Topic 114

virulence pathogen host infection microbiology pathogens infections bacterial fungal cause strains pathogenic immune opportunistic colonization hosts pathogenicity infected disease pathogenesis resistance candida fungi bacteria streptococcus commensal strain albicans causes factors tract growth immunity murine epithelial antifungal response promote pneumoniae interactions mortality during secretion pseudomonas isolates intracellular bacterium responses genes toxin author production vivo model invasive worldwide human mediated survival intestinal species effector secreted macrophages associated required mutants microbial susceptibility virulent causing innate threatening resistant cryptococcus invasion vitro effectors environment mutant ability diseases pneumonia fungus pneumococcal adaptation tuberculosis susceptible factor spp involved antimicrobial tissue role contribute against including colonize persistence mycobacterium

234 items. Top items listed below.

Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model system 114 27 3

The small RNA ErsA plays a role in the regulatory network of Pseudomonas aeruginosa pathogenicity in airways infection 114 52 12 3

Intracellular Group A Streptococcus induces Golgi fragmentation to impair host defenses through Streptolysin O and NAD-glycohydrolase 114 79 27 3

Functional insights from KpfR, a new transcriptional regulator of fimbrial expression that is crucial for Klebsiella pneumoniae pathogenicity 114 79 52 12 3

Systematic characterization and genetic interaction analysis of adhesins in Candida albicans virulence 114 79 12

Aerobic metabolism in Vibrio cholerae is required for population expansion during infection 114 79 67 12

Amoeba predation of Cryptococcus neoformans results in pleiotropic changes to traits associated with virulence 114 12 5

Sterol-response pathways mediate alkaline survival in diverse fungi 114 79 12 3

Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling Through the Interleukin-1 Receptor 114 27 10 3

Pseudomonas aeruginosa isolates co-incubated with Acanthamoeba castellanii exhibit phenotypes similar to chronic cystic fibrosis isolates 114 79 12 5

Mycobacterium tuberculosis evasion of Guanylate Binding Protein-mediated host defense in mice requires the ESX1 secretion system. 114 27 12 3

Identification of colonisation and virulence determinants of Streptococcus pneumoniae via experimental evolution in mouse infection models 114 79 12 10

Exploration of bacterial bottlenecks and Streptococcus pneumoniae pathogenesis by CRISPRi-seq 114 12

Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells 114 79 12 10 3

Transposon mobilization in the human fungal pathogen Cryptococcus deneoformans is mutagenic during infection and promotes drug resistance in vitro 114 12 10 5

A partial pathogenicity chromosome in Fusarium oxysporum is sufficient to cause disease and can be horizontally transferred 114 12 5

Transcriptome analysis uncovers a link between copper metabolism, and both fungal fitness and antifungal sensitivity in the opportunistic yeast Candida albicans 114 79 9 3

Integrated metabolic modeling, culturing and transcriptomics explains enhanced virulence of V. cholerae during co-infection with ETEC 114 12

The transcription factor Pdr802 regulates Cryptococcus neoformans Titan cell production and pathogenicity 114 79 12 3

Spatially-targeted proteomics of the host-pathogen interface during staphylococcal abscess formation 114 79 12

Functional characterization of clinical isolates of the opportunistic fungal pathogen Aspergillus nidulans 114 12 10

Toxoplasma gondii GRA28 is required for specific induction of the regulatory chemokine CCL22 in human and mouse cells. 114 27 3

Redundant Trojan horse and endothelial-circulatory mechanisms for host-mediated spread of Candida albicans yeast 114 27

Capsular polysaccharide switching in Streptococcus suis modulates host cell interactions and virulence 114 12 10

Candida auris phenotypic heterogeneity determines pathogenicity in vitro 114 12

Step-specific adaptation and trade-off over the course of an infection by GASP-mutation small colony variants 114 12 5

Revisiting the Genomic Structure of the Genus Pseudomonas with Whole Genome Data: Insights into Diversity and Host-related Genetic Determinants 121 114 12 5

Biosynthetic gene clusters, secondary metabolite profiles, and cards of virulence in the closest nonpathogenic relatives of Aspergillus fumigatus 114 12 5

Identification of zinc-dependent mechanisms used by Group B Streptococcus to overcome calprotectin-mediated stress 114 79 12 10 3

A tractable Drosophila cell system enables rapid identification of Acinetobacter baumannii host factors 114 52 41 12 3

A novel mycovirus evokes transcriptional rewiring in the fungus Malassezia and stimulates interferon-β production in macrophages 114 41 12 10 3

Transcriptional profiling of three Pseudomonas syringae pv. actinidiae biovars reveals different responses to apoplast-like conditions related to strain virulence 79 12 3

Static growth alters PrrF- and 2-alkyl-4(1H)-quinolone regulation of virulence trait expression in Pseudomonas aeruginosa 114 79 12 3

Host association induces genome changes in Candida albicans which alters its virulence 114 79 12 5

Model-based prediction of bacterial population dynamics in gastrointestinal infection 114 12 10

A novel Hsp90 phospho-switch modulates virulence in the major human fungal pathogen Candida albicans 114 79 12 3

Salmonella Enteritidis Effector AvrA suppresses autophagy by reducing Beclin-1 protein 114 27 3

Comparative genomics identified a genetic locus in plant-associated Pseudomonas spp. that is necessary for induced systemic susceptibility 143 114 79 12 5

Comparative genomics identified a genetic locus in plant-associated Pseudomonas spp. that is necessary for induced systemic susceptibility 143 114 79 12 5

High resolution genome-wide occupancy in Candida spp. using ChEC-seq 114 31 12 9

Population analysis of Legionella pneumophila reveals the basis of resistance to complement-mediated killing 121 114 12 5

Genome-wide mutagenesis identifies factors involved in Enterococcus faecalis vaginal adherence and persistence 114 79 12 10 3

Virulence phenotypes result from an interaction between pathogen ploidy and genetic background 114 12 5

Protective Plant Immune Responses are Elicited by Bacterial Outer Membrane Vesicles 114 79 12 3

Glucose promotes resistance of human commensal Escherichia coli against contact-killing by pandemic Vibrio cholerae 158 79 12 3

Large-scale transcriptomics to dissect two years of the life of a fungal phytopathogen interacting with its host plant 114 16 9 5

IlvY is an important regulator of Shigella infection in vitro and in vivo 52 12 10

Genomic and phenotypic heterogeneity of clinical isolates of the human pathogens Aspergillus fumigatus, Aspergillus lentulus and Aspergillus fumigatiaffinis 121 114 107 12 5

A Universal Stress Protein upregulated by hypoxia may contribute to chronic lung colonisation and intramacrophage survival in cystic fibrosis. 79 12 3

Comparative genomics reveals different population structures associated with host and geographic origin in antimicrobial-resistant Salmonella enterica 107 52 12 5

Pleiotropy and Epistasis Within and Between Signaling Pathways Defines the Genetic Architecture of Fungal Virulence 114 12 5

The transcriptional aftermath in two independently formed hybrids of the opportunistic pathogen Candida orthopsilosis 114 21 5

PQS-Induced Outer Membrane Vesicles Enhance Biofilm Dispersion in Pseudomonas aeruginosa 52 12 10 3

A systematic analysis of hypermucoviscosity and capsule reveals distinct and overlapping genes that impact Klebsiella pneumoniae fitness 114 12

Conditional antagonism in co-cultures of Pseudomonas aeruginosa and Candida albicans: an intersection of ethanol and phosphate signaling distilled from dual-seq transcriptomics 114 79 12 3

Intracellular Staphylococcus aureus perturbs the host cell Ca2+-homeostasis to promote cell death 114 69 27 12 10 3

Heterologous production of 1-tuberculosinyladenosine in Mycobacterium kansasii models pathoevolution towards the transcellular lifestyle of Mycobacterium tuberculosis. 114 79 12 10

FasR regulates fatty acid biosynthesis and is essential for virulence of Mycobacterium tuberculosis 114 79 12 3

Exploiting oxalotrophic bacteria to control Aspergillus niger lung infections 114 12 10

The adaptive transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress 114 79 12 3

Evolutionary epidemiology of Streptococcus iniae: linking mutation rate dynamics with adaptation to novel immunological landscapes 114 21 12 5

Dual RNAseq highlights the kinetics of skin microbiome and fish host responsiveness to bacterial infection 114 12 5

ROS-dependent innate immune mechanisms control Staphylococcus aureus MRSA virulence in the Drosophila larval model 114 52 12 10 3

Leptospiral LPS escapes mouse TLR4 internalization and TRIF?associated antimicrobial responses through O antigen and associated lipoproteins 114 27 12 10 3

Same, Same, but Different: Molecular Analyses of Streptococcus pneumoniae Immune Evasion Proteins Identifies new Domains and Reveals Structural Differences between PspC and Hic Variants 121 114 12 9 8

Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue 114 27 12 10 3

Differential Host Gene Signatures in Response to Mycobacterium tuberculosis Infection 114 27 12 9 3

Effect of light and darkness on the growth and development of downy mildew pathogen Hyaloperonospora arabidopsidis. 114 16 12 3

A novel role for the C-terminal domain of the influenza A virus host shutoff endoribonuclease PA-X in mediating rapid turnover of the PA-X protein 41 3

PacC-dependent adaptation and modulation of host cellular pH controls hemibiotrophic invasive growth and disease development by the rice blast fungus 114 79 16 3

Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication 41 27 3

Genome-scale mapping reveals complex regulatory activities of RpoN in Yersinia pseudotuberculosis 79 31 12 9 3

Horizontal gene transfer in the human and skin commensal Malassezia: a bacterially-derived flavohemoglobin is required for NO resistance and host interaction 143 114 79 12 3

Transcriptome analysis reveals infection strategies employed by Fusarium graminearum as a root pathogen 114 12

Control of ss-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence 114 79 27 12 10 3

In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome 41 27 12 10

Experimental Evolution in vivo to Identify Selective Pressures During Pneumococcal Colonization 114 21 12 5

NAIP-NLRC4-deficient mice are susceptible to shigellosis 114 27 10 3

The multiplicity of infection does not affect interactions between Cryptococcus neoformans and macrophages 27 10 3

Oestrogen promotes innate immune evasion of Candida albicans through inactivation of the alternative complement system 114 79 12 10 3

Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection 114 12 5

Pneumolysin is responsible for differential gene expression and modifications in the epigenetic landscape of primary monocyte derived macrophages. 27 3

Aspergillus fumigatus G-protein coupled receptors GprM and GprJ are important for the regulation of the cell wall integrity pathway, secondary metabolite production, and virulence 114 79 12 3

A Murine Model for the Transition of Streptococcus pneumoniae from Asymptomatic Colonizer to Systemic Pathogen 114 27 10

The evolution of virulence in Pseudomonas aeruginosa during chronic wound infection 114 21 12 5

Novel Immune Modulators Enhance Caenorhabditis elegans Resistance to Multiple Pathogens 114 90 12 10 3

Metabolic profiling reveals nutrient preferences during carbon utilization in Bacillus species 158 114 79 12 5

A bacterial symbiont protects honey bees from fungal disease 114 12 5

Brucella suppress innate immunity by down-regulating STING expression in macrophages 174 27 3

Colonization of the murine oropharynx by Streptococcus pyogenes is governed by the Rgg2/3 quorum sensing system 114 79 27 12 10 3

Ex vivo Immune Profiling in Patient Blood enables Quantification of innate immune Effector Functions 27 10

Strain background, species frequency and environmental conditions are important in determining population dynamics and species co-existence between Pseudomonas aeruginosa and Staphylococcus aureus 99 5

Targeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence 114 12

Gnotobiotic rainbow trout (Oncorhynchus mykiss) model reveals endogenous bacteria that protect against Flavobacterium columnare infection 114 12 5

Transcriptional and immunological analysis of the putative outer membrane protein and vaccine candidate TprL of Treponema pallidum 114 79 12

The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins 143 79 12 3

An Animal Model to Study Klebsiella pneumoniae Gastro-Intestinal Colonization and Host-to-Host Transmission 114 52 12 10

Identification of a novel LysR-type transcriptional regulator in Staphylococcus aureus that is crucial for secondary tissue colonization during metastatic bloodstream infection 114 79 12 3

Biofilm Formation and Virulence of Shigella flexneri is Modulated by pH of Gastrointestinal Tract 114 79 12 10 3

Prevalence of genetically similar Flavobacterium columnare phages across aquaculture environments reveals a strong potential for pathogen control 52 12 5