Topic 52

antibiotic antibiotics resistance resistant antimicrobial microbiology infections bacterial bacteria isolates coli drug escherichia strains multidrug aeruginosa gram treatment susceptibility against pathogen pseudomonas aureus staphylococcus clinical pathogens pneumoniae biofilm klebsiella mic virulence antibacterial threat acinetobacter biofilms baumannii antimicrobials strain plasmid hospital emergence health amr carbapenem negative lactam lactamase efflux spread susceptible mdr spectrum treat concentrations beta isolated global infection nosocomial genes ciprofloxacin plasmids inhibitory efficacy opportunistic pathogenic isolate clinically mrsa killing methicillin pump ampicillin multi transfer presence combat therapy public colistin bactericidal agents concern lactamases drugs dissemination carbapenemase prevalence promising phage tetracycline mutations combination phages planktonic salmonella classes could tolerance horizontal

380 items. Top items listed below.

Collateral Sensitivity Associated with Antibiotic Resistance Plasmids 52 12 5

Linking phenotype, genotype and ecology: antimicrobial resistance in the zoonotic pathogen Streptococcus suis 107 52 12 5

Tamoxifen repurposing to combat infections by multidrug-resistant Gram-negative bacilli 52 10

Bacteriophages targeting Acinetobacter baumannii capsule induce antimicrobial resensitization 52 12 10

Comparison of transcriptional responses of three multidrug resistant model microorganisms, Staphylococcus aureus ATCC BAA-39, Escherichia coli ATCC BAA-196 and Acinetobacter baumannii ATCC BAA-1790, on exposure to iodine-containing nano-micelle drug FS-1 52 12 10

Genomic characterisation and context of the blaNDM-1 carbapenemase in Escherichia coli ST101. 107 52 25 12 5

Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane 52 12 10 3

Bacterial defenses against a natural antibiotic promote collateral resilience to clinical antibiotics 52 12 10 5

Unravelling mechanisms of meropenem induced persistence facilitates identification of GRAS compounds with anti-persister activity against Acinetobacter baumannii 52 12 10

Heterogenous response to R-pyocin killing in populations of Pseudomonas aeruginosa sourced from cystic fibrosis lungs 52 12 10

In vitro evolution of colistin resistance in the Klebsiella pneumoniae complex follows multiple evolutionary trajectories with variable effects on fitness and virulence characteristics. 52 12 10

Uncovering the hidden antibiotic potential of Cannabis 52 12 10

Comparative genomics reveals different population structures associated with host and geographic origin in antimicrobial-resistant Salmonella enterica 107 52 12 5

Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients. 52 12 10

Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections 52 12 10

Isopropoxy benzene guanidine kills Staphylococcus aureus without detectable resistance 52 12 10

Analysis of selection methods to develop novel phage therapy cocktails against antimicrobial resistant clinical isolates of bacteria 107 52 12

Mapping the Role of AcrAB-TolC Efflux Pumps in the Evolution of Antibiotic Resistance Reveals Near-MIC Treatments Facilitate Resistance Acquisition 52 12 5

Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa 52 12 10

Evolution of Honey Resistance in Experimental Populations of Bacteria Depends on the Type of Honey, and Has no Major Side Effects for Antibiotic Susceptibility 52 12 5

Integrative and Conjugative Elements (ICE) and Associated Cargo Genes within and across Hundreds of Bacterial Genera 107 52 12 5

The small RNA ErsA plays a role in the regulatory network of Pseudomonas aeruginosa pathogenicity in airways infection 114 52 12 3

The antimicrobial peptide DGL13K is active against resistant gram-negative bacteria and subinhibitory concentrations stimulate bacterial growth without causing resistance 52 12 10

Upregulation of gluconeogenesis leads to increased tolerance to antibiotics targeting the MreB elongosome in E. coli 52 12 3

Investigating the impact of combination phage and antibiotic therapy: a modeling study 52 12 10

Limited and strain-specific transcriptional and growth responses to acquisition of a multidrug resistance plasmid in genetically diverse Escherichia coli lineages 52 12 5

Characterization of the antimicrobial activity of the cell-penetrating peptide TAT-RasGAP317-326 52 12

High-throughput cell-based assays for the preclinical development of DsbA inhibitors as antivirulence therapeutics. 52 12

IlvY is an important regulator of Shigella infection in vitro and in vivo 52 12 10

The generation of persister cells is regulated at the initiation of translation by (p)ppGpp 52 12 3

Rapid evolution drives the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection 52 12 5

Non-clonal emergence of colistin resistance associated with mutations in the BasRS two component system in Escherichia coli bloodstream isolates 107 52 12

PQS-Induced Outer Membrane Vesicles Enhance Biofilm Dispersion in Pseudomonas aeruginosa 52 12 10 3

Allelic polymorphism shapes community function in evolving Pseudomonas aeruginosa populations 52 12 5

Bacterial single-cell genomics enables phylogenetic analysis and reveals population structures from in vitro evolutionary studies 107 52 12 9 5 4

Weakest link dynamics predict apparent antibiotic interactions in a model cross-feeding community. 52 12 5

Computational Model to Quantify the Growth of Antibiotic Resistant Bacteria in Wastewater 52 12 5

Prevalence of Diversified Antibiotic Resistant Bacteria within Sanitation Related Facilities of Human Populated Workplaces in Abbottabad 52 12 5

Correlation of pathogenic factors with antimicrobial resistance of clinical Proteus mirabilis strains 52 12 5

Inoculum effect of antimicrobial peptides 52 12

Diversity of Antimicrobial-Resistant Aeromonas Species Isolated from Aquatic Environments in Brazil 107 52 12 5

Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability 52 12 3

Collateral sensitivity interactions between antibiotics depend on local abiotic conditions 52 12 5

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections 52 12 10

Antimycobacterial potential of Mycobacteriophage under disease-mimicking conditions 52 12 10

Manganese complex Br increases antibiotic sensitivity in multidrug resistant Streptococcus pneumoniae 52 12 10

Phage infection and sub-lethal antibiotic exposure mediate Enterococcus faecalis type VII secretion system dependent inhibition of bystander bacteria 52 12 10 3

Differential gene expression and alternation of patterns of DNA methylation in the multidrug resistant strain Escherichia coli ATCC BAA-196 caused by iodine-containing nano-micelle drug FS-1 that induces antibiotic resistance reversion 52 12 9

Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations 7

Idiosyncratic variation in the fitness costs of tetracycline-resistance mutations in Escherichia coli 52 21 5

Ceragenins and antimicrobial peptides kill bacteria through distinct mechanisms 52 12

Genes influencing phage host range in Staphylococcus aureus on a species-wide scale 52 12 5

Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone-resistance evolution 52 12 5

Clinical extended-spectrum beta-lactamase antibiotic resistance plasmids have diverse transfer rates and can spread in the absence of antibiotic selection 107 52 12 5

Prevalence of genetically similar Flavobacterium columnare phages across aquaculture environments reveals a strong potential for pathogen control 52 12 5

An adjunctive therapy approach prevents antibiotic resistance emergence in opportunistic pathogens colonizing the gut 52 12 10

Targeted-Antibacterial-Plasmids (TAPs) combining conjugation and CRISPR /Cas systems achieve strain-specific antibacterial activity 52 33 12

Identification and characterization of pleiotropic high-persistence mutations in the beta subunit of the bacterial RNA polymerase 52 12

Genomic Surveillance of Pseudomonas aeruginosa in the Philippines from 2013-2014 107 52 12 5

Triclosan depletes the membrane potential in Pseudomonas aeruginosa biofilms inhibiting aminoglycoside induced adaptive resistance 52 12 10 3


Characterizing the response of Acinetobacter baumannii ATCC 17978 to azithromycin in multiple in vitro growth conditions 52 12 10


The antimicrobial peptide TAT-RasGAP317-326 inhibits the formation and the expansion of bacterial biofilms in vitro 52 12 10

Granadaene Photobleaching Reduces the Virulence and Increases Antimicrobial Susceptibility of Streptococcus agalactiae 52 12 10

Resident microbial communities inhibit growth and antibiotic resistance evolution of Escherichia coli in human gut microbiome samples 158 143 29 12 5

Functional and structural characterization of H105Y mutation in MtrR protein of Neisseria gonorrhoeae 52 8

Predicting antibiotic-associated virulence of Pseudomonas aeruginosa using an ex-vivo lung biofilm model 52 12 10

The length of lipoteichoic acid polymers controls Staphylococcus aureus cell size and envelope integrity 52 12 3

Bacteriophage activity against and characterisation of avian pathogenic Escherichia coli isolated from colibacillosis cases in Uganda 107 52 12 5

Multiplex CRISPRi-Cas9 silencing of planktonic and stage-specific biofilm genes in Enterococcus faecalis 52 12

Simulation-guided engineering of antibiotics for improved bacterial uptake 52 12 8

Insights into the diversity and survival strategies of soil bacterial isolates from the Atacama Desert 52 29 12 5

Predicting Antimicrobial Resistance Using Conserved Genes 182 107 52 26 4

Phenotypic delay in the evolution of bacterial antibiotic resistance: mechanistic models and their implications 185 21 5

Bacterial behavior in human blood reveals complement evaders with persister-like features 52 12 10

Selective antibiofilm properties and biocompatibility of nano-ZnO and nano-ZnO/Ag coated surfaces 52 12

Explore the Potential of a Plant Phospholipase as an Antimicrobial 52 12

Plasmidome analysis of carbapenem-resistant Enterobacteriaceae isolated in Vietnam 107 52 25 12 5

Harnessing Ultrasound-Stimulated Phase Change Contrast Agents to Improve Antibiotic Efficacy Against Methicillin-Resistant Staphylococcus aureus Biofilms 52 12 10

AMPlify: attentive deep learning model for discovery of novel antimicrobial peptides effective against WHO priority pathogens 52 12 4

The safety profile of Bald's eyesalve for the treatment of bacterial infections 52 12 10

Acidification of Cytoplasmic pH in Escherichia coli Provides a Strategy to Cope with Stress and Facilitates Development of Antibiotic Resistance 52 12 3

Genomic and phenotypic diversity of Enterococcus faecalis isolated from endophthalmitis 107 52 12 5

See and Sequence: Integrating Whole-Genome Sequencing Within the National Antimicrobial Resistance Surveillance Program in the Philippines 107 52 12 5

Multi-omic surveillance of Escherichia coli and Klebsiella spp. in hospital sink drains and patients 107 52 12 5

A potent antibiofilm agent inhibits and eradicates mono- and multi-species biofilms 52 12 10

Identification of a peroxidase inhibitor that enhances kanamycin activity 52 12 10

Comparison of de-duplication methods used by WHO Global Antimicrobial Resistance Surveillance System (GLASS) and Japan Nosocomial Infections Surveillance (JANIS) in the surveillance of antimicrobial resistance 107 52 12 5

Phenotypic and multi-omics characterization of Escherichia coli K-12 adapted to quaternary ammonium compounds identifies lipid A and cell envelope alterations regulated by mar-sox-rob and stress inducible pathways 52 12 9

A dual-mechanism antibiotic targets Gram-negative bacteria and avoids drug resistance 52 12

The household resistome - frequency of beta-lactamases, class 1 integron and antibiotic resistant bacteria in the domestic environment 107 52 12 5

Differential effects of antibiotic treatment with piperacillin/tazobactam or ceftriaxone on the murine gut microbiota 101 52 29 12 10

In Silico identification of potential drug targets by subtractive genome analysis of Enterococcus faecium DO. 52 12

Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli 52 27 12 10 3

Phage-Antibiotic Synergy Is Driven By A Unique Combination Of Antibacterial Mechanism Of Action And Stoichiometry 52 12 10

CAUTI's Next Top Model - model dependent Klebsiella biofilm inhibition by bacteriophages and antimicrobials 52 7

Capsicumine: a new peptide from red peppers turns out to be a powerful antibiofilm agent and displays a new mechanism of action, matrix anti-assembly 52 12

Characterising the mechanism of action of an ancient antimicrobial, honey, using modern transcriptomics 52 12

Pseudomonas aeruginosa is capable of natural transformation in biofilms 79 52 12 5