Topic 192

chromatin transcriptional methyltransferase stem transcription gene regulator expression methylation epigenetic program differentiation regulatory cells regulation required biology accessibility during cell developmental repression regulates elements remain promoter h3k79 factor histone programs activation understood cis poorly genes dot1l repressive silencing induced prevents normal element dnmt1 dna demethylation mechanistically h3k27 polycomb pluripotent loss sufficient embryonic mechanisms g9a motifs involved promotes molecular proliferation induce tumors pluripotency identify here states expressed p53 locus development inhibition factors induction murine atac hypomethylation repressor driving ablation prc2 response activity fate critical identity maintenance wnt hematopoietic cpg seq dependent distal myeloid accessible induces stemness mediates cancer within binds senescent

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The transcription factor CLAMP is required for neurogenesis in Drosophila melanogaster. 192 133 20 3

DOT1L Methyltransferase Activity Preserves SOX2-Enhancer Accessibility And Prevents Activation of Repressed Genes In Murine Stem Cells 192 93 31 20 3

Chromatin accessibility and histone acetylation in the regulation of competence in early development 192 31 20 3

DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A 192 93 31 3

Alternative splicing is a developmental switch for hTERT expression 192 31 20 3

G9a methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation 192 142 108 14 3

Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1 and TIA1 192 20 9 3

Epigenetic regulation of Wnt7b expression by the cis-acting long noncoding RNA lnc-Rewind in muscle stem cells 192 93 20 3

RNA LEVER Mediates Long-Range Regulation of ε-globin by Keeping PRC2 in Check 192 93 31 20 3

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation 192 93 27 20 3

Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function 192 27 20 3

A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb targets 192 31 9 3

Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive demethylation in mammals 192 93 20 3

A Transcriptional Switch Governing Fibroblast Plasticity Underlies Reversibility of Chronic Heart Disease 192 31 3

Three-dimensional regulation of HOXA cluster genes by a cis-element in hematopoietic stem cell and leukemia. 192 31 20 3

ATF3 drives senescence by reconstructing accessible chromatin profiles 192 31 3

G9a Promotes Breast Cancer Recurrence Through Repression of a Pro-inflammatory Program 192 108 93 14 3

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus 192 87 31 20 3

ATF4 mediates fetal globin upregulation in response to reduced β-globin 192 3

Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs 192 93 20 3

Developmental chromatin programs determine oncogenic competence in melanoma 192 142 20 3

Requirement of DNMT1 to orchestrate epigenomic reprogramming during NPM-ALK driven T cell lymphomagenesis 192 142 108 93 14 3

SRF is a non-histone methylation target of KDM2B and SET7 in the regulation of myogenesis 192 93 31 20 3

Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injury 192 31 3

In vivo CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer 192 88 31 27 3

A regulatory program for initiation of Wnt signaling during posterior regeneration 192 118 20 3

Creb5 establishes the competence for Prg4 expression in articular cartilage 192 31 20 3

A cis-regulatory element promoting increased transcription at low temperature in cultured ectothermic Drosophila cells 192 31 9 3

PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells 192 57 20 3

Changing and stable chromatin accessibility supports transcriptional overhaul during neural stem cell activation 31 20 3

Early growth response 2 (EGR2) is a novel regulator of the senescence program 192 3

NAD modulates DNA methylation and cell differentiation 192 87 3

Multiomics analysis reveals extensive epigenome remodeling during cortical development 31 9 3

ATR expands embryonic stem cell fate potential in response to replication stress 192 20 3

Optimal transcriptional regulation of cellular responses to sudden environmental shifts 192 38 31 21

dnmt1 function is required to maintain retinal stem cells within the ciliary marginal zone of the zebrafish eye 192 20 3

Dot1L interacts with Zc3h10 to activate UCP1 and other thermogenic genes 192 39 20 3

Elements at the 5' end of Xist harbor SPEN-independent transcriptional antiterminator activity 192 31 20 3

Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs 109 93 31 3

SOX9 is sufficient to drive endothelial cells towards a mesenchymal fate by altering the chromatin landscape. 31 20 3

STAT5 regulation of sex-dependent hepatic CpG methylation at distal regulatory elements mapping to sex-biased genes 31 9 3

Aging leads to stochastic loss of silencing at transposons in mammary luminal epithelial cells 81 31 9 3

Cell signaling coordinates global Polycomb Repressive Complex 2 recruitment and gene expression in murine embryonic stem cells 93 31 20 3

Chromatin accessibility landscapes activated by cell surface and intracellular immune receptors 31 9 3

Oct4 mediated inhibition of Lsd1 activity promotes the active and primed state of pluripotency enhancers 192 20 3

The Drosophila MLR COMPASS-like complex regulates bantam miRNA expression differentially in the context of cell fate 20 3

Single cell resolution regulatory landscape of the mouse kidney highlights cellular differentiation programs and renal disease targets 31 20 9 3

CHD4-NURD controls spermatogonia survival and differentiation 20 3

Planarian CREB-binding protein (CBP) gene family regulates stem cell maintenance and differentiation 20 3

Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma 192 57 20 9 3

Identification of MAZ as a novel transcription factor regulating erythropoiesis 31 9 3

β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture 31 20 9 3

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation. 93 31 20 3

Three-dimensional Genome Organization Maps in Normal Haematopoietic Stem Cells and Acute Myeloid Leukemia 142 31 14 3

scATAC-Seq reveals epigenetic heterogeneity associated with an EMT-like process in male germline stem cells and its regulation by G9a 98 31 9 3

Mapping the landscape of chromatin dynamics during naïve CD4+ T-cell activation. 31 9 3

Selective silencing rather than targeted activation of gene expression underlies fate choice in human hematopoietic stem cells. 31 20 9 3

HIF1a-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia 192 95 3

Cytokine priming of naive CD8+ T lymphocytes modulates chromatin accessibility that partially overlaps with changes induced by antigen simulation 192 88 27 10 3

Genome-wide Studies Reveal the Essential and Opposite Roles of ARID1A in Controlling Human Cardiogenesis and Neurogenesis from Pluripotent Stem Cells 31 20 3

DOT1L primarily acts as a transcriptional repressor in hematopoietic progenitor cells 93 20 3

Integrative Analysis Reveals Histone Demethylase LSD1/KDM1A Associates with RNA Polymerase II Pausing 31 20 3

TINC - a method to dissect transcriptional complexes at single locus resolution - reveals novel Nanog regulators in mouse embryonic stem cells 31 9 3

Endothelial-to-hematopoietic transition is induced by Notch glycosylation and upregulation of Mycn 192 20 3

Transcriptional networks are dynamically regulated during cell cycle progression in human Pluripotent Stem Cells 31 20 9 3

Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukemia 31 9 3

The methyltransferase DOT1L limits activation and the Th1 program in CD4+ T cells during infection and inflammation 93 27 3

CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression 89 31 20 3

ETV4 is necessary for estrogen signaling and growth in endometrial cancer cells 31 3

The regulatory genome of the malaria vector Anopheles gambiae: integrating chromatin accessibility and gene expression 31 9 3

A long-range chromatin interaction regulates SATB homeobox 1 gene expression in trophoblast stem cells 31 20 3

CTCF-binding element regulates ESC differentiation via orchestrating long-range chromatin interaction between enhancers and HoxA 89 20 3

Loss of the Pioneer Factor FOXA1 Results in Genome-wide Epigenetic Reprogramming and activation of Interferon-Response Genes including CD274/PD-L1 31 9 3

High throughput screening identifies SOX2 as a Super Pioneer Factor that inhibits DNA methylation maintenance at its binding sites 93 31 3

BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes 31 3

Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity. 94 20 3

Transcriptome and epigenome characterization of mouse spermatogonial cells reveals distinct chromatin regulatory landscapes in postnatal and adult testis 31 9 3

Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition 98 20 3

PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency 93 31 20 3

mTOR inhibition in primary neurons and the developing brain represses transcription of cholesterol biosynthesis genes and alters cholesterol levels 133 31 3

Analysis of genomic DNA methylation and gene transcription modulation induced by DNMT3A deficiency in HEK293 cells 93 31 9 3

Mitotic retention of H3K27 acetylation promotes rapid topological and transcriptional resetting of stem cell-related genes and enhancers upon G1 entry 31 20 9 3

IER5, a DNA-damage response gene, is required for Notch-mediated induction of squamous cell differentiation 142 108 14 3

Myeloid lncRNA LOUP Mediates Opposing Regulatory Effects of RUNX1 and RUNX1-ETO in t(8;21) AML 31 3

Auxin-degron system identifies immediate mechanisms of Oct4 20 3

ID4 represses myoepithelial differentiation of mammary stem cells through its interaction with HEB 20 3

SOX11 is a lineage-dependency factor and master epigenetic regulator in neuroblastoma 31 9 3

The histone variant H2A.Z is required to establish normal patterns of H3K27 methylation in Neurospora crassa 93 31 9 3

H3K27me3 is dispensable for early differentiation but required to maintain differentiated cell identity 93 20 3

Defining a critical enhancer near Nanog using chromatin-focused approaches identifies RNA Pol II recruitment as required for expression 31 9

Chromatin accessibility analysis uncovers regulatory element landscape in prostate cancer progression 31 9 3

USP9X deubiquitinase couples the pluripotency network and cell metabolism to regulate ESC differentiation potential 20 3

Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant common complex traits 7 3

Epigenetic regulations follow cell cycle progression during differentiation of human pluripotent stem cells. 20 9 3

Regulation of human development by ubiquitin chain editing of chromatin remodelers 20 3

The lncRNA APOLO interacts with the transcription factor WRKY42 to trigger root hair cell expansion in response to cold 31 16 3

UHRF1 suppresses viral mimicry through both DNA methylation-dependent and -independent mechanisms 142 3

ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming 142 31 20 3

Pan-Cancer chromatin analysis of the human vtRNA genes uncovers their association with cancer biology. 31 9 3

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancer 108 14 3