Topic 87

methylation epigenetic dna methylated cpg epigenome cpgs age genomics bisulfite wide genome associated clocks differentially methylome aging hypermethylation genes chronological differential blood sites association dnam clock changes variation differences cg alterations hypomethylated gene biomarkers regions methylomes dmrs patterns array samples levels expression associations ageing were sequencing hypermethylated profiles promoter cytosine loci whole cohorts ewas biological identified illumina enriched related between marks at infinium tissues genomic genetic molecular environmental risk genetics beadchip epic developmental regulation unmethylated epigenetics older exposure wgbs arrays dinucleotides accelerated studies years adult analysis cohort methylationepic meta tissue horvathmammalmethylchip40 epigenetically island status methylomic was significant region positions modifications

147 items. Top items listed below.

Epigenetic aging of classical monocytes from healthy individuals 87 9

Widespread methylation quantitative trait loci and their role in schizophrenia risk 87 19 9 5

Region-level Epimutation Rates in Arabidopsis thaliana 87 21 5

Body weight at young adulthood and association with epigenetic aging and lifespan in the BXD murine family 87 9 5

Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia. 87 9

An Integrative Analysis of the Age-Associated Genomic, Transcriptomic and Epigenetic Landscape across Cancers 87 9

Epigenome-wide change and variation in DNA methylation from birth to late adolescence 87 9 5

Epigenetic signatures associated with the observed link between maternal tobacco use during pregnancy, and offspring conduct problems in childhood and adolescence 87 7 5

Epigenetic age-predictions in mice using pyrosequencing, droplet digital PCR or barcoded bisulfite amplicon sequencing 87 9 4

Low-Pass Whole Genome Bisulfite Sequencing of Neonatal Dried Blood Spots Identifies a Role for RUNX1 in Down Syndrome DNA Methylation Profiles 87 9

Epigenetic clock and methylation studies in vervet monkeys 87 9

A transcriptome based aging clock near the theoretical limit of accuracy 87 9 4

Epigenome Prediction of Gene Expression using a Dynamical System Approach 87 38 9 4

Assessing the co-variability of DNA methylation across peripheral cells and tissues: implications for the interpretation of findings in epigenetic epidemiology 87 19 9 5

Birth weight predicts psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population 87 15 9

Epigenetic clock and methylation studies in the rhesus macaque 87 9

A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing 87 4

Epigenetic clock and methylation studies in cats 87

Epigenetic clock and methylation studies in elephants 87 9

Minimal detection and low biological fluctuation of mitochondrial CpG methylation at the single-molecule level 87 9

Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging 87 15 5

Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human Cortex 87 26 4

Simultaneous transcriptome and methylome profiles of single mouse oocytes provide novel insights on maturation and aging 87 9 3

Histone acetylation at the sulfotransferase 1a1 gene is associated with its hepatic expression in normal aging 87 9

Aging leads to stochastic loss of silencing at transposons in mammary luminal epithelial cells 81 31 9 3

Meta-analysis of genome-wide DNA methylation and integrative OMICs in human skeletal muscle. 87 9 4

DNA methylation landscapes of matched primary and recurrent high grade serous ovarian cancers are preserved throughout disease progression and chemoresistance. 87 9

Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma 87 9

Epigenetic drift during long-term culture of cells in vitro 87 31 9 3

The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis 87 9

Reversing age: dual species measurement of epigenetic age with a single clock 87 15 9

Mining the Selective Remodeling of DNA Methylation in Promoter Regions to Identify Robust Gene-Level Associations with Phenotype 87 19 9 4

Gene set enrichment analysis for genome-wide DNA methylation data 87 4

DNA methylation covariation in human whole blood and sperm: implications for studies of intergenerational epigenetic effects 87 9

A maternal effect regulates global DNA methylation patterns 87 9 5

Genome-wide variation in DNA methylation linked to developmental stage and chromosomal suppression of recombination in white-throated sparrows 87 9 5

A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin-associated histone modifications 87 9

General DNA methylation patterns and environmentally-induced differential methylation in the eastern oyster (Crassostrea virginica) 87 9 5

Age-related DNA methylation changes are sex-specific: a comprehensive assessment 87 56 9

Deconvolution of cellular subsets in human tissue based on targeted DNA methylation analysis at individual CpG sites 87 9 4

The Transition from Acute to Chronic Pain: Dynamic Epigenetic Reprogramming of the Mouse Prefrontal Cortex up to One Year Following Nerve Injury 87 9 2

LINE-1 DNA methylation in response to aging and vitamin D 87 9

Epigenetic clock and DNA methylation studies of roe deer in the wild 87 56 5

Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity 87 9

Sex-specific expression and DNA methylation in a species with extreme sexual dimorphism and paternal genome elimination 56 9 5

An evolutionary perspective of DNA methylation patterns in skeletal tissues using a nonhuman primate model of osteoarthritis 87 9 5

STAT5 regulation of sex-dependent hepatic CpG methylation at distal regulatory elements mapping to sex-biased genes 31 9 3

Pair bonding slows epigenetic aging and alters methylation in brains of prairie voles 87 9

Comparative Genome-Wide DNA Methylation Analysis In Myocardial Tissue From Donors With And Without Down Syndrome 87 9

Genome-wide methylation prediction of biological age using reproducing kernel Hilbert spaces and Bayesian ridge regressions 87 15 4

DNA methylation site loss for plasticity-led novel trait genetic fixation 87 21 5 3

Bumblebee worker castes show differences in allele-specific DNA methylation and allele-specific expression. 87 9 5

Age-dependent ribosomal DNA variations and their effect on cellular function in mammalian cells 87 49 9 3

Effect of short-term prescription opioids on DNA methylation of the OPRM1 promoter 87 15 9

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan 87 19 15 9 5

Promoter activity-based case-control association study on SLC6A4 highlighting hypermethylation and altered amygdala volume in male patients with schizophrenia 87 15 9

Disentangling age-dependent DNA methylation: deterministic, stochastic, and nonlinear 87 38

Structural Dynamics of DNA Depending on Methylation Pattern 87 8

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers 87 31 9 3

Childhood location correlates with epigenetic age and methylation stability in British-Bangladeshi migrants 87 15 5

Gene body methylation is under selection in Arabidopsis thaliana 87 21 5

Patterns of gene-body-methylation conservation and its divergent association with gene expression in Pigeonpea and Soybean 87 40 21 9 5

A robust mean and variance test with application tohigh-dimensional phenotypes 87 19 4

Integrative genomic strategies applied to a lymphoblast cell line model reveal specific transcriptomic signatures associated with clozapine response 9 3

Microbiota Accelerates Age-Related CpG island Methylation in Colonic Mucosa 87 10

Methylation-Based Age Estimation in a Wild Mouse 87 4

Genome wide efficiency profiling reveals modulation of maintenance and de novo methylation by Tets 87 31 9

Intra- and Inter-Specific Investigations of Skeletal DNA Methylation and Femur Morphology in Primates 87 9 5

Parental CG and CHG methylation variation is associated with allelic-specific expression in elite hybrid rice 87 53 9 5

GeneDMRs: an R package for Gene-based Differentially Methylated Regions analysis 87 62 4

Evolutionary and functional genomics of DNA methylation in maize domestication and improvement 87 21 9 5

Cancer methylomes characterization enabled by Rocker-meth 87 9 4

Integrated Analysis of Methylome and Transcriptome Following Developmental Atrazine Exposure in Zebrafish Reveals Aberrant Gene-Specific Methylation of Neuroendocrine and Reproductive Pathways 87 64 9

Genome Methylation Predicts Age and Longevity of Bats 31 9

DNA methylation across the genome in aged human skeletal muscle tissue and stem cells: The role of HOX genes and physical activity 87 9 3

Novel epigenetic clock for fetal brain development predicts fetal epigenetic age for iPSCs and iPSC-derived neurons. 57 20 11 9

Genome-wide comparison of DNA methylation between life cycle stages of Drosophila melanogaster using high-throughput sequencing techniques. 87 9

Neighborhood environment, social cohesion, and epigenetic aging 87 15 5

A pan-cancer atlas of transcriptional dependence on DNA methylation and copy number aberrations 87 9 4

GREM1 is epigenetically reprogrammed in muscle cells after exercise training and controls myogenesis and metabolism 87 57 20 3

The costs of competition: high social status males experience accelerated epigenetic aging in wild baboons 87 5

The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome 87 14 9

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption 87 9

Purifying selection acts on germline methylation to modify the CpG mutation rate at promoters 87 21

Meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex 87 32 19 9 4

A DNAmRep epigenetic fingerprint for determining cellular replication age 87 31 3

Greenhouse spatial effects detected in the barley (Hordeum vulgare L.) epigenome underlie stochasticity of DNA methylation 87 16 5

Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods 81 40 31 21 9 5

The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability 87 9

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus 192 87 31 20 3

Expression quantitative trait methylation analysis reveals methylomic associations with gene expression in childhood asthma 87 9

Targeted bisulfite sequencing: A novel tool for the assessment of DNA methylation with high sensitivity and increased coverage 87 4

IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions 87 9 4

Non-CG methylation and multiple epigenetic layers associate child abuse with immune and small GTPase dysregulation 87 31 9

DNA methylation signatures of duplicate gene evolution in angiosperms 87 16 5

CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity 31 9 3

LuxUS: DNA methylation analysis using generalized linear mixed model with spatial correlation 13 4

Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent MS risk 87 3

Maternal DNMT3A-dependent de novo methylation of the zygotic paternal genome inhibits gene expression in the early embryo 87 20 9 3

The absence of C-5 DNA methylation in Leishmania donovani allows DNA enrichment from complex samples 87