Topic 90

elegans caenorhabditis nematode worms conserved animals lifespan mutants daf nematodes germline developmental genetics longevity rnai aging stress neurons organism regulate worm signaling acts regulates pathway dependent required foxo suggesting transcription neuronal defects protein factor extension function regulated promote genes organisms ortholog dauer insulin mutant regulating response modulate mammals screen animal nervous show find identify soma dietary biology expression regulation food mediated body mutation mechanism affects wild genetic germ understood mitochondrial mammalian gene manner pathways organismal generations somatic mutations chemosensory muscles role unc through rescue environment kinase processes age extends locomotion 16 system vulva sensory many inheritance homeostasis metabolism defective autonomously

166 items. Top items listed below.

NHR-49 acts in distinct tissues to promote longevity versus innate immunity 90 3

The SEM-4 transcription factor is required for regulation of the oxidative stress response in Caenorhabditis elegans 128 90 3

The O-GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress 90 3

The heat shock transcription factor HSF-1 protects Caenorhabditis elegans from peroxide stress 90 3

Nutrient sensing pathways regulating adult reproductive diapause in C. elegans 90 67 3

FHOD formin and SRF promote striated muscle development through separate pathways in C. elegans. 90 3

Comparative Transcriptomics of heads and tails between Steinernema carpocapsae and Caenorhabditis elegans 90 9

Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans 90 79 3

Lactobacilli in a clade ameliorate age-dependent decline of thermotaxis behavior in Caenorhabditis elegans 90 30

The RNA Polymerase II core subunit RPB-9 directs transcriptional elongation at piRNA loci in Caenorhabditis elegans 90 49 31 20 3

Intergenerational pathogen-induced diapause in C. elegans is modulated by mir-243. 90 79 74 12 3

piRNAs prevent runaway amplification of siRNAs from ribosomal RNAs and histone mRNAs 90 49 3

NHR-8 regulated P-glycoproteins uncouple xenobiotic stress resistance from longevity in chemosensory C. elegans mutants 90 3

Whole-organism mapping of the genetics of gene expression at cellular resolution 19 9 4

Host immunity alters successional ecology and stability of the microbiome in a C. elegans model 90 29 17 5

Notch-Directed Germ Cell Proliferation Is Mediated by Proteoglycan-Dependent Transcription 90 20 3

CREB non-autonomously regulates Reproductive Aging through Hedgehog/Patched Signalling 90 20 3

Genome-wide RNAi screen for regulators of UPRmt in Caenorhabditis elegans mutants with defects in mitochondrial fusion 90 3

Roles for the RNA polymerase III regulator MAFR-1 in regulating sperm quality in Caenorhabditis elegans 90 56 49 3

Mitochondria surveillance systems trigger innate immune responses to bacterial pathogens via AMPK pathway in C. elegans 90 27 3

The predicted RNA-binding protein ETR-1/CELF1 acts in muscles to regulate neuroblast migration in Caenorhabditis elegans 90 20 3

Atypical TGF-beta Signaling Controls Neuronal Guidance in Caenorhabditis elegans 90 20 3

C. elegans ELT-3 regulates cuticle collagen expression in response to environmental stimuli 90 20 3

Reduced insulin signalling in adulthood protects soma and germline under mutation accumulation 90 21 5

A comparative analysis of Caenorhabditis and Drosophila transcriptional changes in response to pathogen infection 90 12 5

Serotonin signaling by maternal neurons upon stress ensures progeny survival 90 20 3

Axin-mediated regulation of lifespan and muscle health in C. elegans involves AMPK-FOXO signaling 90 3

eIF2B extends lifespan through inhibition of the integrated stress response 90 49 3

NHR-49/PPAR-α and HLH-30/TFEB promote C. elegans host defense via a flavin-containing monooxygenase 90 27 3

FOXO regulates neuromuscular junction homeostasis during Drosophila aging 90 3

FHOD-1 is the only formin in Caenorhabditis elegans that promotes striated muscle growth and Z-line organization in a cell autonomous manner 90 20 3

Discriminating between sleep and exercise-induced fatigue using computer vision and behavioral genetics 90 30

Social chemical communication determines recovery from L1 arrest via DAF-16 activation 90 3

Feeding recombinant Royalactin: Measures of improved lifespan and mitochondrial function in Caenorhabditis elegans 90 67

Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons 90 3

A transcriptome based aging clock near the theoretical limit of accuracy 87 9 4

C. elegans processes sensory information to choose between freeloading and self-defense strategies 90 11

Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1 independent transcriptional response. 90 3

Oleic acid protects Caenorhabditis mothers from mating-induced death 90 67 56 3

Optogenetic control of gut bacterial metabolism to promote longevity 158 90 67 12

Transcriptome analysis of the Nematode Caenorhabditis elegans in acidic stress environments 90 67 5

Genetic or toxicant induced disruption of vesicular monoamine storage and global metabolic profiling in Caenorhabditis elegans 90 11 3

Two Caenorhabditis elegans calponin-related proteins have overlapping functions to maintain cytoskeletal integrity and are essential for reproduction 90 55 34 3

Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling 69 34 3

Ahr-bacterial diet interaction modulates aging and associated pathologies in C. elegans 90 3

AdipoR2 is Essential for Membrane Lipid Homeostasis in Response to Dietary Saturated Fats 90 34 3

Mutator foci are regulated by developmental stage, RNA, and the germline cell cycle in Caenorhabditis elegans 90 20 3

Microbial colonization induces histone acetylation critical for inherited gut-germline-neural signaling 90 79 3

Inhibition of mTOR decreases insoluble protein burden by reducing translation in C. elegans 90 3

The G-protein coupled receptor SRX-97 is required for concentration dependent sensing of Benzaldehyde in Caenorhabditis elegans 90 11 3

Evolutionary causes of lifespan extension by dietary restriction: linking theory and mechanisms 90 21 5

Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism 90 67 34 3

KH domain containing RNA-binding proteins coordinate with microRNAs to regulate Caenorhabditis elegans development 74 49 9 3

The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 during aging and confers resistance to environmental stress in postreproductive adult C. elegans 90 3

From pathogen to commensal to probiotic: modification of Microbacterium nematophilum-C. elegans interaction during chronic infection by the absence of host insulin signalling 90 12 10

Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease 54 3

Gap junctions deliver malonyl-CoA from soma to germline to support embryogenesis in Caenorhabditis elegans 90 67 20 3

Natural variation in a glucuronosyltransferase modulates propionate sensitivity in a C. elegans propionic acidemia model 90 19 9

PINK1-parkin-mediated mitophagy generates stereotyped somatic mosaicism of the mitochondrial genome 90 3

Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development 90 20 3

Combining auxin-induced degradation and RNAi screening identifies novel genes involved in lipid bilayer stress sensing in Caenorhabditis elegans 90 69 3

Non-autonomous regulation of germline stem cell proliferation bysomatic MPK-1/MAPK activity in C. elegans 90 20 3

Histone modifications at the transcription start site of non-coding RNA revealed regulatory patterns of activation in Caenorhabditis elegans embryo 31 9 3

The Regulation of Developmental Diapause is Coordinated with Molting and Olfaction 90 3

The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1 90 46 34 3

Short-term heritable variation overwhelms two hundred generations of mutational variance for metabolic traits in Caenorhabditis elegans 90 21 5

Conserved and divergent aspects of Robo receptor signaling and regulation between Drosophila Robo1 and C. elegans SAX-3 90 20 3

Novel Immune Modulators Enhance Caenorhabditis elegans Resistance to Multiple Pathogens 114 90 12 10 3


CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression 90 3

Neuronal perception of the social environment intergenerationally controls germline development and generation time in C. elegans 90 30 11

Comparative transcriptomics across nematode life cycles reveal gene expression conservation and correlated evolution in adjacent developmental stages 90 40 5

The genetic paradigms of dietary restriction fail to extend life span in cep-1(gk138) mutant of C. elegans p53 due to possible background mutations 90 3

DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence 90 20 3

C. elegans aversive olfactory learning generates diverse intergenerational effects 90

Trans-generational inheritance of centromere identity requires the CENP-A N-terminal tail in the C. elegans maternal germ line 90 68 34 20 3

A functional non-coding RNA is produced from xbp-1 mRNA 90 49 3

Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans 20 3

SNPC-1.3 is a sex-specific transcription factor that drives male piRNA expression in C. elegans 90 20 3

Girdin regulates dendrite morphogenesis and cilium position in two specialized sensory neuron types in C. elegans 90 20 3

The female-specific VC neurons are mechanically activated, feed-forward motor neurons that facilitate serotonin-induced egg laying in C. elegans 154 90 11 2

Selfish mitochondria exploit nutrient status across different levels of selection 90 21 5

Transcriptional Control Of Calmodulin By CAMTA Regulates Neural Excitability 90 31 3

An extracellular protein regulates patched-related/DAF-6-mediated sensory compartment formation in C. elegans 90 34 20 3

The effect of E-liquid exposure on Caenorhabditis elegans. 90 67

C. elegans dauer recovery varies with worm-bacteria interactions 90 5

Inversion of pheromone preference optimizes foraging in C. elegans 90 30

A quiescent state following mild sensory arousal in Caenorhabditis elegans is potentiated by stress 90 11 2

Population scale nucleic acid delivery to Caenorhabditis elegans via electroporation 33 18

Evolutionarily Conserved Transcription Factors Drive the Oxidative Stress Response in Drosophila 134 31 9 3

Opposing effects of an F-box protein and the HSP90 chaperone network on microtubule stability and neurite growth in Caenorhabditis elegans 90 34 20 3

Arc1 modulates microbiota-responsive developmental and metabolic traits in Drosophila 90 3

Reduction of insulin/IGF-1 receptor rejuvenates immunity via positive feedback circuit 90 3

Harmonization of L1CAM Expression Facilitates Axon Outgrowth and Guidance of a Motor Neuron 90 20 3

Sensitivity to perturbations of a cell migration under temporal regulation 90 20

Gα/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca 90 34 3

Chromosome-level assembly of the Caenorhabditis remanei genome reveals conserved patterns of nematode genome organization 25 21 5

Preconditioning of Caenorhabditis elegans to Anoxic Insult by Inactivation of Cholinergic, GABAergic, and Muscle Activity 90 11 3

Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1 90 3

CCP1, a tubulin deglutamylase, increases survival of rodent spinal cord neurons following glutamate-induced excitotoxicity 90 34 3