Topic 19

association genetics gwas genetic wide genome variants loci traits trait associations biobank snps uk risk snp studies polygenic causal heritability individuals genes variation statistics associated summary allele variant phenotypes identified genotype genomics mendelian architecture genomic disease quantitative linkage effect population analyses power mapping scores effects disequilibrium european ancestry variance score phenotypic locus sample significant complex gene data randomization large qtl polymorphisms identify estimates sizes analysis across diseases statistical study rare method phenotype meta eqtl regression candidate eqtls cohorts cohort common ld estimate discovery breeding methods using heritable conducted pleiotropy alleles populations nucleotide selection shared correlations applied performed identifying disorder 000

616 items. Top items listed below.

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations 19 5 4

Pathway Analysis within Multiple Human Ancestries Reveals Novel Signals for Epistasis in Complex Traits 19 4

Detection of complex genetic architecture using two-locus population differentiation: modeling epistasis 19 9 4

Controlling for off-target genetic effects using polygenic scores improves the power of genome-wide association studies 19 4

Quantifying genetic effects on disease mediated by assayed gene expression levels 19 9 4

Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics. 19 4

Multi-trait genome-wide analyses of the brain imaging phenotypes in UK Biobank 19 4

Leveraging functional annotation to identify genes associated with complex diseases 19 9 4

The role of gene expression on human sexual dimorphism: too early to call 19 9 5

MRLocus: identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity 19 13 4

Estimation of Non-null SNP Effect Size Distributions Enables the Detection of Enriched Genes Underlying Complex Traits 19 4

Gene-based association analysis identified 190 genes with polymorphisms affecting neuroticism 19 9 5

An integrated platform to systematically identify causal variants and genes for polygenic human traits. 19 9 4

Polygenic risk score based on weight gain trajectories is a strong predictor of childhood obesity 19 4

A robust two-sample Mendelian Randomization method integrating GWAS with multi-tissue eQTL summary statistics 19 4

Learning polygenic scores for human blood cell traits 19 4

Using prior information from humans to prioritize genes and gene-associated variants for complex traits in livestock 19 9 5 4

Improving the coverage of credible sets in Bayesian genetic fine-mapping 19 4

Comparison of methods for estimating genetic correlation between complex traits using GWAS summary statistics 19 4

How robust are cross-population signatures of polygenic adaptation in humans? 19 5 4

Polygenic scores for height in admixed populations 19 4

Modeling regulatory network topology improves genome-wide analyses of complex human traits 19 9 4

GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background 19 9 5

Recessive effects in cancer predisposition exposed by genome-wide and proteome-wide association studies 19 9 5

Investigating regions of shared genetic variation in attention deficit/hyperactivity disorder and major depressive disorder: A GWAS meta-analysis 19 9 5

Demographic history impacts stratification in polygenic scores 19 5 4

Gene-level heritability analysis explains the polygenic architecture of cancer 19 9

Non-parametric polygenic risk prediction using partitioned GWAS summary statistics 19 4

Multi-tissue transcriptome-wide association studies 19 4

A new approach of dissecting genetic effects for complex traits 19 4

Impact of cell-type and context-dependent regulatory variants on human immune traits 19 9

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits 19 9 5

Identifying Causal Variants by Fine Mapping Across Multiple Studies 19 4

A powerful subset-based gene-set analysis method identifies novel associations and improves interpretation in UK Biobank 19 4

Genetic signatures of human brain structure: A comparison between GWAS and relatedness-based regression 19 4

Schizophrenia Risk Alleles Often Affect The Expression of Many Genes and Each Gene May Have a Different Effect On The Risk; A Mediation Analysis. 19 9 5

Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure 89 19 9 4

Partitioning gene-based variance of complex traits by gene score regression 19 13 4

A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma 19 4

Open Targets Genetics: An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci 19 9 4

Linkage Disequilibrium and Heterozygosity Modulate the Genetic Architecture of Human Complex Phenotypes 19 5 4

Scalable unified framework of total and allele-specific counts for cis-QTL, fine-mapping, and prediction 19 4

Estimating genetic nurture with summary statistics of multi-generational genome-wide association studies 19 4

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations 19 4

GxEsum: genotype-by-environment interaction model based on summary statistics 19 4

Localizing components of shared transethnic genetic architecture of complex traits from GWAS summary data 19 5 4

Whole-organism mapping of the genetics of gene expression at cellular resolution 19 9 4

Leveraging expression from multiple tissues using sparse canonical correlation analysis (sCCA) and aggregate tests improves the power of transcriptome-wide association studies (TWAS) 19 4

Unbalanced Sample Size Introduces Spurious Correlations to Genome-wide Heterozygosity Analyses 145 19 4

Powerful Variance-Component TWAS method identifies novel and known risk genes for clinical and pathologic Alzheimer's dementia phenotypes 19 9 4

Bayesian transcriptome-wide association study method leveraging both cis- and trans- eQTL information through summary statistics 19 9 4

The impact of non-additive genetic associations on age-related complex diseases. 19 9 4

Nonlinear post-selection inference for genome-wide association studies 19 4

Reconstructing Genotypes in Private Genomic Databases from Genetic Risk Scores 19 4

MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies 19 9 4

Germline genetic contribution to the immune landscape of cancer 19 9 5

Allele-specific alternative splicing in human tissues 19 9 4

Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors 19 4

TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders 19 4

Mendelian randomization identifies folliculin expression as a mediator of diabetic retinopathy. 19 9

Incorporation of Heterogeneity in a Case-Control Study Through a Mixture Model 19 4

Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank 19 9

Sexual differences in genetic architecture in UK Biobank 19 5

Common genetic variants with fetal effects on birth weight are enriched for proximity to genes implicated in rare developmental disorders 19 7 5

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments 19 4

Mendelian imputation of parental genotypes for genome-wide estimation of direct and indirect genetic effects 19 7 4

Improving brain age estimates with deep learning leads to identification of novel genetic factors associated with brain aging 19 7 4 2

Efficient variance components analysis across millions of genomes 19 4

A genome-wide case-only test for the detection of digenic inheritance in human exomes 145 19 4

Controlling for Human Population Stratification in Rare Variant Association Studies 145 123 19 4

Genome wide association study reveals plant loci controlling heritability of the rhizosphere microbiome 19 5 4

Ten Genetic Loci Identified for Milk Yield, Fat, and Protein in Holstein Cattle 19 9 5 4

Negative short-range genomic autocorrelation of causal effects on human complex traits 19 5 4

Systematic quantification of health parameters from UK Biobank abdominal MRI using deep learning 19 9 4

The distribution of common-variant effect sizes 19 5 4

Genome-wide maps of enhancer regulation connect risk variants to disease genes 19 9 3

Power analysis of transcriptome-wide association study: implications for practical protocol choice 145 123 19 4

Estimating the effective sample size in association studies of quantitative traits 19 4

Insights into dispersed duplications and complex structural mutations from whole genome sequencing 706 families 97 19 4

The Parkinson's Disease GWAS Locus Browser 19 9 4

Tissue-specific multiOMICs analysis of atrial fibrillation 19 9

Gene-environment interactions using a Bayesian whole genome regression model 19 4

Multitrait genetic-phenotype associations to connect disease variants and biological mechanisms 19 9 4

Identifying genomic markers associated with female re-mating rate in Drosophila pseudoobscura by replicated bulk segregant analysis. 19 5 4

Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes 19 9

Efficient gene-environment interaction tests for large biobank-scale sequencing studies 19 4

Mendelian pathway analysis of laboratory traits reveals distinct roles for ciliary subcompartments in common disease pathogenesis 19 9

Large-scale multivariate multi-ancestry Interaction analyses point towards different genetic mechanisms by population and exposure. 19 9 5 4

Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis 31 9 3

Variable expression quantitative trait loci analysis of breast cancer risk variants 19 9

Natural selection influenced the genetic architecture of brain structure, behavioral and neuropsychiatric traits 19 5

A Comprehensive Evaluation of Methods for Mendelian Randomization Using Realistic Simulations and an Analysis of 38 Biomarkers for Risk of Type-2 Diabetes 19 4

Accurate, ultra-low coverage genome reconstruction and association studies in Hybrid Swarm mapping populations 145 19 4

Multivariate genome-wide association study identifies 1735 unique genetic loci associated with cortical morphology. 19 9 4

Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for twelve immune-mediated diseases 19 9 4

Estimating colocalization probability from limited summary statistics 19 13 4

Investigating the Genetic Architecture of Non-Cognitive Skills Using GWAS-by-Subtraction 19 9 5

Modeling Epistasis in Mice and Yeast Using the Proportion of Two or More Distinct Genetic Backgrounds: Evidence for "Polygenic Epistasis" 19 5 4

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes 19 9

Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus 19 9