Topic 39

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229 items. Top items listed below.

PHOSPHO1, a novel skeletal regulator of insulin resistance and obesity 39 10 3

Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia 39 10 3

ANGPTL4 from adipose, but not liver, is responsible for regulating plasma triglyceride partitioning 39 7 3

Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice 39 10 3

Lack of Adipocyte Purinergic P2Y6 Receptor Greatly Improves Whole Body Glucose Homeostasis 39 10 3

Impairment of the Gβγ-SNAP25 brake on exocytosis enhances insulin action, protects against diet-induced obesity, and promotes adipocyte browning 39 10 3

Inhibition of Mitochondrial Fission and iNOS in the Dorsal Vagal Complex Protects from Overeating and Weight Gain 39 10 3

Role of sex and high fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer's disease 39 32 10

Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver-specific conditional knockouts. 39 10 3

Early life stress reduces voluntary exercise and its prevention of diet-induced obesity and metabolic dysfunction in mice 39 10 3

IF1 connects obesity and insulin resistance through mitochondrial reprogramming in association with ANT2 39 10 3

FFAR1 and FFAR4 additively cooperate to control glucose tolerance and insulin secretion in male mice 109 39 10 3

Chronic low-dose dioxin exposure accelerates high fat diet-induced hyperglycemia in female mice 109 39 10 3

Systemic benefits of Gc inhibition to preserve insulin sensitivity 39 10 3

Breast cancer endocrine therapy exhausts adipocyte progenitors promoting weight gain and glucose intolerance 39 10 3

Egr1 loss-of-function promotes beige adipocyte differentiation and activation specifically in inguinal subcutaneous white adipose tissue 39 3

Gut microbiota impairs insulin clearance during obesity 39 10 3

The Epidermal Barrier is Indispensable for Systemic Energy Homeostasis 39 10 3

Caloric Restriction recovers impaired β-cell-β-cell coupling, calcium oscillation coordination and insulin secretion in prediabetic mice 109 39 10 3

Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease 39 27 10 3

Soluble mannose receptor induces pro-inflammatory macrophage activation and metaflammation 39 27 10 3

Reduced expression of TCF7L2 in adipocyte impairs glucose tolerance associated with decreased insulin secretion, incretins levels and lipid metabolism dysregulation in male mice 39 10 3

m6A Regulates Liver Metabolic Disorders and Hepatogenous Diabetes 39 3

Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activity 109 39 10 3

Beige adipocytes independently improve impaired glucose metabolism in the absence of brown adipose tissues in vivo 39 10 3

Sustained anti-obesity effects of life-style change and anti-inflammatory interventions after conditional inactivation of the activin receptor ALK7 39 10 3

Codon-optimized FAM132b prevents diet-induced obesity by modulating adrenergic response and insulin action 39 10 3

TRPM7 is a critical regulator of pancreatic endocrine development and high-fat diet-induced β-cell proliferation. 109 39 20 3

Adipocyte REVERBα dictates adipose tissue expansion during obesity 39 3

Beta-cell specific insulin resistance promotes glucose-stimulated insulin hypersecretion 109 39 10 3

RIPK2 dictates insulin responses to tyrosine kinase inhibitors in obese mice 39 10 3

Chop/Ddit3 depletion in β-cells alleviates ER stress and corrects hepatic steatosis 109 39 10 3

The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess 109 39 3

T cells are present in non-diabetic islets and accumulate during aging. 109 39 10 3

The role of elevated branched chain amino acids in the potent effects of vertical sleeve gastrectomy to reduce weight and improve glucose regulation in mice 39 10

High-fat diet impacts the colon and its transcriptome in a sex-dependent manner that is modifiable by estrogens 39 10 3

Is there a role for the RNA-binding protein LARP1 in β-cells? 109 39 10 3

NUPR1 protects liver from lipotoxic injury by improving the endoplasmic reticulum stress response 39 10 3

A common human variant of GIPR improves systemic glucose homeostasis in a sexual dimorphic manner 39 10 3

The long non-coding RNA Pax6os1/PAX6-AS1 modulates pancreatic β-cell identity and function. 109 39 3

Spontaneous restoration of functional β-cell mass in obese SM/J mice 109 39 10 3

Cold-mediated regulation of systemic retinol transport controls adipose tissue browning 39 10 3

Loss of Bone Morphogenetic Protein-binding Endothelial Regulator Causes Insulin Resistance 39 7 3

KD-64 - a new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist - caffeine does not reduce diet-induced obesity in mice 39 10

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis 109 39 10 3

Mouse models for V103I and I251L gain of function variants of the human MC4R display reduced adiposity and are not protected from a hypercaloric diet 39 10

Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver disease 39 10 7

STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesity 39 27 10 3

Liver-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice 39 7 3

HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signaling 39 3

Consumption of a high energy density diet triggers microbiota dysbiosis, hepatic lipidosis, and microglia activation in the nucleus of the solitary tract in rats. 39 10

Chronic Exposure to Palmitic Acid Downregulates AKT in Beta-Cells through Activation of mTOR 109 39 10 3

Impact of high-fat diet on lifespan, metabolism, fecundity and behavioral senescence in Drosophila 39 15 10

Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation in murine models of chemically- and obesity-induced liver injury 39 10 3

Inhibiting LXRα Phosphorylation in Hematopoietic Cells Reduces Inflammation and Attenuates Atherosclerosis and Obesity 39 27 10 3

Berberine alleviates adiposity and cardiac dysfunction in offspring exposed to gestational diabetes mellitus 39 10

Female mice exposed to low-doses of dioxin during pregnancy and lactation have increased susceptibility to diet-induced obesity and diabetes 109 39 10

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages 39 10 3

A high fat containing chicken egg-only diet suppresses fatty liver induced by a lipid-rich methionine and choline deficient diet. 39 7 3

Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in liver and adipose tissue 39 10 3

A Critical Role of Hepatic GABA in The Metabolic Dysfunction and Hyperphagia of Obesity 39 10 3

Antisense oligonucleotides against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1 6 3

Bariatric surgery normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice 39 10 3

Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue 39 7 3

Flattened circadian glucocorticoid oscillations cause obesity due to increased lipid turnover and lipid uptake 39 10 3

LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity 39 3

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high fat diet 109 39 10 3

A novel female-specific circadian clock mechanism regulating metabolism 39 3

Perilipin2 down-regulation in beta cells impairs insulin secretion under nutritional stress and damages mitochondria 109 39 10 3

The helminth glycoprotein omega-1 improves metabolic homeostasis in obese mice through type-2 immunity-independent inhibition of food intake 39 10 3

A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β-cells 109 39 3

Brown Adipose Tissue is Associated with Improved Cardiometabolic Health and Regulates Blood Pressure 39 10

Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment 39 10 3

Maternal vitamin D deficiency increases the risk of obesity in male mice offspring by affecting the immune response 39 27 10 3

Physiological and Metabolic Features of Mice with CRISPR/Cas9-Mediated Loss-of-Function in Growth Hormone-Releasing Hormone 39 10 3

Activation of the Crtc2/Creb1 transcriptional network in skeletal muscle enhances weight loss during intermittent fasting 39 3

C/EBPβ regulates hypertrophic versus hyperplastic fat tissue growth 39 10 3

Adipose tissue developmental growth constraints uncouple fat distribution from glucose metabolism in two mouse models of obesity 39 10 3

Gut Microbiota Mediates the Protective Effects of Andrographolide Inhibits Inflammation and Nonalcoholic Fatty Liver Disease(NAFLD) in High-Fat Diet induced ApoE(-/-) Mice 39 10 3

Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis 39 3

SWELL1-LRRC8 complex regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism 39 3

Peripheral sgp130-mediated trans-signaling blockade induces obesity and insulin resistance in mice via PPARα suppression 39 10 3

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner 39 10

Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice 109 39 10 3


EP3 signaling is decoupled from regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance 109 39 10 3

Identification of DNA response elements regulating expression of CCAAT/enhancer-binding protein (C/EBP) β and δ during early adipogenesis 39 31 3

Temporal Metabolic Characteristics and Transcriptomic Landscape of Islets and Liver Reveal Dynamic Pathophysiology and Interorgan Crosstalk in High-fat Diet-induced Diabetes 109 39 10 9 3

Eurycomanone regulates lipid metabolism by activating the cAMP/PKA pathway 39 10 3

Celastrol directly inhibits PFKM to induce weight loss and leptin sensitization 39 10 3

CRISPR-enhanced human adipocyte 'browning' as cell therapy for metabolic disease 39 10 3

Adipose Tissue is a Critical Regulator of Osteoarthritis 7 3

The Prorenin Receptor and its Soluble Form Contribute to Lipid Homeostasis 39 10 3

Glucose clearance and uptake is increased in the SOD1G93A mouse model of amyotrophic lateral sclerosis through an insulin-independent mechanism 61 39 10 3

AGO HITS-CLIP in Adipose Tissue Reveals miR-29 as a Post-Transcriptional Regulator of Leptin 74 39 9 3

Effect of the p75 Neurotrophin Receptor on Glycemic Control of Obese Mice during Time-Restricted Feeding 39 10 3

Metabolic and functional impairment of CD8+ T cells from the lungs of influenza-infected obese mice 39 27 10 3

The negative adipogenesis regulator DLK1 is transcriptionally regulated by TIS7 (IFRD1) and translationally by its orthologue SKMc15 (IFRD2) 39 3

Holistic Characterization of Single Hepatocyte Transcriptome Responses to High Fat Diet 39 9 3

Thermogenic genes are blunted whereas brown adipose tissue identity is preserved in human obesity 39 9 3