Topic 63
biochemistry binding crystal structural domain residues site substrate structure catalytic enzyme protein terminal structures molecular active domains enzymes conserved conformational pocket activity family interaction residue allosteric amino conformation bind bound biochemical recognition acid ligand mechanism affinity binds docking proteins loop specificity its substrates mutagenesis basis interactions interface simulations motif peptide helix hydrophobic inhibitors transmembrane ray catalysis fold complex enzymatic ligands beta function selectivity design acids mutations molecule molecules nmr sequence bond target tyrosine hydrogen solved unique dimer conformations drug characterization cofactor chain activation homology region assays cysteine protease coupled small helical class complexes hydrolysis report dynamics biophysics kinetic inhibition biosynthesis
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