Topic 118

developmental embryonic embryo patterning biology development embryos morphogenesis embryogenesis during axis drosophila vertebrate early formation signaling tissue zebrafish morphogenetic tissues cell anterior posterior mesoderm lineage cells along pattern dorsal body specification epithelial developing gastrulation stages apical expression progenitors shape tube wnt epithelium organ organs fate elongation disc muscle conserved regulatory wing endoderm defects imaginal ventral how larval axial regulated process polarity melanogaster mammalian gene coordinated ectopic mouse morphological regulate ectoderm mechanisms positioning patterned understood patterns cellular epiblast imaging vertebrates multicellular stage propose mutant show form morphology regulation migration distinct mutants bmp spinal primitive epithelia differentiation transcription growth precursors nuclei throughout

267 items. Top items listed below.

Timed mesodermal FGF and BMP govern the multi-step thyroid specification 118 20 3

Akt is required for artery formation during embryonic vascular development 94 20 3

Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium of Drosophila embryos 118 20 3

Multi-tissue patterning drives anterior morphogenesis of the C. elegans embryo 118 20 18

A spatially resolved single cell atlas of human gastrulation 118 20 9

Eomesodermin is functionally conserved between zebrafish and mouse in spite of different mutant phenotypic severities, and controls left/right organiser formation via interlocking feedforward loops 118 20 3

From local resynchronization to global pattern recovery in the zebrafish segmentation clock 118 7

Furry is required for cell movements during gastrulation and functionally interacts with NDR1 118 20 3

Patterning the embryonic pulmonary mesenchyme 118 20 3

Sox2 and canonical Wnt signaling interact to activate a developmental checkpoint coordinating morphogenesis with mesodermal fate acquisition 118 20 3

Characterising open chromatin identifies novel cis-regulatory elements important for paraxial mesoderm formation and axis extension 118 31 20 9 3

The Drosophila MLR COMPASS-like complex regulates bantam miRNA expression differentially in the context of cell fate 20 3

Epithelial organ shape is generated by patterned actomyosin contractility and maintained by the extracellular matrix 118 55 20 3

The conserved regulatory basis of mRNA contributions to the early Drosophila embryo differs between the maternal and zygotic genomes 31 20 9 5

Essential amnion signals for primate primitive streak formation resolved by scRNA map 118 20 3

Single-cell morphometrics reveals ancestral principles of notochord development 118 20 18

Gastruloids generated without exogenous Wnt activation develop anterior neural tissues 118 20 3

Self-organized patterning of cell morphology via mechanosensitive feedback 118 20 18

A dual role for Axin in establishing the anterior-posterior axis in the early sea urchin embryo 118 20 3

Evolved differences in cis and trans regulation between the maternal and zygotic mRNA complements in the Drosophila embryo 118 20 9 5

A unified mechanism for spatiotemporal patterns in somitogenesis 118 20

Notch Signaling Commits Mesoderm to the Cardiac Lineage 20 3

A single-cell analysis of the molecular lineage of chordate embryogenesis 118 20 9 3

Transcriptome profiling of the branchial arches reveals cell type composition and a conserved signature of neural crest cell invasion 120 118 20 9 3

Modulation of the promoter activation rate dictates the transcriptional response to graded BMP signaling levels in the Drosophila embryo 7 3

Geminin is required for Hox gene regulation to pattern the developing limb 118 20 3

Gain of gene regulatory network interconnectivity at the origin of vertebrates 118 20 9 3

Gene regulatory network (GRN) embedded agents connect cellular decision making to human pluripotent stem cell derived germ layer-like pattern formation 118 20 3

Septate junction proteins are required for egg elongation and border cell migration during oogenesis in Drosophila 118 20 3

Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition 49 20 3

CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish 118 20 3

Spatiotemporal contribution of neuromesodermal progenitor-derived neural cells in the elongation of developing mouse spinal cord 118 20 3

Programmed cell senescence in the mouse developing spinal cord and notochord 118 20 3

Anomalous incisor morphology indicates tissue-specific roles for Tfap2a and Tfap2b in tooth development 118 20 3

Precision of Tissue Patterning is Controlled by Dynamical Properties of Gene Regulatory Networks 118 20 9 3

Morphogenesis is transcriptionally coupled to neurogenesis during peripheral olfactory organ development 118 20 3

Apical Constriction Reversal upon Mitotic Entry Underlies Different Morphogenetic Outcomes of Cell Division 118 20 3

Multidimensional Chromatin Regulation of Cell Lineage Differentiation in a Metazoan Embryo 118 20 9 3

Geometric models for robust encoding of dynamical information into embryonic patterns 118 20

An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution 118 20 9 3

A Transgenic System for Targeted Ablation of Reproductive and Maternal-Effect genes 118 20 9 3

Cadherin clustering controls heterogeneous, asymmetric junction dynamics during vertebrate axis elongation 118 55 20 18 8 3

Spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation 118 20 3

Mechanism of cell polarisation and first lineage segregation in the human embryo 118 20 3

A regulatory program for initiation of Wnt signaling during posterior regeneration 192 118 20 3

Independence of 3D chromatin conformation and gene regulation during Drosophila dorsoventral patterning 89 7 3

The Wg and Dpp morphogens regulate gene expression by modulating the frequency of transcriptional bursts 118 20 3

Spatiotemporal single-cell RNA sequencing of developing hearts reveals interplay between cellular differentiation and morphogenesis 120 20 9 3

Spatiotemporal expression of regulatory kinases directs the transition from mitotic growth to cellular morphogenesis 118 20 3

Adrenergic activation modulates the signal from the Reissner fiber to cerebrospinal fluid-contacting neurons during development 118 20 3

Variability of an early developmental cell population underlies stochastic laterality defects 118 20

Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry 118 20 3

The tolerance to hypoxia is defined by a time-sensitive response of the gene regulatory network in sea urchin embryos 118 20 3

Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites 118 20 3

Growth factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development 118 20 3

Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans 20 3

Cell state transitions and collective cell movement generate an endoderm-like region in gastruloids 118 20 3

Rab7 mediates Wnt-dependent mesoderm patterning and gastrulation in Xenopus 118 20 3

A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development 118 20 3

Suspensor-derived somatic embryogenesis in Arabidopsis 118 20 16 3

Gene-environment interactions characterized by single embryo transcriptomics 118 20 3

Evolutionarily conserved regulation of embryonic fast-twitch skeletal muscle differentiation by Pbx factors 118 20 3

Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure 118 20 3

Correct regionalisation of a tissue primordium is essential for coordinated morphogenesis 118 20 3

In vitro endoderm emergence and self-organisation in the absence of extraembryonic tissues and embryonic architecture 118 20 3

Flexibility and constraint in preimplantation gene regulation in mouse 118 20 9

Single cell visualisation of mir-9a and Senseless co-expression during Drosophila melanogaster embryonic and larval peripheral nervous system development 118 20 3

A novel Golgi-associated Vangl2 translational variant required for PCP regulation in vertebrates 118 20 3

Cell Fate Clusters in ICM Organoids Arise from Cell Fate Heredity & Division - a Modeling Approach 118 20

Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell fates in embryonic stem cells 20 3

Light-Sheet Fluorescence Imaging Charts the Gastrula Origin of Vascular Endothelial Cells in Early Zebrafish Embryos 118 20 18 4

Dual function of perivascular fibroblasts in vascular stabilization in zebrafish 94 20 3

Differential expression of transposable elements in stem cell lineages of the preimplantation embryo 81 20 9 3

Early neurulation recapitulated in assemblies of embryonic and extraembryonic cells 118 20 3

Dynamics of the cell fate specifications during female gametophyte development in Arabidopsis 118 16 3

A dynamic and spatially periodic micro-pattern of HES5 expression underlies the probability of neuronal differentiation in the mouse spinal cord 118 20 3

Implantation and Gastrulation Abnormalities Characterize Early Embryonic Lethal Mouse Lines 118 20 9 3

Intronic enhancers regulate the expression of genes involved in tissue-specific functions and homeostasis 20 9 3

Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature 118 55 20 3

A Reaction-Diffusion Network model predicts a dual role of Cactus/IκB to regulate Dorsal/NFκB nuclear translocation in Drosophila 118 3

A multiscale analysis of early flower development in Arabidopsis provides an integrated view of molecular regulation and growth control 118 9 4

Interplay between medial nuclear stalling and lateral cellular flow underlies cochlear duct morphogenesis 118 20 3

System-level analyses of keystone genes required for mammalian tooth development 120 20 9 3

Dynamics of primitive streak regression controls the fate of neuro-mesodermal progenitors in the chicken embryo 118 20

Lmo7a Coordinates Neural Crest Migration and Lineage Specification by Regulating Cell Adhesion Dynamics 118 20 3

Cell intercalation driven by SMAD3 underlies secondary neural tube formation 118 20 3

CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression 89 31 20 3

Pdgfra and Pdgfrb genetically interact in the murine neural crest cell lineage to regulate migration and proliferation 118 20 3

Gradient in cytoplasmic pressure in the germline cells controls overlying epithelial cell morphogenesis 118 20 3

Temporal coordination of collective migration and lumen formation by antagonism between two nuclear receptors 118 20 3

Computational Modelling of Cell Movements and Aggregations during Kidney Organogenesis 118 38 20

Ciliary signaling-patterned smooth muscle drives tubular elongation 118 20 3

BMP signalling directs a fibroblast-to-myoblast conversion at the connective tissue/muscle interface to pattern limb muscles 118 20 3

Transcriptional control of apical protein clustering drives de novo cell polarity establishment in the early mouse embryo 20 3


Systematic comparison of developmental GRNs explains how novelty is incorporated in early development 118 20 5

A spatiotemporal translatome of mouse tissue development 120 9

X-chromosome dosage compensation dynamics in human early embryos 118 20 9

Multiscale analysis of single and double maternal-zygotic Myh9 and Myh10 mutants during mouse preimplantation development 118 20 3

Cytokinetic abscission is part of the mid-blastula transition switch in early zebrafish embryogenesis 118 20 3