Topic 142

cancer tumor oncogenic cancers suppressor tumors mutations biology tumorigenesis transcriptional driver genes somatic gene cells expression proliferation oncogene cell oncogenes mutation progression mutational normal malignancies tp53 alterations transcription loss therapeutic kras malignant aggressive patient drive human myc transformation leukemia frequently development driven factor adenocarcinoma metastasis epigenetic regulator chromatin mutated lymphoma lines survival drivers braf novel associated pathways genetic colorectal activation aberrant growth promote melanoma patients signaling wnt targets mechanisms metastatic crispr tissue lineage regulatory tumorigenic deregulation dna tcga identify gain reprogramming epithelial including breast initiation lung differentiation mediated p53 mutant pathway subtype program aml poor programs key catenin most role

167 items. Top items listed below.

Induction of intracellular wild-type p53 amyloids leading to cellular transformation and tumor formation in mice 142 108 14 3

The Oncogenic Function of PLAGL2 is Mediated via Specific Target Genes Through a Wnt-independent Mechanism in Colorectal Cancer 142 108 14 3

Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation 142 108 14 9 3

SMARCA4 supports the oncogenic landscape of KRAS-driven lung tumors 142 108 14 3

Three-dimensional Genome Organization Maps in Normal Haematopoietic Stem Cells and Acute Myeloid Leukemia 142 31 14 3

Single cell analysis of colorectal cancer identifies mitogen-activated protein kinase as a key driver of tumor cell plasticity 152 148 142 14 9 3

RRM2B is frequently amplified across multiple tumor types: non-oncogenic addiction and therapeutic opportunities 142 14 9 3

Cellular transformation by combined lineage conversion and oncogene expression 142 108 14 3

Mathematical Model of Colorectal Cancer Initiation 142 14

Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity 142 9 3

Genetic determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo 142 14 10 3

Respiratory complex and tissue lineage drive mutational patterns in the tumor mitochondrial genome 142 14 9 3

HDAC3 regulates senescence and lineage-specific transcriptional programs in non-small cell lung cancer 142 108 14 3

RNF40-dependent epigenetic regulation of actin cytoskeletal dynamics is required for HER2-driven mammary tumorigenesis 142 108 14 3

A non-canonical EZH2 function sensitizes solid tumors to genotoxic stress 142 108 14 3

Use of signals of positive and negative selection to distinguish cancer genes and passenger genes 142 14 9 3

Lineage reversion drives WNT independence in intestinal cancer 142 108 14 3

Allele-specific endogenous tagging and quantitative analysis of β-catenin in colon cancer cells 142 108 3

ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to PARP inhibition in lung cancer 142 14 9 3

DORGE: Discovery of Oncogenes and Tumor SuppressoR Genes Using Genetic and Epigenetic Features 142 9

Snord67 promotes lymph node metastasis and regulates U6-mediated alternative splicing in breast cancer 142 49 14 3

Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma 87 9

Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukemia 31 9 3

Methyl-CpG binding domain protein 2 plays a causal role in breast cancer growth and metastasis 142 14 3

ISL2 is an epigenetically silenced tumor suppressor and regulator of metabolism in pancreatic cancer 108 14 3

A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors 142 108 14 3

Identification of Relevant Genetic Alterations in Cancer using Topological Data Analysis 173 142 14 9 4

Activation of Notch1 drives the development of radiation-induced thymic lymphoma in p53 wild-type mice 142 108 14 3

Differential transcriptional reprogramming by wild type and lymphoma-associated mutant MYC proteins as B-cells convert to lymphoma-like cells 142 9 3

EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma 186 142 31 3

P4HA2 is associated with prognosis, promotes proliferation, invasion, migration and EMT in glioma 98 14 3

Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53-associated features 142 14 9 3

Requirement of DNMT1 to orchestrate epigenomic reprogramming during NPM-ALK driven T cell lymphomagenesis 192 142 108 93 14 3

Loss of prdm1a accelerates melanoma onset and progression 142 14 3

Non-coding germline GATA3 variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemia 142 31 9 3

Hypersilencing of SRRM4 suppresses basal microexon inclusion and promotes tumor growth across cancers 142 108 14 3

RBMS1 suppresses colon cancer metastasis through targeted stabilization of its mRNA regulon 152 142 14 9 3

Aging leads to stochastic loss of silencing at transposons in mammary luminal epithelial cells 81 31 9 3

In silico saturation mutagenesis of cancer genes 142 97 9 4

Mobile Element Insertions and Associated Structural Variants in Longitudinal Breast Cancer Samples 97 9

UHRF1 drives the poor prognosis associated with RB loss in osteosarcoma 108 14 3

IER5, a DNA-damage response gene, is required for Notch-mediated induction of squamous cell differentiation 142 108 14 3

Functional loss of a non-canonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation 142 108 14 3

Integrated genomics and comprehensive validation reveal novel drivers of genomic evolution in esophageal adenocarcinoma 14 9 3

Functional mapping of androgen receptor enhancer activity 31 9 3

G9a methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation 192 142 108 14 3

LSD1 promotes secretory cell specification to drive BRAF mutant colorectal cancer 142 14 3

An integrative oncogene-dependency map identifies unique vulnerabilities of oncogenic EGFR, KRAS, and RIT1 in lung cancer 7 3

Most commonly mutated genes in High Grade Serous Ovarian Carcinoma are nonessential for ovarian surface epithelial stem cell transformation 142 14 9

Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure 89 19 9 4

Identifying Cancer-Relevant Mutations in the DLC START Domain using Evolutionary and Structure-Function Analyses 142 63 3

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through interaction with Host Cell Factor-1 142 108 14 3

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy 152 14 9 3

UBR-Box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target 108 14 3

PIWIL1 Promotes Gastric Cancer via a piRNA-Independent Mechanism 142 49 3

Mutational, transcriptional and viral shedding dynamics of the marine turtle fibropapillomatosis tumor epizootic 142 14 9

A novel role of MNT as a negative regulator of REL and the NF-κB pathway 142 102 31 3

The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGF-beta; signaling in triple-negative breast cancer 142 108 14 3

Oncogenic mutation or overexpression of oncogenic KRAS or BRAF is not sufficient to confer oncogene addiction. 142 108 14 3

Persistent cell proliferation signals correlates with increased glycolysis in tumor hypoxia microenvironment across cancer types 186 9

Oncogenes hijack a constitutively active TP53 promoter in osteosarcoma 142 108 14 9 3

SREBP1 regulates mitochondrial metabolism in oncogenic KRAS expressing NSCLC 108 95 14 3

YAP/TAZ and EZH2 synergize to impair tumor suppressor activity of TGFBR2 in non-small cell lung cancer 74 14 3

A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer 152 142 14 9 3

EFA6B regulates a stop signal for collective invasion in breast cancer 142 14 3

Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation 31 9 3

Machine learning-based investigation of the cancer protein secretory pathway 112 14 9 4

Systematic characterization of somatic mutation-mediated microRNA regulatory network perturbations 74 9

Targeting uncoupling of copy number and gene expression in cancers 142 14 9 3

Subtype-specific epigenomic landscape and 3D genome structure in bladder cancer 31 9 3

PTENP1-AS contributes to BRAF inhibitor resistance and is associated with adverse clinical outcome in stage III melanoma 142 108 14 10 3

Nuclear Transport Factor 2 (NTF2) suppresses metastatic melanoma by modifying cell migration, metastasis, and gene expression 108 14 3

Relationship Between Neuroendocrine and Immune Gene Expression in Small Cell Lung Cancer 14 9 3

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma 108 14 3

UHRF1 suppresses viral mimicry through both DNA methylation-dependent and -independent mechanisms 142 3

The Evolution of Human Cancer Gene Duplications across Mammals 142 21 9 5

Oncogenic KRAS engages an RSK1/NF1 complex in pancreatic cancer 142 108 14 3

Oncogenic H-Ras Signaling Differentially Targets Replicative and Specialized DNA Polymerases for Depletion 7 3

Classic oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer 142 9 3

An Integrative Analysis of the Age-Associated Genomic, Transcriptomic and Epigenetic Landscape across Cancers 87 9

Dampened PI3K/AKT signaling contributes to cancer resistance of the naked mole rat 186 142 108 14 3

Identification of PIM1 substrates reveals a role for NDRG1 in prostate cancer cellular migration and invasion 108 102 14 3

RIT1: A Novel Biomarker in Glioblastoma 186 142 14 9 3

Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to Oesophageal Adenocarcinoma 142 31 9 3

Gene network modeling via TopNet reveals robust epistatic interactions between functionally diverse tumor critical mediator genes 142 14 9 3

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancer 108 14 3

Patient-Derived Mutant Forms of NFE2L2/NRF2 Drive Aggressive Murine Hepatoblastomas 142 108 14 3

Discovery of novel tumor suppressors from CRISPR screens reveals lipid-sensitive subtype of AML 142 14 9 3

LncRNA Hmrhl regulates expression of cancer related genes in Chronic Myelogenous Leukemia through chromatin association 142 9 3

CIP2A interacts with TopBP1 and is selectively essential for DNA damage-induced basal-like breast cancer tumorigenesis 142 108 14 3

Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis 142 108 14 3

STIL a novel link in Shh and Wnt signaling, endowing oncogenic and stem like attributes to colorectal cancer 108 14 3

Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation 142 108 3

PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity 108 14 10 3

PROX1 transcription factor is a master regulator of myogenic and oncogenic features of rhabdomyosarcoma 142 108 14 3

A novel role for the tumor suppressor gene ITF2 in lung tumorigenesis and chemotherapy response 186 14 9 3

Cell-type-specific epigenomic variations associated with BRCA1 mutation in pre-cancer human breast tissues 142 9 3

Pan-Cancer chromatin analysis of the human vtRNA genes uncovers their association with cancer biology. 31 9 3

Loss of CPAP expression promotes sustained EGFR signaling and Epithelial-Mesenchymal Transition in oral cancer cells 98 14 3

The landscape of metabolic pathway dependencies in cancer cell lines 186 9 3