Topic 51

cryo em electron structures structure structural microscopy resolution biophysics bound binding biochemistry domain conformation complex conformational basis particle subunit complexes subunits molecular site reveals report reveal membrane atomic mechanism assembly tomography pore ring residues conformations ray determined channel architecture here atp protein helix domains crystallography conserved transmembrane proteins states terminal into form catalytic hydrolysis eukaryotic interactions resolutions closed cryoem present ion native averaging state pocket lipid crystal interface determination atpase forms helical active filaments inner ribosome adopts linker loop open helices reconstruction allosteric outer near maps transport side macromolecular at how central its insights reconstructions channels rings gating core substrate

301 items. Top items listed below.

Cryo-EM structure of the MgtE Mg2+ channel pore domain in Mg2+-free conditions reveals cytoplasmic pore opening 51 8 3

Structure of the Mammalian Mediator 51 8 3

Extraction of Protein Dynamics Information Hidden in Cryo-EM Map Using Deep Learning 111 51 8 4

Structural basis for the recognition of the 2019-nCoV by human ACE2 36 1

Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1 51 7 3

Structures of an intact yeast V-ATPase alone and in complex with bacterial effector VopQ 51 8 3

Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs 51 8 3

Emap2sec+: Detecting Protein and DNA/RNA Structures in Cryo-EM Maps of Intermediate Resolution Using Deep Learning 111 51 26 8 4

The mechanical inhibition of the isolated Vo from V-ATPase for proton conductance 51 8 3

Structure of the ancestral TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium 51 8 3

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors 51 8

CryoDRGN: Reconstruction of heterogeneous structures from cryo-electron micrographs using neural networks 111 51 4

Structure of human ferroportin bound to hepcidin reveals mechanisms of iron homeostasis 51 8 3

High-resolution cryo-EM structure of photosystem II: Effects of electron beam damage 111 51 8

Atomistic Mechanism of Force Generation, Translocation, and Coordination in a Viral Genome Packaging Motor 51 8

Structural studies of Cardiovirus 2A protein reveal the molecular basis for RNA recognition and translational control 51 8 3

Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state 51 8 3

Structures, conformations and distributions of SARS-CoV-2 spike protein trimers on intact virions 36 1

Structural basis for lipid transport by the MLA complex 51 8 3

TRPV2 interaction with small molecules and lipids revealed by cryo-EM 51 8

Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15 51 1

Fe-S protein assembly involves bipartite client binding and conformational flexibility in the CIA targeting complex 51 8 3

Crystal and cryo-EM structures of the cytosolic G protein alpha chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1 51 8 3

Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site. 51 8 3

Single-particle cryo-EM at atomic resolution 111 51 8 4

The cryo-electron microscopy structure of the human CDK-activating kinase 119 51 8 3

Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism 51 8 3

Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex 51 8

Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin. 51 8

Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14 51 8 3

In situ structure determination using single particle cryo-electron microscopy images 111 51 18 8 4

The 3.2A resolution structure of human mTORC2 51 8 3

Structure of the Bacterial Ribosome at 2 A Resolution 111 51 8 4

Structure of bacterial phospholipid transporter MlaFEDB with substrate bound 51 8 3

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients 51 8 3

Sub-3 A resolution structure of apoferritin using a multi-purpose TEM with a side-entry cryo-holder 111 51 18 8 4


Saccharomyces cerevisiae Ecm2 Modulates the Catalytic Steps of pre-mRNA Splicing 51 49 8 3

Cryo-EM structure of yeast 90S preribosome at 3.4 Angstrom resolution 51 8

Breaking the next Cryo-EM resolution barrier - Atomic resolution determination of proteins! 111 51 18 8 4

Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation 51 8 3

Lattice micropatterning of electron microscopy grids for improved cellular cryo-electron tomography throughput 111 51 18 8 4

Structural insights into the mammalian late-stage initiation complexes 136 51 8

Nonameric structures of the cytoplasmic domain of FlhA and SctV in the context of the full-length protein 51 8

Structure and mechanism of TRAPPIII-mediated Rab1 activation 51 34 8 3

Specific features and assembly of the plant mitochondrial complex I revealed by cryo-EM 51 8 3

Insights into actin polymerization and nucleation using a coarse grained model 111 51 8

Molecular basis for the ATPase-powered substrate translocation by the Lon AAA+ protease 51 8

Structural insights into assembly and function of the RSC chromatin remodeling complex 51 8 3

Structural basis for the allosteric regulation of Human Topoisomerase 2α 51 8 3

Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates 51 8 3

A dynamic regulatory interface on SARS-CoV-2 RNA polymerase 44 1

CryoFold: Ab-initio structure determination from electron density maps using molecular dynamics 111 51 8 4

Structure and conformational cycle of a bacteriophage-encoded chaperonin 51 8

In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution 51 8 3

3D Variability Analysis: Directly resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM images 111 51 18 8 4

Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.7 A inside cells 111 51 18 8 4

Structure and mechanism of a primate ferroportin 51 8 3

Structural basis of SARS-CoV-2 spike protein induced by ACE2 36 1

Cryo-EM reveals the complex architecture of dynactin's shoulder and pointed end 51 8

High-resolution Structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition 51 8

Molecular mechanism for direct actin force-sensing by α-catenin 55 51 8 3

Cryo-EM structures reveal two distinct conformational states in a picornavirus cell entry intermediate. 51 8

Structure of a proton-powered molecular motor that drives protein transport and gliding motility 51 8 3

Structural basis of Rgg protein binding to their regulatory pheromones and target DNA promoters 51 8 3

Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation 51 8 3

Large domain movements through lipid bilayer mediate substrate release and inhibition of glutamate transporters 51 8 3

Alternative Conformations and Motions Adopted by 30S Ribosomal Subunits Visualized by Cryo-Electron Microscopy. 51 8

Progressive and accurate assembly of multi-domain protein structures from cryo-EM density maps 111 51 26 4

A general role of zinc binding domain revealed by structures of σ28-dependent transcribing complexes 119 51 31 8 3

eIF3b and eIF3i relocate together to the ribosomal subunit interface during translation initiation and modulate start codon selection 136 51 49 8

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2 136 51 1

In situ structure determination of virus capsids imaged within cell nuclei by correlative light and cryo-electron tomography. 111 51 18 8 4

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms 51 8

Structural investigation of ACE2 dependent disassembly of the trimeric SARS-CoV-2 Spike glycoprotein 36 1

Distinct conformational states of SARS-CoV-2 spike protein 103 1

Novel cryo-electron tomography structure of Arp2/3 complex in cells reveals mechanisms of branch formation 51 8 3

A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit 136 51 8

Structure of the Lifeact F-actin complex 51 8 3

Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution 36 1

A 3.4-A cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles 36 1

Cryo-EM structures of inactive and Gi-coupled GABAB heterodimer 51 8 3

Cryo-EM structures of the ATP release channel pannexin 1 51 8 3

Structure and reconstitution of a MCU-EMRE mitochondrial Ca2+ uniporter complex 51 8 3

How to build a water-splitting machine: structural insights into photosystem II assembly 51 8

Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes 51 8 3

Escherichia coli NusG links the lead ribosome with the transcription elongation complex 119 51 8 3

A Deep Dive into the SARS-Cov-2 Polymerase Assembly: Identifying Novel Allosteric Sites and Analyzing the Hydrogen Bond Networks and Correlated Dynamics 51 8 1

Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies 36 24 1

The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion. 51 41 8 3

Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex 51 8

Deep learning enables the atomic structure determination of the Fanconi Anemia core complex from cryoEM 111 51 26 8 4

SARS-CoV-2 Nsp1 binds ribosomal mRNA channel to inhibit translation 7 1

Routine sub-2.5 A cryo-EM structure determination of B-family G protein-coupled receptors 111 51 8 4

Structure of a type IV CRISPR-Cas effector complex 51 8 3

The architecture of EMC reveals a path for membrane protein insertion 51 8 3

Structural basis for stereospecific inhibition of ASCT2 from rational design 51 8 3

The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states. 51 8 3

Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP 51 8 3

On the functional annotation of open-channel structures in the glycine receptor 51 8