Topic 109

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69 items. Top items listed below.

Spontaneous restoration of functional β-cell mass in obese SM/J mice 109 39 10 3

The long non-coding RNA Pax6os1/PAX6-AS1 modulates pancreatic β-cell identity and function. 109 39 3

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a new regulator of insulin secretion 109 89 31 9 3

Synchronized beta cell response to glucose is lost concomitant with loss of islet architecture in Robo deficient islets of Langerhans in vivo 109 20 3

Testosterone enhances GLP-1 efficacy at the plasma membrane and endosomes to augment insulin secretion in male pancreatic β cells 109 39 10 3

EP3 signaling is decoupled from regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance 109 39 10 3

Caloric Restriction recovers impaired β-cell-β-cell coupling, calcium oscillation coordination and insulin secretion in prediabetic mice 109 39 10 3

Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activity 109 39 10 3

Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice 109 39 10 3

Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs 109 93 31 3

Chronic low-dose dioxin exposure accelerates high fat diet-induced hyperglycemia in female mice 109 39 10 3

TRPM7 is a critical regulator of pancreatic endocrine development and high-fat diet-induced β-cell proliferation. 109 39 20 3

Dynamic changes in β-cell electrical activity and regulates NFATc3 activation and downstream gene transcription 109 82 3

Chop/Ddit3 depletion in β-cells alleviates ER stress and corrects hepatic steatosis 109 39 10 3

Free-fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice 109 39 10 3

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high fat diet 109 39 10 3

A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β-cells 109 39 3

Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion 109 3

SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic beta-cells 109 39 3

Furin controls β cell function via mTORC1 signaling 109 3

Perilipin2 down-regulation in beta cells impairs insulin secretion under nutritional stress and damages mitochondria 109 39 10 3

FFAR1 and FFAR4 additively cooperate to control glucose tolerance and insulin secretion in male mice 109 39 10 3

T cells are present in non-diabetic islets and accumulate during aging. 109 39 10 3

Islet Gene View - a tool to facilitate islet research 109 9

The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess 109 39 3

Chronic Exposure to Palmitic Acid Downregulates AKT in Beta-Cells through Activation of mTOR 109 39 10 3

Imeglimin Amplifies Glucose-Stimulated Insulin Release from Diabetic Islets via a Distinct Mechanism of Action 109 64 10 3

AVP-induced counter-regulatory glucagon is diminished in type 1 diabetes 109 39 10 3

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis 109 39 10 3

Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes 109 31 9 3

Is there a role for the RNA-binding protein LARP1 in β-cells? 109 39 10 3

The TFIID subunit Taf4 is required for pancreatic beta cell function and identity. 109 31 3

Inhibition of inositol-requiring enzyme 1 RNase activity protects pancreatic beta cell and improves diabetic condition in insulin mutation-induced diabetes 109 64 10 3

Pancreatic beta-cell specific deletion of VPS41 causes diabetes due to defects in insulin secretion 109 34 3

Mouse Single Pancreatic β Cell Transcriptomics Reveal Sexual Dimorphism of Transcriptomes and Identify Sex-dependent Type 2 Diabetes Altered Genes 109 39 9 3

Engineering Functional Pseudo-Islets of Defined Sizes from Primary Murine Cells Using PEG Microwell Devices 109 85 57 10 3

Temporal Metabolic Characteristics and Transcriptomic Landscape of Islets and Liver Reveal Dynamic Pathophysiology and Interorgan Crosstalk in High-fat Diet-induced Diabetes 109 39 10 9 3

Beta-cell specific insulin resistance promotes glucose-stimulated insulin hypersecretion 109 39 10 3

Purification of age-distinct insulin secretory granules through antigen restriction using the CLIP-tag 109 34

In vitro pancreatic islet cluster expansion facilitated by hormones and chemicals 109 57 10

Molecular and genetic regulation of pig pancreatic islet cell development 109 9 3

Female mice exposed to low-doses of dioxin during pregnancy and lactation have increased susceptibility to diet-induced obesity and diabetes 109 39 10

Pancreatic α and β cells are globally phase-locked 109 18 3

Microtubules regulate pancreatic beta cell heterogeneity via spatiotemporal control of insulin secretion hot spots 109 3

Overexpression of HLA class I predominantly on alpha cell in at risk individuals for type 1 diabetes 109 88 27 10 3

Glucose-dependent activation, activity, and deactivation of beta cell networks in acute mouse pancreas tissue slices 109

Telmisartan potentiates insulin secretion via ion channels, independent of the AT1 receptor and PPARγ 109 82 10 3

Antagonistic epistasis of Hnf4a and FoxO1 networks through enhancer interactionsin beta-cell function 109 31 3

Morphogenesis of the islets of Langerhans is guided by extra-endocrine Slit2/3 signals 109 20 3

Antidiabetic drug therapy alleviates type 1 diabetes in mice by promoting pancreatic alpha-cell transdifferentiation 109 10 3

Pharmacologic activation of the mitochondrial phosphoenolpyruvate cycleenhances islet function in vivo 109 39 10 3

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development 109 20 9 3

Pancreatic beta cell selective deletion of mitofusins 1 and 2 (Mfn1 and Mfn2) disrupts mitochondrial architecture and abrogates glucose-stimulated insulin secretion in vivo 109 95 39 10 3

The role of islet lipid composition remodeling in regulation of beta-cell death via ADP-ribosyl-acceptor glycohydrolase ARH3 signaling in insulitis 109 10 3

Differential effects of voclosporin and tacrolimus on insulin secretion from human islets 109 10 3

Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia 39 10 3

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis 109 3

Reduced expression of TCF7L2 in adipocyte impairs glucose tolerance associated with decreased insulin secretion, incretins levels and lipid metabolism dysregulation in male mice 39 10 3

Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling 109 3

A common human variant of GIPR improves systemic glucose homeostasis in a sexual dimorphic manner 39 10 3

Expansion of Functional Regulatory T Cells Using Soluble RAGE Prevents Type 1 Diabetes 109 10 3

A reference map of the human proinsulin biosynthetic interaction network 109 45 3

Systemic benefits of Gc inhibition to preserve insulin sensitivity 39 10 3

Pancreatic Beta Cell Autophagy is Impaired in Type 1 Diabetes 109 10

Three-dimensional FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse beta cells 109 34 8 3

Crude Necator americanus worm extract diminishes pancreatic islets destruction in diabetic non-obese mice (NOD) 109 27 10 3

Gut microbiota impairs insulin clearance during obesity 39 10 3

The Harmine and Exendin-4 Combination Markedly Expands Human Beta Cell Mass In Vivo: Quantification and Visualization By iDISCO+ 3D Imaging 109 10 3

Bariatric surgery reveals a gut-restricted TGR5 agonist that exhibits anti-diabetic effects 109 39 10 3

RIPK2 dictates insulin responses to tyrosine kinase inhibitors in obese mice 39 10 3

Impairment of the Gβγ-SNAP25 brake on exocytosis enhances insulin action, protects against diet-induced obesity, and promotes adipocyte browning 39 10 3

A novel mutation in KCNK16 causing a gain-of-function in the TALK-1 potassium channel: a new cause of maturity onset diabetes of the young. 109 10 3

In vivo imaging of individual islets across the mouse pancreas reveals a heterogeneous insulin secretion response to glucose 109 18

If Metformin Inhibited the Mitochondrial Glycerol Phosphate Dehydrogenase It Might Not Benefit Diabetes 109 10

PHOSPHO1, a novel skeletal regulator of insulin resistance and obesity 39 10 3

Role of sex and high fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer's disease 39 32 10

Acute changes in systemic glycaemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis 109 39 10 3

Diabetes induced decreases in PKA signaling in cardiomyocytes: the role of insulin 102 95 3

ANGPTL4 from adipose, but not liver, is responsible for regulating plasma triglyceride partitioning 39 7 3

Adipose tissue macrophages orchestrate β cell adaptation in obesity through secreting miRNA-containing extracellular vesicles 7 3

Berberine alleviates adiposity and cardiac dysfunction in offspring exposed to gestational diabetes mellitus 39 10

Optoacoustic imaging of GLP-1 Receptor with a near-infrared exendin-4 analog 109 18

The role of elevated branched chain amino acids in the potent effects of vertical sleeve gastrectomy to reduce weight and improve glucose regulation in mice 39 10

Lack of Adipocyte Purinergic P2Y6 Receptor Greatly Improves Whole Body Glucose Homeostasis 39 10 3

SARS-CoV-2 receptor Angiotensin I-Converting Enzyme type 2 (ACE2) is expressed in human pancreatic β-cells and in the human pancreas microvasculature 36 1

Inhibition of Mitochondrial Fission and iNOS in the Dorsal Vagal Complex Protects from Overeating and Weight Gain 39 10 3

Loss of Bone Morphogenetic Protein-binding Endothelial Regulator Causes Insulin Resistance 39 7 3

m6A Regulates Liver Metabolic Disorders and Hepatogenous Diabetes 39 3

Breast cancer endocrine therapy exhausts adipocyte progenitors promoting weight gain and glucose intolerance 39 10 3

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells 36 1

Glucose clearance and uptake is increased in the SOD1G93A mouse model of amyotrophic lateral sclerosis through an insulin-independent mechanism 61 39 10 3

Mitochondrial and insulin gene expression in single cells shape pancreatic beta cells' population divergence 120 9 3

Type 2 Diabetes: One Disease, Many Pathways 39 10

Functional characterization of thousands of type 2 diabetes-associated and chromatin-modulating variants under steady state and endoplasmic reticulum stress 19 9 3

Mitophagy protects beta cells from inflammatory damage in diabetes 95 10 3

Establishing cell-intrinsic limitations in cell cycle progression controls graft growth and promotes differentiation of pancreatic endocrine cells 57 20 3

Effects of gypenosides on enteroendocrine L-cell function and GLP-1 secretion 64 10 3

Early life stress reduces voluntary exercise and its prevention of diet-induced obesity and metabolic dysfunction in mice 39 10 3

A multi-omic integrative scheme characterizes tissues of action at loci associated with type 2 diabetes 19 9 4

A transcriptional regulatory atlas of human pancreatic islets reveals non-coding functional signatures at GWAS loci 31 9