Topic 46

dna repair strand double breaks damage recombination replication homologous dsb dsbs break chromosome meiotic yeast fork meiosis chromatin genome forks stranded rad51 chromosomes instability cells joining cerevisiae formation chromosomal during end biology helicase repaired genetics integrity segregation mitotic saccharomyces replicative complex checkpoint cycle mediated molecular dependent stress telomere sites stability lesions show phase loops pol telomeric crossover recruitment nhej maintenance crossovers cancer genomic synthesis defects telomeres promotes pathway template polymerase mutation ssdna budding resection mutants 53bp1 absence mutations foci essential biochemistry ends mitosis sister cohesin single atr accumulation stalled binding ddr induced role lagging progression hr loop polymerases complexes g1

311 items. Top items listed below.

The bakerss yeast Msh4-Msh5 associates with double-strand break hotspots and chromosome axis during meiosis to promote crossovers 46 34 8 3

De novo deletion mutations at recombination hotspots in mouse germlines 46 34 3

HIV Vpr modulates the host DNA damage response at two independent steps to damage DNA and repress double-strand DNA break repair 46 41 3

Replication protein A binds RNA and promotes R-loop formation 46 8 3

A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks 46 34 8 3

Recruitment of MRE-11 to complex DNA damage is modulated by meiosis-specific chromosome organization 46 34 3

Sister chromatid repair maintains genomic integrity during meiosis in Caenorhabditis elegans 46 34 3

C. elegans BRC-1-BRD-1 functions at an early step of DSB processing and inhibits supernumerary crossovers during male meiosis 46 34 3

BLM-dependent Break-Induced Replication handles DSBs in transcribed chromatin upon impaired RNA:DNA hybrids dissolution. 46 3

RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis. 46 34 16 3

The S-phase Cyclin Clb5 Promotes rDNA Stability by Maintaining Replication Initiation Efficiency in rDNA 46 34 3

Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells 46 14 3

Homology-directed repair involves multiple strand invasion cycles in fission yeast 46 34 3

Double-strand breaks can induce DNA replication and damage amplification in G2 phase-like oocytes of mice 46 3

Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and -deficient cells 46 34 3

R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements 46 9

Super-resolution imaging of RAD51 and DMC1 in DNA repair foci reveals dynamic distribution patterns in meiotic prophase 46 34 8

ATR inhibition enhances 5-fluorouracil sensitivity independent of non-homologous end-joining and homologous recombination repair pathway 46 14 10 3

Dynamic configurations of meiotic hotspot determinants 46 34 8 3

Genome-wide analysis of DNA replication and DNA double strand breaks by TrAEL-seq 46 18 4

RecA mediated homology search finds segregated sister locus in minutes after a double stranded break 46 18 8

Activation of meiotic recombination by nuclear import of the DNA break hotspot-determining complex 46 34 8 3

Loop extrusion as a mechanism for DNA Double-Strand Breaks repair foci formation 46 31 3


NLRP3 controls ATM activation in response to DNA damage. 46 3

PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts 46 34 3

DNA break formation induces Scc2/cohesin-dependent recruitment of condensin to meiotic chromosomes 46 34 31 8 3

Dynamic localization of SPO11-1 and conformational changes of meiotic axial elements during recombination initiation of maize meiosis 46 34 8 3

XAB2 prevents abortive recombinational repair of replication-associated DNA double-strand breaks and its loss is synthetic lethal with RAD52 inhibition 46 3

Evolutionary and Comparative Analysis of bacterial Non-Homologous End Joining Repair 46 40 21 5

The conserved Cdc14 phosphatase ensures effective resolution of meiotic recombination intermediates. 46 34 3

Mechanisms preventing Break-Induced Replication during repair of two-ended DNA double-strand breaks 46 34 3

Mechanism of in vivo activation of the MutLγ-Exo1 complex for meiotic crossover formation 46 34 3

Schizosaccharomyces pombe KAT5 contributes to resection and repair of a DNA double strand break 46 34 3

High-resolution analysis of Merkel Cell Polyomavirus in Merkel Cell Carcinoma reveals distinct integration patterns and suggests NHEJ and MMBIR as underlying mechanisms 46 31 9

A Reporter Mouse for In Vivo Detection of DNA Damage in Embryonic Germ Cells 46 20 3

The Dystonia Gene THAP1 Controls DNA Double Strand Break Repair Choice 46 3

Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex 46 34 3

Site-specific targeting of a light activated dCas9-KIllerRed fusion protein generates transient, localized regions of oxidative DNA damage. 46 33

Super-resolution visualization of distinct stalled and broken replication fork structures 46 8 3

Poly(ADP-ribose)-binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions 46 31 3

EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis 46 34 3

BARD1 links histone H2A Lysine-15 ubiquitination to initiation of BRCA1-dependent homologous recombination 46 34 3

shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination 46 34 3

Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence 46 34 3

RADX Sustains POT1 Function at Telomeres to Counteract RAD51 Binding, which Triggers Telomere Fragility 46 34 8 3

A single Ho-induced double-strand break at the MAT locus is lethal in Candida glabrata 46 33 3

DNA damage alters nuclear mechanics through chromatin reorganisation. 46 3

Role of PARylation and PTEN Mutation on PARP and PARG Inhibitor Efficacy on Glioblastoma 138 126 46 7 3

Topoisomerases modulate the timing of meiotic DNA breakage and chromosome morphogenesis in Saccharomyces cerevisiae 46 31 3

A meiosis-specific factor MRM/C19orf57 modulates localization of RAD51 and DMC1 recombinases to DSBs in mouse meiotic recombination 46 34 3

Poly(ADP-ribose) glycohydrolase promotes formation and homology-directed repair of meiotic DNA double-strand breaks independent of its catalytic activity 46 34 3

Meiotic sister chromatid exchanges are rare in C. elegans 46 34

Single-molecule live cell imaging of the Smc5/6 DNA repair complex 46 34 3

FUS-dependent liquid-liquid phase separation is an early event in double-strand break repair 46 34 3

Evolution of Chi motifs in Proteobacteria 46 40 12 5

Functional interaction between Fanconi anemia and mTOR pathways during stalled replication fork recovery 46 3

Rdh54/Tid1 Inhibits Rad51-Rad54-Mediated D-loop Formation and Limits D-loop Length 46 34 3

Checkpoint phosphorylation sites on budding yeast Rif1 protect nascent DNA from degradation by Sgs1-Dna2 46 34 3

ERCC1-XPF Interacts with Topoisomerase IIβ to Facilitate the Repair of Activity-induced DNA Breaks 46 31 3

Efficient replacement of long DNA fragments via non-homologous end joining at non-doding regions 33

Sir2 mitigates an intrinsic imbalance in origin licensing efficiency between early and late replicating euchromatin 46 34 31 3

The RAD51 recombinase protects mitotic chromatin in human cells 68 46 34 3

ZEB1 is Required for NHEJ-Mediated DSB Repair in Euchromatin 46 3

Comprehensive synthetic genetic array analysis of alleles that interact with mutation of the Saccharomyces cerevisiae RecQ helicases Hrq1 and Sgs1 46 9

Fused in sarcoma regulates DNA replication timing and progression 61 46 31 3

Wide-spectrum cancer killing by ENDOD1 ablation 138 46 14 10 3

A FOXO-dependent replication checkpoint restricts proliferation of damaged cells 46 34 3

Persistent broken chromosome inheritance drives genome instability 46 21 3

A Rad51-Independent P{-}ath{-}way Promotes Single-Strand Template Repair in Gene Editing 46 33 3

IGF targeting perturbs global replication through ribonucleotide reductase dysfunction 46 3

Discovery and Development of Novel DNA-PK Inhibitors by Targeting the unique Ku-DNA Interaction 46 33 3

Topoisomerase 1 dependent R-loop deficiency as a mechanism underlying oncogene-induced replication stress and genomic instability 46 3

Precision digital mapping of endogenous andinduced genomic DNA breaks by INDUCE-seq 46 33 4

Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance 46 33 31

Trapped Topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast 46 3

Heat Stress Interferes with Formation of Double-Strand Breaks and Homology Synapsis in Arabidopsis thaliana 46 16 3

ZmMTOPVIB is essential for double-strand break formation and bipolar spindle assembly in maize meiosis 46 16 3

CDK-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity 46 3

Centromere scission drives chromosome shuffling and reproductive isolation 46 33 5

Low replication stress leads to specific replication timing advances associated to chromatin remodelling in cancer cells 46 31 3

The NHEJ Repair of DNA Double Strand Breaks in Physcomitrella patens Depends on the Kleisin NSE4 of the SMC5/6 Complex. 46 3

PCNA-K164 ubiquitination facilitates origin licensing and mitotic DNA synthesis 46 7 3

Rad21l1 cohesin subunit is dispensable for spermatogenesis but not oogenesis in zebrafish 46 34 3

PARP inhibition in Ewing sarcoma: impact of germline DNA damage repair defects and activation of immunoregulatory pathways 138 126 14 10 3

Cas9-induced large deletions and small indels are controlled in a convergent fashion 46 33 3

Human CTC1 primarily functions in telomere maintenance/protection and promotes CHK1 phosphorylation in response to global replication stress 46 3

Enhancing CRISPR deletion via pharmacological delay of DNA-PK 33 3

Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP- ribosyltransferase PARP14 in replication fork stability controlled by ATR 46 3

Maturation of telomere 3'-overhangs is linked to the replication stress response 46 34 3

The Synaptonemal Complex Central Region Modulates Crossover Pathways and Feedback Control of Meiotic Double-strand Break Formation 46 34 3

Homologous recombination defects in Shwachman-Diamond syndrome and Diamond-Blackfan anemia 46 3

Nutrient restriction, inducer of yeast meiosis, induces mammalian meiosis 46 20 3

A genome-wide screen for genes affecting spontaneous direct-repeat recombination in Saccharomyces cerevisiae 46 9

Regulation of the MLH1-MLH3 endonuclease in meiosis 46 34 3

Spontaneous replication fork collapse regulates telomere length homeostasis in wild type cells 46 34 8 3

RAD50 promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes 46 34 3

Temporal modulation of the NF-κB RelA network in response to different types of DNA damage 46 3

Overexpression of MutS impairs DNA mismatch repair and causes cell division defect in E.coli 46 3

Recombinational repair of nuclease-generated mitotic double-strand breaks with different end structures in yeast 46