Topic 67

metabolic metabolism carbon production growth acid glucose flux enzymes energy synthesis biosynthesis pathway acids pathways fatty oxidation metabolites engineering enzyme metabolite phosphate oxidative glycolysis amino coli conditions biosynthetic nutrient product mitochondrial transport cycle oxygen biomass strain under atp nitrogen fermentation cellular yeast aerobic redox biochemistry electron escherichia co2 chain dehydrogenase uptake products coa reactions respiration substrate industrial availability mitochondria concentrations source photosynthesis consumption balance anaerobic systems engineered microbiology glycolytic microbial nutrients bacteria intracellular rate pyruvate lipid organisms producing photosynthetic produce synthetic stress limiting synthase organic acetyl heterologous glycerol biology chemicals strains glutamine lipids physiological intermediates sustainable levels bacterium tca supplementation

399 items. Top items listed below.

Escherichia coli metabolism under short-term repetitive substrate dynamics: Adaptation and trade-offs 67 12 5

Machine Learning and Optimal Control of Enzyme Activities to Preserve Solvent Capacity in the Cell 67 38 26 4

Effects of substrate availability on growth and metabolism in soil microbes: Insights from theoretical modeling of studies of the Warburg effect and substrate-induced respiration 158 67 29 17 12

Proteome constraints reveal targets for improving microbial fitness in nutrient-rich environments 158 67 38 12

Formaldehyde-responsive proteins, TtmR and EfgA, reveal a tradeoff between formaldehyde resistance and efficient transition to methylotrophy in Methylorubrum extorquens 67 12 3

The Arabidopsis mitochondrial dicarboxylate carrier 2 maintains leaf metabolic homeostasis by uniting malate import and citrate export 67 16 3


A roadmap for the characterization of energy metabolism in human cardiomyocytes derived from induced pluripotent stem cells 95 67 57 10 3

Novel two-stage processes for optimal chemical production in microbes 7

A Single Chromosome Strain of S. cerevisiae Exhibits Diminished Ethanol Metabolism and Tolerance. 67 16 3

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited 67 3

Cell-free styrene biosynthesis at high titers 67 18 12

Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae 69 34 3

Aerobic metabolism in Vibrio cholerae is required for population expansion during infection 114 79 67 12

Metabolism of long-chain fatty acids affects disulfide bond formation in Escherichia coli and activates envelope stress response pathways as a combat strategy 67 12 3

Metabolite sequestration enables rapid recovery from fatty acid depletion in Escherichia coli 158 67 38 12

Analysis of Metabolic Network Disruption in Engineered Microbial Hosts due to Enzyme Promiscuity 67 38 33 12

Post-translational control of PlsB is sufficient to coordinate membrane synthesis with growth in Escherichia coli 67 8 3

Calm on the surface, dynamic on the inside. Molecular homeostasis in response to regulatory and metabolic perturbation of Anabaena sp. 7120 nitrogen metabolism 67 16

Exploring Mechanisms of Glucose Uptake Regulation and Dilution Resistance in Growing Cancer Cells 67 38 3

Raman spectroscopy-based measurements of single-cell phenotypic diversity in microbial communities 158 38 18 17 5

Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast 67 3

Genetic dissection of the fermentative and respiratory contributions supporting Vibrio cholerae hypoxic growth 79 67 12

FGFR Signaling Coordinates the Balance Between Glycolysis and Fatty Acid β-Oxidation in Lymphatic Endothelial Cells 95 67 3

A multi-phase flux balance model reveals flexibility of guard cell central carbon metabolism 67 16

Increased demand for NAD+ relative to ATP drives aerobic glycolysis 95 67 3

Sterol 14α-demethylase is vital for mitochondrial functions and stress tolerance in Leishmania major 95 67 12 3

Proteomic analysis of metabolic pathways shows chloroplast-mitochondria cross-talk in a Cu-limited diatom 117 67 16 12

Computational study on ratio-sensing in yeast galactose utilization pathway 158 38

Resource reallocation in engineered Escherichia coli strains with reduced genomes 67 12

PCNA has specific functions in regulation of metabolism in haematological cells 67 3

Autotrophic and mixotrophic metabolism of an anammox bacterium revealed by in vivo 13C and 2H metabolic network mapping 67 12

Transcriptome-guided parsimonious flux analysis improves predictions with metabolic networks in complex environments 158 112 4

Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis (ALS) 61 39 10

Control and regulation of acetate overflow in Escherichia coli 67 38 3

Proteome overabundance enables respiration but limitation onsets carbon overflow 67

Metabolism of glucose and glutamine is critical for skeletal muscle stem cell activation. 95 67 3

C/EBPβ-LIP dually activates glycolysis and the malate aspartate shuttle to maintain NADH/NAD+ homeostasis 67 3

Laboratory evolution of multiple E. coli strains reveals unifying principles of adaptation but diversity in driving genotypes 67 21 5

Emergence of diauxie as an optimal growth strategy under resource allocation constraints in cellular metabolism 158 67 38 18

Mitochondrial fatty acid synthesis coordinates mitochondrial oxidative metabolism 95 67 3

Integrating cyanobacterial flavodiiron proteins within the chloroplast photosynthetic electron transport chain maintains carbohydrate turnover and enhances drought stress tolerance in barley 117 106 67 16 12 3

Increased glycolysis is an early outcome of palmitate-mediated lipotoxicity 95 67 39 10 3

Impaired chloroplast positioning affects photosynthetic capacity and regulation of the central carbohydrate metabolism during cold acclimation 117 16 5

Disruption of CYCLOPHILIN 38 function reveals a photosynthesis-dependent systemic signal controlling lateral root emergence 16 3

Xylose Metabolism and the Effect of Oxidative Stress on Lipid and Carotenoid Production in Rhodotorula toruloides: Insights for Future Biorefinery 67 12

L-ascorbic acid (vitamin C) fermentation by the human pathogen Vibrio cholerae 67 12

AMP-activated-kinase (AMPK) is essential sensor and metabolic regulator of retinal neurons and their integrated metabolism with RPE. 72 3

Translational control of methionine and serine metabolic pathways underpin the paralog-specific phenotypes of Rpl22 ribosomal protein mutants in cell division and replicative longevity 67 49 3

Benchmarking kinetic models of Escherichia coli metabolism 38 4

Physicochemical and metabolic constraints for thermodynamics-based stoichiometric modelling under mesophilic growth conditions 67 38 4

Bacterial evolution in high osmolarity environments 158 21 5

Charting the metabolic landscape of the facultative methylotroph Bacillus methanolicus 67 38 12

Dynamic metabolic reprogramming in dendritic cells: an early response to influenza infection that is essential for effector function 27 10 3

Genetically encoded biosensors for branched-chain amino acid metabolism to monitor mitochondrial and cytosolic production of isobutanol and isopentanol in yeast 67 12

Investigation of microbial community interactions between lake Washington methanotrophs using genome-scale metabolic modeling 158 67 29 17 5

Noise propagation in metabolic pathways: the role of growth-mediated feedback 67 38

RIP140 inhibits glycolysis-dependent proliferation of cancer cells by regulating transcriptional crosstalk between hypoxia induced factor and p53 108 67 3

A Lysate Proteome Engineering Strategy for Enhancing Cell-Free Metabolite Production 67 18

Effects of light/dark diel cycles on the photoorganoheterotrophic metabolism of Rhodopseudomonas palustris for differential electron allocation to PHAs and H2 67 12

Integrated metabolic modeling, culturing and transcriptomics explains enhanced virulence of V. cholerae during co-infection with ETEC 114 12

Single amino acid-promoted reactions link a non-enzymatic chemical network to the early evolution of enzymatic pentose phosphate pathway 129 67 63 8

Deglutarylation of GCDH by SIRT5 controls lysine metabolism in mice 199 67 63 3

Dynamic allocation of carbon storage and nutrient-dependent exudation in a revised genome-scale model of Prochlorococcus 67 29

Evolutionarily Conserved Transcription Factors Drive the Oxidative Stress Response in Drosophila 134 31 9 3

Dynamic control over feedback regulation identifies pyruvate-ferredoxin oxidoreductase as a central metabolic enzyme in stationary phase E. coli. 67 3

Methionine synthase is essential for cancer cell proliferation in physiological folate environments 67 14 3

Anaplerotic pathways in Halomonas elongata: the role of the sodium gradient 67 12

Fructose fuels tumor growth through the polyol pathway and GLUT 8 transporter 67 3

Crucial role of ppGpp in the resilience of Escherichia coli to growth disruption 158 79 67 12

Resistance to serine in Bacillus subtilis: Identification of the serine transporter YbeC and of a metabolic network that links serine and threonine metabolism 79 67 12 3

DIA-based systems biology approach unveils novel E3-dependent responses to a metabolic shift 45 4

Transcriptome signature in E. coli under a prolonged starvation environment 158 79 12 9 5

A Data-Independent-Acquisition-based proteomic approach towards understanding the acclimation strategy of Microchloropsis gaditana CCMP526 in hypersaline conditions 67 16 12

Modeling a co-culture of Clostridium autoethanogenum and Clostridium kluyveri to increase syngas conversion to medium-chain fatty-acids 7

Mitochondrial uncoupling protein 2 (UCP2), but not UCP3, is sensitive to oxygen concentration in cells 7 3

Depletion of cardiolipin induces major changes in energy metabolism in Trypanosoma brucei bloodstream forms 95 67 34 3

Short chain fatty acid butyrate promotes virus infection by repressing interferon stimulated genes 27 10 3

Error propagation in constraint-based modeling of Chinese hamster ovary cells 67 38

Efficient reaction deletion algorithms for redesignof constraint-based metabolic networks for metabolite production with weak coupling 67 4

Metabolic profiling reveals nutrient preferences during carbon utilization in Bacillus species 158 114 79 12 5

The landscape of metabolic pathway dependencies in cancer cell lines 186 9 3

Enzyme-constrained models and omics analysis of Streptomyces coelicolor reveal metabolic changes that enhance heterologous production 199 67 12

Development of a growth coupled dynamic regulation network balancing malonyl-CoA node to enhance (2S)-naringenin synthesis in E. coli 67 18

The defining genomic and predicted metabolic features of the Acetobacterium genus 121 67 12 5

Prebiotics and community composition influence gas production of the human gut microbiota 101 29 12 5

Amino Sugars Reshape Interactions between Streptococcus mutans and Streptococcus gordonii. 12 5

Environmental and physiological factors affecting high-throughput measurements of bacterial growth 158 67 12

The genome of a nonphotosynthetic diatom provides insights into the metabolic shift to heterotrophy and constraints on the loss of photosynthesis 67 12 5

Computational genomic discovery of diverse gene clusters harboring Fe-S flavoenzymes in anaerobic gut microbiota 143 29 12 5

Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth in vitro and in vivo 108 14 10 3

Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans 67 12 3

Temporal changes in metabolism late in seed development affect biomass composition in soybean 67 16

EfgA is a conserved formaldehyde sensor that halts bacterial translation in response to elevated formaldehyde 79 67 12 3

Representing Organic Matter Thermodynamics in Biogeochemical Reactions via Substrate-Explicit Modeling 38 4

Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in PC12 cells 95 10 3

Predicting trajectories and mechanisms of antibiotic resistance evolution 158 21 5

Effect of Cysteine, Yeast Extract, pH Regulation and Gas Flow on Acetate and Ethanol Formation and Growth Profiles of Clostridium ljungdahlii Syngas Fermentation 67 12

A Failure Mode and Effect Analysis of plant metabolism reveals why cytosolic fumarase is required for temperature acclimation in Arabidopsis 159 16

Nutrient sensing pathways regulating adult reproductive diapause in C. elegans 90 67 3