is required for XIAP binding and NOD signaling activity 102 34 3

Proximity Labeling-assisted Identification of Endogenous Kinase Substrates 102 45 3

EPH tyrosine kinase receptors regulate epithelial morphogenesis and phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks 102 34 3

Abelson-induced phosphorylation of TACC3 modulates its interaction with microtubules and affects its impact on axon outgrowth and guidance 102 34 3

Smoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits 7 3

Itk promotes the integration of TCR and CD28 costimulation, through its direct substrates, SLP-76 and Gads 102 34 3

β-catenin-Mediated Wnt Signal Transduction Proceeds Through an Endocytosis-Independent Mechanism 20 3

Cyclin-dependent kinase 2 (Cdk2) controls phosphatase-regulated signaling and function in platelets 7 3

Differential activation of P-TEFb complexes in the development of cardiomyocyte hypertrophy following activation of distinct GPCRs 102 31 3

The low complexity regions in the C-terminus are essential for the subcellular localisation of Leishmania casein kinase 1 but not for its activity 34 3

A bacterial effector protein prevents MAPK-mediated phosphorylation of SGT1 to suppress plant immunity 102 16 3

Insulin-like Growth Factor-1 Regulates the Mechanosensitivity of Chondrocytes by Modulating TRPV4 102 3

Calcium-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells 150 88 27 3

Cyclin G2 inhibits oral squamous cell carcinoma growth and metastasis by binding to insulin-like growth factor binding protein 3 and regulating the FAK-SRC-STAT signaling pathway 108 14 10 3

Phosphoproteomics after nitrate treatments reveal an important role for PIN2 phosphorylation in control of root system architecture. 16 9 3

The Abelson tyrosine kinase and the Nedd4-family ubiquitin ligase Suppressor of Deltex converge at the Notch PPxY motif to regulate endosomal trafficking and signaling 102 34 3

Mutant p53 suppresses innate immune signaling to promote tumorigenesis 108 102 3

Regulation of T cell receptor signaling by protein acyltransferase DHHC21 102 3

Paladin is a PI(4,5)P2 phosphoinositide phosphatase that regulates endosomal signaling and angiogenesis 94 34 3

Spt5 phosphorylation and the Rtf1 Plus3 domain promote Rtf1 function through distinct mechanisms 119 102 49 31 3

Large-scale identification of ubiquitination sites on membrane-associated proteins in Arabidopsis thaliana seedlings 102 16 3

mTOR inhibition in primary neurons and the developing brain represses transcription of cholesterol biosynthesis genes and alters cholesterol levels 133 31 3

A novel role of MNT as a negative regulator of REL and the NF-κB pathway 142 102 31 3

Membrane receptor MerTK is a newly identified transcriptional regulator that associates to chromatin as nanoclusters during human DC differentiation 150 102 3

Yorkie-independent negative feedback couples Hippo pathway activation with Kibra degradation 102 34 3

Bimodal evolution of Src and Abl kinase substrate specificity revealed using mammalian cell extract as substrate pool 102 63 8 3

Tyrosine phosphorylation of ACLY regulates lipid metabolism and oncogenesis in ALK positive Anaplastic Large Cell Lymphoma 102 3

PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation 102 3

MAPK signaling links the injury response to Wnt-regulated patterning in Hydra regeneration 102 3

Computational response modeling reveals context dependent Akt activity in luminal breast cancer cells 186 102 14 3

Concurrent depletion of Vps37 proteins evokes ESCRT-I destabilization and profound cellular stress responses 108 102 3

WSB1 Regulates c-Myc Expression Through β-catenin Signaling and Forms a Feedforward Circuit Promoting the Development of Cancer. 108 14 3

The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-kB activation 102 3

Integrin-linked kinase is a key signal factor involved in Nogo-66-induced inhibition of neurite outgrowth 102 3

PP2A-Rts1 antagonizes Rck2-mediated hyperosmotic stress signaling in yeast 102 45 34 3

CBL mutations promote activation of PI3K/AKT signaling via LYN kinase 186 108 102 14 3

Foam cell induction activates AMPK but uncouples its regulation of autophagy and lysosomal homeostasis 102 3

Regulation of kinase activity by combined action of juxtamembrane and C-terminal regions of receptors 102 63 8 3

LZTR1 inactivation promotes MAPK/ ERK pathway activation in glioblastoma by stabilizing oncoprotein RIT1 108 102 14 3

Autoregulatory control of microtubule binding in the oncogene, doublecortin-like kinase 1 102 63 8 3

MSK-mediated phosphorylation of Histone 3 Ser28 couples MAPK signaling with early gene induction and cardiac hypertrophy 102 3

Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling 69 34 3