Topic 178

diaphorina citri citrus uap usmg5 cryofib psyllid report hemipterans insects characterization insect funnelled cytoarchitectural vitrified pyrophosphorylase wnt2 leigh chs hemopexin wnt9 doughnut wnt8 isn04 myodns myogenetic odns fib exoskeleton hydrated wnt16 huanglongbing consecutively acetylglucosamine skeletal extraordinarily udp responsible hemolytic devastated guanines hgfat2 gfats histag rhgfat2 chitin hlb arrow revisiting gg oligodeoxynucleotides vilps dcvilp 75nmol lcdv sgiv dcvilps lymphocystis pathologic berberine conformational frozen frizzled advancement comparable sem ror potential affinity nucleolin rhamnosus iridoviridae erythrocyte genes glutaminase 15th synthesis disruptions iridovirus grouper hemoglobin voxel polysaccharide alkaloid stack heme glucose noncanonical like muscle insulins gfat pave myotube tends amidotransferase glut4 pest histidine aptamers

7 items. Top items listed below.

Characterization of Wnt Signaling Genes in Diaphorina citri 178 118

Chitin Biosynthesis Genes in Diaphorina citri 178 129

Characterization of Viral Insulins Reveals White Adipose Tissue Specific Effects in Mice 178 3

Updates on enzymatic and structural properties of human glutamine: fructose-6-phosphate amidotransferase 2 (hGFAT2) 178 63 8

Revisiting the interaction of heme with hemopexin: Recommendations for the responsible use of an emerging drug 178 63 8

Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin 178 3

Serial cryoFIB/SEM reveals profound cytoarchitectural disruptions caused by a pathogenic mutation in Leigh syndrome patient cells 178 95 8

The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae 102 34 3

Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1 90 3

Peptide-based Inhibitors of Protein-Protein Interactions of Src Homology 2 Domain-Containing Phosphatase 2 102 63 3

Insulin-Induced Conformational Changes in the Full-Length Insulin Receptor: Structural Insights Gained from Molecular Modeling Analyses 91 8

Comprehensive in-vivo secondary structure of SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms 1

Elucidating the differences in the molecular mechanism of receptor binding between 2019-nCoV and the SARS-CoV viruses using computational tools 36 1

Characterization of gustatory receptor 7 in the brown planthopper reveals functional versatility 8

The electrostatic allostery could be the trigger for the changes in dynamics for the PDZ domain of PICK1 63 8 3

LPS induces GFAT2 expression to promote O-GlcNAcylation and attenuate inflammation in macrophages 150 110 27 3

Deep learning enables the design of functional de novo antimicrobial proteins 105 26 4

Salicylic acid mediated immune response of Citrus Sinensis to varying frequencies of herbivory and pathogen inoculation 16 3

Human microglia upregulate cytokine signatures and accelerate maturation of neural networks 57 20 9 3

Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure 89 19 9 4

Potential modes of COVID-19 transmission from human eye revealed by single-cell atlas 36 1

The phylogenetic range of bacterial and viral pathogens of vertebrates 143 121 5

Structural characterization of LsrK to target quorum sensing and comparison between X-ray and homology model 91 63 8

Various miRNAs are involved in efficient HCV replication 41 8 3

High Affinity binding of Yeast Nucleolin Nsr1 to Co-transcriptionally Formed G4 DNA Obstructs Replication and Elevates Genome Instability 46 8 3

A dynamic regulatory interface on SARS-CoV-2 RNA polymerase 44 1

State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane 163 91 82 8 3

Bcr-Abl tyrosine kinase inhibitor imatinib as a potential drug for COVID-19 36 1

A conserved role for SFPQ in repression of pathogenic cryptic last exons 49 3

CLPX regulates erythroid heme synthesis by control of mitochondrial heme synthesis enzymes and iron utilization 95 3

Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease 78 8

Replication protein A binds RNA and promotes R-loop formation 46 8 3

Phosphoproteomics after nitrate treatments reveal an important role for PIN2 phosphorylation in control of root system architecture. 16 9 3

Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation 51 8 3

Same, Same, but Different: Molecular Analyses of Streptococcus pneumoniae Immune Evasion Proteins Identifies new Domains and Reveals Structural Differences between PspC and Hic Variants 121 114 12 9 8

Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling 102 63 3

Leigh Syndrome-inducing Mutations Affect LRPPRC / SLIRP Complex Formation 49 8 3

Noncanonical targeting contributes significantly to miRNA-mediated regulation. 7

Exploring the genomic and proteomic variations of SARS-CoV-2 spike glycoprotein: a computational biology approach 37 1

RNA and DNA G-quadruplexes bind to human Dicer and inhibit its activity 74 49 8 3

Identification and Mechanistic Characterization of a Novel Peptide Inhibitor of Glycogen Synthase Kinase (GSK3) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein 63 8 3

No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor 36 1

Structural characterization of the essential cell division protein FtsE and its interaction with FtsX in Streptococcus pneumoniae 63 8 3

Endogenous viral element-derived piRNAs are not required for production of ping-pong-dependent piRNAs from Diaphorina citri densovirus 41 12

Amino Sugars Reshape Interactions between Streptococcus mutans and Streptococcus gordonii. 12 5

Novel functional insights from the Plasmodium falciparum sporozoite-specific proteome by probabilistic integration of 26 studies 60 9

Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells 150 27 3

Biochemical characterization of recombinant UDP-sugar pyrophosphorylase and galactinol synthase from Brachypodium distachyon 129 67 63 16 8

Small Molecule Targeting IRES Domain Inhibits Enterovirus 71 Replication via an Allosteric Mechanism that Stabilizes a Ternary Complex 44 41 8

Evolutionary arms race between virus and host drives genetic diversity in bat SARS related coronavirus spike genes 36 1

A forward genetic screen identifies Dolk as a regulator of startle magnitude through the potassium channel subunit Kv1.1 154 11 3

Insight into vaccine development for Alpha-coronaviruses based on structural and immunological analyses of spike proteins 24 1

Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation 31 9 3

Sterol 14α-demethylase is vital for mitochondrial functions and stress tolerance in Leishmania major 95 67 12 3

Structural and dynamic characterization of the C-terminal tail of ErbB2: disordered but not random 149 63 8 3

Defining a critical enhancer near Nanog using chromatin-focused approaches identifies RNA Pol II recruitment as required for expression 31 9

Structural basis for the recognition of the 2019-nCoV by human ACE2 36 1

Gene co-expression analysis of human RNASEH2A reveals functional networks associated with DNA replication, DNA damage response, and cell cycle regulation 120 9 3

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites 1

Transcription initiation mapping in 31 bovine tissues reveals complex promoter activity, pervasive transcription, and tissue-specific promoter usage 134 9

Functional anatomy of the full length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis 63 8

Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation 34 8 3

In Silico Identification, Characterization and Diversity Analysis of RNAi Genes and their Associated Regulatory Elements in Sweet Orange (Citrus sinensis L) 134 16 9 3

Computational simulations reveal the binding dynamics between human ACE2 and the receptor binding domain of SARS-CoV-2 spike protein 36 1

Transcription factor binding dynamics shape noise across biological processes 134 31 9 3

SARS-CoV-2 Nucleocapsid protein is decorated with multiple N- and O-glycans. 103 1

Optimizing model comparison for enzymatic mechanism analysis 129 63 8

Rapid formation of peptide/lipid co-aggregates by the amyloidogenic seminal peptide PAP248-286 78 8

Ebola virus inclusion body formation and RNA synthesis are controlled by a novel domain of NP interacting with VP35 41 34 3

Molecular mechanism of evolution and human infection with the novel coronavirus (2019-nCoV) 36 1

Dimerization mechanism and structural features of human LI-cadherin 63 8 3

Discovery and characterization of llama VHH targeting the RO form of human CD45 63 8 3

Computational analysis on the ACE2-derived peptides for neutralizing the ACE2 binding to the spike protein of SARS-CoV-2 36 1

A roadmap for the characterization of energy metabolism in human cardiomyocytes derived from induced pluripotent stem cells 95 67 57 10 3

Arthropod IGF, Relaxin and Gonadulin, putative orthologs of Drosophila insulin-like peptides 6, 7 and 8, likely originated from an ancient gene triplication 7 5

Polymer Stiffness Regulates Multivalent Binding and Liquid-Liquid Phase Separation 78 8

Rerouting of ribosomal proteins into splicing in plant organelles 136 49 16 3

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors 44 1

Comparative transcriptome analyses reveal genes associated with SARS-CoV-2 infection of human lung epithelial cells 73 1

PelX is a UDP-N-acetylglucosamine C4-epimerase involved in Pel polysaccharide-dependent biofilm formation 79 12 8 3

Differential Antibody Recognition by Novel SARS-CoV-2 and SARS-CoV Spike Protein Receptor Binding Domains: Mechanistic Insights and Implications for the Design of Diagnostics and Therapeutics 24 1

Computational analysis of microRNA-mediated interactions in SARS-CoV-2 infection 74 41 1

Exploring Conformational Transition of 2019 Novel Coronavirus Spike Glycoprotein Between Its Closed and Open States Using Molecular Dynamics Simulations 36 1

Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism 54 3

The global and local distribution of RNA structure throughout the SARS-CoV-2 genome 1

Trypanosoma cruzi senses intracellular heme levels and regulates heme homeostasis by modulating TcHTE protein expression 3

A 3.4-A cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles 36 1

Monoclonal antibodies for the S2 subunit of spike of SARS-CoV cross-react with the newly-emerged SARS-CoV-2 36 1

Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs 51 8 3

Resources for genome editing in livestock: Cas9-expressing chickens and pigs 33 9

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin. 1

New insights into nCOVID-19 binding domain and its cellular receptors 36 1

Increased processing of SINE B2 non coding RNAs unveils a novel type of transcriptome de-regulation underlying amyloid beta neuro-pathology 32 31 3

A conserved amino acid in the C-terminus of HPV E7 mediates binding to PTPN14 and repression of epithelial differentiation 142 108 3

Sex-specific expression and DNA methylation in a species with extreme sexual dimorphism and paternal genome elimination 56 9 5

Potential microenvironment of SARS-CoV-2 infection in airway epithelial cells revealed by Human Protein Atlas database analysis 36 1

Mutational analysis of the structure and function of the chaperone domain of UNC-45B 8 3

Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses 88 27 10 3

Structural and functional characterization of allatostatin receptor type-C of Thaumetopoea pityocampa revealed the importance of Q2716.55 residue in G protein-dependent activation pathway 91 63 8

Small Molecule Modulation of Microbiome Ecosystem: A Systems Pharmacology Perspective 112 4