Topic 93

histone epigenetic chromatin h3 lysine repressive methylation h3k27me3 methyltransferase marks modifications polycomb trimethylation prc2 transcriptional heterochromatin dna transcription silencing regulation repression expression genes gene methyltransferases active h3k27 modification mark deposition promoters h3k4me3 biology h3k9 demethylation h2a maintenance molecular acetylation 27 h3k36me3 embryonic complex stem genome nucleosome h3k9me3 subunit transcriptionally dependent heterochromatic histones dnmt1 loss cells differentiation role nucleosomes epigenome euchromatic tri regulates genomic demethylase h3k9me2 ezh2 inhibition catalytic recruitment h3k4 at cell required activation mechanism rna regulated h3k36 developmental chip complexes dimethylation specific show demethylases mediated nuclear domains bivalent cycle jarid2 h3k27ac epigenetically epigenomic prc1 here occupancy immunoprecipitation arabidopsis regulator

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Altering PRC2 activity partially suppresses ddm1 mutant phenotypes in Arabidopsis 93 81 31 16 9 3

H3K27me3 is dispensable for early differentiation but required to maintain differentiated cell identity 93 20 3

The histone variant H2A.Z is required to establish normal patterns of H3K27 methylation in Neurospora crassa 93 31 9 3

DNA polymerase epsilon is a central coordinator of heterochromatin structure and function in Arabidopsis 93 31 3

Analysis of Polycomb Repressive Complexes binding dynamics during limb development reveals the prevalence of PRC2-independent PRC1 occupancy 93 31 20 3

Polycomb-mediated Genome Architecture Enables Long-range Spreading of H3K27 methylation 93 31 20 9 3

Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs 109 93 31 3

Identification of a PRC2 accessory subunit required for subtelomeric H3K27 methylation in Neurospora 93 31 9 3

A new role for histone demethylases in the maintenance of plant genome integrity 93 31 16 3

SUV39 SET domains mediate crosstalk of heterochromatic histone marks 93 7 3

Cell signaling coordinates global Polycomb Repressive Complex 2 recruitment and gene expression in murine embryonic stem cells 93 31 20 3

Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation 93 31 3

SETD2 deficiency impairs β-catenin destruction complex to facilitate renal cell carcinoma formation 93 3

An atlas of lamina-associated chromatin across thirteen human cell types reveals cell-type-specific and multiple subtypes of peripheral heterochromatin 93 31 20 9 3

DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A 192 93 31 3

JARID2 and AEBP2 regulate PRC2 activity in the presence of H2A ubiquitination or other histone modifications 93 51 8 3

Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntingtons Disease 93 31 9 3

DOT1L Methyltransferase Activity Preserves SOX2-Enhancer Accessibility And Prevents Activation of Repressed Genes In Murine Stem Cells 192 93 31 20 3

Proteasome activator PA200 maintains stability of histone marks during transcription and aging 93 31 3

PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency 93 31 20 3

Bone morphogenetic protein 4 reduces global H3K4me3 to inhibit proliferation and promote differentiation of human neural stem cells 93 20 3

High throughput screening identifies SOX2 as a Super Pioneer Factor that inhibits DNA methylation maintenance at its binding sites 93 31 3

Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing 93 31 9 3

Allele-specific gene regulation by KDM6A 93 20 3

Epigenetic memory as a time integral over prior history of Polycomb phase separation 93 78 31 8 3

H3 K27M and EZHIP impede H3K27-methylation spreading by inhibiting allosterically stimulated PRC2 93 3

Histone modification dynamics as revealed by a multicolor immunofluorescence-based single-cell analysis 93 31

The TAZ2 domain of CBP/p300 directs acetylation towards H3K27 within chromatin 93 31 20 3

Iterative Epigenomic Analyses in the Same Single Cell 93 31 9 4

Computational modeling reveals cell-cycle dependent kinetics of H4K20 methylation states during Xenopus embryogenesis 93 31 20 3

Functional correlation of H3K9me2 and nuclear compartment formation 93 31 20 3

ASXL1 Directs Neutrophilic Differentiation via Modulation of MYC and RNA Polymerase II. 93 31 9 3

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation. 93 31 20 3

β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture 31 20 9 3

Loss of PRC2 subunits primes lineage choice during exit of pluripotency 93 20 3

Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3 93 51 31 8 3

Epigenome dysregulation resulting from NSD1 mutation in head and neck squamous cell carcinoma 93 31 9 3

G9a/GLP-Sensitivity of H3K9me2 Demarcates Two Types of Genomic Compartments 93 31 20 9 3

Transcriptional elongation machinery controls vulnerability of breast cancer cells to PRC2 inhibitors 93 31 3

Delivery of cell-penetrating chromatin sensor-actuators to human osteosarcoma cells 93 31 14 3

An embryonic stem cell-specific heterochromatin state allows core histone exchange in the absence of DNA accessibility 93 31 20 3

Loss of Polycomb Protein EZH2 causes major depletion of H3K27 and H3K9 tri-methylation and developmental defects in the fungus Podospora anserina 93 31 20 3

Site-specific phosphorylation of histone H1.4 is associated with transcription activation. 93 31 3

Removal of repressive histone marks creates epigenetic memory of recurring heat in Arabidopsis 93 16 3

CHD8 Suppression Impacts on Histone H3 Lysine 36 Trimethylation and Alters RNA Alternative Splicing. 93 31 9 3

The methyltransferase DOT1L limits activation and the Th1 program in CD4+ T cells during infection and inflammation 93 27 3

Genome-wide shifts in histone modifications at early stage of rice infection with Meloidogyne graminicola 93 16 9 3

RNA LEVER Mediates Long-Range Regulation of ε-globin by Keeping PRC2 in Check 192 93 31 20 3

Histone lysine crotonylation regulates cell-fate determination of neural stem/progenitor cells by activating bivalent promoters 93 31 20 3

The H3.3 chaperone Hira complex orchestrates oocyte developmental competence 93 31 20 3

Imaging the response to DNA damage in heterochromatin domains reveals core principles of heterochromatin maintenance 93 46 31 20 3

Epigenetic regulation of Wnt7b expression by the cis-acting long noncoding RNA lnc-Rewind in muscle stem cells 192 93 20 3

An optogenetic switch for the Set2 methyltransferase provides evidence for rapid transcription-dependent and independent dynamics of H3K36 methylation 93 31 3

The disordered regions of SETD2 govern H3K36me3 deposition by regulating its proteasome-mediated decay 93 49 31 3

RNA matchmaking remodels lncRNA structure and promotes PRC2 activity 93 31 8 3

Cooperation between Caenorhabditis elegans COMPASS and condensin in germline chromatin organization 93 31 3

Single-cell analysis of chromatin silencing programs in developmental and tumor progression 93 31 9 4 3

Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19 93 63 8 3

Chromatin features define adaptive genomic regions in a fungal plant pathogen 93 31 9

Accurate imputation of histone modifications using transcription 93 31 9

Histone modifications during the life cycle of the brown alga Ectocarpus 93 31 9 5

The histone variant H2A.W promotes heterochromatin accessibility for efficient DNA methylation in Arabidopsis 93 16 3

C. elegans nuclear RNAi factor SET-32 deposits the transgenerational heritable histone modification, H3K23me3 93 31 3

Host infection by the grass-symbiotic fungus Epichloë festucaerequires catalytically active H3K9 and H3K36 methyl transferases 93 16 3

STAT5 regulation of sex-dependent hepatic CpG methylation at distal regulatory elements mapping to sex-biased genes 31 9 3

DOT1L primarily acts as a transcriptional repressor in hematopoietic progenitor cells 93 20 3

Large domains of heterochromatin direct the formation of short mitotic chromosome loops 93 68 46 31 8 3

Selective translation of epigenetic modifiers drives the developmental clock of neural stem cells 93 20 3

Mitotic activity shapes stage-specific histone modification profiles during Xenopus embryogenesis 93 20 3

Npac Is a Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse ES Cells 93 31 20 3

Sequential enrichment at the nuclear periphery of H2A.Zac and H3K9me2 accompanies pluripotency loss in human embryonicstem cells 93 20 3

SOX9 is sufficient to drive endothelial cells towards a mesenchymal fate by altering the chromatin landscape. 31 20 3

Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells 93 31 9 3

Mechanics of DNA Replication and Transcription Guide the Asymmetric Distribution of RNAPol2 and Nucleosomes on Replicated Daughter Genomes 93 31 8

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation 192 93 27 20 3

Histone loaders CAF1 and HIRA restrict Epstein-Barr virus B-cell lytic reactivation 93 41 31 3

SRF is a non-histone methylation target of KDM2B and SET7 in the regulation of myogenesis 192 93 31 20 3

The Drosophila HP1 family is associated with active gene expression across chromatin contexts 31 9 3

Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis 93 31 16 3

Simultaneous Epigenetic Perturbation and Genome Imaging Reveal Distinct Roles of H3K9me3 in Chromatin Architecture and Transcription 89 31 20 3

Smchd1 is a maternal effect gene required for autosomal imprinting 93 31 20 3

Low Dose Lead Exposure Induces Alterations on Heterochromatin Hallmarks Persisting Through SH-SY5Y Cell Differentiation 93 87 3

Epigenetic silencing of clustered tDNAs in Arabidopsis 93 31 9 3

Analysis of genomic DNA methylation and gene transcription modulation induced by DNMT3A deficiency in HEK293 cells 93 31 9 3

Loss of the Pioneer Factor FOXA1 Results in Genome-wide Epigenetic Reprogramming and activation of Interferon-Response Genes including CD274/PD-L1 31 9 3

H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation 93 16 3

Suppression of canonical TGF-β signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis 93 31 3

The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice 31 9 3

Poly(ADP-ribose)-binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions 46 31 3

TIP60 acetylates H2AZ and regulates doxorubicin-induced DNA damage sensitivity through RAD51 transcription 93 46 31 3

Intact nucleosomal context enables chromodomain reader MRG15 to distinguish H3K36me3 from -me2 93 8

Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive demethylation in mammals 192 93 20 3

Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones 93 31 3

Role of Udd protein and heterochromatin in transcriptional selection of individual rRNA genes in the Drosophila germline 93 31 20 3

Positioning of nucleosomes containing γ-H2AXprecedes active DNA demethylation and transcription initiation 93 31 3

Protein kinase D1 phosphorylates CBX8 to facilitate the disassociation of PRC1 complex from p16 promoter and promotes cell senescence 93 3

The histone variant macroH2A1.1 regulates gene expression by direct association with their transcription start site. 31 9 3

Aging leads to stochastic loss of silencing at transposons in mammary luminal epithelial cells 81 31 9 3

DNA methyltransferase 1 (DNMT1) function is implicated in the age-related loss of cortical interneurons 104 93 11 3 2

Deregulation of the histone H3K9 dimethylation landscape suppresses Wnt signaling in embryonal rhabdomyosarcoma 93 14 3