Topic 41

virus viral viruses replication infection microbiology host antiviral infected rna infections hiv cells proteins virions influenza protein infectious particles zika immune capsid virion cellular transmission interferon dengue mosquito entry infect human author innate genome mediated during stranded hepatitis infectivity inhibit polymerase mosquitoes cycle restriction lytic translation herpesviruses herpes herpesvirus zikv transmitted efficient borne latency interactions against flaviviruses mechanism pathogen target rnas interaction flavivirus required dsrna reactivation cytomegalovirus chikungunya inhibits immunodeficiency antivirals enveloped machinery previously simplex pathogenesis vitro unknown factors infecting vector spread envelope pathogens cause aedes nuclear shown packaging fever genomes binding cell efficiently inhibition hsv retroviral latent ifn hosts

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Computational analysis of microRNA-mediated interactions in SARS-CoV-2 infection 74 41 1

Host-derived Circular RNAs Display Proviral Activities in Hepatitis C Virus - Infected Cells 41 27 3

Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production 41 3

Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication 41 27 3

A novel role for the C-terminal domain of the influenza A virus host shutoff endoribonuclease PA-X in mediating rapid turnover of the PA-X protein 41 3

Modulating the transcriptional landscape of SARS-CoV-2 as an effective method for developing antiviral compounds 73 44 1

Ebola virus inclusion body formation and RNA synthesis are controlled by a novel domain of NP interacting with VP35 41 34 3

Critical role of type III interferon in controlling SARS-CoV-2 infection, replication and spread in primary human intestinal epithelial cells 73 1

Cellular co-infection can modulate the efficiency of influenza A virus production and shape the interferon response 41 27

Immunocapture of dsRNA-bound proteins provides insight into tobacco rattle virus replication complexes and reveals Arabidopsis DRB2 to be a wide-spectrum antiviral effector 41 16 12

Identification of an antiretroviral small molecule that appears to be a host-targeting inhibitor of HIV-1 assembly 41 12 10 3

Viral RNA is a target for Wolbachia-mediated pathogen blocking 41 12

Serotonergic drugs inhibit CHIKV infection at different stages of the cell entry pathway 41 1

Intracellular Lipid Droplet Accumulation Occurs Early Following Viral Infection and Is Required for an Efficient Interferon Response 41 27 3

<h1>The low-density lipoprotein receptor-related protein-1 is essential for Dengue virus infection <o:p></o:p></h1> 41 1

Potential for virus endogenization in humans through testicular germ cell infection: the case of HIV 41 12

The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection 41 9

In-silico analysis of SARS-CoV-2 genomes: Insights from SARS encoded non-coding RNAs 37 1

Virion-associated spermidine transmits with Rift Valley fever virus particles to maintain infectivity 41 3

Short chain fatty acid butyrate promotes virus infection by repressing interferon stimulated genes 27 10 3

Human Dicer helicase domain acts as an interaction platform to recruit PKR and dsRNA binding proteins during viral infection 41 27 3

Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection 103 1

Acrylamide Inhibits Vaccinia Virus Through Vimentin-independent Anti-Viral Granule Formation 41 3

Wolbachia-conferred antiviral protection is determined by developmental temperature 48 41 12 5

A Glu-Glu-Tyr sequence in the cytoplasmic tail of the M2 protein renders IAV susceptible to restriction of HA-M2 association in primary human macrophages 41 34 8 3

Aedes aegypti SNAP and a calcium transporter ATPase influence dengue virus dissemination. 48 41 12

ETV7 limits antiviral gene expression and control of SARS-CoV-2 and influenza viruses 41 27 3 1

A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in Mosquitoes 41 12

Genome-wide CRISPR-Cas9 screen reveals the importance of the heparan sulfate pathway and the conserved oligomeric golgi complex for synthetic dsRNA uptake and Sindbis virus infection 41 27 3

Comprehensive single cell analysis of pandemic influenza A virus infection in the human airways uncovers cell-type specific host transcriptional signatures relevant for disease progression and pathogenesis. 73 27 9 1

Modelling within-host macrophage dynamics in influenza virus infection 27 10 1

Evidence for a role of phenotypic mutations in virus adaptation 41 21

Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins 41 27 10 3

SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus 73 1

Inhibition of Anti-viral Stress Granule Formation by infectious bronchitis virus endoribonuclease nsp15 Ensures Efficient Virus Replication 41 27 3

Mapping RNA dependent RNA polymerase activity and immune gene expression using PRO-seq 41 1

Ilaprazole and other novel prazole-based compounds that bind Tsg101 inhibit viral budding of HSV-1/2 and HIV from cells 41 8 1

Collective interactions augment influenza A virus replication in a host-dependent manner 41 12

Autophagic degradation of the Cucumber mosaic virus virulence factor 2b balances antiviral RNA silencing with proviral plant fitness and virus seed transmission 41 16 3

The Ebola virus interferon antagonist VP24 undergoes active nucleocytoplasmic trafficking 41 27 3

Th2 Cytokine Modulates Herpesvirus Reactivation in a Cell Type Specific Manner 41 27 10 3

Production of Noncapped Genomic RNAs is Critical to Sindbis Virus Disease and Pathogenicity 41 27 10 3

Dissecting HSV-1-induced host shut-off at RNA level 41 31 3

Characterisation of the Semliki Forest Virus-host cell interactome reveals the viral capsid protein as an inhibitor of nonsense-mediated mRNA decay 41 3

HCFC1R1 Deficiency Blocks Herpes Simplex Virus-1 Infection by Inhibiting Nuclear Translocation of HCFC1 and VP16 41 10 3

Comprehensive in-vivo secondary structure of SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms 1

Reovirus σ3 protein limits interferon expression and cell death induction 41 27 3

HIV Vpr modulates the host DNA damage response at two independent steps to damage DNA and repress double-strand DNA break repair 46 41 3

Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication 41 34 3

Alteration of the premature tRNA landscape by gammaherpesvirus infection 49 41 31 9 3

Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication 36 1

Deletion of Murine Gammaherpesvirus Gene M2 in AID-Expressing B Cells Impairs Host Colonization and Viral Reactivation 41 27 3

Various miRNAs are involved in efficient HCV replication 41 8 3

Temperature alters gene expression in mosquitoes during arbovirus infection 48 41 12

HIV-1 RNA genomes initiate host protein packaging in the cytosol independently of Gag capsid proteins 41 34 3

DWV infection and replication at the early stage in vitro using honey bee pupal cells 41 12

Analysis of cell-associated DENV RNA by oligo(dT) primed 5' capture scRNAseq 41

Imd pathway-specific immune assays reveal NF-κB stimulation by viral RNA PAMPs in Aedes aegypti Aag2 cells 48 41 27

Interferon-induced Protein-44 and Interferon-induced Protein 44-like restrict replication of Respiratory Syncytial Virus 41 27 10 3

Chemical Stabilization of the HIV-1 Capsid Results in Efficient HIV-1 Reverse Transcription in vitro 41 8 3

Genetic analysis of the novel SARS-CoV-2 host receptor TMPRSS2 in different populations. 36 1

Assessing in vivo mutation frequencies and creating a high-resolution genome-wide map of fitness costs of Hepatitis C virus 21 5

A versatile reporter system to monitor virus infected cells and its application to dengue virus and SARS-CoV-2 41 1

Antiviral effects of miRNAs in extracellular vesicles against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mutations in SARS-CoV-2 RNA virus 73 1

Potential for transmission of Elizabethkingia anophelis by Aedes albopictus and the role of microbial interactions in Zika virus competence 48 41 29 12 5

Proteomic Analysis Uncovers Measles Virus Protein C Interaction with p65/iASPP/p53 Protein Complex 41 3

Chikungunya virus requires an intact microtubule network for efficient viral genome delivery 41 34

RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to Yellow fever virus 41 27 3

In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome 41 27 12 10

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early genes. 41 3

Development of a fluorescence based, high-throughput SARS-CoV-2 3CLpro reporter assay 44 1

Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults 148 41 9

Differentiating the Roles of UL16, UL21 and Us3 in the Nuclear Egress of Herpes Simplex Virus Capsids 41 34 3

Vpr R36W and R77Q Mutations Alter HIV-1 Replication and Cytotoxicity in T Lymphocytes 41 27 10 3

Non-retroviral endogenous viral element limits cognate virus replication in Aedes aegypti ovaries 41 33 12

Gut-associated bacteria invade the midgut epithelium of Aedes aegypti and stimulate innate immunity and suppress Zika virus infection in cells. 48 41 12 10

Suppression of Cytotoxic T Cell Functions and Decreased Levels of Tissue Resident Memory T cell During H5N1 infection 27 10 3

Disparate temperature-dependent virus - host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium 73 41 1

A virion-based assay for glycoprotein thermostability reveals key determinants of filovirus entry and its inhibition 41 8

Host population diversity as a driver of viral infection cycle in wild populations of green sulfur bacteria with long standing virus-host interactions 41 5

BPIFB3 interacts with ARFGAP1 and TMED9 to regulate non-canonical autophagy and RNA virus infection 41 34 3

The SARS-CoV-2 Envelope and Membrane proteins modulate maturation and retention of the Spike protein, allowing optimal formation of VLPs in presence of Nucleoprotein 103 1

Quantifying the dynamics of viral recombination during free virus and cell-to-cell transmission in HIV-1 infection 41 21

Novel phenotype of Wolbachia strain wPip in Aedes aegypti challenges assumptions on mechanisms of Wolbachia-mediated dengue virusinhibition . 48 41 12

An interferon lambda 4-associated variant in the hepatitis C virus RNA polymerase affects viral replication in infected cells 41 19 9

Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein 41 8

Minimising severity of dengue serotype 1 infection bytransmissible interfering particles 41

Structure of the full SARS-CoV-2 RNA genome in infected cells 1

Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations 41 10

High-Throughput Human Primary Cell-Based Airway Model for Evaluating Influenza, Coronavirus, or other Respiratory Viruses in vitro 1

The Viral Polymerase Complex Mediates the Interaction of vRNPs with Recycling Endosomes During SeV Assembly 41 34 3

Dynamic metabolic reprogramming in dendritic cells: an early response to influenza infection that is essential for effector function 27 10 3

Virally derived peptide inhibitors of the herpes simplex virus type 1 nuclear egress complex 41 12

Protein covariance networks reveal interactions important to the emergence of SARS coronaviruses as human pathogens 37 1

An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication 41 9

Identification of TMEM106B as proviral host factor for SARS-CoV-2 73 1

Direct evidence of abortive lytic infection-mediated establishment of Epstein-Barr virus latency during B-cell infection 41 9

Single-cell transcriptomics reveals immune response of intestinal cell types to viral infection 41 27 9 3

A functional RNA structure in the influenza A virus ribonucleoprotein complex for segment bundling 41 8

Favipiravir-resistant influenza A virus shows potential for transmission 41 12