Topic 136

ribosome ribosomes translation ribosomal mrna trna translating rrna cryo em subunit 40s initiation elongation 80s site conserved codon nascent complexes eukaryotic codons sites factors molecular protein proteins structural peptidyl translational polypeptide biochemistry yeast structure release tunnel dalgarno 18s termination synthesis shine stop intermediate decoding maturation peptide reading biogenesis center biology rna folding reveal start sequence amino nucleotide factor large particle subunits mrnas anticodon stalled 48s structures electron bacterial assembly conformation chains translocation binding containing collisions eukaryotes 16s promotes recycling biochemical escherichia promote exit arginine competent frameshifting pre mechanism single atpase stalk fidelity sequences state microscopy puromycylated rearrangements arabidopsis bound frame

50 items. Top items listed below.

eEF3 promotes late stages of tRNA translocation on the ribosome 136 7 3

Direct measurements of mRNA translation kinetics in living cells 136 49 8

Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation 136 49 1

An opened pre-40S platform enables regulation of Fap7 late in ribosomal assembly 136 49 8 3

Pairs of amino acids at the P- and A-sites of the ribosome predictably and causally modulate translation-elongation rates 136 49 8

Translational accuracy of a tethered ribosome 136 49 8

Molecular Functions of Conserved Developmentally-Regulated GTP-Binding Protein Drg1 in Translation 136 7 3

Transcriptome-wide sites of collided ribosomes reveal principles of translational pausing 136 49 31 8 3

Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching 136 49 8

Structural insights into the mammalian late-stage initiation complexes 136 51 8

Structural basis for bacterial ribosome quality control 136 51 49 8 3

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2 136 51 1

Disome-seq reveals widespread ribosome collisions that recruit co-translational chaperones 136 49 8 3

A Ribosome Interaction Surface Sensitive to mRNA GCN Periodicity 136 49 8

Differences in structure and hibernation mechanism highlight diversification of the microsporidian ribosome. 136 51 8

Selective inhibition of human translation by a drug-like compound that traps terminated protein nascent chains on the ribosome 136 51 8 3

Bud23 promotes the progression of the Small Subunit Processome to the pre-40S ribosome in Saccharomyces cerevisiae 136 49 34 8 3

eIF3b and eIF3i relocate together to the ribosomal subunit interface during translation initiation and modulate start codon selection 136 51 49 8

The Halastavi arva virus intergenic region IRES promotes translation by the simplest possible initiation mechanism 136 51 8 3

Structural inventory of native ribosomal ABCE1-43S pre-initiation complexes 136 51 8 3

Arabidopsis mTERF9 protein promotes chloroplast ribosomal assembly and translation by establishing ribonucleoprotein interactions in vivo. 136 49 16 3

Genome-wide effects of the antimicrobial peptide apidaecin on translation termination 136 49 3

GCN sensitive protein translation in yeast 136 49

Elongation Inhibitors do not Prevent the Release of Puromycylated Nascent Polypeptide Chains from Ribosomes 136 49 8

Ribosome rescue inhibitors clear Neisseria gonorrhoeae in vivo using a new mechanism 136 51 12 8 3

A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit 136 51 8

Simplification of ribosomes in bacteria with tiny genomes 136 121 40 12 5

Inferring efficiency of translation initiation and elongation from ribosome profiling 136 49 38

Extending the spacing between the Shine-Dalgarno sequence and P-site codon reduces the rate of mRNA translocation 136 49 8

Large ribosomal subunit, eIF5B, Met-tRNAiMet and mRNA cooperate to complete accurate initiation. 136 49 8

Ribosome fingerprinting with a solid-state nanopore 136 18 8 4

Ribosome assembly factors modulate the RNA folding landscape to prevent misfolding 136 8

Structural basis of transcription-translation coupling 136 51 49 8 3

Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. 136 51 8 3

Loss of macp{Psi} ribosomal RNA modification is a major feature of cancer 136 49 3

Sequencing and analysis of Arabidopsis thaliana NOR2 reveal its distinct organization and tissue-specific expression of rRNA ribosomal variants 136 25 16 9

Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon-anticodon pairing 136 49 8

Structural studies of Cardiovirus 2A protein reveal the molecular basis for RNA recognition and translational control 51 8 3

The Giardia lamblia ribosome structure reveals divergence in translation and quality control pathways 136 49 8

The folding and unfolding behavior of ribonuclease H on the ribosome 136 8

Light-dependent translation change of Arabidopsis psbA correlates with RNA structure alterations at the translation initiation region 136 49 16 3

Puromycin reactivity does not accurately localize translation at the subcellular level 136 8

Rerouting of ribosomal proteins into splicing in plant organelles 136 49 16 3

mRNA secondary structure stability regulates bacterial translation insulation and re-initiation 136 49 3

Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM 61 51 49 8 3

SARS-CoV-2 Nsp1 binds ribosomal mRNA channel to inhibit translation 7 1

Arabidopsis REI-LIKE proteins activate ribosome biogenesis during cold acclimation 136 16 3

Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA. 103 1

The final step of 40S ribosomal subunit maturation is controlled by a dual key lock 136 51 8 3

Oxidized RNA Bodies compartmentalize translation quality control in Saccharomyces cerevisiae 49 34 3

Dynamic regulation of translation quality control associated with ribosome stalling 49 8

Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi 136 8 3

A Novel Stress Response Pathway Regulates Ribosome Biogenesis 49 34 3

Prokaryotic rRNA-mRNA interactions are involved in all translation steps and shape bacterial transcripts 49 21 5

Structure of the Bacterial Ribosome at 2 A Resolution 111 51 8 4

VELCRO-IP RNA-seq explores ribosome expansion segment function in translation genome-wide 7

LincRNA sequences are biased to counteract their translation 49 9

Nutrient-dependent trade-offs between ribosomes and division protein synthesis control bacterial cell size and growth 158 127 38 12 8

GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis 49 3

Various miRNAs are involved in efficient HCV replication 41 8 3

Alternative Conformations and Motions Adopted by 30S Ribosomal Subunits Visualized by Cryo-Electron Microscopy. 51 8

Escherichia coli NusG links the lead ribosome with the transcription elongation complex 119 51 8 3

Cotranslational Folding Stimulates Programmed Ribosomal Frameshifting in the Alphavirus Structural Polyprotein 8 3

Discovery of 20 novel ribosomal leaders in bacteria and archaea 49 31 8

Force transduction creates long-ranged coupling in ribosomes stalled by arrest peptides 91 8

Activation of the antiviral factor RNase L triggers translation of non-coding mRNA sequences 49 41 3

Ribosome Profiling in Archaea Reveals Leaderless Translation, Novel Translational Initiation Sites, and Ribosome Pausing at Single Codon Resolution 49 9 3

The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication but essential for the production of infectious virus. 136 49 41 8

Translation regulation of Japanese encephalitis virus revealed by ribosome profiling 49 41 3

Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit 136 34 8 3

SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism 103 1

On translational control by ribosome speed in Saccharomyces cerevisiae 49

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit 102 34 3

Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in protein translation 49 16 3

Mosaic changes to the global transcriptome in response to inhibiting ribosome formation versus inhibition of ribosome function 49 3

A systematic survey of PRMT interactomes reveals the key roles of arginine methylation in the global control of RNA splicing and translation 49 3

METTL5, an 18S rRNA-specific m6A methyltransferase, modulates expression of stress response genes 49 3

Direct visualization of translational GTPase factor-pool formed around the archaeal ribosomal P-stalk by high-speed atomic force microscopy 7

Ribosome profiling reveals ribosome stalling on tryptophan codons upon oxidative stress in fission yeast 49 3

Potential role of the X circular code in the regulation of gene expression 49 38 4

Deep conservation of ribosome stall sites across RNA processing genes 49 9

TRAP-based allelic translation efficiency imbalance analysis to identify genetic regulation of ribosome occupancy in specific cell types in vivo. 49 9

TRIBE editing reveals specific mRNA targets of eIF4E-BP in Drosophila and in mammals 49 3

mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding 51 49 8 3

Diversity and prevalence of ANTAR RNAs across actinobacteria 49 31 8 3

Light-induced psbA translation in plants is triggered by photosystem II damage via an assembly-linked autoregulatory circuit 117 16 3

The RNA helicase DHX30 coordinates cytoplasmic translation and mitochondrial function contributing to cancer cell survival 49 3

Genetic removal of p70 S6K1 corrects coding sequence length-dependent alterations in mRNA translation in fragile X syndrome mice 49 3

Matrix metalloproteinase-2 mediates ribosomal RNA transcription by cleaving nucleolar histones 49 3

Alteration of ribosome function upon 5-fluorouracil treatment favours cancer cell drug-tolerance 49 14 3

Saccharomyces cerevisiae Ecm2 Modulates the Catalytic Steps of pre-mRNA Splicing 51 49 8 3

Activity-dependent translation in astrocytes 49 11 3

The Arabidopsis NOT4A E3 ligase coordinates PGR3 expression to regulate chloroplast protein translation 49 16 3

FMRP Links Optimal Codons to mRNA stability in Neurons 49 3

The Human Fragile X Mental Retardation Protein Inhibits the Elongation Step of Translation through its RGG and C-terminal domains 49 3

Polysome fractionation analysis reveals features important for human nonsense-mediated mRNA decay 49 9 3

Genes with 5' terminal oligopyrimidine tracts preferentially escape global suppression of translation by the SARS-CoV-2 NSP1 protein 49 41 31 3

ARF suppresses 5'-terminal oligopyrimidine mRNA translation 49 3

Erosion of human X chromosome inactivation causes major remodelling of the iPSC proteome 49 3

Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation 49 31 9 3